Lion's Mane Mushroom

[Lukee]

Hi @Uklawyer. It's getting slightly better, as of late. Since my last post on this thread, I'd say that my tinnitus has diminished even a bit further.

How are you?

I've looked it all up and I am fairly certain that the following supplements, which I've marked in black, work as anti-glutamate busters:

- Wild blue berries (2 tbsp)
- Cacao Nibs (2 tbsp)
- Vegan multivitamins (just to be sure)
- 2x Lutein pills (20 mg each)
- 2x pills NAC (600 mg each)
- 1 x pill Mega Green Tea Extract (725 mg per pill)
- 1x pill Quercetin with vitamin C (950 mg)
- 2x pills Double Strength Theracumin
- 2x pills Vrill Omega oil (Omega 3 algae oil with Astaxanthin)
- 3x pills Magnesium L-Threonate (500 mg per pill)
- 2x pills Probiotics
- 3x-4x pills Niacin/B3 (100 mg per pill)
- 0.9-1.2 grams of Psilocybe Mexicana truffels
- 4x-5x pills Lion's Mane (500 mg per pill)
- 2x pills Resveratrol-VT (250 mg per pill)
- 2x pills Taurine (500 mg per pill)
- 1x pill Vitamin D3 (75 micrograms per pill)
- 1x pill Nicotinamide Riboside (300 mg per pill)
- 1x pill Vitamin B1 (100 mg per pill)

This is great news. I wish you continued success. How much would you say you are down overall? Has your tinnitus ever been so low? Has it affected your hyperacusis?

 

[Christiaan]

This is great news. I wish you continued success. How much would you say you are down overall? Has your tinnitus ever been so low? Has it affected your hyperacusis?

Well @Lukee, I would say that my HF tinnitus went down 1/10. So it is mostly a 3/4 on the scale to 10. The sound feels way more softer than before, thus making it easier to ignore. The LF drone is also a bit less prominent.

I must add that I've tried to up my dose in Psilocybin. Last week was quite fun! I tried 2.5 -3 grams of Psilocybe Mexicana and I felt almost detached from my tinnitus & felt so damn sleepy that I really needed to take a nap in the morning. Maybe the higher dose of Psilocybe has also played a part in the change of my tinnitus?

My hyperacusis remained mild for the last two months. No trouble whatsoever, except warm ears after prolonged exposure to music.

 

[Ben Winders]

@Christiaan, I know it's probably hard to pinpoint from that long list of supplements you are taking, but if you would have to guess, which one of them would potentially benefit LF drone the most?

4x-5x pills Lion's Mane (500 mg per pill)?

I still don't know if the drone is caused by low frequency hearing loss or if it is a fun side effect of my high frequency tinnitus (20 dB dip at 4000 Hz) I have. Both the drone and high frequency tinnitus are in the right ear.

 

[Christiaan]

@Christiaan, I know it's probably hard to pinpoint from that long list of supplements you are taking, but if you would have to guess, which one of them would potentially benefit LF drone the most?

4x-5x pills Lion's Mane (500 mg per pill)?

I still don't know if the drone is caused by low frequency hearing loss or if it is a fun side effect of my high frequency tinnitus (20 dB dip at 4000 Hz) I have. Both the drone and high frequency tinnitus are in the right ear.

It's indeed hard to pinpoint with all of this mess Sorry for the inconvenience!

It's a good question and I really don't know which supplement in particular would be the most beneficial for a specific kind of tinnitus. I've actually tried this all-or-nothing approach in hopes that a synergy between all kinds of supplements compounds the effect of nerve regrowth, neurogenesis, neuroplasticity and maybe even address chronic inflammation.

It's indeed a super expensive hobby of mine. And if you want to experiment with BDNF & NGF supplements yourself, you can start small with Stamets' stack. Here's a link to a Dutch smart shop that doesn't ask outlandish prices: https://www.sirius.nl/magictruffleshop/microdoseren-paul-stamets-stack-formule/

 

[Uklawyer]

Hi @Uklawyer. It's getting slightly better, as of late. Since my last post on this thread, I'd say that my tinnitus has diminished even a bit further.

Excellent news @Christiaan - may you continue to see improvement.

Thanks for the info. There is someone else on here who takes NAC, Quercetin and L-Theanine, but she claims that it is for neuroexcitotoxicity. I believe @Lukee is trying/has tried this also and commented on it in a different thread.

It's very complicated. I brought antioxidants/anti-inflammatory supplements, but am weary of just taking everything. I also have CBG/CBD oil, but am waiting for results from another thread to see how taking CBG alone compares (plus I'm not sure if that made me more tired, and with ME/CFS, that's a no-no!).

It's all a bit of a minefield. I find it tough with any level of internal noise (apart from the previous minor one that I could easily mask with a fan at night) - I honestly would like to get to full healing (or habituation if that is, effectively, that same thing). I believe you achieved that previously?

Best

 

[Christiaan]

Excellent news @Christiaan - may you continue to see improvement.

Thanks for the info. There is someone else on here who takes NAC, Quercetin and L-Theanine, but she claims that it is for neuroexcitotoxicity. I believe @Lukee is trying/has tried this also and commented on it in a different thread.

It's very complicated. I brought antioxidants/anti-inflammatory supplements, but am weary of just taking everything. I also have CBG/CBD oil, but am waiting for results from another thread to see how taking CBG alone compares (plus I'm not sure if that made me more tired, and with ME/CFS, that's a no-no!).

It's all a bit of a minefield. I find it tough with any level of internal noise (apart from the previous minor one that I could easily mask with a fan at night) - I honestly would like to get to full healing (or habituation if that is, effectively, that same thing). I believe you achieved that previously?

Best

I'm sorry to hear that you struggle with ME/CFS. It's a smart move that you try to play it safe with all kinds of supplements.

CBD oil seems like a good choice. I've tried pure CBD before and it really helped to relax a little. But I do hope you don't use the CBD kind with THC, which seems to work negatively on tinnitus, at least from what I've read on Tinnitus Talk.

Do you also have multi tonal tinnitus? I do think that it's harder to deal with this kind of tinnitus when I'm constantly stimulated, no matter how intense it is. I am actually chronically overstimulated and that doesn't particularly help with my hypersensitivity to senses or ability to focus (thank you High-Functioning Autism & ADHD ).

It was a different story with my tinnitus in 2016. That was just a low drone that could easily be masked and I was even able to combine two academic bachelors + work 3 days in a week. Oh well, hopefully we all get to live our old lives again, someday.

 

[Uklawyer]

@Christiaan, thank you, you are very kind.

I am trying THC-free CBD/CBG at the moment.

My tinnitus is strange. At first, it was a humming sound with some morse code-type beeping. Then I managed to pick up what sounded like a chain saw (following a trip to my father-in-law's, in which he used one to cut some doors) I had some reactive tinnitus too. I then went to a psychiatric hospital, was given Valium (in addition to my AD), which, pretty much knocked it out completely (apart from very occasional fleeting tinnitus), and when I returned home, it was more like vibration/buzzing, almost to a hiss, but with some more pronounced sound/hum coming through. I also get some higher frequency broken whistling/beeping - usually when stressed.

It doesn't bother me so much in the day (except when in quiet rooms), but waking up with it kills me. With the fatigue I feel so ill if I wake up in the night - it seems to be so much worse than when I did not have it. And in the mornings I feel exhausted with it. It's strange but i feels like even with the same amount of sleep, I am so much more tired/worse.

I try to be positive in the day, and even when going to bed at night. I do meditation and am reading about neuroplasticity (and doing accompanying meditations), but nights/mornings seem to bring me down again.

You did amazingly well with 2 degrees and working. I was proud to get through a first degree then law school with me ME/CFS but this tinnitus on top of it is making me extremely concerned about being able to work further.

 

[Christiaan]

@Christiaan, thank you, you are very kind.

I am trying THC-free CBD/CBG at the moment.

My tinnitus is strange. At first, it was a humming sound with some morse code-type beeping. Then I managed to pick up what sounded like a chain saw (following a trip to my father-in-law's, in which he used one to cut some doors) I had some reactive tinnitus too. I then went to a psychiatric hospital, was given Valium (in addition to my AD), which, pretty much knocked it out completely (apart from very occasional fleeting tinnitus), and when I returned home, it was more like vibration/buzzing, almost to a hiss, but with some more pronounced sound/hum coming through. I also get some higher frequency broken whistling/beeping - usually when stressed.

It doesn't bother me so much in the day (except when in quiet rooms), but waking up with it kills me. With the fatigue I feel so ill if I wake up in the night - it seems to be so much worse than when I did not have it. And in the mornings I feel exhausted with it. It's strange but i feels like even with the same amount of sleep, I am so much more tired/worse.

I try to be positive in the day, and even when going to bed at night. I do meditation and am reading about neuroplasticity (and doing accompanying meditations), but nights/mornings seem to bring me down again.

You did amazingly well with 2 degrees and working. I was proud to get through a first degree then law school with me ME/CFS but this tinnitus on top of it is making me extremely concerned about being able to work further.

Hi @Uklawyer, I wish there was an easy solution for all of us with multi-tonal tinnitus. Your story is a tough pill to swallow, I have to say. Maybe I'm reading too much between the lines, but it feels to me like you have a warm and loving family that has helped support you during some turbulent times. If so, I'm happy that you have such firm support from loved ones.

I'm also glad that Valium did at least some good things to make your tinnitus somewhat lighter to handle, even though I understand that it's still very difficult at times to muddle through.

I recognise in your words that tinnitus is a complete mood killer in the morning and evening. I sometimes struggle with that too, but there is a positive trend lately.

From all the supplements I've tried so far, I'd dare to say that probiotics has probably the most profound effect on feeling a bit more happy and relaxed. There also seems to be a lot of studies that confirm this idea that probiotic supplementation plays a key role in improving mood (e.g. the connection between gut bacteria and oxytocin, dopamine). Have you also tried this as well? Maybe it could make all the difference in your mornings and evenings.

What kind of meditation to you perform, if I may ask? And has it helped you a bit?

 

[Uklawyer]

@Christiaan, I do have a supportive family, but this affects them too. It's the last thing I want to impose on them.

I recognise in your words that tinnitus is a complete mood killer in the morning and evening. I sometimes struggle with that too, but there is a positive trend lately.

Can you say anything more about this trend? How are you feeling at night or in the morning?

I have not looked specifically at probiotics, though I try and eat relatively healthily now (cut down on sugar and salt, more fresh fruit and veg etc).

Meditation-wise, I used to do transcendental meditation (with a fan). Recently, I have been listening to some of the meditations from Joe Dispenza after reading his book You are the Placebo. I have just bought another of his books Becoming Supernatural. In simple terms, he says that if you think certain positive thoughts (e.g. a clear intention like being healthy or finding silence again) during meditation and then feel the effect of that intention - i.e. with positive emotion, your body will start respond to your way of thinking and feeling. It is about priming your body and mind for recovery, success etc - looking forwards and shifting focus from bad habits and the past. He has done lots of workshops and apparently has studied neuroscience and epigenetics and quantum physics and has seen great results, including with neurodegenerative disease. You can find some of his meditations on YouTube. They may sound slightly odd if you have read any of his books, but, essentially, it is about neuroplasticity. And I like that the meditations are guided and have some music in them. They are nice to do and reinforce positive thinking.

 

[Christiaan]

@Christiaan, I do have a supportive family, but this affects them too. It's the last thing I want to impose on them.

Can you say anything more about this trend? How are you feeling at night or in the morning?

I have not looked specifically at probiotics, though I try and eat relatively healthily now (cut down on sugar and salt, more fresh fruit and veg etc).

Meditation-wise, I used to do transcendental meditation (with a fan). Recently, I have been listening to some of the meditations from Joe Dispenza after reading his book You are the Placebo. I have just bought another of his books Becoming Supernatural. In simple terms, he says that if you think certain positive thoughts (e.g. a clear intention like being healthy or finding silence again) during meditation and then feel the effect of that intention - i.e. with positive emotion, your body will start respond to your way of thinking and feeling. It is about priming your body and mind for recovery, success etc - looking forwards and shifting focus from bad habits and the past. He has done lots of workshops and apparently has studied neuroscience and epigenetics and quantum physics and has seen great results, including with neurodegenerative disease. You can find some of his meditations on YouTube. They may sound slightly odd if you have read any of his books, but, essentially, it is about neuroplasticity. And I like that the meditations are guided and have some music in them. They are nice to do and reinforce positive thinking.

I understand @Uklawyer, it's still nice to hear you have their support.

I'd say that the longer I am on probiotics, the better my mood is (whether that's in the morning or evening). So, it's a bit of an incremental process. At the start of my supplement journey, I felt like absolute shit, but that slowly changed over time. I still hear my tinnitus in silent rooms and I'm quite annoyed by it, but the supplements have helped me to feel better in my own skin, as if I've lost that dreadful feeling that something imminently bad is going to happen to me. Though I can't pinpoint it clearly which supplement does what, my hunch is that probiotics plays a vital role in this, given the clinical evidence of its effects on emotional wellbeing.

Joe Dispenza seems to have an interesting take on meditation. I'm not familiar with his work, but perhaps there's some truth that positive affirmation, in combination with relaxation, may influence neuroplasticity. There are similar stories of people who experience a positive change in their tinnitus after doing specific kinds of meditation, like Mindfulness & vipassana. So why wouldn't this work for you too? Hopefully you'll reap the benefits by practicing this kind of meditation.

Anyway, namasté from a fellow TM & Zen practitioner

 

[Ben Winders]

@Christiaan, I've read up on Psilocybin and am contemplating trying it.

I read the good stories and the bad. Most epic recovery stories seem to come from people that tried "heroic" dosage of around 5 g. They mostly speak of a worsening before it getting better.

For myself, I don't think I'm heroic enough to immediately dive into 5 g as I've never even taken any drugs in my entire life (apart from alcohol ).

Would you mind shining light on which Psilocybin I should try? I'm ordering through the Dutch website Zamnesia.
It also seems mushrooms are better (more potent?) than truffles (the ones you are taking) - not sure if true.

 

[Christiaan]

@Christiaan, I've read up on Psilocybin and am contemplating trying it.

I read the good stories and the bad. Most epic recovery stories seem to come from people that tried "heroic" dosage of around 5 g. They mostly speak of a worsening before it getting better.

For myself, I don't think I'm heroic enough to immediately dive into 5 g as I've never even taken any drugs in my entire life (apart from alcohol ).

Would you mind shining light on which Psilocybin I should try? I'm ordering through the Dutch website Zamnesia.
It also seems mushrooms are better (more potent?) than truffles (the ones you are taking) - not sure if true.

Ey Ben,

That 5 grams thing is also a biggie for me. I'm practically knock-out on regular Psilocybin truffels >3.5 grams, so I don't know if I want to push it even further than that, lol. Maybe I'll go for shrooms if the HD-tDCS trial in Antwerp fails, who knows?

Hmmm, I don't know about that potency thing. Maybe someone more knowledgeable like @Lukee can chip in? But from what I've researched, there are apparently truffels that seem to be more potent than shrooms, like Psilocybe Mexicana truffels vs. Psilocybe Cubensis. Here's a link to a nifty shroom/truffel calculator if you want to figure out the required dosage of your product vis-à-vis weight:

https://www.dutch-headshop.nl/blog/paddo-truffels-dosering-calculator

I guess the mantra with trying soft drugs is this: ''start slow, go slow''. You can start with 0.6 gram and slowly work your way up to the desired dosage if you feel comfortable doing that.

If you're a beginner, I'd suggest you try Psilocybe Mexicana truffels. Personally, I don't think they taste that yucky and they are in terms of psychedelic & drowsy-like effects quite modest/moderate vis-à-vis other popular variants (from what I've seen on shroom forums).

 

[OptimusPrimed]

Anyone else try the Stamets stack or Lion's Mane lately? I am thinking of trying Niacin and Lion's Mane. Desperate for some relief.

 

[Uklawyer]

Would you mind shining light on which Psilocybin I should try? I'm ordering through the Dutch website Zamnesia.
It also seems mushrooms are better (more potent?) than truffles (the ones you are taking) - not sure if true.

@Ben Winders - did you try these in the end? Any help?

 

[Joey72]

I've been doing Om branded Lion's Mane, one tablespoon per day, for a month now. I believe my tinnitus is caused by TMJ.

No changes in my tinnitus.

 

[Christiaan]

Hey everyone. For those who are interested, here's a new list of my anti-inflammatory, BDNF/NGF protocol.

Diet

Morning:
- Wild blue berries (3 tbsp)
- Cacao Nibs (1 tbsp)
- Almond yogurt (3 tbsp)
- Muesli mix with nuts & seeds (3 tbsp)
- Nuts & seeds mix (2 tbsp of sunflower seeds, pumpkin seeds, flax seeds, almonds & max. 2 Brazil nuts)
- Cinnamon powder (Ceylon)

Afternoon:
-Salad (mostly cherry tomatoes, cucumber, gem lettuce, walnuts, pomegranate seeds, sunflower/pumpkin seeds, mustard, virgin olive oil, lemon juice)
- Mixed nuts & seeds bar

Dinner:
- Vegetable soup/hummus pizza with grilled vegetables/falafel salad/pasta dish/Indonesian tofu dish, etc.

Snacks:
-Dried banana chips/dried apple chips/dried mango chips/Medjool dates

Supplements
- 1x Vegan multivitamins
- 2x Lutein pills (20 mg each)
- 1x pill NAC (800 mg)
- 2x pills Organic turmeric with organic ginger & organic black pepper (1520 mg per 2 capsules)
- 2x pills Vrill Omega oil (Omega 3 algae oil with Astaxanthin)
- 3x pills Magnesium L-Threonate (500 mg per pill)
- 2x pills Probiotics
- 1x pill Niacin/B3 (100 mg per pill)
- 1x pill Vitamin D3 (75 mg per pill)
- 1x pill Vitamin B1 (100 mg per pill)
- 1x pill Full Spectrum CBD oil (20 mg)
- 2x pills Choline & Inositol (500 mg per pill)
- 1 tbsp of MCT C8 oil

Optional
- 4-5x per week HIIT exercise
- Psilocybe Mexicana truffels (0,6-3,5 grams)
- 4x-5x pills Lion's Mane (500 mg per pill)
- 1x pill Nicotinamide Riboside (150 mg per pill)

Things to avoid
- Generally food that contains a lot of sugar & saturated fat
- Stressful situations

Other details
- Vegan diet (+/- 80% organic)
- Tailored notched therapy
- HIIT exercise (rowing machine / spinning bike: 20 minutes of exercise at minimum)

Sources
Diet:

• Anti-inflammatory effects of plant-based foods and of their constituents
• Top 10 Foods to Boost Your BDNF
• Oleic acid -- a key to activating the brain's 'fountain of youth'
• An increase in plasma brain derived neurotrophic factor levels is related to n-3 polyunsaturated fatty acid efficacy in first episode schizophrenia: secondary outcome analysis of the OFFER randomized clinical trial
• Widely available supplement may explain brain boost from exercise

Supplements:

• 9 Nerve Growth Factor (NGF) Effects + What May Increase It
• How to Increase BDNF: 10 Ways to Rescue Your Brain
• Oral consumption of α-linolenic acid increases serum BDNF levels in healthy adult humans
• Protective effect of astaxanthin on acute cerebral infarction in rats
• Prebiotic feeding elevates central brain derived neurotrophic factor, N-methyl-d-aspartate receptor subunits and d-serine
• Short-term curcumin supplementation enhances serum brain-derived neurotrophic factor in adult men and women: a systematic review and dose-response meta-analysis of randomized controlled trials
• Cannabidiol Induces Rapid and Sustained Antidepressant-Like Effects Through Increased BDNF Signaling and Synaptogenesis in the Prefrontal Cortex
• Impact of exercise and vitamin B1 intake on hippocampal brain-derived neurotrophic factor and spatial memory performance in a rat model of stress
• Choline up-regulates BDNF and down-regulates TrkB neurotrophin receptor in rat cortical cell culture
• Top 9 Benefits of NAC (N-Acetyl Cysteine)
• Enhancement of Learning and Memory by Elevating Brain Magnesium
• Lutein Supplementation Increases Serum Brain-Derived Neurotrophic Factor (BDNF) in Humans
• Developmental Vitamin D3 deficiency alters the adult rat brain
• Niacin Treatment of Stroke Increases Synaptic Plasticity and Axon Growth in Rats
• Medium Chain Triglycerides induce mild ketosis and may improve cognition in Alzheimer's disease. A systematic review and meta-analysis of human studies
• Serum proBDNF Is Associated With Changes in the Ketone Body β-Hydroxybutyrate and Shows Superior Repeatability Over Mature BDNF: Secondary Outcomes From a Cross-Over Trial in Healthy Older Adults
• Psychedelics and Neuroplasticity: A Systematic Review Unraveling the Biological Underpinnings of Psychedelics
• Cognitive Vitality - Lion's Mane

HIIT:

• High-intensity interval training evokes larger serum BDNF levels compared with intense continuous exercise

Saturated fat, sugar & stress:

• A high-fat, refined sugar diet reduces hippocampal brain-derived neurotrophic factor, neuronal plasticity, and learning
• Chronic stress, as well as acute stress, reduces BDNF mRNA expression in the rat hippocampus but less robustly

Tailor-made notched therapy:

• Listening to tailor-made notched music reduces tinnitus loudness and tinnitus-related auditory cortex activity

 

[Uklawyer]

Excellent information with source material @Christiaan.

Are you having success with this regime?

Best.

 

[Christiaan]

Excellent information with source material @Christiaan.

Are you having success with this regime?

Best.

Hi @Uklawyer, even though I try to be careful with making bold claims, I do think it has played a positive role in the reduction of my tinnitus. Mind you, my tinnitus was a 10 out of 10 from 03/2020 to +/- 12/2020 (with many ups & downs though). I only noticed a positive change in my tinnitus after a few months on this regime. It's now more than a year since I have followed this tight schedule, and I notice that my tinnitus has incrementally lowered to a level that makes it easier for me to work, sleep, travel, read books, etc. So I consider that a success, in some respects.

 

[Uklawyer]

@Christiaan, that's great news - happy that it is moving in the right direction. It is always hard to say, after a period of time, what the cause of any improvement is. Perhaps, however, we can sometimes know or have a strong sense of what it is that has been helping.

Have you considered reducing your supplement stack at all to see if those gains are maintained?

 

[Christiaan]

@Christiaan, that's great news - happy that it is moving in the right direction. It is always hard to say, after a period of time, what the cause of any improvement is. Perhaps, however, we can sometimes know or have a strong sense of what it is that has been helping.

Have you considered reducing your supplement stack at all to see if those gains are maintained?

Well, in a way, I sort of tweaked my supplement stack. It's not to see if any dietary change would alter my tinnitus per se, but foremost for budgetary reasons. So far, I've noticed that it hasn't negatively altered my tinnitus, quite the opposite really.

 

[Krolo]

So. I just have to write this since I feel it is warranted although I'm only on day three. I have tried many different things to keep control of my tinnitus and I must say my mind is blown by my latest combo.

I discontinued my old regimen and for the past three days I have been using Innate Response Ultra 20-14 probiotic and 1 gram of Lion's Mane per day.

My tinnitus has been milder for all these three days but mainly the weird tinnitus brain fog migraine without the migraine pain is literally gone. Definitely the closest point to how I felt before my crazy tinnitus and hyperacusis started in September 2018. Strange to feel this calm.

Will try to include the flush Niacin to see if it helps things even more in a week.

Hope you all are doing well.

 

[Sam Marksmen]

Can anyone with severe tinnitus report back on Lion's Mane mushrooms? I've tried so many things that made my tinnitus worse.

I almost think Cordyceps may have caused a spike but it could have been something else.

 

[MaxRabbit]

So. I just have to write this since I feel it is warranted although I'm only on day three. I have tried many different things to keep control of my tinnitus and I must say my mind is blown by my latest combo.

I discontinued my old regimen and for the past three days I have been using Innate Response Ultra 20-14 probiotic and 1 gram of Lion's Mane per day.

My tinnitus has been milder for all these three days but mainly the weird tinnitus brain fog migraine without the migraine pain is literally gone. Definitely the closest point to how I felt before my crazy tinnitus and hyperacusis started in September 2018. Strange to feel this calm.

Will try to include the flush Niacin to see if it helps things even more in a week.

Hope you all are doing well.

Hi. Which brand for Lion's Mane are you taking? I have a bottle of Lion's Mane but due to reading people saying it made it worse, I've been afraid to try. Glad you are feeling better!

 

[Kasia]

The Lion's Mane probably is the spiking culprit, but am not 100% sure. I'll know as soon as I'm going off it until the tinnitus goes back to baseline & I try once more.

How was your Lion's Mane second try?

 

[SmallRonnie]

Strange to feel this calm.

I'm really happy for you!

I just ordered some Lion's Mane now too and looking into many similar supplements.

How are you doing with it now?

 

[SmallRonnie]

I personally subscribe to the models developed by @100Hz when it comes to the middle ear. I may not be doing them justice here, but to summarise, noxious (pain) signals coming from the cochlea (when exposed to sound) leads to a flight/fight response in the amygdala/brain that causes the middle ear to tense up and become hyperactive towards sound, leading to all sorts of issues such as TTTS, which can cause other problems such as trigeminal neuralgia as the relevant nerve innervates the middle ear. These spasms/flutters cause us to be more stressed and so you then have an awful negative feedback loop. This may be why CBT/yoga/meditation has some merit in that it calms the nervous system down, but they never really seem to cure anyone with hyperacusis and I suspect that is because the underlying issue (a cochlea sending pain signals) has still not been resolved. This is where you need a drug that inhibits upregulated pain receptors or a regenerative drug to replace the faulty calcium channels (the latter is my own opinion).

In short, I think middle ear issues are a consequence of the underlying issue, which is cochlea damage and sensitivity.

@Jerad, this above is a better answer than the one I gave to your question today.

 

[SmallRonnie]

Does anyone have recommendations for people who don't feel comfortable with the mushrooms? I'm just nervous about accidentally getting addicted to them

It's impossible to become physically addicted to mushrooms because the tolerance build up is so high. After one full dose you need to wait at least one full week before being able to dose again. There is a very small chance of becoming mentally addicted but it is extremely rare.

Magic mushrooms are being clinically trialed to help people who have addictions with other substances.

 

[Aaron91]

@Jerad, this above is a better answer than the one I gave to your question today.

I should probably make it known that I've actually since changed my opinion. I'm no longer convinced that the cochlea has a role in this chain (at least in most cases), and that the entire pathology is middle-ear related (which is sustained/worsened by negative feedback loops with the brain), as per Norena.

 

[Ela Stefan]

I should probably make it known that I've actually since changed my opinion. I'm no longer convinced that the cochlea has a role in this chain (at least in most cases), and that the entire pathology is middle-ear related (which is sustained/worsened by negative feedback loops with the brain), as per Norena.

This for hyperacusis or tinnitus, Aaron?

 

[SmallRonnie]

I should probably make it known that I've actually since changed my opinion. I'm no longer convinced that the cochlea has a role in this chain (at least in most cases), and that the entire pathology is middle-ear related (which is sustained/worsened by negative feedback loops with the brain), as per Norena.

I think my noxacusis is nerve damage related, simply because of the burning pain I get which is a very common complaint for people with neuropathy.

There's this peptide called ARA-290 that actually treats neuropathy. The company trialing it ran out of funds recently but you can buy it online in some shops. There's people talking about it helping with nerve issues a lot but you need to continuously dose it and it can be expensive unless you find a good Chinese source.

My pain has been coming and going. Gets very bad with a setback, then takes a month or two to get better. I'm probably going to pick up some of this peptide though and try it.

There might be long term effects if taken for a very long time but nobody knows for sure.