Inner Ear Hair Cell Regeneration — Maybe We Can Know More

[ruben ruiz]

I am in a quandary. I read all this about new possible cures. Yet I dont understand the possibility of getting such cures out to the public. A personal note I cant sleep unless I have meds. It it possible to cure or treat such a person?

 

[lapidus]

"Causative gene for sensorineural hearing loss identified"
https://www.sciencedaily.com/releases/2016/10/161006101029.htm

 

[RB2014]

http://entcolumbia.org/world-s-first-gene-therapy-trial-hearing-loss

I saw this the other day. Is this a different trial than the Novartis one? I wasnt aware of this?

 

[VRZ78]

Yes it's GenVec CGF166

 

[rsmcfar]

Norvartis is a partner with Genvec in the CGF166. It's the same trial.

 

[RB2014]

The reason I was asking is I thought that the trial was in kansas city, not at columbia university? Are they dosing at different places?

News is slow lately. Not much out there.

 

[Mricha37]

I think they are doing multiple locations.

 

[Mricha37]

Anyone have any fun updates they found on the internet? It's been kind of quiet around here

 

[Mario martz]

Anyone have any fun updates they found on the internet? It's been kind of quiet around here

Well i think this is the moment where all the scientist are working on it.
i think well se results next year, 2017 is excited ear wise

 

[Mario martz]

here are some news regarding tinnitus and the ear:

http://www.dailysabah.com/asia/2016...ns-arm-after-he-lost-his-organ-in-an-accident

http://medicalxpress.com/news/2016-11-stem-cells-vitro-deafness.html

http://www.businesswire.com/news/ho...ited-States-Market-Report-Middle-Ear-Implants

 

[spingee]

Anyone have any fun updates they found on the internet? It's been kind of quiet around here

Lets just hope its calm before the storm

 

[Reinier]

I suppose research like this could also eventually be beneficial for NIHL. If only for the gained knowledge about the workings of the inner ear.
http://www.medicalnewstoday.com/releases/314091.php

 

[Penate]

Yeah look like another black Christmas for us , at least for people like me very severe tinnitus and hyperacusiss, the only thing good about is my kids, another year and NOTHING for this horrendous condition.

 

[spingee]

There is bright future ahead of us, with deep learning AI boom today every research will directly or indirectly gain from it, its revolution

 

[Marlino]

There is bright future ahead of us, with deep learning AI boom

This is very likely. I'm following the recent developments of IBM Watson and hope that this technology helps to give hints on how to tackle the t problem.

I think there are so many studies done already and they are of so little use, having only weak confidence level and even are contradictory. An AI screening this huge amount of fuzzy information could really help to understand better what we are missing here.

 

[Marlino]

To give an time estimation:
Another 10 years to achieve AI helpfull to evaluate complex medical data.
( which means 32x more processing power or which is 2x the time since Watson won Jeopardy or age of iphone- just to relate it to other technical time spans)

Another 10 years to use the insights and to develop a treatment.

->in 20 years I estimate a 50% probability of having something helpfull.

 

[spingee]

To give an time estimation:
Another 10 years to achieve AI helpfull to evaluate complex medical data.
( which means 32x more processing power or which is 2x the time since Watson won Jeopardy or age of iphone- just to relate it to other technical time spans)

Another 10 years to use the insights and to develop a treatment.

->in 20 years I estimate a 50% probability of having something helpfull.

I dont undestand, i think its more about gathering enough of data, you can then run super computer for example a year. I mean its not about knowledge or futher reasearch, its just how long you will wait for results.

 

[Marlino]

I dont undestand, i think its more about gathering enough of data, you can then run super computer for example a year. I mean its not about knowledge or futher reasearch, its just how long you will wait for results.

Misunderstanding I guess.
I expect it take take another 10 years for AI to become usefull to evaluate complex, biased, error prone, prosa written, medical data (aka studies).

Calculation time is negligible.

Then it will take another 10 years to do subsequent experiments, studies and trials to eventually have something beneficial.

 

[spingee]

Misunderstanding I guess.
I expect it take take another 10 years for AI to become usefull to evaluate complex, biased, error prone, prosa written, medical data (aka studies).

Calculation time is negligible.

Then it will take another 10 years to do subsequent experiments, studies and trials to eventually have something beneficial.

I think you are too pesimistic I think it is speeding research already

 

[cornelius]

Marlino you are right, it is near 2025 that a common computer is expected to reach a human brain intelligence and near 2050 that it would reach all the human brains from the earth. It is at least guaranteed we would all be fixed if we manage to become old.

 

[Mario martz]

dont wanna sound rude,
but its actually something that its happening everyday.
like i said, right now they are gonna test steam cells for menieres.
and you dont see this in the news.

lets keep it on topic, please!!!!!

 

[Reinier]

something beneficial.

What do you regard as something beneficial?
Don't you expect anything from the Novartis/GenVec trials?
I think it is not black or white.
The first successfully trials will undoubtedly not repair/regenerate everything in the inner ear.
Just parts like nerves or even hair cells at the base of the cochlea where drugs are able to penetrate.

Are you referring to completely map all the processes of inner ear development using AI? Plus for AI to come up with a cocktail of chemicals to regenerate parts of the inner ear?

I expect it take take another 10 years for AI to become usefull to evaluate complex, biased, error prone, prosa written, medical data (aka studies).

Before AI is able to do that and even interpret data we can benefit already considerably from increased computing power.
Perhaps it is wishful thinking on my part.

 

[Marlino]

I think you are too pesimistic I think it is speeding research already

I'm highly optimistic taking into account
a) we currently only know what we do not know about tinnitus.
b) tinnitus bothers mankind for 10.000 years+.

 

[Marlino]

It is at least guaranteed we would all be fixed if we manage to become old.

I don't wanna come pessimistic, but I highly share the concerns about it.

Even if the AI is and stays human friendly the question is about the social impacts on mankind.
First it could start a new cold war of intelligence. Second it could make mankind as useless as horses after henry ford. Third it can lead to a huge depression of useless mankind. Fourth the state of quasi infinite intelligence can also make the AI depressive. Especially if it gets tinnitus.

This topic should have its own thread.

 

[Marlino]

What do you regard as something beneficial?

Something which makes t at least minor annoyance. In other words: when everybody here on tinnitus talk says from day one: Well, I got tinnitus and I can live with it.

 

[Marlino]

Are you referring to completely map all the processes of inner ear development using AI? Plus for AI to come up with a cocktail of chemicals to regenerate parts of the inner ear?

Honestly I don't know. But I expect AI to be able to gather and evaluate better all data we have first. This is what I understand the European Research Initiative tries as well. But still with human brains so far. Another example is Cochrane, which is evaluating studies on meta level.

I think we have a tremendous amount of data available. So many studies, so many patient reports. But it's all fuzzy. Some things seem to help statically significant, like section of the auditory nerve, but are still dismissed and not followed up for decades.

If the AI could find patterns in all the data first and give recommendation on further experiments and then finally help us to find a treatment, I would be not surprised.

 

[Marlino]

Perhaps it is wishful thinking on my part.

Every night before I go to bed I resume the day and if I come to the result I didn't suffer this day, I am thankful.
This is totally different to 10 month ago when I resumed the day only occasionally and evaluated it only for what I'd achieved.

So low demands and wishful thinking are crucial to survive, I guess.

 

[Mentos]

Every night before I go to bed I resume the day and if I come to the result I didn't suffer this day, I am thankful.
This is totally different to 10 month ago when I resumed the day only occasionally and evaluated it only for what I'd achieved.

So low demands and wishful thinking are crucial to survive, I guess.

I do more or less the same. Everyday at the end of the day I consider it a sucess if I managed to go through the day without being close to panic or treating T as minor annoyance. Luckily I have more and more days like that when obviously I didn't like my T, but I was not suffering emotionally because of it. Which means living one day at a time, without thinking about the future and the past but only focusing on current day and my emotional reaction to T (preferrably luck of emotional reaction to T).

 

[Marlino]

Which means living one day at a time, without thinking about the future and the past but only focusing on current day and my emotional reaction to T (preferrably luck of emotional reaction to T).

I would like to discuss that with you.
I will put this into a new thread under support.

 

[rsmcfar]

http://www.express.co.uk/news/scien...congenital-deafness-birth-scientists-research

Link came through in my google news feed.