Inner Ear Hair Cell Regeneration — Maybe We Can Know More

[tomytl]

The problem is that most of these companies are not even in phase I... some aren't even in preclinical.

Yes right, a soild treatment isn't here right now. First of all, they have to proof, that it's possible
to enhance some hearing threshold in human hearing. Nobody knows exactly if it's really working and
embedding in a damaged inner ear.
But that's subject of these intesitive research.
Maybe in 2017 we get some results of the Genvec/Novartis trial. Ofcourse, we can't expect
that there is already a cure for hearing loss. It will take years again.
But next year will be a new enrolment of clinical trials. Probably Audion/Otologic and Sound Pharmaceuticals
will prepare for trials.
We all wish a cure right now, but this is just not realistic. But things are looking great and there is a big development in the field.
As for tinnitus, I guess recover hearing will at least lower perception of tinnitus.
I have both, hearing loss and tinnitus, and when I'm affected with a cold which steal me some extra decibels, Tinnitus is much louder. In my case, regain some hearing would probably also lower tinnitus.

I'm very happy about all this research and hope for a first treatments in the next years.

 

[RB2014]

Yes right, a soild treatment isn't here right now. First of all, they have to proof, that it's possible
to enhance some hearing threshold in human hearing. Nobody knows exactly if it's really working and
embedding in a damaged inner ear.
But that's subject of these intesitive research.
Maybe in 2017 we get some results of the Genvec/Novartis trial. Ofcourse, we can't expect
that there is already a cure for hearing loss. It will take years again.
But next year will be a new enrolment of clinical trials. Probably Audion/Otologic and Sound Pharmaceuticals
will prepare for trials.
We all wish a cure right now, but this is just not realistic. But things are looking great and there is a big development in the field.
As for tinnitus, I guess recover hearing will at least lower perception of tinnitus.
I have both, hearing loss and tinnitus, and when I'm affected with a cold which steal me some extra decibels, Tinnitus is much louder. In my case, regain some hearing would probably also lower tinnitus.

I'm very happy about all this research and hope for a first treatments in the next years.

I take cold ez when I get a cold. It really helps for after the cold when you spend weeks with less hearing as a result. This last time I did every 2-4 hours and cold was gone in 3 days and my hearing was never affected.

Yes, there is big development happening right now. Agreed, it is going to be a while. I don't check the forums as much anymore everyday hoping to find some miracle answer. It will come, in time.

 

[lolkas]

Solid stem cell research is coming from Standford, Massachussetts Eye &Ear, Univ. of Berne, Univ. of Sheffield etc.
and likely not from some rather strange companies who inject you something (you probably don't know what) globally in the body.
If it would really work that way, we would have a solution now and would at least know something about.
I think that stem cell therapies for the inner ear might be the best but also the most complex task.
I guess that waking up dormant cells in the inner ear will be the first approach to be tested in the human ear.

FrequencyTX and mostly others are working on this. Stem cells are likely to be in Universities for research. Probably Roche Pharma does invest in stem cell approach via inception 3 of Versant Ventures.

"Agree to a degree"

You are right, however i would like to comment on stem cell treatments that are availavle right now.

Current stage of stem cell treatments are on early stage and just starting to get on to their "teens".

Right now clinics are taking stems and injecr either on to "damaged" area or via IV. Direct injections require surgery-like setup at that clinic and very skilled surgeon who will prrform injection.

With IV - simple nurse can petform 50% of entire shebang that neess to be done, other 50% is doctor taking stems, prep in lab, giving all that to nurses when needed and other therapies that come along with this to provide greater regeneration.

With IV approach we are shooting with cannon. Taking whole buch of stem cells and delivering to our blood. Is that good or bad? I think its more question of effectiveness. (I heard only 1 case of cancer after treatment but it is not clear if person had it prior, just never got diagnosed).

Some people get lucky and not only their missaligment got cured but also other things that they havent concidered being "that bi

 

[Rasmus]

Guys i would not trust anyone with stem cells until its officiel by you doctor or hospital or where ever it will be. I will not trust a private company for this :/ not now atleast we will most likely have to wait 3-7 years before it will be officiel :/

 

[VRZ78]

This thing is the future http://www.kyoto-u.ac.jp/en/research/research_results/2015/150616_1.html

 

[jdjd09]

So, are there any real timelines out there for hearing loss cures at this point for minor high frequency hearing loss (high frequency on the hearing tests)? Any idea who is working on a cure, what they are doing, ,when they are doing drug trials, and when they hope to release by?

Sorry for all these questions, but I seriously just want some hope. Mainly for a hearing loss cure.

 

[GregCA]

So, are there any real timelines out there for hearing loss cures at this point for minor high frequency hearing loss (high frequency on the hearing tests)?

No timeline that I know of, just speculation.
Given that we don't have a solid blueprint on how to do it yet, I would assume it's not in the near future, but we may stumble on some unexpected results, for example with stem cells, and from that devise better cures with a faster timeline.
Some of the greatest discoveries in history were accidental (like penicillin). It could happen with Tinnitus.

 

[jdjd09]

I'm mainly talking about hearing loss, not tinnitus. I mean, would 10 years be honestly realistic? I have hears some claim that a couple companies are coming out with trials for hearing loss in the next couple of years. Not to mention the one going on currently.

 

[GregCA]

I'm mainly talking about hearing loss, not tinnitus.

That's what I was talking about too.

 

[VRZ78]

I can't remember which but some of the latest drugs developed but turn the supporting cells into 2 cells: a haircell and a supporting cell, so they won't be any loss.

 

[Mricha37]

I'm mainly talking about hearing loss, not tinnitus. I mean, would 10 years be honestly realistic? I have hears some claim that a couple companies are coming out with trials for hearing loss in the next couple of years. Not to mention the one going on currently.

We are supposed to hear the results of the genvec navartis clinical trials sometime in 2017.

http://ir.genvec.com/press-releases...vides-update-on-hearing-loss-clinical-program

I'm so excited I don't have super high hopes for the trial but I do have high hopes that we are starting to actually do clinical trials to help/cure hearing loss.

 

[Derek D]

We are supposed to hear the results of the genvec navartis clinical trials sometime in 2017.

http://ir.genvec.com/press-releases...vides-update-on-hearing-loss-clinical-program

I'm so excited I don't have super high hopes for the trial but I do have high hopes that we are starting to actually do clinical trials to help/cure hearing loss.

I agree with you I am not sure these trials will work but it is good that we are starting to see work done to fix T

 

[Michael Larsen]

Is there someone who can tell me what the difference is between what Professor Marcelo are doing compared to Genvec

 

[RB2014]

https://hearinglosscure.stanford.ed...ohns-basic-and-translational-research-report/

End of year report from Stanford. Seems like more progress was made.

 

[Coleoptere]

Some optimistic news for 2017: http://journals.lww.com/thehearingj...l_2017_Produce_a_Hearing_Breakthrough_.1.aspx

And:

Like Spoor, Rudden expressed the importance of more collaboration between researchers and independent practices. "As the profession's entrepreneurs, private practitioners are often the first to look outside the box' and find creative ways to maximize patient care AND cost-effectiveness." Citing some examples, "Practicing audiologists could participate even more directly with researchers to design clinical protocols and practical documentation methods, provide beta-testing feedback as well as acting as community liaisons for patient/family outreach to assure best measurable outcomes."

That might speed up things.

 

[RB2014]

http://hearinghealthfoundation.org/...=35122953&bbemailid=2970595&bbejrid=206675653

The HRP Shifts Gears for Greater Impact

 

[Coleoptere]

Before shifting gears the need more money as they put several projects on hold. So take your credit card and donate the money you can miss!

 

[jdjd09]

So, what are the timelines for the different companies/organizations on getting hearing loss cured (I didn't say tinnitus, I said hearing loss)? I make that distinction to focus in on my question.

All I want is to know a cure is likely n the next 10 years (or close to it). I just want to recover my hearing to a "normal level" in the 12kHz and below range.

 

[Anonymous2929]

So, what are the timelines for the different companies/organizations on getting hearing loss cured (I didn't say tinnitus, I said hearing loss)? I make that distinction to focus in on my question.

All I want is to know a cure is likely n the next 10 years (or close to it). I just want to recover my hearing to a "normal level" in the 12kHz and below range.

No timeline from any company/organisation.

No cure very unlikely now or in 10 years time. Too little knowledge and too much yet left to discover about the inner ear

I been deaf for 28 years Jd...has anything came out apart from cochlear implants and better hearing aids...nope

 

[Amber]

So, what are the timelines for the different companies/organizations on getting hearing loss cured (I didn't say tinnitus, I said hearing loss)? I make that distinction to focus in on my question.

All I want is to know a cure is likely n the next 10 years (or close to it). I just want to recover my hearing to a "normal level" in the 12kHz and below range.

Cure is not likely in 10 years.

You have been told this a number of times. Try to accept it.

When there is a prospect of a cure coming in 5 to 10 years, you will know about it. It will make international headlines.

 

[jdjd09]

Cure is not likely in 10 years.

You have been told this a number of times. Try to accept it.

When there is a prospect of a cure coming in 5 to 10 years, you will know about it. It will make international headlines.

There is headlines that say it is happening. They just don't give timelines sometimes. I don't accept that because there are people saying that it is occurring. I have heard both stories on here.

 

[jdjd09]

No timeline from any company/organisation.

No cure very unlikely now or in 10 years time. Too little knowledge and too much yet left to discover about the inner ear

I been deaf for 28 years Jd...has anything came out apart from cochlear implants and better hearing aids...nope

The coclear implant came out, which prevents total deafness, so things are progressing. And lots of companies are coming out with stuff too they say. Just no one is saying a timeline is all. This is why I ask. I feel someone out there has some timelines.

 

[Mricha37]

I don't know, seems like the top researchers in the world say that we are pretty close....but hey, what do they know! I'll believe the internet doctors on this forum instead.

We seem to have a pretty solid grasp on how the inner ear works and how we hear.

 

[Foncky]

The coclear implant came out, which prevents total deafness, so things are progressing. And lots of companies are coming out with stuff too they say. Just no one is saying a timeline is all. This is why I ask. I feel someone out there has some timelines.

Around June 2044 I heard.

Man, never trust someone who will give a timeline, there is none. That doesn't mean it can't be close, it's just not how it works.

Ask your therapist why you always ask this very question and work on it to get better, in the meantime.

 

[Mricha37]

Can't really have a timeline for research like this. Just be happy there is forward progress and we're actually in clinical trials. Just be patient and live your life. Again, back when I got T in 2008, there was literally ZERO updates like there is today.

 

[Juan]

Can't really have a timeline for research like this. Just be happy there is forward progress and we're actually in clinical trials. Just be patient and live your life. Again, back when I got T in 2008, there was literally ZERO updates like there is today.

There is probably more research and more awareness about T and H today, although - on the downside - some literature has been discussing T for like 20-30 years and there are not great advances.

Also, some of the renowned doctors that have been writing about T like Baguley or McKenna wrote things that probably dont hold true any more. Have a look at "Living with tinnitus and hyperacusis". The approach these doctors use to explain and give advice about T and H is so basic and plain wrong in many instances. And these are considered well-know "researchers".

Probably (and hopefully) some people today are more serious about their advice and research.

 

[Coleoptere]

No timeline from any company/organisation.

No cure very unlikely now or in 10 years time. Too little knowledge and too much yet left to discover about the inner ear

I been deaf for 28 years Jd...has anything came out apart from cochlear implants and better hearing aids...nope

I very much admire that you can live with that and I hope that you will enjoy the cure in your lifetime. I think a cure and improvements are different things. I do expect improvements within 10 years. A cure in which the medics are in full control will likely take more than 10 years.

 

[Vinnitus]

I very much admire that you can live with that and I hope that you will enjoy the cure in your lifetime. I think a cure and improvements are different things. I do expect improvements within 10 years. A cure in which the medics are in full control will indeed take longer.

Improvements will be enough for a lot of us I guess. Especially those with cochlear synaptopathy, as their (noise) damage is in early stages and probably didn't affect the stereocilia too much (explaining the normal tresholds).

 

[cornelius]

Improvements will be enough for a lot of us I guess. Especially those with cochlear synaptopathy, as their (noise) damage is in early stages and probably didn't affect the stereocilia too much (explaining the normal tresholds).

There were some records (but I don't remember when and where) implying that cochlear synaptopathy was even responsible for some substantial threshold drops which could mean double hope for most of us if grown factors become the first treatment available

 

[RB2014]

I dont know about a cure, but we could see things that come out that provide improvements to hearing. All of those startup companies will probably go bankrupt in less than 10 years and investors don't like to wait that long for their money so we could see some good things come in the near future. There is also a race to see who gets there first and is able to reap all those billions of dollars in unclaimed cash for the victor.
I am pretty hopeful that Decibel and Frequency will have something to us in less than 10 years and I think all of the research will continue to build upon itself.
The HRP is 5 years into its 10 year promise. They said it was harder than they thought, but they are making progress. We might see something that provides a 20 or 30 percent hearing gain, along with help with balance in the next 5 to 10 years.