Rubenslash
Member
Boehringer Ingelheim as well
https://www.boehringer-ingelheim.co...collaboration-develop-hearing-loss-treatments
Inner Ear Hair Cell Regeneration — Maybe We Can Know More
- Thread starter Hopeful
- Start date
https://www.boehringer-ingelheim.co...collaboration-develop-hearing-loss-treatments
MemberAcousia work together with Boeringer Ingelheim. Acousia has people with lonh expertise in hair cell research.
It's promising that there is movement in the field...As far I know, Hough Ear / Otologic Pharma will also preparing for tests in 2017.
I think Otologic Pharmaceuticals only has potential treatments that can be used in the acute phase after acoustic trauma. It would not useful for the vast majority of us on this forum.
Hi,
they have something NAC based for prevention and acute treatment in the clinicl trial.
But they licensed another techique from Hough Ear
http://www.prnewswire.com/news-rele...y-from-the-hough-ear-institute-300150403.html
http://www.acousia.com/pipeline/otoregeneration/
Does anybody know anything about this patented small molecule?
Quote:
During their research the scientific founders, Prof. Löwenheim and Prof. Wiesmüller, identified and patented a small molecule – otopotin – that dedifferentiates otic supporting cells into otic progenitor-like cells that proliferate and redifferentiate into hair cell and supporting cell in vitro.
End quote.
Does anybody know anything about this patented small molecule?
Quote:
During their research the scientific founders, Prof. Löwenheim and Prof. Wiesmüller, identified and patented a small molecule – otopotin – that dedifferentiates otic supporting cells into otic progenitor-like cells that proliferate and redifferentiate into hair cell and supporting cell in vitro.
End quote.
- Jul 21, 2013
- 842
- Tinnitus Since
- 01/2013
- Cause of Tinnitus
- Acoustic trauma from headphones
I'm like a 25 minute drive from all those companies. Maybe it's time to network with someone from those places...I didn't know about Audion
Strange things though is that Audion, Decibel TX and Frequency TX all involves in their core members scientists from Harvard Medical School and Massachusetts Eye and Ear Hospital.
It's strange that's they are starting différents companies... I hope they are not fooling us
Wow, there seems to be a lot of movement with these small molecules. Pretty exciting stuff. So is a small molecule considered a stem cell treatment or gene therapy?
Rings-a-Bell
Member
Not a bad idea. It would be great to get updates from them to see how far out we are really looking at before clinical trials can begin.
I hope the first treatment that comes does not include drilling of a hole in the cochlea.
But there is no research to suggest that the establishment of hearing cells could help T ?
But there is no research to suggest that the establishment of hearing cells could help T ?
- Dec 18, 2015
- 618
- 45
- Tinnitus Since
- 03/2015
- Cause of Tinnitus
- Noise induced, loud rock concert
You're right there's no evidence that regenerated hair cells would supress Tinnitus together with improved hearing. That's why my hopes are rather related to repair of demaged nerve fibers connections to hair cells through delivery of growth factors ie. NT3), I trust Liberman and Decibel theory that it's synaptic demage that causes T
- Dec 18, 2015
- 618
- 45
- Tinnitus Since
- 03/2015
- Cause of Tinnitus
- Noise induced, loud rock concert
Yes exactly, but as far as I know they're still like 2 years before to begin clinical trial. Currently they work on diagnostic platform for cochlear synaptopathy
bill 112
Member
I read somewhere that it takes months to years for SGN's to retract back from its corresponding haircell,not sure how accurate that is but just food for thought.
Didn't they also discover that newly formed haircells i.e regenerated haircells formed new connections after regeneration?
- Dec 18, 2015
- 618
- 45
- Tinnitus Since
- 03/2015
- Cause of Tinnitus
- Noise induced, loud rock concert
Unfortunately this may be too late for us. As @Foncky stated there will be a therapeutic window but they don't know yet how long, I'm affraid 5 years might be too long so I rather plan to sign up for clinical trials to gain the time
I hope it's a very slow process, because my T is almost 13 years old 
But I'm sure there is a way to create new nerves along with new hair cells. The problem is : are they going to work as good as the original ones ?
But I'm sure there is a way to create new nerves along with new hair cells. The problem is : are they going to work as good as the original ones ?
Berlin based company AudioCure raises 9 Mio for research.
http://www.finsmes.com/2016/11/audiocure-pharma-raises-e9m-in-funding.html
So at the moment we have a bigger familiy in companies targeting hearing loss and tinnitus
Audion Therapeutics (Netherlands)
Audio Cure (Germany)
Acousia Therapeutics (Germany)
Böhringer Ingelheim (Germany)
Sensorion Pharma (France)
Soundpharmaceuticals (USA)
Decibel Therapeutics (USA)
Frequency Therapeutics (USA)
Otologic Pharma (Oklahoma USA)
Affichem SA (France)
Otonomy (USA)
Auris Medical (Switzerland)
Novartis (Switzerland)
Roche (Inception3) (Switzerland)
Quark Pharma (USA)
Amazing, 20 years ago there was just one company called Otogene with their regenerative discovery.
This discovery has been further developed by Soundpharmaceuticals and the co fouunder of Otogene now founded Acousia.
http://www.finsmes.com/2016/11/audiocure-pharma-raises-e9m-in-funding.html
So at the moment we have a bigger familiy in companies targeting hearing loss and tinnitus
Audion Therapeutics (Netherlands)
Audio Cure (Germany)
Acousia Therapeutics (Germany)
Böhringer Ingelheim (Germany)
Sensorion Pharma (France)
Soundpharmaceuticals (USA)
Decibel Therapeutics (USA)
Frequency Therapeutics (USA)
Otologic Pharma (Oklahoma USA)
Affichem SA (France)
Otonomy (USA)
Auris Medical (Switzerland)
Novartis (Switzerland)
Roche (Inception3) (Switzerland)
Quark Pharma (USA)
Amazing, 20 years ago there was just one company called Otogene with their regenerative discovery.
This discovery has been further developed by Soundpharmaceuticals and the co fouunder of Otogene now founded Acousia.
There was a study done on mice that saw SGNs deteriorate after just a year, but in humans we see people who have been completely deaf and receive cochlear implants, giving them the ability to hear again after >17 years. The jury is still out on the exact window, but real world evidence tells us it isn't crazy to think it's in the magnitude of years. Probably sooner the better, but even then we'll just have to find a way to regenerate the SGNs,
@attheedgeofscience reported good results from stem cells on TT. He wrote up his experience on his profile page. Click the "Information" tab.
https://www.tinnitustalk.com/members/attheedgeofscience.1629/
His result from stem cells:
"Result: Approximately 50% improvement in tinnitus loudness (both ears)."
His description:
"While I did benefit from LLLT in terms of a hearing improvement, the therapy did little for my tinnitus. After two months of therapy, I therefore decided to pursue other options. As mentioned earlier on, I knew tinnitus is considered incurable by the current medical establishment and so I had to look for uncommon therapies which had not been attempted before i.e. clinical trials or experimental therapies - essentially therapies at-the-edge-of-science. One day while doing research on the Internet, I somehow ended up reading about stem cell therapy. I don't remember the exact circumstances, but one way or another, I found a link to a youtube video featuring the unique story of Chloe Sohl who - so far - is the most successful stem cell recipient for the experimental treatment of hearing loss (presumably because her condition was triggered by an autoimmune disorder). She had regained most of her hearing from the treatment. But there was no mention of tinnitus in the video. I assumed that she probably had suffered from tinnitus as well (after losing almost all of her hearing). I decided to look into this a little further and I was fortunate to discover that her tinnitus improvement was pretty much equal to her hearing loss gain (i.e. approximately 90% improved some 2-3 months post stem cell injections). This was my most important lead and within a couple of weeks I had found and corresponded with three different stem cell clinics who would be willing to offer me a treatment similar to that of Chloe Sohl. I ended up doing two separate stem cell treatments roughly 5 months apart. I have shared my story for both trips (as a journal on this site) and also my reflections on stem cell therapy in general."
But if stem cells really works, there is probably no reason to worry? it's probably just waiting for one of the big firms enter the field, it is not what Frequency Therapeutics is working with?
Solid stem cell research is coming from Standford, Massachussetts Eye &Ear, Univ. of Berne, Univ. of Sheffield etc.
and likely not from some rather strange companies who inject you something (you probably don't know what) globally in the body.
If it would really work that way, we would have a solution now and would at least know something about.
I think that stem cell therapies for the inner ear might be the best but also the most complex task.
I guess that waking up dormant cells in the inner ear will be the first approach to be tested in the human ear.
FrequencyTX and mostly others are working on this. Stem cells are likely to be in Universities for research. Probably Roche Pharma does invest in stem cell approach via inception 3 of Versant Ventures.
Therapy base on stem cells and regenerative médecine are now eligible to a new FDA path that will accelerate their availability for patients in the US :
http://www.sciencemag.org/news/2016...-cell-advocates-expect-regulatory-shortcuts-0
According to the article in the fist version of the law they wanted to make the therapy available to patients as soon as those therapies passed the safety test in clinical trials. Too bad they had to change it to make it pass, but it's something at least
http://www.sciencemag.org/news/2016...-cell-advocates-expect-regulatory-shortcuts-0
According to the article in the fist version of the law they wanted to make the therapy available to patients as soon as those therapies passed the safety test in clinical trials. Too bad they had to change it to make it pass, but it's something at least
Christian78
Member
- Dec 17, 2013
- 965
- Tinnitus Since
- (Sep 2013)
- Cause of Tinnitus
- progressive tinnitus, time of expiring in next 3-6 months
Therapy base on stem cells and regenerative médecine are now eligible to a new FDA path that will accelerate their availability for patients in the US :
http://www.sciencemag.org/news/2016...-cell-advocates-expect-regulatory-shortcuts-0
According to the article in the fist version of the law they wanted to make the therapy available to patients as soon as those therapies passed the safety test in clinical trials. Too bad they had to change it to make it pass, but it's something at least
What will be prices?
The problem is that most of these companies are not even in phase I... some aren't even in preclinical.
And:
Most of these companies talk about curing/improving disabling hearing loss. Very few of these companies talk about curing/improving debilitating tinnitus.
Don't get too excited here!
Most of these companies talk about curing/improving disabling hearing loss. Very few of these companies talk about curing/improving debilitating tinnitus.
Don't get too excited here!
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