MemberI'm still trying to find the exact point ML decided to start living on MPP. Didn't he say he had no intention of commenting here a long time ago?
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- Thread starter threefirefour
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My idea goes like this, and it may be completely futile:
They are still discovering new ways of triggering our ear stem cells to proliferate, even 5 days ago a new paper was published explaining a new method to achieve this.
https://www.nature.com/articles/s41467-019-13157-7
The method involves getting the beta-catenin destruction complex to phosphorylate, allowing beta-catenin to accumulate in the cell and enter the nucleus, which initiates the cell cycle and proliferation and new hair cells.
The problem with achieving this orally, is that you will be doing this systemically, which has a cancer risk because over expression of beta-catenin in other tissues is how you get cancer. This is reflected in the initial studies where rodents' hearing was restored through oral administration of gamma secretase inhibitors, but they got cancer, and their skin changed color, and their hair fell out = bad.
Not all cells, as you are aware, are the same. The cells we want to target are called LGR5+ stem cells.
My belief, hope, is that there may be two or more combinations of pathways unique to the LGR5+ stem cells that can be triggered which will cause the beta-catenin destruction complex to phosphorylate without triggering the same in other tissues, and achieve this through oral substances that could be readily, or easily obtainable.
There is a lot of research out there that has been published that hasn't be synergized that could lead us to this possibility. This is what I am researching when I do research. The answer could already be out there. There could already be pharma corporations that know this and won't tell the public because it won't make them any money.
That is my contention and if anyone just dismisses this notion as being unworthy of pursuit, without explicitly refuting the idea scientifically by showing specifically that there are no combinations of signaling pathways that can be activated in LGR5+ stem cells that will not also trigger other types of cells, then they are goons that are really part of everything wrong with this world, mental tyrants, uninspired cranks.
If someone could help me and ended up finding the combination before me, I will lab rat myself, and show before and after audiograms/ word scores.
If this is possible then it would be superior to RWM administration of gamma secretase and GSK3 inhibitors because it would permeate the entire cochlea.
John is a respected biomedical engineer working on regenerative medicine and I'm a detective/prosecutor going after a health fraudsters and serving justice. It's so fun proving that people with mental illnesses are more qualified to do serious things then people with actual degrees and qualifications.
ajc
Member
- Feb 6, 2018
- 1,170
- Tinnitus Since
- 11/2002; spike 2009; worse 2017-18
- Cause of Tinnitus
- Loud music - noise damage
Thanks, that was really interesting, I'll have to read around it more. Quite a lot of molecular biology (as you know) is just that; trying to target pathways in a specific way because general activation etc of a signalling pathway would have major off target effects. What you describe sounds like the basis for a great PhD project... it would be very hard to work out what to target without laboratory experiments. If you could identify candidate genes involved in pathways specific to the LGR5+ cells linked to the beta-catenin pathway, the usual route is to knock out the genes in cells in the lab and mice, experiments like that.
Could you maybe start by writing a "review" paper on the subject and getting it published in the scientific literature? Patients writing about their own diseases is a growing area; the ME/CFS patients have done this. Then if you can propose a project yourself to a specific lab working in a relevant area, some lab might go for that and find funding.
Mental illness, and physical illness, are not necessarily impediment to achievement even if it can be so much harder. Patients are getting more and more involved in research and campaigning around their diseases each year thanks to social media.
CBT and TRT utilize coping methods most people already know. I've been tolerating nonsense my whole life. I know how to ignore, persevere and block things out to stay calm. I learned this naturally and successfully applied this to moderate tinnitus which I've had my whole life. Now I have severe tinnitus and it's the only thing in life that could shut me down. Three years to grind me to nothing, two years of surviving and now five years later I'm able to talk about it without causing myself anxiety. My life is not as rich with activities as it was before severe tinnitus, but at least I'm not suicidal.
And you have been and still are an integral part of our regime. I don't understand outsiders coming here and telling you what to do.
We are in a brand new age of information and access to it. I have had a vision of sorts of a massive flourishing of human knowledge coming soon, from the ground up, even long before I got tinnitus. I believe we are on the threshold of a new age and the current establishment will not only have no part in leading us there, but will have no part in it period.
I agree, it's very exciting. Patients are starting to be able to do a lot with data online. I've done a lot there with another health issue.
But, scientific advances, real ones, ultimately come about due to careful experimentation in the lab. You've got a degree in biology so absolutely have the means to do a PhD unless it's different in the US
Kain
Member
- Aug 25, 2018
- 365
- 26
- Tinnitus Since
- March, 2018
- Cause of Tinnitus
- excessive loud music through earbuds
Yeah. I was almost going to go for my PhD but I just wanted to go ahead and work and make money.
- Feb 17, 2017
- 10,400
- Tinnitus Since
- February, 2017
- Cause of Tinnitus
- Acoustic Trauma
I understand that it is better to spend money on an actual cure. But in the absence of a cure, treatments that reduce the distress of some sufferers have some value.
- Feb 17, 2017
- 10,400
- Tinnitus Since
- February, 2017
- Cause of Tinnitus
- Acoustic Trauma
I have had a vision of no indoor plumbing by 2040s. Enjoy having it while you still can. We'll just have to wait and see who got it right.
Well - up and down like we all are I guess.
It seems to me that there are two major problems with severe Tinnitus.
*Coping with the eternal noise.
*Coping with the disappointment over what this wretched thing has done to the course of what were clearly beautiful lives.
When one doesn't get you - the other one does.
How about you Manny?
Have you been involved with Lenire yet?
research grants that could be going towards biomedical research and stem cells all go towards CBT and pain killers.
honk honk
- May 29, 2015
- 664
- 30
- Tinnitus Since
- 2012
- Cause of Tinnitus
- I had tinnitus for as long as I can remember. Got bad later.
Every single time I feel that I start the understand one receptor/pathway, more and more variables pop up. I have fantasies of somehow decoding this myself but I always feel like there are important details that emerge that humble me greatly.
Take for example, Dr. Chen's work. It appears he is activating Notch, then subsequently inhibiting it. How would you factor in timing a series of compounds or how to titrate just the right amount.
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