I think that it is going to depend on how the tinnitus came on about.
You can have cochlear damage and still be able to modulate your tinnitus with your neck or jaw. 80% of sufferers experience this. So FX-322, OTO-413, and others will still help if it's noise-induced.
I think I have hyperacusis, or something was causing my ears to generate a pulsing-ringing sound in response to my computer last night, which does make me fret, as these drugs are still years away from release, and could be very expensive. I don't know. I just want this hell to end.
I wouldn't be worried about the treatments not working for you is all I meant.
I think that this can sum up why the work on the device is taking tonnes longer than the time it is taking to get the hearing medicines out. It is incredibly interesting research, however I think that this tends to tell the story of why progress with the device has taken so long and why university orientated projects can take so much longer to complete than private sector projects.
Interesting, what are bush cells? And would those stop firing so rapidly if we restored input to the cochlea by regenerating hair cells and synapses? In other words, would hyperacusis be cured by ceasing the excessive neuronal firing?
Wondering the same thing. Google only gives me stuff about George W. Bush's views on stem cells.
Maybe they meant bushy cell? Apparently located in the cochlear nucleus. If this is the case then it confirms that hyperacusis is the result of synaptopathy.
Neurons misfiring/hyperactivity is definitely what causes mine. I also have visual snow and BFS. My whole body is basically misfiring and is out of sync. I never used headphones or had noise induced tinnitus. Just spontaneously came on one day after having visual snow.
Same here. I got visual snow syndrome one month into hyperacusis. Definitely has to do with overfiring neurons that somehow crossed into the eyes as well, probably something to do with the thalamus. Makes me wonder if curing tinnitus will cure my visual snow syndrome as well.
I read there was a user on here that took part in the Minnesota trial which targets the thalamus. Both his tinnitus and visual snow were reduced or disappeared. So, sounds like you could be right.
It wouldn't surprise me if this was why things have gone quiet in relation to Dr. Shore's device. I'd expect that they might consider a post phase 2 release if their device meets the standards of the FDA and they get approval from the FDA for compassionate use/right to try.
She's filed patents on the device as far back as 2014. The most current patent application shows as being granted this year, but filed in 2017.
Or Susan Shore is looking forward to being a patent troll and suing Lenire while never coming to market with her device.
No clue. Google Patent search pulls up more info. Maybe someone familiar with the process can extract more info from this.
The problem with this area is that there are going to be many people who will be putting out basically what will be marketing propaganda and the like to try and drum up support for their treatment. Then there are also those who will put out hatchet job stuff on medicine like FX-322 as we saw in that article a few weeks ago which was basically criticising FX-322 and also Frequency Therapeutics.
I think Dr. Shore's patents are already holding back the effectiveness of Lenire. None of the Lenire timings that I have seen in their literature are the same as the timings published by Dr. Shore that were shown to have a positive effect on tinnitus. The only reason I can think of that Neuromod would not use timings similar to Dr. Shore's are the patents.
This would make sense since Dr. Shore could not necessarily patent the device because the device is too generic but she definitely could patent the signal timings because these are the specific part of her treatment and as a result meet the requirement of having unique and specific elements of something to get patented.
If Dr. Shore's timings are effective, it's just unfortunate for tinnitus sufferers that the timings can't be incorporated into a device that's already released like Lenire. I get why from a financial and IP perspective, but it could potentially reduce the time it'd take to get a consistently working treatment out to us.
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