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https://www.tinnitustalk.com/thread...ural-avian-bird-hair-cell-regeneration.29646/
RIP probably got removed because it isn't research. so i'll just repost here.
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As you all should know all non modern mammalian vertebrates seem to have the ability to regenerate cochlear hair cells, however there may be a possibility they may be mediocre at this process.
https://www.ncbi.nlm.nih.gov/pubmed/10516389
In a nutshell this 1999 study is saying that the birds they deafened successfully regenerate their low frequency hair cells but only partially regenerate high frequency hair cells. High freq hair cells regenerate without any or little synaptic connections making them less efficient.
This seems concerning because most hearing loss is high frequency related not low.
This might be a problem that bio tech like Frequency Therapeutics might encounter with clinical trials in humans.
However the good news maybe the fact that this might be easily explained by the fact that these birds had intentionally suffered a severe degree of hearing loss due to being intentionally deafened by ototoxic drugs and loud noise that completely killed the high frequency progenitor cells. The cells necessary for regenerating hearing hair cells which Frequency Therapeutics is making use of to regenerate human hearing. Frequency Therapeutics has also openly stated incases of progenitor cell death (severe hearing loss) they may not be able to repair hearing.
So hopefully the case is that mild to moderate hearing loss allows high frequency hair cells to reform correctly and that this poor bird was just to far damage to be rehabilitated.
Don't panic but we won't know until http://frequencytx.com/ begins stage 2 clinical trials.
RIP probably got removed because it isn't research. so i'll just repost here.
-------------------------------------------------------------------------------------
As you all should know all non modern mammalian vertebrates seem to have the ability to regenerate cochlear hair cells, however there may be a possibility they may be mediocre at this process.
https://www.ncbi.nlm.nih.gov/pubmed/10516389
In a nutshell this 1999 study is saying that the birds they deafened successfully regenerate their low frequency hair cells but only partially regenerate high frequency hair cells. High freq hair cells regenerate without any or little synaptic connections making them less efficient.
This seems concerning because most hearing loss is high frequency related not low.
This might be a problem that bio tech like Frequency Therapeutics might encounter with clinical trials in humans.
However the good news maybe the fact that this might be easily explained by the fact that these birds had intentionally suffered a severe degree of hearing loss due to being intentionally deafened by ototoxic drugs and loud noise that completely killed the high frequency progenitor cells. The cells necessary for regenerating hearing hair cells which Frequency Therapeutics is making use of to regenerate human hearing. Frequency Therapeutics has also openly stated incases of progenitor cell death (severe hearing loss) they may not be able to repair hearing.
So hopefully the case is that mild to moderate hearing loss allows high frequency hair cells to reform correctly and that this poor bird was just to far damage to be rehabilitated.
Don't panic but we won't know until http://frequencytx.com/ begins stage 2 clinical trials.
MPP is a very complicated thread filled with unorganized science papers mixed in with lots of shitposting.
pure definition of autism
pure definition of autism
Omg. I agree. Tinnitus ruined my life permanently, when you add in the Severe H it is truly a shit storm.
This is the only thing I can find on the entire internet from a trust worthy scientist saying reversing hearing loss will not fix tinnitus and unlike what Dr. Schaette showed and what Cochlear Implants show decades after tinnitus I can't find his theory.
He was associated with Auris Medical that had two failed drug candidate for treating acute hearing loss and tinnitus.
How do you explain cochlear implants reducing tinnitus years after the fact?
Also there trials never generated hair cells and failed.
He was associated with Auris Medical that had two failed drug candidate for treating acute hearing loss and tinnitus.
How do you explain cochlear implants reducing tinnitus years after the fact?
Also there trials never generated hair cells and failed.
Someone on this TinnitusTalk sent Charles Liberman an email back in 2016 if reversing hearing loss would reduce tinnitus based on something he mentioned in a paper and Charles said it is still a hypothesis.
Here's a good copy pasta I can use just like Michael Leigh does for TRT shilling but just the alternative
Hello Welcome to Tinnitus Talk!
Melatonin and Clonazepam as well as mindfulness and avoiding stress and loud noise may help somewhat reduce the volume of tinnitus. Masking with environmental noise is a good idea as well.
https://www.ncbi.nlm.nih.gov/pubmed/22626945
Clonazepam
https://www.tinnitustalk.com/thread...al-especially-in-preventing-hearing-loss.401/
Melatonin
Lots of researchers are saying help is on the way for tinnitus and hearing loss.
https://www.tinnitustalk.com/forums/research-news.4/
Two active clinical trials may be available in the early 2020's.
https://www.tinnitustalk.com/threads/frequency-therapeutics-—-hearing-loss-regeneration.18889/
Cure for hearing loss + (possibly tinnitus)
https://www.tinnitustalk.com/threads/new-university-of-michigan-tinnitus-discovery-—-signal-timing.2805/
Device directly targets areas in the brain associated with tinnitus, it will allow temporarily reduction for tinnitus.
https://www.cochlearpro.com
more info here
Enjoy your stay on Tinnitus Talk.
Hello Welcome to Tinnitus Talk!
Melatonin and Clonazepam as well as mindfulness and avoiding stress and loud noise may help somewhat reduce the volume of tinnitus. Masking with environmental noise is a good idea as well.
https://www.ncbi.nlm.nih.gov/pubmed/22626945
Clonazepam
https://www.tinnitustalk.com/thread...al-especially-in-preventing-hearing-loss.401/
Melatonin
Lots of researchers are saying help is on the way for tinnitus and hearing loss.
https://www.tinnitustalk.com/forums/research-news.4/
Two active clinical trials may be available in the early 2020's.
https://www.tinnitustalk.com/threads/frequency-therapeutics-—-hearing-loss-regeneration.18889/
Cure for hearing loss + (possibly tinnitus)
https://www.tinnitustalk.com/threads/new-university-of-michigan-tinnitus-discovery-—-signal-timing.2805/
Device directly targets areas in the brain associated with tinnitus, it will allow temporarily reduction for tinnitus.
https://www.cochlearpro.com
more info here
Enjoy your stay on Tinnitus Talk.
Tinnitus with a Normal Audiogram: Physiological Evidence for Hidden Hearing Loss and Computational Model | Journal of Neuroscience
http://www.jneurosci.org/content/31/38/13452
http://www.jneurosci.org/content/31/38/13452
http://scarysymptoms.com/2017/02/hearing-loss-detected-exams-go-8000-hz/
Hearing loss typically begins at frequencies that are much higher than what a hearing test detects. You could be losing hearing at higher frequencies without this being detected on a routine test.
So let’s say your hearing loss is beginning at 19,000 Hz and gradually getting lower. You won’t know you’re experiencing hearing loss at these higher frequencies!
However, one way you could find out is if you establish a baseline by testing your hearing range off of a YouTube sine wave tone and then check back yearly.
Once you think you’ve determined the upper limit in Hertz, you should then listen to a few other YouTube audios at that same frequency to see if you can hear them.
After all, these YouTube audios may not be accurate and are no replacement for an audiologist’s audiogram.
But certainly, if your limit is, say, 13,000 Hz, you’re not going to be able to detect a 17,000 Hz tone on YouTube.
So with that said, we can assume that as a generality, YouTube can give you an idea, an approximation, of what frequency neighborhood you can just barely hear with your computer volume turned up.
But what about at the audiologist’s office? Why does the standard hearing test go up to only 8,000 or 6,000 Hz?
“To me it seems obvious there is no need to test or necessarily know about hearing loss that is outside of the critical hearing range for humans,†says Rachel Raphael, M.A., CCC-A, an audiologist with Mercy Medical Center in Baltimore.
“The ‘speech banana’ (frequencies needed for speech understanding) ranges roughly from 250 Hz to 6kHz, so when we test 250 Hz to 8kHz on a standard test, it gives us the important information we need.
“Testing beyond 12kHz will not give useful or practical information for humans and the range at which we need to hear.â€
Super Hearing
When I was in college my brother built a gadget the size of a thick wallet that emitted a very high frequency pitch. My siblings could not hear it, but I could and it hurt.
I could hear it from across a room. I would hear that thing even without knowing my brother was pressing the button (I’d suddenly hear it, turn, and there he was), which rules out any chance of imaginary hearing from a self-fulfilling prophecy.
He said it was 25,000 Hz. I don’t know how he calculated this, but he could barely hear it in his hand; nobody else heard it at all; and I could hear it from across a room. So if it wasn’t 25,000 Hz, it still must have been pretty high up there nonetheless.
Imagine my dismay recently when I decided to test my frequency on YouTube and could not hear above 11,000 Hz!
(My “other†kind of hearingâ€"being able to decipher voices from a distance and amid a noisy roomâ€"is still impressive.)
So all these years, I’ve been losing my hearing at higher frequencies. Several years ago I had a hearing test just for the heck of it. But this standard hearing test did not tell me how many Hz I could detect.
Instead the results were in the form of how well my hearing was, relative to other people in my age bracketâ€"for both high frequency and the ability to decipher soft sounds and sounds amid other noise.
Had I known that I’d been losing my very high frequency hearing all these years, I would have been more aggressive about hearing protection (which I’ve always thought I was, but I suppose I could have been more strict).
“A first hearing test serves as a baseline, from which we can document later changes in hearing,†says Raphael. “We are not often lucky enough to have information/test data preceding trauma such as a motor vehicle accident.
“It’s always helpful and useful for a person to get a hearing test (to serve as a baseline) whenever they begin to notice or suspect some hearing loss and/or tinnitus.
“They may not end up acting on the loss (remediation) until many years later, as hearing loss slowly progresses. Anyone who works in a loud work environment (like in construction, factory work, etc.) would probably benefit from a baseline audiogram early in their career, and perhaps annually thereafter.
“Without an earlier (baseline) hearing test, we can only infer (based on typical age-related hearing loss norms) which portion of hearing loss is age related and which is from other factors, such as trauma.
“Nevertheless, most people have their hearing tested/ screened in first grade (average age six), and not tested again until as an adult they present to the doctor/audiologist with some subjective loss and/or tinnitus.â€
Okay, so I’ve lost my amazing high frequency hearing. It had always pleased me greatly to be able to hear the high frequency pitch of jewelry store alarms that nobody else could hear.
Hearing loss typically begins at frequencies that are much higher than what a hearing test detects. You could be losing hearing at higher frequencies without this being detected on a routine test.
So let’s say your hearing loss is beginning at 19,000 Hz and gradually getting lower. You won’t know you’re experiencing hearing loss at these higher frequencies!
However, one way you could find out is if you establish a baseline by testing your hearing range off of a YouTube sine wave tone and then check back yearly.
Once you think you’ve determined the upper limit in Hertz, you should then listen to a few other YouTube audios at that same frequency to see if you can hear them.
After all, these YouTube audios may not be accurate and are no replacement for an audiologist’s audiogram.
But certainly, if your limit is, say, 13,000 Hz, you’re not going to be able to detect a 17,000 Hz tone on YouTube.
So with that said, we can assume that as a generality, YouTube can give you an idea, an approximation, of what frequency neighborhood you can just barely hear with your computer volume turned up.
But what about at the audiologist’s office? Why does the standard hearing test go up to only 8,000 or 6,000 Hz?
“To me it seems obvious there is no need to test or necessarily know about hearing loss that is outside of the critical hearing range for humans,†says Rachel Raphael, M.A., CCC-A, an audiologist with Mercy Medical Center in Baltimore.
“The ‘speech banana’ (frequencies needed for speech understanding) ranges roughly from 250 Hz to 6kHz, so when we test 250 Hz to 8kHz on a standard test, it gives us the important information we need.
“Testing beyond 12kHz will not give useful or practical information for humans and the range at which we need to hear.â€
Super Hearing
When I was in college my brother built a gadget the size of a thick wallet that emitted a very high frequency pitch. My siblings could not hear it, but I could and it hurt.
I could hear it from across a room. I would hear that thing even without knowing my brother was pressing the button (I’d suddenly hear it, turn, and there he was), which rules out any chance of imaginary hearing from a self-fulfilling prophecy.
He said it was 25,000 Hz. I don’t know how he calculated this, but he could barely hear it in his hand; nobody else heard it at all; and I could hear it from across a room. So if it wasn’t 25,000 Hz, it still must have been pretty high up there nonetheless.
Imagine my dismay recently when I decided to test my frequency on YouTube and could not hear above 11,000 Hz!
(My “other†kind of hearingâ€"being able to decipher voices from a distance and amid a noisy roomâ€"is still impressive.)
So all these years, I’ve been losing my hearing at higher frequencies. Several years ago I had a hearing test just for the heck of it. But this standard hearing test did not tell me how many Hz I could detect.
Instead the results were in the form of how well my hearing was, relative to other people in my age bracketâ€"for both high frequency and the ability to decipher soft sounds and sounds amid other noise.
Had I known that I’d been losing my very high frequency hearing all these years, I would have been more aggressive about hearing protection (which I’ve always thought I was, but I suppose I could have been more strict).
“A first hearing test serves as a baseline, from which we can document later changes in hearing,†says Raphael. “We are not often lucky enough to have information/test data preceding trauma such as a motor vehicle accident.
“It’s always helpful and useful for a person to get a hearing test (to serve as a baseline) whenever they begin to notice or suspect some hearing loss and/or tinnitus.
“They may not end up acting on the loss (remediation) until many years later, as hearing loss slowly progresses. Anyone who works in a loud work environment (like in construction, factory work, etc.) would probably benefit from a baseline audiogram early in their career, and perhaps annually thereafter.
“Without an earlier (baseline) hearing test, we can only infer (based on typical age-related hearing loss norms) which portion of hearing loss is age related and which is from other factors, such as trauma.
“Nevertheless, most people have their hearing tested/ screened in first grade (average age six), and not tested again until as an adult they present to the doctor/audiologist with some subjective loss and/or tinnitus.â€
Okay, so I’ve lost my amazing high frequency hearing. It had always pleased me greatly to be able to hear the high frequency pitch of jewelry store alarms that nobody else could hear.
MPP has an official rating system that I have been using for a while now
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