Inner Ear Hair Cell Regeneration — Maybe We Can Know More

[tomytl]

Thanks for motivation, guys! I have also close contact to a top hair cell researcher for years and he once told, that he is very optimistic and excitied about their findings.... ofcourse, he can't say anything in years, but it's about his vision and his deepest interest to help us suffering people.
And I think Hudson is also right, for the Pharma, this unmet market has huge pontential...

So head up again and wait the next positive news.

By the way: Genvec will held a presentation next week:
http://ir.genvec.com/phoenix.zhtml?c=124130&p=irol-newsArticle&ID=1905264&highlight=

 

[tomytl]

Stem Cell Clinical Trial
http://www.hearingloss.org/content/research-treatment-sensorineural-hearing-loss

 

[NeoM]

@Hudson I agree there's potential for a company to make significant money, especially if it's the only company with a treatment. They don't even have to cure hearing loss really to make this money, but instead offering something that could say...restore 50% of someone's hearing. Same principle in regards to tinnitus too.

I think within the next 30 to 40 years there will most definitely have to be some type of treatment because you figure that 10 to 20 years should be enough for them to get the science to a level where they can perhaps have multiple treatments to clinically try.

@Champ I agree that just taking one or two at their word isn't that great, but who knows. The other person in the article, I think Ruebel (sp?), stated 20 years. The Hearing Restoration Project (HRP) and the Stanford Initiative to Cure Hearing Loss really both began I think in 2012. Both have roughly the same time line of 10 years for a cure and if you follow the HRP's time line then the upper limits time wise for this is about 13 years before clinical testing. However, I really don't know because I'm not a researcher.

I'm definitely interested to see how the Genvec clinical goes and whether it's effective at all or safe.

 

[rainman]

http://www.futuretimeline.net/21stcentury/2022.htm

In the final quarter of the page "Deafness is fully curable" by 2022. I think it's a pretty reasonable prediction. I hope by then it's going to be widely available and some of it covered by health care - very optimistic, i know.

 

[tomytl]

A interesting meeting takes place at the 8th of march.
Stefan Heller from Stanford Hearing Loss Cure will present latest
info in Hair Cell Regeneration. There must be a webcast

http://us2.campaign-archive1.com/?u...al&utm_source=twitter.com&utm_campaign=buffer

 

[tomytl]

When the researchers speak about HCR

 

[NeoM]

A interesting meeting takes place at the 8th of march.
Stefan Heller from Stanford Hearing Loss Cure will present latest
info in Hair Cell Regeneration. There must be a webcast

http://us2.campaign-archive1.com/?u...al&utm_source=twitter.com&utm_campaign=buffer

I would like to see what he says. So if there isn't a webcast, then maybe hopefully they will record it and post it online.

 

[GMac14]

Man, I really wish my ears could have waited 10 years before giving up on me.

 

[NeoM]

Man, I really wish my ears could have waited 10 years before giving up on me.

It's ok. I have a feeling we're both gonna make it.

 

[katriina]

Man, I really wish my ears could have waited 10 years before giving up on me.

Same here... And with my luck I get some other thing which is not curable just before tinnitus can be cured... Knocking on wood! Haha well trying to stay positive...

 

[frohike]

So, deafening a bird, for example, it turns out to be a very temporary, thing. Within several weeks, all of the dead sensory cells, the damaged sensory cells, will be replaced by new cells.

WANT!

 

[tomytl]

Small Interview wih Chairwoman of the hearin health foundation Shari Eberts

http://www.earnestparenting.com/201...gn=Feed:+EarnestParenting+(Earnest+Parenting)

 

[tomytl]

Today's/Tonight's (where ever you are located) genvec presentation about their haircell regeneration strategy.
http://ir.genvec.com/phoenix.zhtml?c=124130&p=irol-newsArticle&ID=1905264&highlight=
you can register here to see the webcast:
http://wsw.com/webcast/roth28/GNVC/

 

[Grace]

Same here... And with my luck I get some other thing which is not curable just before tinnitus can be cured... Knocking on wood! Haha well trying to stay positive...

Lol i have shitty luck too that would be my luck also... But its not happenin! Will be curedddd!!!!!

 

[katriina]

Small Interview wih Chairwoman of the hearin health foundation Shari Eberts

http://www.earnestparenting.com/2014/03/08/the-hearing-health-foundation-sees-a-possible-cure-for-hearing-loss-tinnitus/?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed: EarnestParenting (Earnest Parenting)

They are saying that cure for tinnitus could be here in 10 years, it woud be silly if even before that there wouldn't be any treatment to reduce the sound! And after ten years I'm only 28 so I guess I have many years of silence left Imagine how weird it's going to be when we can sleep in TOTALLY SILENCE again... I bet that I still have to keep my white noise maskers beside me because they have been there for so long and I can't sleep without them anymore haha

 

[Hudson]

They are saying that cure for tinnitus could be here in 10 years, it woud be silly if even before that there wouldn't be any treatment to reduce the sound! And after ten years I'm only 28 so I guess I have many years of silence left Imagine how weird it's going to be when we can sleep in TOTALLY SILENCE again... I bet that I still have to keep my white noise maskers beside me because they have been there for so long and I can't sleep without them anymore haha

Some guarded optimism is in order. I firmly believe there will be treatments available, either something that keeps tinnitus from getting worse or reduces the symptoms to a degree. I don't know if there will be anything that totally silences it in that time frame, but hell, I could be totally wrong. 10 years goes by much quicker than you think.

To quote Pink Floyd:

"And then one day you find,
ten years have got behind you,
No one told you when to run,
You missed the starting gun"

 

[JohnG]

http://www.cell.com/neuron/abstract/S0896-6273(12)00953-1

"The drug, codenamed LY411575, triggers the regeneration of sensory hair cells."

Seems doable before 10 years.

 

[JohnG]

good video on the right

 

[katriina]

I always think smartphones when we have to speak about timelines, it seems like it was just yesterday when they developed the first touchscreen phone and now we have iPhone 5!

 

[JohnG]

Opps, tried to post a link and it failed. But Google: Neuron, Volume 77, Issue 1, 58-69, 9 January 2013

It has a nice video on the right

 

[JohnG]

seem doable before 10 years with Notch inhibition.

 

[Erlend]

Seriously, regardless of its potential to help me; hacking biology like this, millions of years of evolution is amazing. I follow the iphone jailbreaking community, and it's all about finding vulnerabilities in apples code, feels a lot like this. Find a piece of code in the human body that we can exploit and turn to our advantage!

 

[Stina]

I always think smartphones when we have to speak about timelines, it seems like it was just yesterday when they developed the first touchscreen phone and now we have iPhone 5!

By 20124 mobiles shall be so small we will be able to see them only under a microscope

 

[rainman]

Theyll be so smart that its going to be Planet of the Phones, we are their slaves by then.

 

[GMac14]

Theyll be so smart that its going to be Planet of the Phones, we are their slaves by then.

And then the ringing will NEVER STOP!

 

[tomytl]

Did you guys see the GenVec presentation? So they will start there clinical programm with human patients soon for safety and efficacy.
I think, it's looking a way positive. From what I understood, the delivery adenovirus is
FDA approved?
You can watch the presentation webcast (but you have to switch the slides by your self, upper right)
http://ir.genvec.com/phoenix.zhtml?c=124130&p=irol-newsArticle&ID=1905264&highlight=

Greets
tomytl

 

[JohnG]

Did you guys see the GenVec presentation? So they will start there clinical programm with human patients soon for safety and efficacy.
I think, it's looking a way positive. From what I understood, the delivery adenovirus is
FDA approved?
You can watch the presentation webcast (but you have to switch the slides by your self, upper right)
http://ir.genvec.com/phoenix.zhtml?c=124130&p=irol-newsArticle&ID=1905264&highlight=

Greets
tomytl

Thanks for that link Tomytl...I had to miss it. I remember about 20 years ago in university, I studied how inert viruses could be a vector to deliver treatment (like retroviruses) to splice in RNA/DNA sequences at specific loci. I'll watch this. Like one poster said..this is hacking nature like the jailbreak of the iPhone. But the iPhone is a simple ARM processor...crap really. The DNA is governed by many proteins that turn on/off replication for little protein factories that will make some protein that up/down regulates some part of the cell. Waaay more cool than a crappy iPhone. I'll go through this...

 

[JohnG]

Listened to GenVec. They claim 2 months out...regeneration has been observed in animal models. So the phase I trails will have an efficacious dose from the first patient. So this is happening fast if they are already talking about phase I FDA trials and getting a Novartis milestone after treating the first patient.

Interesting...too...an ENT will drill a hole in the staple..push in the syringe and inject the adnovirus.

 

[Stina]

Does this mean that they are basically ready to try regenerate cells in human? (After phase I of course) They are moving very fast then. I thought trials would be possible after decades....

 

[tomytl]

Does this mean that they are basically ready to try regenerate cells in human? (After phase I of course) They are moving very fast then. I thought trials would be possible after decades....

Yes I think they will do some human trials soon. The adenovirus transport was used in other trials with safety, from,what I understood.
So they probably can go forward to PhaseI to test safety and effacity of the regeneratimg drug.....
Would be interestimg what other researchers find about. So they also think, they can regenerate hearing in adults.
Very interesting, if it really works.