Lenire — Bimodal Stimulation Treatment by Neuromod

[ChrisBoyMonkey]

People were talking about 2023, now it's 2020? Don't get it...

The estimated study completion date is 2023. Even so, Dr. Shore has said before she aims for 2020 commercialization, and a recent email from her posted onto this forum reaffirmed that.

 

[Candy]

Ah, that's amazing... Do we think having one treatment will preclude from another one?

 

[BigNick]

Did they give you any odds of improvement?

The product specialist just reiterated the trial results regarding two thirds of patients had clinically significant results. The audiologist was pretty positive, which was reassuring.

I'll let the group know how I get on with it.

 

[GlennS]

Do we think having one treatment will preclude from another one?

I seriously doubt these devices would be mutually exclusive.

 

[Fabrikat]

The estimated study completion date is 2023. Even so, Dr. Shore has said before she aims for 2020 commercialization, and a recent email from her posted onto this forum reaffirmed that.

I wonder if Lenire hitting the market has incentivised Dr. Shore to now seek commercialisation of her device a little sooner than she intended. I have never seen 2020 mentioned as a release date.

If it has, then it demonstrates the power of competition. A good thing!
There's too much money to be made from this to dawdle any longer.

 

[GlennS]

I wonder if Lenire hitting the market has incentivised Dr. Shore to now seek commercialisation of her device a little sooner than she intended. I have never seen 2020 mentioned as a release date.

If it has, then it demonstrates the power of competition. A good thing!
There's too much money to be made from this to dawdle any longer.

It's one thing for Neuromod to rush ahead with a release before peer review, but why would Shore commercialize in 2020 despite the study not completing until 2023? She's not motivated by investors the same way Neuromod is, so would be reluctant to stick her neck out like this. I think most likely it won't get commercialized until the study is over, meaning not until 2023 or earlier IF they wrap the study earlier. We shall see.

 

[linearb]

I think most likely it won't get commercialized until the study is over, meaning not until 2023 or earlier IF they wrap the study earlier. We shall see.

You think this, despite multiple statements to the contrary from both Shore and other people in her lab, based on what exactly?

They told me at the conclusion of the Phase-I that their plan was to do a longer, rolling phase-II, but that they hoped to have enough data to go to market once they had completed part of that study. So, the messaging and signaling around that has been consistent for at least the last 4 years.

 

[GlennS]

You think this, despite multiple statements to the contrary from both Shore and other people in her lab, based on what exactly?

Is there another active thread here where this information is presented in as much detail as Neuromod info is here? Everything I've read about her progress so far paints a portrait of, again, the Sloth from Zootopia.

 

[ajc]

Is there another active thread here where this information is presented in as much detail as Neuromod info is here? Everything I've read about her progress so far paints a portrait of, again, the Sloth from Zootopia.

Dr. Shore has a thread here, a whopping 46 pages long.

New University of Michigan Tinnitus Discovery — Signal Timing

 

[GlennS]

Dr. Shore has a thread here, a whopping 46 pages long.

New University of Michigan Tinnitus Discovery — Signal Timing

Thanks. The last post there I read was @annV talking about 2023. I've now added it to my watch list.

 

[linearb]

Is there another active thread here where this information is presented in as much detail as Neuromod info is here? Everything I've read about her progress so far paints a portrait of, again, the Sloth from Zootopia.

If the research-backed institution appears to be moving at a slower pace than the for-profit venture backed firm, we should think about why that might be...

 

[JohnAdams]

Can we get tongue tips that are flavored?

 

[Lurius]

After talking to my audiologist yesterday, she showed me something, they've been trying to get a CE certificate for the last 2 years.

Brexit complicated things a lot, she said.

The principle was very similar to Neuromod, but required surgery (a box is placed somewhere under your armpit). This box then sends signals to the brain.

I'm going to ask her about the name of this device so I can look it up and share it with you guys.

But the bottom line is that I'm now getting the impression that there is a LOT of very exciting news for us with tinnitus in the future.

It looks like things are happening faster and faster, something we deserve - no one should suffer from this crap anymore.

I'm going ahead with Neuromod as soon as I get my 2020 appointment booked and confirmed, but knowing that there's going to be other options is very nice to know indeed.

 

[Bndsmheowqhe]

If the research-backed institution appears to be moving at a slower pace than the for-profit venture backed firm, we should think about why that might be...

My gut is telling me that Shore's device will be the more effective of the two. I feel like she's more concerned with getting it right than she is with the money.

 

[KMc24]

My gut is telling me that Shore's device will be the more effective of the two. I feel like she's more concerned with getting it right than she is with the money.

Dr. Shore's device is being directed at treating somatic tinnitus. My tinnitus is somatic, and I'm very excited about a possible treatment in the U.S. for my particular form.

Unfortunately, I don't think there will be a "one size fits all" treatment. One might work better for some than for others. It's all a roll of the dice.

 

[AliceW]

Lurius, the device your audiologist talked to you about must be Microtransponder, no?

 

[Skinjob]

Can we get tongue tips that are flavored?

I'll be sure to let my cat pee on one and save it for you.

 

[spedgas]

I have a tendency to obsess over thoughts. It's not making any of this easy. I'm pretty sold on this device. I'm not questioning their motives or the clinical studies they took to get to this point. I don't need to see peer reviewed papers to convince me that this device has a decent chance of helping me. The cost is not an issue. I just have one mental hurdle that I'm struggling with regarding this device.

I'm struggling with the fact that some people reported getting worse during use. They stated that most of these cases "resolved", but even the small chance that it could occur to me is scary. I've backed out of other medical procedures before because of perceived risk. I hope these fears can be mitigated by the time it's available to me.

 

[RichL]

Dr. Shore's device is being directed at treating somatic tinnitus. My tinnitus is somatic, and I'm very excited about a possible treatment in the U.S. for my particular form.

Unfortunately, I don't think there will be a "one size fits all" treatment. One might work better for some than for others. It's all a roll of the dice.

I don't mean to disappoint, but Dr. Shore's device isn't directed at only somatic tinnitus at all, Its mainly directed at subjective and sensory tinnitus, I can understand the confusion in how its stated though, this is a quote from the study notes...

"They recruited a particular kind of tinnitus sufferer for their study: those who can temporarily alter their symptoms if they clench their jaws, stick out their tongues, or turn or flex their necks."
"These maneuvers, Shore says, appear to be self-discovered ways of changing the activity of fusiform cells, providing an external somatosensory signal to modulate their tinnitus."

Most subjective and sensory tinnitus sufferers can increase the volume of their tinnitus by doing said movements.
These sufferers can increase the volume of their tinnitus by placing pressure on the scalp as well.

https://medicine.umich.edu/dept/oto...pecially-timed-signals-ease-tinnitus-symptoms

 

[BrStan@]

I wish all the people success and huge improvement using Lenire.

You guys just concentrate on your health and stay positive as it makes a huge difference. I totally believe trusting your doctor or your treatment can really change the results.

Best wishes for all

Thank you so much for the best wishes to everyone on getting better. But it is hard to be positive especially when you had this condition for very long time. I am with it since 1999 and during the years only got worse. And during this time there were no forum like this. I had MRI 3 weeks ago I was with earplugs but still my loud tinnitus got louder and very bad. I need to be on antibiotics now, Ampicillin/Sulbactam, as I have infection on my cheek but I am refusing to take it, I can not risk my tinnitus getting any worse. It's better to let the infection kill me.

 

[Rich69]

Hello (I write from France),

This is the first time I'm posting: I've seen this thread about bimodal stimulation talking about Lenire™'s solution (I've been on the Microtransponder guest list, since their first call - using a non-invasive chip that's improving - and there's also Susan Shore's stimulator device: apparently, sensory stimulation to break the "neural network" that listens to and amplifies the tinnitus, is an active research axis).

[Off-topic ON]
I am still following the development of continuous biochemical molecules, such Auris Medical's Keyzilen (AM-101) studies, a Swiss solution; in fact, I continue to follow it: 1°) because the molecule has really been effective on laboratory rats - they have not "over-intellectualized" their behaviors, when showing that they were feeling an substantial improvement, with the treatment they were receiving; 2°) because the boss of Auris Medical's has participated in the creation of Insulin pumps and he places tokens in start-ups, that work on such micro-pumps to fit inside the inner ear; 3°) after processing their statistical studies that were rejected at TACTT3, they have identity that a recently traumatized population was waiting for a full and complete recovery: in other words, very small or medium improvements were ignored by their "guests" ==> a new TACTT3 test with new and more precise modalities for measuring an improvement, and new modalities in the choice of guests is being prepared (if the AM-101 finally succeeds in being recognized as an improvement, they will resume its use in another study, for those who have had recurrent tinnitus for a long time).
There is also the "soothing molecule" of Cannabis which will also be tested in France for its calming qualities, which may be another source of improvement in tinnitus.
Anyway, I do not believe in a miracle solution, but in a mix of 2, 3 solutions.
[/Off-topic OFF]

My question is for Irish people, living if possible, in or near Dublin: (this thread is long to read ) I've understood that the Lenire™ device would have been put up for sale in Dublin... and then removed .

➔ So, pragmatically, if I take a Lyon-Dublin flying ticket this next week, is it possible to still find a shop (where, at which address?) that still sells the Lenire™'s solution (or do I have to stay tuned to this feed, to know when they will put it back on sale...)?

Thank you in advance for your answer(s).

Best regards.

 

[Zach1230]

I keep hearing about Neuromod.

Has anyone tried this yet? Sticking something on your tongue?

How much does it cost because I bet you the NHS won't cover it?

 

[grate_biff]

I need to be on antibiotics now, Ampicillin/Sulbactam, as I have infection on my cheek but I am refusing to take it, I can not risk my tinnitus getting any worse. It's better to let the infection kill me.

I was recently on two antibiotics ending -cilin. They didn´t affect my tinnitus.
Just for your information.
I think it is the -mycin kind that can be ototoxic, but do not take my word for it.

 

[Autumnly]

How much does it cost because I bet you the NHS won't cover it?

Lenire payment plans (posting this on behalf of one of our members):
View attachment 30654

 

[Candy]

@Rich69

They are selling the system at their offices in Ireland now. They have a website.

https://www.neuromodmedical.com/

 

[Rich69]

@Candy: Thank you very much for the information.

 

[El BUZZ]

I'm struggling with the fact that some people reported getting worse during use. They stated that most of these cases "resolved", but even the small chance that it could occur to me is scary. I've backed out of other medical procedures before because of perceived risk. I hope these fears can be mitigated by the time it's available to me.

I have read about that worsening issue due to using Lenire a few times here but no one have backed it with any link or credible quote. Could you do so? I think every case of worsening has resolved once the treatment was stopped.

Anyway, I bet anyone desperate enough would give it a try even risking a permanent worsening.

Maybe your case is complicated by your obsessive thoughts but your tinnitus is not that bad.

 

[Agrajag364]

I have read about that worsening issue due to using Lenire a few times here but no one have backed it with any link or credible quote. Could you do so? I think every case of worsening has resolved once the treatment was stopped.

Anyway, I bet anyone desperate enough would give it a try even risking a permanent worsening.

Maybe your case is complicated by your obsessive thoughts but your tinnitus is not that bad.

"Have patients gotten worse? There were a small number of patients who have gotten worse, erm not dramatically, their tinnitus might have gotten, you know, elevated. These patients, they were asked whether they wanted to discontinue the treatment or continue, a lot of them continued. Eh, most of those cases then resolved, so we haven't had any serious adverse events in the study, and eh so we haven't had any very... just very, kind of, yeah well this term "serious adverse events", you know so there aren't any patients we're very very concerned about. And the majority of patients did actually, in patients that, some patients experience some change at the start which is probably to be expected at the start if you are doing something, if you are disrupting this kind of neural processes there is going to be change".

I recently posted with the full quotation on this from the video interview Neuromod did with Tinnitus Talk.

 

[eagerUser]

Thank you so much for the best wishes to everyone on getting better. But it is hard to be positive especially when you had this condition for very long time. I am with it since 1999 and during the years only got worse. And during this time there were no forum like this. I had MRI 3 weeks ago I was with earplugs but still my loud tinnitus got louder and very bad. I need to be on antibiotics now, Ampicillin/Sulbactam, as I have infection on my cheek but I am refusing to take it, I can not risk my tinnitus getting any worse. It's better to let the infection kill me.

I'm deeply sorry to hear that you have a hard time. I know it's easier said than done but let's hope that it gets better, let's hope that methods like Lenire are on their way to the market to help, to Lenire (soothe) the pain.

 

[Tinniger]

These sufferers can increase the volume of their tinnitus by placing pressure on the scalp as well.

Where'd you read about "pressure on the scalp"?
That's exactly the symptom that I have (next to the permanent hissing on the left).

Here I have addressed the topic myself, but had hardly any resonance.
https://www.tinnitustalk.com/thread...-scalp-does-anyone-know-the-phenomenon.26685/