My Posting Place

[Contrast]

it's so fucking weird my hyperacusis goes away completely, then comes back in a very mild form (sometimes worsens)

i don't want to manage it, i just want it gone entirely like it never existed, no one is going to repair my audiotory nerve, outer hair cells and their type II afferent fibers, cochlear ribbon synapses, trigeminal nerve, doral cochlear nucleus or whatever the fuck is causing this chronic ear pain.

I JUST WANT IT TO GO AWAY AND NOT COME BACK!
i wouldn't give a fuck about science if it went away and I'd go back to being the retard that I am.

haha i must be really fucking crazy for wanting to solve this problem instead of being a cuck and accepting it.

 

[Ed209]

i'm so pathetic i literally mock and insult people that can manage/habituate/tolerate these conditions.

I don't see it that way. I see someone who is suffering and desperately wants help. This is why Tinnitus Talk exists, because it's not easy for everybody to live with this condition. Just because some people habituate doesn't mean everybody will; I can't claim that it's possible for everyone to habituate because I have no idea. This is why I'd rather see more objective help that can make things happen in the real world. I wanna see us reach all those people who feel they are being left behind, and feel isolated. I never wanna see another tinnitus related suicide ever again.

 

[Contrast]

I don't see it that way. I see someone who is suffering and desperately wants help. This is why Tinnitus Talk exists, because it's not easy for everybody to live with this condition. Just because some people habituate doesn't mean everybody will; I can't claim that it's possible for everyone to habituate because I have no idea. This is why I'd rather see more objective help that can make things happen in the real world. I wanna see us reach all those people who feel they are being left behind, and feel isolated. I never wanna see another tinnitus related suicide ever again.

my tinnitus is not the biggest issue, it's the ear pain and muffled hearing.

I can go the rest of my life with tinnitus, (even the reactive annoyance aspects) if it doesn't worsen
mine did fade. the effects of muffled hearing have not improved since the first 4-5 months, the ear pain may go away entirely based on recover but the fact that it comes back once and a while shows I have to so cautious.

I still care about my friends who have louder/worse tinnitus.

 

[Ed209]

my tinnitus is not the biggest issue, it's the ear pain and muffled hearing.

That's what I was getting at. To me they all come under the same umbrella.

 

[Contrast]

That's what I was getting at. To me they all come under the same umbrella.

yes I believe SNHL, tinnitus, hyperacusis, TTTS, even TMD, trigeminal neurugia, phantom pain, various forms of nerve damage all have some common pathologies that need to be bio-medically researched and treatment for one may help most others or atleast learn something new.

Cross-discipline research doesn't exist. Tinnitus conferences and research now is more like a TRT/CBT coffee club and palliative medicine is an industry of it's own. ENT's are literally amazing at throwing sufferers under the bus.

 

[Contrast]

Treating tinnitus like an issue of it's own separate from these conditions is holding back research.

What if tinnitus is a equivalent of phantom limb perception
and some form of hyperacusis is equivalent of phantom limb pain
(i'm just hypothesizing here)

I am convinced tinnitus has some parallels to phantom conditions, but when it comes
to hyperacusis I am hearing several contradicting hypothesis or suggestions of their being different subtypes or separate pathologies entirely.

I screwed up an extremely complex biological sensory organ and now I act like a nutjob when I find out no one can fix or even provides a rational explanation. Pallative medicine literally thrives off scientific ignorance.

Palliative medicine and therapies don't require understanding the extreme technical complex properties of the cochlea/vestbiluar system or auditory brain.

I have a medicore understanding at best at anything I read about otological conditions but I just got so fed up with people parroting no one knows anything, but reality suggest their may be some hope if the community is vocal.


once again the community won't be vocal, the typical cochlear synaptopathy,hyperacusis victim is just going to get moving on with life and not demand a treatment.

 

[JohnAdams]

once again the community won't be vocal

Just think, there could be a drug or two sitting in cabinets somewhere right now that could cure you, us, but there are legal barriers as deep as the ocean stopping you from legally trying them out.

 

[Contrast]

View attachment 23174

microsoft edge.

that browsers cancer, it makes Google Chrome look good.

use firefox quantum.

 

[Jazzer]

I have decided to now completely work with my wife and friends for fundraising - at my pace for various reasons including health.

Good decision I reckon Greg.
Sylvie and I run three charity appeals every year, involving donors from 14 countries, supporting three major London hospitals.
While the appeals are running they virtually take over our lives, for every spare minute.
Whereas I am proud of our efforts, I will not be aparty to a survey that seeks to query the motivation and the details.

 

[85dB T]

Also why do people have sounds in their heads? wtf evolution??

re."evolution "

Strange that lower vertebrates (fishes, amphibians, reptiles, and birds) can spontaneously regrow hair cells and humans can not.

Some scientist claim birds are descendants of dinosaurs and creatures of the sea would have survived a meteor strike. Maybe this is why they have evolved the ability to regenerate hair cells. They've had time to evolve this, like a birds ability to fly.

If only we had this ability, that of a bird or fish.

quote: "research shows that mammalian cochlear hair cells do not regenerate, either spontaneously or after damage. However, lower vertebrates (fishes, amphibians, reptiles, and birds) can spontaneously regrow hair cells, under normal conditions and/or after damage. Hair cell regeneration allows birds to hear again."

 

[Contrast]

re."evolution "

Strange that lower vertebrates (fishes, amphibians, reptiles, and birds) can spontaneously regrow hair cells and humans can not.

Some scientist claim birds are descendants of dinosaurs and creatures of the sea would have survived a meteor strike. Maybe this is why they have evolved the ability to regenerate hair cells. They've had time to evolve this, like a birds ability to fly.

If only we had this ability, that of a bird or fish.

quote: "research shows that mammalian cochlear hair cells do not regenerate, either spontaneously or after damage. However, lower vertebrates (fishes, amphibians, reptiles, and birds) can spontaneously regrow hair cells, under normal conditions and/or after damage. Hair cell regeneration allows birds to hear again."

it's already proven birds evolved from ceolosaurian theropods. (dinosaurs that are bird like)

the wishbone, joint movement, and imprints of feathers and a ton of other similar features give it away.
however back 10 years ago after finding direct evidence of feathered dinosaurs there still were denieres who said NOBODY KNOWS ANYTHING ABOUT AVIAN EVOLUTION..

just like nobody knows anything about tinnitus today, you just have to ignore facts about hearing loss, the DCN, and fusiform cells and phantom pain/sensation in other conditions.

 

[85dB T]

Anyone familiar with the "Tectorial Membrane"?

How do we know this membrane is not the culprit?

How do we know it is damaged hair cells and not a dysfunctional Tectorial Membrane?

This Membrane (along with the cilia) is required to create vibratory signals to the auditory nerve.

 

[85dB T]

it's already proven birds evolved from ceolosaurian theropods.

Agree. I just stated "some scientist claim" to avoid those who would argue.

 

[Contrast]

99.9% of life scientist, especially expert paleontologist believe birds are Coelurosaurian theropods.

it's a fringe debunked minority that birds are not dinosaurs. just like idiots that say bent hair cells cause tinnitus.
( full peripheral tinnitus hypothesis.)

most of them state alternative archosaurian evolution like birds came from fuzzy tree climbing crocodillians, or pterosaurs. They've been debunked and theirs one weirdo scientist on deviant art that lies to people that birds evolved from lizards.

early on these hypothesis seemed legit but fell apart as new facts came a long.

Problem is science moves at a snails pace, and Young earthers/TRT proponents are always holding things back.

 

[Contrast]

 

[Contrast]

 

[Manny]

Anyone familiar with the "Tectorial Membrane"?

How do we know this membrane is not the culprit?

How do we know it is damaged hair cells and not a dysfunctional Tectorial Membrane?

This Membrane (along with the cilia) is required to create vibratory signals to the auditory nerve.



View attachment 23480

Indeed there may be several or many biological dysfunctions due noise in NIHL. But remember that hair cell regeneration treatment caused mice with NIHL to partially recover hearing.

 

[85dB T]

Indeed there may be several or many biological dysfunctions due noise in NIHL. But remember that hair cell regeneration treatment caused mice with NIHL to partially recover hearing.

Yes, could be anything.

But this Tectorial Membrane plays a key role in transforming sound to mechanical stimulation and allows the cilia to vibrationally function.

Also it's gel-like and 97% water!

If your hair cells are healthy and your Tectorial Membrane is damaged the hair cells don't have "vibrational tension".

Maybe our Tectorial Membranes need hydration?

 

[Manny]

Yes, could be anything.

But this Tectorial Membrane plays a key role in transforming sound to mechanical stimulation and allows the cilia to vibrationally function.

Also it's gel-like and 97% water!

If your hair cells are fine and your Tectorial Membrane is damaged the hair cells don't have "vibrational tension".

Maybe my Tectorial Membrane needs hydration?

Yeah well...this is why we need clinical trials n stuff.

Also tectorial membrane sounds like an earthquake safety net.

 

[85dB T]

Yeah well...this is why we need clinical trials n stuff.

Also tectorial membrane sounds like an earthquake safety net.

Yes, probably should have made a meme instead of researching this.

Anyone have a good Tectorial tectonic meme?

*Actually, the Tectorial Membrane is a "tectonic plate". It's an integral part of the vibrational mechanism of the hair cell. Surely that's why it's reflected in its name.

 

[Contrast]

Yes, could be anything.

But this Tectorial Membrane plays a key role in transforming sound to mechanical stimulation and allows the cilia to vibrationally function.

Also it's gel-like and 97% water!

If your hair cells are healthy and your Tectorial Membrane is damaged the hair cells don't have "vibrational tension".

Maybe our Tectorial Membranes need hydration?

wouldn't that problem be solved by

 

[Manny]

wouldn't that problem be solved by
View attachment 23487

Water+curcumin+quadcopter=cure.
I was always good at arithmetic.

 

[Manny]

Yes, probably should have made a meme instead of researching this.

Sorry. I totally didn't mean to offend.

 

[85dB T]

Sorry. I totally didn't mean to offend.

No, that's okay. Today I'm pretending to be a scientist and doing research.

I'll be watering some mice this evening to establish the hydration effects upon their tectorial membranes.

My human trials and results should be available in eight years.

*actually the Membrane is a gel-like tissue, not sure what liquid substance it would contain, if any.

 

[JohnAdams]

I still have not gotten a good answer from anyone as to why there is

i'm so pathetic i literally mock and insult people that can manage/habituate/tolerate these conditions.

You're not pathetic. You could probably meme better. Pick yourself up soldier and be strong.

 

[Contrast]

I still have not gotten a good answer from anyone as to why there is

You're not pathetic. You could probably meme better. Pick yourself up soldier and be strong.

the strong have habituated and managed.

 

[JohnAdams]

the strong have habituated and managed.

Theres a difference between being strong and being an NPC.

 

[JohnAdams]

I just drank early in the afternoon. Forgot I even had tinnitus for like 4 hours. It's so awesome to welcome it back.

 

[1000]

 

[85dB T]

Question please?

When we experience a loud noise our ears ring instantly. Sometimes this subsides and the ringing fades away.

Other times the ringing is permanent leaving us with tinnitus.

In the first instance 'tinnitus' is experienced and goes away. So the hair cells were not damaged yet the person experienced tinnitus. So why do we assume the hair cells are damaged with permanent tinnitus? (I'm sure in many cases they're damaged, but in all cases?)

Below are some interesting things I read about in the past hour. Seems like so many things can be the cause of tinnitus other than lack of hair cells (which currently seems to be the focus).

Mechanoelectrical Transduction - (mechanisms by which hair cells convert mechanical stimulus into electrochemical activity):
In the cochlea, a shearing movement between the tectorial membrane and the basilar membrane deflects the stereocilia (cilia/haircell), affecting the tension on the tip-link filaments, which then open and close the non-specific ion channels.[2] When tension increases, the flow of ions across the membrane into the hair cell rises as well. Such influx of ions causes a depolarization of the cell, resulting in an electrical potential that ultimately leads to a signal for the auditory nerve and the brain. The identity of the mechanosensitive channels in the stereocilia is still unknown.

And gene regulation is interesting:
Regrowth of Cochlear Hair Cells:
Researchers have identified a mammalian gene that normally acts as a molecular switch to block the regrowth of cochlear hair cells in adults.[23] The Rb1 gene encodes the retinoblastoma protein, which is a tumor suppressor. Rb stops cells from dividing by encouraging their exit from the cell cycle.[24][25] Not only do hair cells in a culture dish regenerate when the Rb1 gene is deleted, but mice bred to be missing the gene grow more hair cells than control mice that have the gene. Additionally, the sonic hedgehog protein has been shown to block activity of the retinoblastoma protein, thereby inducing cell cycle re-entry and the regrowth of new cells.[26]