Is This One Possible Way Anti-Histamines May Reduce Tinnitus?

[JasonP]

I have used antihistamines a few times and a few times they dropped my tinnitus. I remember especially after I combined it with melatonin and woke up the next day with lower T. I also remember not taking it with melatonin and it seemed to lower my T the next day but I don't remember it lowering it after that. I have heard others that have used anti-histamines to lower tinnitus. According to Wikipedia

"Histamine release in the brain triggers secondary release of excitatory neurotransmitters such as glutamate and acetylcholine via stimulation of H1 receptors in the cerebral cortex."

https://en.wikipedia.org/wiki/Antihistamine

Is it possible that it has something to do with affecting glutamate levels? There may be another mechanism so if you know, please tell me.

 

[DebInAustralia]

I have used antihistamines a few times and a few times they dropped my tinnitus. I remember especially after I combined it with melatonin and woke up the next day with lower T. I also remember not taking it with melatonin and it seemed to lower my T the next day but I don't remember it lowering it after that. I have heard others that have used anti-histamines to lower tinnitus. According to Wikipedia

"Histamine release in the brain triggers secondary release of excitatory neurotransmitters such as glutamate and acetylcholine via stimulation of H1 receptors in the cerebral cortex."

https://en.wikipedia.org/wiki/Antihistamine

Is it possible that it has something to do with affecting glutamate levels? There may be another mechanism so if you know, please tell me.

Which anti histamines did you use

 

[JasonP]

Which anti histamines did you use

Hydroxyizine and meclizine but I can't remember if it works for 2 days in a row.

 

[stophiss]

I am far from an expert but it may have something to do with freeing up Eustachian Tube blockage...sinus drainage etc.

 

[JasonP]

I am far from an expert but it may have something to do with freeing up Eustachian Tube blockage...sinus drainage etc.

Yeah, that was my first thought as well. That could be it.

 

[DebInAustralia]

Bumping this thread.

I think histamine interacts (inhibits) KV channels and has an effect on Glutamate release = excitation.

I'm pretty sure that's the proposed mechanism of Quercetin and Cilantro on the KV channels via their histamine lowering ability.

 

[bigfoot]

I feel a direct correlation to my level of hissing with histamine foods. I spike quickly and now am being more aware of the trigger foods. I had a nice piece of fresh, sustainably caught poached salmon with scallions and capers. Nope, the scallions were raw and capers in vinegar. Spiked within 2 hours after a mild day.

 

[blamingeverything]

Diphenhydramine and Doxylamine Succinate both reduce my tinnitus significantly.