MemberI'm also at the 7-8 month mark but I'm still hoping for my T to fade or lower in pitch. Lower pitch is way, way easier to deal with for me than my glass-cutting shriek sound.
Yeah might be survival instinct twisting my logic. IDK.
Hugz
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- Thread starter threefirefour
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Yeah might be survival instinct twisting my logic. IDK.
Hugz
Someday, when robust cures for T, H and HL exist, Jastreboof and the pro-TRT movement will be remembered as irrelevant relics.
Much like hearing aids will be (I'm not bashing hearing aids here).
His false legacy will not last.
We will toast to the obsolescence of a man who bets beer on our continued suffering now.
Much like hearing aids will be (I'm not bashing hearing aids here).
His false legacy will not last.
We will toast to the obsolescence of a man who bets beer on our continued suffering now.
I have never had TRT or CBT, nor any other such therapy.
Presumably there are members who it has helped.
I would like to know how it helped?
I've done CBT several years back for a condition completely unrelated to tinnitus. It did help me.
And if I look past my biases, I think that the processes contained within what has become known as TRT do certainly help some people with tinnitus as well.
The presentation of and funding of TRT is what I find massively problematic.
So regrowth of cochlear hair cells is not only associated with notch1 inhibition but also decreased levels of the genes
Hes1, Hes5, Hey1, HeyL, and Jagged1.
"Expression changes of genes in the Notch pathway were measured using immunostaining and in situ hybridization, with most changes observed in the apical one-third of the cochlea where the majority of HC regeneration occurs. Expression of the Notch target genes Hes1, Hes5, Hey1, HeyL, and Jagged1 were decreased."
https://www.frontiersin.org/articles/10.3389/fncel.2018.00120/full
Hes1:
"Treatment with curcumin resulted in downregulation of Notch1 and its downstream target, Hes1"
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5517797/
Hes5:
"Curcumin, isolated from Turmeric, inhibits the development of pulmonary arterial hypertension via down regulation of Notch3 and its target gene Hes-5"
https://genomediscovery.org/2017/08...arterial-hypertension-via-down-regulation-of/
Hey1:
Compared with control, there was a reduction of Notch-1, Hes-1, Hey-1 and Hey-2 mRNA levels after curcumin
treatment, suggesting that curcumin resulted in the transcriptional inactivation of Notch-1 signaling pathway"
https://www.google.com/url?sa=t&sou...FjADegQICBAB&usg=AOvVaw0qrRfrpFI6A27pclNWUqnE
HeyL:
No data, yet.
Jagged1:
"Our studies demonstrate that curcumin inhibits the expression of Jagged-1 and the Notch-1 receptor. Curcumin also inhibits γ-secretase complex proteins, thereby inhibiting cleavage of the Notch receptor."
https://www.google.com/amp/s/www.re...f-Jagged-1-and-the-Notch-1_fig8_221859732/amp
Hes1, Hes5, Hey1, HeyL, and Jagged1.
"Expression changes of genes in the Notch pathway were measured using immunostaining and in situ hybridization, with most changes observed in the apical one-third of the cochlea where the majority of HC regeneration occurs. Expression of the Notch target genes Hes1, Hes5, Hey1, HeyL, and Jagged1 were decreased."
https://www.frontiersin.org/articles/10.3389/fncel.2018.00120/full
Hes1:
"Treatment with curcumin resulted in downregulation of Notch1 and its downstream target, Hes1"
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5517797/
Hes5:
"Curcumin, isolated from Turmeric, inhibits the development of pulmonary arterial hypertension via down regulation of Notch3 and its target gene Hes-5"
https://genomediscovery.org/2017/08...arterial-hypertension-via-down-regulation-of/
Hey1:
Compared with control, there was a reduction of Notch-1, Hes-1, Hey-1 and Hey-2 mRNA levels after curcumin
treatment, suggesting that curcumin resulted in the transcriptional inactivation of Notch-1 signaling pathway"
https://www.google.com/url?sa=t&sou...FjADegQICBAB&usg=AOvVaw0qrRfrpFI6A27pclNWUqnE
HeyL:
No data, yet.
Jagged1:
"Our studies demonstrate that curcumin inhibits the expression of Jagged-1 and the Notch-1 receptor. Curcumin also inhibits γ-secretase complex proteins, thereby inhibiting cleavage of the Notch receptor."
https://www.google.com/amp/s/www.re...f-Jagged-1-and-the-Notch-1_fig8_221859732/amp
People with severe ear conditions suffer so much. I feel so goddamn bad for all of us. There's so much suffering. I will not sugarcoat it.
We need to be careful on publicly viewed threads. He looks like the kind of doosh that would sue for libel and defamation.
I'm don't really agree with your first sentence but I definitely agree with the second.
- Aug 14, 2013
- 2,455
- Tinnitus Since
- Resolved since 2016
- Cause of Tinnitus
- Unknown (medication, head injury)
The amount of quality shit-posting that takes place here on MPP is close to unbelievable but, yes... from time-to-time, I have also quietly wondered about the defamation aspect being raised. Without a doubt, there is sufficient evidence for Jastreboff (aka. the Polish engineer) to file a defamation suit (if he wanted). And yes... from time-to-time, I have also been surprised at the number of VIPs lurking this forum (you can count the CEOs of more than two otology pharmas having read TinnitusTalk in the past...).
Honestly I'm really not very worried about getting sued for libel or whatever.
I'm not sure how much longer I can survive at all.
Everything else feels pretty irrelevant to me at such a point.
I'm not sure how much longer I can survive at all.
Everything else feels pretty irrelevant to me at such a point.
How did Lipoflavonoid become so recommended by ENTs exactly?
Then again we're talking about people who rely on a 250-8000 hz audiogram, so I'm not particularly surprised.
Then again we're talking about people who rely on a 250-8000 hz audiogram, so I'm not particularly surprised.
If any researchers, scientist, employee's or or even CEO's of bio companies are lurking MPP. I would like to take a moment to say thank you.
Your hard work is greatly appreciated beyond any word I can think of. even if you think we are nutjob's and loons.
a novel treatment for SNHL is the only thing that gives me hope.
Your hard work is greatly appreciated beyond any word I can think of. even if you think we are nutjob's and loons.
a novel treatment for SNHL is the only thing that gives me hope.
Also I love how all these scams tell you that the thing they're selling will help with "tinnitus symptoms". Nice move there. Yeah. Notice how the item doesn't help with actual tinnitus. (Neither does it help with any "symptoms" for that matter, but yeah whatever.)
Yes, thank you!!
I'm no loon and neither are many of us.
Many of us are tortured beyond belief that is all.
Don't let that be a dream friend. I hope soon we will go back to those good days, or at least close.
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