Inner Ear Hair Cell Regeneration — Maybe We Can Know More

[Foncky]

If you are so worried about your T levels, you may have read that noise-cancelling headphones have made it worse for some people.

You don't want to end your life. You want your T to stop and I get that, me too. It's loud and prevents me to just live. So don't be so pessimistic and angry, there are many things going on right now. People in the scientific field care about us. It's a new trend, that was not the case 10 years ago. Give it a little bit more time.

 

[lolkas]

@Christian78 man tge only thing i can tell you us we do feel your pain here. i dont have T as bad as you and it is torture for me so i understand what you are through on daily basis. please dont end your life like that. If things are so unberable for you - sign up to be on of these people that would not mind going through experiment with stem cells. i am sure big shots in research would be glad to have some one that they can test new approach without lengthy process of official human trials.

Also, please dont use active noise cancelling headphones! they actually produce "negative" sound wave that you dont hear much but it effectively screws up your cochlea. i wanted to buy these bose headphones - went to store, tried and moment i turned on noise cancelling feature my head almost exploded and i threw them sh*ts aeay.

If you want true noise cancelling, you need Shure SE215 with fiam tips or etymiotic earbuds.

 

[lolkas]

I did not follow too deeply Ateos experience with stem cell therapy, did finally his T symptoms improved after his treatment in Thailand?

I think it did improve but he got IV with stem cells, no one from this forum or on any resourse had them shot in to cochlea.

 

[lymebite]

I did not follow too deeply Ateos experience with stem cell therapy, did finally his T symptoms improved after his treatment in Thailand?

The story and results of ATEOS are posted on his TTalk profile page at this link (click the "Information" tab). For stem cells he reports: "Result: Approximately 50% improvement in tinnitus loudness (both ears)."

https://www.tinnitustalk.com/members/attheedgeofscience.1629/

 

[serendipity1996]

Reading the past few pages of this thread has been really quite uplifting, I think we have reason to be cautiously optimistic about the future. Idk about any of you but I've gone from viewing my hearing damage as a 'life sentence' to something that will be fixed....it's just a waiting game. I'm not nearly as knowledgeable as some of the members on this forum but I really think we are finally reaching a point where our understanding of the inner ear is such that we will see some very exciting advances in the coming years!

 

[tomytl]

Frequency Therapeutics finally updated their webpage with a very optimistic approach described in following link.

http://www.frequencytx.com/our-approach/hearing-and-beyond.php

 

[lolkas]

Frequency Therapeutics finally updated their webpage with a very optimistic approach described in following link.

http://www.frequencytx.com/our-approach/hearing-and-beyond.php

This is most informative and yet technically correct article i have seen, nice. However i don`t see any timelines for their therapy to be available.

 

[Christian78]

That is not what we want to hear (-;
But I am glad that you take the effort to post this on this forum. What I understand is that you are very knowledgeable.
It is so easy to get get caught up in a frenzy of hope.
I just hope that there is room for relief between where we are no and an actual cure for inner ear hair cell/nerve damage.
Also @Aaron123 an excellent post. I downloaded the document you suggested.
Read, read, read...that is all I can do at the moment.
In a few years time I will be able to better understand the different research. Especially the ones that are written for the layman (-;
I hope in the meantime natural adaptation of my brain will make this condition more bearable.
Patience..........

If it gets effective beleave me country as Turkey will push to make it happen for europe... their laws are not so strict. Hair transplantation with proces of reseeding 4000 hairs one by one, is 2000€ (inluding taxy from airpot, + hotel 3 night + all medication needed for operation and after operation + online check up by doctor ((in medication goes in blood plasma that is very expencive + they do HIV + STD + hepatit test and ordinary blood tests))

So I think if this proves to have effect Turkey will do it in a blink of eye

 

[Christian78]

Hearing loss cures in 5-10 years? No way. Not a chance. Also, one doesn't simply inject stem cells into the ear and expect hair cells and nerve fibers to be replaced. This thread has completely lost touch with reality.

It will not be cured, but it may maybe help up tome limit.

NEVER WILL PRODUCERS OF HEAIRNG AID LET THEIR MONEY TO GO AWAY. NOTE MY WORDS. MONEY IS MOST IMPORTANT THING ON THIS PLANET. IT KILLS MILLIONS OF PEOPLE PER YEAR BY POLLUTION, POLLUTED WATER, ILLNESSES THAT HAVE CURE. SO DONT BE NAIVE MONEY RULES, AND MONEY KNOW NOTHING BUT ITSELF, UNLESS DEAF PEOPLE WILL PAY PER MONTH INSTED OF HEARING AID IT IS STUPID TO PRODUCE PERMANENT SOLLUTION.

IF I WERE BILLIONARE AND HAD A HEARING AIDS COMPANY I WOULD DO ALL THAT TECHNICAL STUFF OF THOSE PRODUCES GET INTO EXCIDENT LIKE PLAIN CRUSH, CAR CRUSH, OR SIMPLY THEIR FAMILLY GET EXPLAINED THEY WILL NOT EXIST IF THEIR FAMILLY MEMBER CONTINUE RESERS. I DONT CARE FOR PEOPLE I CARE FOR MY MONEY.

SO THEREFORE:

Money is GOD, and it is mine, and I will never ever as long as i can alow some thing to be produced and i lose those people whom I am milking and getting money from 70 million people. I am not going to alow it and so it is simple. I seen people beeng taken out... dont think it is funny it is truth... Guys in croatia were inventing sounds for tinnitus that proved effective for people with good hearing and then they suddenly stopped, and after it one of them had excident where his car just simply hit a bump on a road and was smashed in peaces.

Dont imagine things that even if there are people who produce cure will let them be exposed, they will do a tests in hiding to avoid this happening to them, and than they will sell their product to some rich monster who can protect them. Unless that monster ressel product to owners of heairng aid producers, and ENT universaties.

Company rules today by money. Democracy is story, imagination, people thing they go and vote for someone cos he is going to represent them, please... wake up... democracy does exist only in theory

 

[tomytl]

This is most informative and yet technically correct article i have seen, nice. However i don`t see any timelines for their therapy to be available.

yes, there is no timetable but it
looks like they following solid research.
MIT and Harvard sounds good and some people on the board have a top reputation.
Do you guys think it's siRNA method? If so, I think it will take some time using this approach....

 

[tomytl]

There is an interview with the CEO of Pharma Company Novartis in a Swiss boulevard online mag.
It's in German. He especially speaks from their next generation of therapies they want to release and he especially mention muscle and hearing regeneration.

http://www.blick.ch/news/wirtschaft...erden-dramatisch-laenger-leben-id5848142.html

 

[HomeoHebbian]

This is most informative and yet technically correct article i have seen, nice. However i don`t see any timelines for their therapy to be available.

Frequency Therapeutics is a spin out from a technology developed under the guidance of Albert Edge at Mass. Eye and Ear Infirmary and Bob Langer, a serial entrepreneur/scientist from MIT of great renown. The company is young and, last I heard, is still in pre-clinical testing (i.e., animal models).

Yes, they inject the compound into the ear. Where else would they "deliver" it? It's whats in the syringe that matters. One of the company's founders worked on inner ear stem cell biology for his PhD thesis at Mass. Eye and Ear. I'm not sure what approach they are pursuing for their first product.

 

[Zeneth]

This is great! whether tinnitus is caused by a sinus infections or something other than hearing loss, the problem is that the cochlea hair cells are damaged! which causes T, so if we can regenerate them or heal them then tinnitus should massively reduce or even go away, hopefully this comes to America soon!

 

[Mricha37]

Well Atoh1 results will be announced in 2017. That will give us a good idea of where this whole regeneration stands as it is a US approved clinical trial.

 

[Mricha37]

FGF20 Gene discovered. Check this out! In other articles I have read, it seems scientist have grown hair cells rather easily outside the body, just delivering healthy cells to the inner hear seems to be a big roadblock :-/ But these scientists seems to think they could activate the dormant FGF20 gene to repair inner ear hair cells. Definitely have some hurdles but I'm excited about all these discoveries and advancements.

http://reflectionofmind.org/scientists-discover-cure-deafness-hearing-loss/

 

[Aaron123]

FGF20 Gene discovered. Check this out! In other articles I have read, it seems scientist have grown hair cells rather easily outside the body, just delivering healthy cells to the inner hear seems to be a big roadblock :-/ But these scientists seems to think they could activate the dormant FGF20 gene to repair inner ear hair cells. Definitely have some hurdles but I'm excited about all these discoveries and advancements.

This is old news. Here's a story from 2013: http://www.hear-it.org/discovery-of-gene-brings-treatment-for-hearing-loss-a-step-closer and the paper is from 2012 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3250500/

 

[Rings-a-Bell]

Regenerative therapy using Stem Cells in wired news: https://www.wired.com/2016/12/future-regenerative-medicine-inject-see/

 

[Mricha37]

Regenerative therapy using Stem Cells in wired news: https://www.wired.com/2016/12/future-regenerative-medicine-inject-see/

This!

 

[Stephen1144]

I think there's no sense of urgency in the medical field because tinnitus isn't life threatening as far as physical death from it is concerned. Just my opinion.

But I would think that the money to be made would motivate them.

 

[Foncky]

What do you think about Frequency TX work ? It seems like they are onto something with the Lgr5+ thing.

A study involving Lgr5+ cells transdifferentiation : https://www.ncbi.nlm.nih.gov/pubmed/25849379

"Both Type I and II HCs are regenerated, and regenerated HCs display stereocilia and synapses."

Brilliant, isn't it ?

 

[VRZ78]

What do you think about Frequency TX work ? It seems like they are onto something with the Lgr5+ thing.

A study involving Lgr5+ cells transdifferentiation : https://www.ncbi.nlm.nih.gov/pubmed/25849379

"Both Type I and II HCs are regenerated, and regenerated HCs display stereocilia and synapses."

Brilliant, isn't it ?

Yeah im sure that with them, Decibel TX, Sound Pharmaceutical, Auris Medical, OT plus all the researchers that are not yet affiliated to a company we will have something at some point... Plus all the research using stem cells...

 

[grate_biff]

What do you think about Frequency TX work ? It seems like they are onto something with the Lgr5+ thing.

A study involving Lgr5+ cells transdifferentiation : https://www.ncbi.nlm.nih.gov/pubmed/25849379

"Both Type I and II HCs are regenerated, and regenerated HCs display stereocilia and synapses."

Brilliant, isn't it ?

I have high hopes for Frequency. They are the only one also, as far as I know, to have treating chronic T as a principle target!

 

[VRZ78]

I don't know if you guys have seen this but it seems pretty cool :

http://stankovic.hms.harvard.edu/optical-imaging-inner-ear

http://stankovic.hms.harvard.edu/files/konstantina-stankovic-md-phd/files/iyeretal2016.pdf

If this thing ever comes out it will help us a lot in knowing what's broken in our ears.

I wonder if that's what Lieberman is going to use to diagnose hidden hearing loss in his patients next summer. But I think that's a bit too optimistic

 

[Rubenslash]

http://www.einnews.com/pr_news/3579...-treat-and-prevent-sensorineural-hearing-loss

 

[VRZ78]

http://www.einnews.com/pr_news/3579...-treat-and-prevent-sensorineural-hearing-loss

Their website: http://www.acousia.com/pipeline/otoregeneration/

So that's 4 companies that are likely to start clinical trials for hearing loss within 5 y or maybe less for one or two

 

[Michael Larsen]

It will be interesting to see which company is hitting the market first with a treatment,
I pray every day that it might also help T.
And what become most effective, stem cells or gene therapy

 

[Reinier]

www.einnews.com/pr_news/357987143/acousia-therapeutics-receives-eur-2-5-million-to-develop-innovative-therapy-to-treat-and-prevent-sensorineural-hearing-loss
This time no "could", "might" or not even "should".
Just: will replace, will develop, will restore....
quote: "The new therapeutic approach will replace lost sensory hair cells, the key cells for hearing in the inner ear, by cellular regeneration originating from supporting cells. Acousia will develop drugs for local application, which will restore hearing in patients who have lost their hearing ability due to various reasons, e.g. noise trauma, treatment with ototoxic drugs or sudden deafness."
I like it, I like it.

 

[Foncky]

Their website: http://www.acousia.com/pipeline/otoregeneration/

So that's 4 companies that are likely to start clinical trials for hearing loss within 5 y or maybe less for one or two

Acousia, Frequency, Audion and Decibel or Sound Pharma ?

 

[VRZ78]

I didn't know about Audion
Strange things though is that Audion, Decibel TX and Frequency TX all involves in their core members scientists from Harvard Medical School and Massachusetts Eye and Ear Hospital.
It's strange that's they are starting différents companies... I hope they are not fooling us

 

[Nathalie]

If there truly was a cure to regenerate cells in the inner ear one day in the near future, I would be the happiest person on the planet. It seems like wishful thinking however, too good to be true. I sincerely hope they will actually find a cure and in about 5 years max. It would be a miracle.