I need to take a break from Tinnitus Talk lol. The seed of doubt this study has planted in our minds for regenerative medicine is stressful. I would be pissed if I spent 10s of thousands on these drugs and it didn't do anything for noxacusis, although hopefully type II pain fibers can be desensitized once the cochlea is regenerated. Guess we'll find out soon enough.
Yeah, it's just speculation - sort of piqued by this excerpt from the 2015 study from the same authors: "Alterations in the relative contributions of type II and type I afferents' activity after hearing loss might contribute to both tinnitus and noxacusis."
Still planning to hiatus more and drop by less for a bit, but I did want to comment on this reply to make my original post more clear.
I feel you - I don't think this study necessarily spells doom for regenerative medicine though. I'm just trying to keep in mind the bigger picture - that noxacusis ultimately is a consequence of an underlying problem - noise-induced hearing loss. Hopefully this paper will be presented an at upcoming conference or something so we can put it into context and what it means for hyperacusis sufferers.
Yeh I just had another look at that. I think what's confusing now is, is this type II synapse increase upon noise trauma the actual act of sensitization? Or is sensitization something yet again different?
The Anoveros finding is really interesting -one thing I am confused about, however, is that they found that the Type 2s still respond to noxious noise even if they're deaf. How do they define noxious noise? Since we know that even in a healthy cochlea the type 2s will show activity once you hit 120 dB+. So is that study demonstrating how type 2s respond in a damaged cochlea? If so that's a really interesting find.
This is also something I wonder especially given how common hearing damage is yet noxacusis is frightfully rare in comparison.
I also had a similar question some time ago. I'd need to find the study, but it had something to do with mice exhibiting some very obvious behaviours which are known in lab research to be associated with mice experiencing pain, and these knock out mice were exhibiting those behaviours in that noxacusis study. Now you could say that perhaps something else was triggering some other kind of pain upon exposure to noxious sound, but that seems quite a stretch to me.
Interesting that Amitriptyline is one of the drugs they infused IT.
Great find and good news because in true scientific spirit this is another team replicating another team's results (Otonomy's), which is exactly what we need.
I haven't but I do want to point out this is the supplier that sells me my Phenibut and they've been pretty reliable.
This study was supposed to be finished in early February 2020. Since then, there has been no update and there have been no further news about STR001. Because of that I wrote an e-mail to Strekin AG whether they could provide me with some information about the current status of STR001. It has been 10 days and I haven't received an answer.
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