My Posting Place

[JohnAdams]

You are cherry picking studies, John. It would take a lot more analysis to get a better understanding of the underlying mechanisms. People with SSHL usually have other factors compounding the issue such as circulation problems, menieres, trauma, infections, etc.

There's a lot more to it then you are letting on.

No, you're overcomplicating the obvious implications of all of these studies.

And that is that there are many ways to induce inner ear sensory neurons to regenerate, which results in an improvement of hearing loss, which will obviously alleviate tinnitus.

 

[JohnAdams]

"Proliferation was also induced by epidermal growth factor (EGF) when supplemented with insulin, but not EGF alone. These observations suggest that stimulation of the EGF receptors by TGF-alpha binding, or EGF (plus insulin) binding, stimulates cell proliferation in the mature mammalian vestibular sensory epithelium."

Induction of cell proliferation in mammalian inner-ear sensory epithelia by transforming growth factor alpha and epidermal growth factor.
H Yamashita and E C Oesterle
PNAS April 11, 1995 92 (8) 3152-3155

These two growth factors are a component of platelet rich plasma.

This would explain the amazing recovery that Dana White experienced after getting platelet rich plasma injections.

 

[Ed209]

No, you're overcomplicating the obvious implications of all of these studies.

And that is that there are many ways to induce inner ear sensory neurons to regenerate, which results in an improvement of hearing loss, which will obviously alleviate tinnitus.

You are assuming a lot. Are you saying you are more qualified and knowledgeable then the worlds leading experts in this field?

John Adams from TT has all the answers to this extremely complex question? You probably don't even understand many of the studies that you are reading. Without specialist knowledge, you cannot claim to understand every study that you come across. Even well educated academics struggle to understand the finer implications of some of the studies they read, and there's no shame in that. I certainly don't understand everything I read.

 

[85dB T]

I'm just presenting the facts of reality. I wish people were generally more charitable and giving to the rest of society, but that's not real life. The whole debate from last year was hinged on what is realistic and what isn't, and most of your posts are bordering on the fantasy side of the spectrum. I'm not saying that to be horrible, I'm just saying it as I see it.

John's just wanting some insider information (don't we all).

Except he may be more able to following this closer than some. His educational background, interest and knowledge of the subject is more fitting to someone on the inside. He doesn't like being on the "ousside".

Maybe he'll be an insider someday.

Also he's sharing his personal feelings and frustrations in this thread. Something we all have in common.

Nothing wrong with a little passion. It's something that fuels people to reach higher.

 

[JohnAdams]

Without specialist knowledge, you cannot claim to understand every study that you come across.

I have a bachelor's degree in Biomedical Engineering Technology.

You're just projecting your own ignorance onto me.

 

[Ed209]

John's just wanting some insider information (don't we all).

Except he may be more able to following this closer than some. His educational background, interest and knowledge of the subject is more fitting to someone on the inside. He doesn't like being on the "ousside".

Maybe he'll be an insider someday.

Also he's sharing his personal feelings and frustrations in this thread. Something we all have in common.

Nothing wrong with a little passion. It's something that fuels people to reach the inside.

Nothing wrong with that. Some of the posts I've seen him write, however, are a bit out there.

I have a bachelor's degree in Biomedical Engineering Technology.

You're just projecting your own ignorance on me.

I already know you do. You've said so many times. That doesn't mean a thing, however. It in no way means you understand this subject in the kind of detail you think you do. I can show studies to some of my friends, but I can't guarantee they will fully understand the implications, even with their backgrounds in medicine.

You come across as being easily influenced by anything you read. I think you're the kind of guy who could be easily ripped off and not see it coming.

 

[Daniel Lion]

Lord have mercy. How is this remotely helpful, the latter comments from Ed209. This condition is. Awful. I applaud JA for fighting the good fight. I am thankful he is researching and advocating for us, and raising the level of discourse, and not settling for mediocrity and the status quo. Stop beating up on the guy, it is becoming redundant on this forum.

 

[JohnAdams]

You come across as being easily influenced by anything you read. I think you're the kind of guy who could be easily ripped off and not see it coming.

thanks for the personal attacks.

 

[Ed209]

thanks for the personal attacks.

How is that a personal attack? I see you as quite vulnerable.

I'm really laid back, so if you see that as an attack then how do you define the many posts I've received from you, that were hateful?

Anyway, none of this really matters.

 

[JohnAdams]

I see you as quite vulnerable.

good for you.

 

[85dB T]

Nothing wrong with that. Some of the posts I've seen him write, however, are a bit out there.



I already know you do. You've said so many times. That doesn't mean a thing, however. It in no way means you understand this subject in the kind of detail you think you do. I can show studies to some of my friends, but I can't guarantee they will fully understand the implications, even with their backgrounds in medicine.

You come across as being easily influenced by anything you read. I think you're the kind of guy who could be easily ripped off and not see it coming.

Perhaps JohnAdams is suffering from tinnitus.

 

[JohnAdams]

FACT:

There is ample scientific evidence that several methods including the use of various growth factors present in blood derived platelet rich plasma are implicated in the regeneration of cochlear hair cells, which are actually peripheral nerves. The problem with getting this sort of treatment to patients is the astronomical costs involved in the FDA approval process. This means that economic factors relating to corporate profit margins, not merely safety concerns, contribute to the lack of practical treatments and possibly cures for many diseases.

 

[Artemis2K]

Nothing wrong with that. Some of the posts I've seen him write, however, are a bit out there.



I already know you do. You've said so many times. That doesn't mean a thing, however. It in no way means you understand this subject in the kind of detail you think you do. I can show studies to some of my friends, but I can't guarantee they will fully understand the implications, even with their backgrounds in medicine.

You come across as being easily influenced by anything you read. I think you're the kind of guy who could be easily ripped off and not see it coming.

You're questioning his reading comprehension abilities and the value of his degree. That definitely sounds insulting to me. I don't see how he wouldn't be able to understand the material. Do you have a better background than him? I would think that his degree would definitely enable him to understand the material a lot better than the average person.

 

[Jack Straw]

 

[Ed209]

You're questioning his reading comprehension abilities and the value of his degree. That definitely sounds insulting to me. I don't see how he wouldn't be able to understand the material. Do you have a better background than him? I would think that his degree would definitely enable him to understand the material a lot better than the average person.

I don't want to go down this route, but yea, I am questioning his ability. His grammar leaves a lot to be desired and then he goes on to say that others can't understand the studies as he does? In that instance, I thought he came across as a bit condescending, but you could say that I am doing that now. However, I've said many times that I'm not here to pat everyone on the back; if nobody debates these issues and you all go off on a feeding frenzy then it's easy for gullible newcomers to get sucked in. These debates need some push and pull, and it's for this reason we have the peer review process.

Why aren't any of the worlds foremost experts in this field acknowledging any of this as a cure, even though it's in the literature?

John seems to jump from one cure to another, and will post about whatever the flavour of the week is like it's gospel. He seems to believe anything he reads, and that's my honest assessment and it is not a personal attack. If you see it that way then you'd have a hard time dealing in business or politics.

 

[JohnAdams]

His grammar leaves a lot to be desired

Well, usually I'm typing on my cell phone and I could care less to focus on proper grammar and punctuation. Also, the spell check on my phone seems to have a mind of its own.

 

[JohnAdams]

If platelet rich plasma and or stem cells can indeed help treat tinnitus and meniere's disease then that means that the equipment and expertise to offer us relief is already deployed in our communities.

There are stem cell clinics, and PRP clinics all over the place, we would just need our PRP to be given to an ENT and then injected into our eardrums. The only thing stopping that is the FDA which requires very very costly clinical trials and I simply don't see any corporations being interested in footing that bill.

 

[JohnAdams]

Seriously, what if many of us with hidden hearing loss could be helped by this:

"The researchers designed and synthesized a molecule combining DHF and bisphosphonate, which latches onto bone, then tested its neurotrophic activity. In cell cultures, the combo molecule bound bone mineral, while maintaining the ability to stimulate spiral ganglion neuron outgrowth. This new molecule also regenerated synapses in mouse inner ear tissue that had been damaged. Future work will test the potential of the molecule in animal models of hearing loss."

https://www.news-medical.net/news/2...novel-approach-to-restoration-of-hearing.aspx

I've got some 7,8 DHF in my desk. All I would need is an ENT to mix it with some fosamax, which is at the pharmacy, and inject my eardrum. I know that there's yet to be an in vivo experiment with this, but why the wait? Why aren't these scientists doing this already?

There's very little to nothing I can do about the complex interplay between corporations and the FDA but I still can voice my opinion.

Why can't I legally request an ENT inject my eardrum with some of my own PRP here in America?
People can get other types of medically unnecessary procedures done that carry a risk of death, just look at Joan Rivers, RIP. I don't think the FDA is simply trying to keep us safe. I think they are there to also regulate markets as if the health of certain pharmaceutical markets are more important than human health.

 

[Artemis2K]

I don't want to go down this route, but yea, I am questioning his ability. His grammar leaves a lot to be desired and then he goes on to say that others can't understand the studies as he does? In that instance, I thought he came across as a bit condescending, but you could say that I am doing that now. However, I've said many times that I'm not here to pat everyone on the back; if nobody debates these issues and you all go off on a feeding frenzy then it's easy for gullible newcomers to get sucked in. These debates need some push and pull, and it's for this reason we have the peer review process.

Why aren't any of the worlds foremost experts in this field acknowledging any of this as a cure, even though it's in the literature?

John seems to jump from one cure to another, and will post about whatever the flavour of the week is like it's gospel. He seems to believe anything he reads, and that's my honest assessment and it is not a personal attack. If you see it that way then you'd have a hard time dealing in business or politics.

With all due respect, I do think you should change your approach. I'm sorry, but the way you are writing can certainly sound antagonizing and shallow to somebody. This isn't a matter of politics or business, we should be working together as we want the same thing.

 

[Ed209]

With all due respect, I do think you should change your approach. I'm sorry, but the way you are writing can certainly sound antagonizing and shallow to somebody. This isn't a matter of politics or business, we should be working together as we want the same thing.

I have always been respectful and honest on this site. unfortunately, this isn't always returned and in some instances, his posts have gone way below the belt, and unnecessarily so. I let it slide time and time again, and continued defending him but now I don't care. I'll just say it as I see it because I've lost all respect.

I haven't posted in a while but I see it's the same old arguments clogging up every thread. You'll be thrilled to know that I have no interest anymore anyway, so just ignore my last few posts.

This isn't a matter of politics or business, we should be working together as we want the same thing.

This sentence, in particular, stood out for me as I truly wish the community would work together, but I can't ever see it happening. There are people busting their ass to make things happen whilst others hide in the shadows criticising everything that gets done. Some even feel the need to create multiple accounts to make their attacks appear more legitimate by liking and commenting on their own posts. It's all just so pathetic.

I admire and respect many members here, but some are just toxic. To be fair to John, I wouldn't put him in the toxic bracket, but he his definitely a bit of a loose cannon.

Anyway, I'm aware this will probably just stir the pot, but that's my honest assessment.

 

[Snake]

Hasn't kelpie participated in the Minnesota Bi-Modal stimulation trial from what i remember?

@kelpiemsp They got the timing right? How do you hear silence?

 

[Leoglobe]

@Ed209 the toxic people are those that are happy with the statu quo and there are heaps of them.

A quick example: I am on another group and one of the admins is appreciated because he has good manners, excellent grammar and the kind of leader personality that people like. What surprised me with him is that he keeps dowplaying any progress made by the biotechs. He makes some assumptions such as «most tinnitus sufferers don't have hearing loss». this guy has actually created a big network of TRT and sophrology shops.

We obviously don't need this type of guys. We need some hope for a better future and TT without the research area would be a very boring forum. I personally like John's comments on the prp thread and on the fx one. They are interesting.

 

[JohnAdams]

I have always been respectful and honest on this site.

most of your posts are bordering on the fantasy side of the spectrum.

John Adams from TT has all the answers to this extremely complex question

You probably don't even understand many of the studies that you are reading.

I think you're the kind of guy who could be easily ripped off and not see it coming.

I see you as quite vulnerable.

Some of the posts I've seen him write, however, are a bit out there.

His grammar leaves a lot to be desired

I am questioning his ability.

John seems to jump from one cure to another, and will post about whatever the flavour of the week is like it's gospel.

I have always been respectful and honest on this site.

 

[Contrast]

View attachment 25541

Was it an adhominem when I criticized Jasterboff's website for being extremely archaic in design not being updated in over 20 years?

That in a way reflects the mans personality and mindset towards tinnitus research.

 

[JohnAdams]

Was it an adhominem when I criticized Jasterboff's website for being extremely archaic in design not being updated in over 20 years?

That in a way reflects the mans personality and mindset towards tinnitus research.

yeah but you've also worked your way down from the top of the pyramid on that guy.
you're good man.

 

[Ed209]

Well, usually I'm typing on my cell phone and I could care less to focus on proper grammar and punctuation. Also, the spell check on my phone seems to have a mind of its own.

Every message I've ever made on here has been typed on my phone, and saying "I could care less" means you're interested in it.

@Ed209 the toxic people are those that are happy with the statu quo and there are heaps of them.

A quick example: I am on another group and one of the admins is appreciated because he has good manners, excellent grammar and the kind of leader personality that people like. What surprised me with him is that he keeps dowplaying any progress made by the biotechs. He makes some assumptions such as «most tinnitus sufferers don't have hearing loss». this guy has actually created a big network of TRT and sophrology shops.

We obviously don't need this type of guys. We need some hope for a better future and TT without the research area would be a very boring forum. I personally like John's comments on the prp thread and on the fx one. They are interesting.

The toxic people on here are complete fruit loops. Some create multiple accounts to talk to themselves, and some generally just go around abusing other members. They literally do nothing and add no value to TT whatsoever.

I couldn't care less about people's grammar, but I do if they try and pull intellectual superiority over others, whilst barely being able to string a sentence together and using words that don't exist.

As I said, John isn't all that bad, but he often flies off the handle for no reason. I believe he means well, though.

 

[Contrast]

Some create multiple accounts to talk to themselves

who do you suspect is using alts?

 

[TuxedoCat]

I've got some 7,8 DHF in my desk. All I would need is an ENT to mix it with some fosamax, which is at the pharmacy, and inject my eardrum.

How much DHF and how much bisphosphonate should be mixed together? What about excipients and carriers? Will the stuff go thru a syringe? Is DHF a liquid? What about the excipients in the Fosamax? Maybe the stuff will set like cement in your ear. Too much bisphosphonate can alter bone metabolism to the point it becomes necrotic. Besides doesn't the DHF have to be chemically attached to the bisphosphonate. Yep, it does. So forget the simple mixing,. You'll need the whole method for synthesis. Order the equipment. Oh, and whats the yield from the reaction? What else is being formed as a byproduct of the reaction? Are the byproducts safe? Of course you'll need analytical methods and a lab to do the analysis.

It can go on and on from here.

So once you figure out how to synthesize the molecule and compound the drug into an injectable form you'll have to find an ENT to do it. Good luck with that. You're probably aware that doctors take the Hippocratic Oath and promise to do no harm? What you are requesting has not been proven safe and effective. The learned intermediary is not an intermediary because there's no drug company involved. Also I'm sure you're aware that there's a little something called malpractice?

So John, if your going to make the drug yourself why don't you just go the whole 9 yards and inject yourself?

Anyway John, that was fun. I think you know all this stuff and are just trying to wind people up, as they say.

Take care,
Tuxedo

 

[Contrast]

LETS TAKE THEM DOWN!

 

[Kain]

i turn 21 in april and can't wait to not do anything like i originally planned but this time with a twist! The Big T™