Member- Jul 21, 2013
- 842
- Tinnitus Since
- 01/2013
- Cause of Tinnitus
- Acoustic trauma from headphones
the mods have let us have our fun for too long, looks like we're finally done for good
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- Thread starter threefirefour
- Start date
Partly surprised no mod who was quitting didn't shut down MPP as a last act just to watch the site descend into chaos.
I think that claim that TRT can restore normal sensitivity to sound is an outright lie.
shutting down MPP is a great way to preserve the status quo and go around the TRT circlejerk for another decade
pawel jastreboff will report MPP and demand legal rights to remove all memes and negative content about him.
mods comply, give him our IP, email, activity logs, tracking cookies they had on us
TRT deathsquads arrive on our front door the next morning
mods comply, give him our IP, email, activity logs, tracking cookies they had on us
TRT deathsquads arrive on our front door the next morning
Guys take it easy. It seems quite apparent that the mods here are very good about freedom of speech. Everyone chill. Lol.
Okay. So it's not just notch inhibition that causes cochlear hair cells to regenerate. It has to accompany wnt activation
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341835/
A food product called carageenan does this.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341835/
A food product called carageenan does this.
"We present a two-step gene manipulation, Wnt activation followed by Notch inhibition, to accomplish mitotic regeneration of HCs (hair cells) while partially preserving the SC (supoorting cell, progenitor cell) number."
So maybe the formula is some carageenan (wnt activator) in the morning and then curcumin (notch inhibitor) for lunch?
Or carageenan for a week then curcumin for a week?
So maybe the formula is some carageenan (wnt activator) in the morning and then curcumin (notch inhibitor) for lunch?
Or carageenan for a week then curcumin for a week?
Yeah I agree. Trust me most of the internet is not even remotely as well modded as this site. The "mods will surely ban us for x post" thing is kind of a meme about how they won't.
protection against further damage?
https://www.sciencedirect.com/science/article/pii/S0165587617302495
https://www.sciencedirect.com/science/article/pii/S0165587617302495
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0030590
"Curcumin is a potent inhibitor of esophageal cancer growth that targets the Notch-1 activating γ-secretase complex proteins. These data suggest that Notch signaling inhibition is a novel mechanism of action for curcumin during therapeutic intervention in esophageal cancers."
"Curcumin is a potent inhibitor of esophageal cancer growth that targets the Notch-1 activating γ-secretase complex proteins. These data suggest that Notch signaling inhibition is a novel mechanism of action for curcumin during therapeutic intervention in esophageal cancers."
http://en.cnki.com.cn/Article_en/CJFDTotal-BHON201212028.htm
"To study the mechanism of Curcumin in inhibiting human keratinocyte cell line HaCaT cell proliferation induced by IFN-γ,and lay the experimental foundation for clinical use of curcumin in the treatment of psoriasis"
"To study the mechanism of Curcumin in inhibiting human keratinocyte cell line HaCaT cell proliferation induced by IFN-γ,and lay the experimental foundation for clinical use of curcumin in the treatment of psoriasis"
It has to be curcumin. everything I've read shows that it performs the same function of ly411575, and DAPT, which are notch1 gamma secretase inhibitors. If you read the patent info for fx322, it says they are either using ly411575 of DAPT. Nobody can explain to me why it wouldnt work. It's not toxic, basically. I havent been taking it consistently in high enough doses but now I'm gonna do it. 8grams a day for 7 days. But then it may be 3 months to see any full affects.
https://www.liebertpub.com/doi/abs/10.1089/scd.2006.15.165
Curcumin-induced Histone Hypoacetylation Enhances Caspase-3-dependent Glioma Cell Death and Neurogenesis of Neural Progenitor Cells
Glioma is a brain tumor.
Neurogenesis of Neural Progenitor Cells
Neurogenesis of Neural Progenitor Cells
Neurogenesis of Neural Progenitor Cells
Neurogenesis of Neural Progenitor Cells
Neurogenesis of Neural Progenitor Cells
Neurogenesis of Neural Progenitor Cells
Neurogenesis of Neural Progenitor Cells
Neurogenesis of Neural Progenitor Cells
Curcumin-induced Histone Hypoacetylation Enhances Caspase-3-dependent Glioma Cell Death and Neurogenesis of Neural Progenitor Cells
Glioma is a brain tumor.
Neurogenesis of Neural Progenitor Cells
Neurogenesis of Neural Progenitor Cells
Neurogenesis of Neural Progenitor Cells
Neurogenesis of Neural Progenitor Cells
Neurogenesis of Neural Progenitor Cells
Neurogenesis of Neural Progenitor Cells
Neurogenesis of Neural Progenitor Cells
Neurogenesis of Neural Progenitor Cells
my wife runs a university database of subscription based science journals. I cannot copy and paste the subscription based journals here. But I did just find an article titled:
"Regeneration of human auditory nerve. In vitro/in video demonstration of neural progenitor cells in adult human and guinea pig spiral ganglion"
So there are progenitor cells in the human auditory nerve that can regenerate.
Curcumin kills brain tumor cells and can cause neurogenesis of neural progenitor cells.
Curcumin is a Notch1 inhibitor.
Notch 1 inhibition causes cochlear hair cells to regenerate, maybe even auditory nerves.
"Regeneration of human auditory nerve. In vitro/in video demonstration of neural progenitor cells in adult human and guinea pig spiral ganglion"
So there are progenitor cells in the human auditory nerve that can regenerate.
Curcumin kills brain tumor cells and can cause neurogenesis of neural progenitor cells.
Curcumin is a Notch1 inhibitor.
Notch 1 inhibition causes cochlear hair cells to regenerate, maybe even auditory nerves.
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From a Babylonian medical paper from 1000 BC it says curcumin is a treatment for tinnitus.
**If a person's head seems to roar, you mix harmunu, aktam, imbuˆ tamtim, kukru, bura¯sˇujuniper, ere¯nu-cedar, sˇurme¯nu-cypress, ata¯ isˇu, kurkanuˆ, s ˙ as ˙ untu, sı¯ hu, arga¯nu-tree, barira¯tu and 'lone plant' with oil and wax. You massage it into leather and bandage him with it. (BAM 3 ii 4751 [ref. 6])
kurkanu is Curcuma Longa. Curcumin.
Citation:
Scurlock, J., & Stephens, D. (2008). A ringing endorsement for Assyro-Babylonian medicine: The diagnosis and treatment of tinnitus in 1st Millenium BCE Mesopotamia. Audiological Medicine, 2008, Vol.6(1), P.4-15, 6(1), 4-15.
**If a person's head seems to roar, you mix harmunu, aktam, imbuˆ tamtim, kukru, bura¯sˇujuniper, ere¯nu-cedar, sˇurme¯nu-cypress, ata¯ isˇu, kurkanuˆ, s ˙ as ˙ untu, sı¯ hu, arga¯nu-tree, barira¯tu and 'lone plant' with oil and wax. You massage it into leather and bandage him with it. (BAM 3 ii 4751 [ref. 6])
kurkanu is Curcuma Longa. Curcumin.
Citation:
Scurlock, J., & Stephens, D. (2008). A ringing endorsement for Assyro-Babylonian medicine: The diagnosis and treatment of tinnitus in 1st Millenium BCE Mesopotamia. Audiological Medicine, 2008, Vol.6(1), P.4-15, 6(1), 4-15.
So essentially I should be going to the nearest store and buying curcumin supplements and take them faithfully for the next 3 or so months? I'm willing to do that
I found a tea with the following incredients:
Celery salt, fennel, tomato, cumin, green tea, garlic salt, turmeric, ginger, black pepper, chili peppers, cloves, silicon dioxide.
What do you think?
Was this a tea to help our range of conditions? If so, I should say the active ingredient is not enough to have a curative affect, but would be very healthy nonetheless. And by the way, I have no bad blood with you. I love you immensely. I watched Tales from the Hood last night because of your avatar and my wife and I were thoroughly entertained. I havent seen that movie since I was 12 and I was blown away.
No. Here's the deal, honestly based on honesty: the notch1 inhibitors make lgr5+ cells in the cochlea regenerate into hair cells, however they grow out of progenitor cells. It takes a process called wnt (pronounced wint) activation to multiply the progenitor cells. So if you activate all your progenitor cells with notch inhibition in your cochlea to regenerate into hair cells the you will run out of progenitor cells. The fx322 has a process to multiply progenitor cells and stimulate cochlear hair cell regeneration. There is a natural food product called carageenan that induces wnt activation but there is scant, no, scientifically published evidence that it can achieve this, that I am aware of, only conjecture from me. This is DIY gene therapy.
Curcumin is a notch1 inhibitor. FACT. Just like DAPT akd ly411575 which is the thing that they have discovered that induces cochlear progenitor hair cell regeneration. TOTAL FACT. It also seems to kill cancer, and perhaps induce neuronal progenitor cells to activate. If you look up the molecular shape of ly411575, DAPT, and curcuminoid, they all are basically the same except ly411575 and DAPT are toxic because they have flouride and nitrogen molecules attached whereas curcuminoid is totally organic. Curcumin's bio availability is low when taken orally, however because of its non toxicity in a wide range of doses, it is well tolerated. To have a therapeutic effect, you need to have large amounts of this in your blood stream for only about a week, in my estimation. Once you trigger regeneration it's happening, no need to stay on this for a long duration. My theory is that you take large doses of it just long enough to initiate progenitor cell activation, I am guessing is one week.
To achieve therapeutic levels of this I have determined, whether right or wrong, that you cannot take it orally. Either up the poop chute or injections.
If curcumin has a similar affect as the chemicals they have used to restore hearing in mice, then it should take about 3 months after the 5-7 day long treatment to manifest.
Any other questions about this I am happy to answer as much as I can.
No bad blood at all. Yes, I love Tales from the Hood, it's way ahead of its' time, brilliant film. It truly is "the shit".
No, it's not a tea specifically designed for tinnitus. I looked up curcumin supplements which, most seem to be kind of useless. I figure tea would be a good way to go.
Thank you for the response.
No problem. I may be stupid, but I think we can conquer this. Knowledge is power.
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