New University of Michigan Tinnitus Discovery — Signal Timing

[AfroSnowman]

When the commercial version of Dr. Shore's device comes out, do you think that the less than 40 dB hearing loss requirement will still be a thing or is that just for the clinical study?

I suspect that is just a study requirement.

I touch just at 40 dB of hearing loss in my left ear at 8000 Hz, the rest of my hearing is below that threshold.

 

[Paul1980]

Is it worth it getting an MRI to be able to join the trial?

Here is the trial criteria:

https://clinicaltrials.gov/ct2/show/NCT03621735

Are you talking about a different trial? If not, then why are you worried about an MRI?

A lot of misinformation and misunderstanding on this forum... I can't say I haven't been guilty of it myself. But I notice people took modulation to mean quieting. Modulation does not mean quieting.

Yes, I advise people with tinnitus not to get an MRI unless absolutely medically necessary. I wouldn't even get one until you have a CT scan if for the purpose of ruling out other tinnitus causes.

Cheers.

 

[twa]

I commend your integrity. You rather commit suicide (I read your comments in the Suicidal thread) than lie your way into a clinical trial and possibly skew the results of the trial.

I hope you get better and don't need to leave this Earth.

Rather harsh.

 

[Tomas80]

The trial treatment should last for 6 weeks. But the results are not expected until May 2022. Unbelievable how long it all takes. At this rate, it will be on the market in year 3500.

 

[hurtingdream]

Here is the trial criteria:

https://clinicaltrials.gov/ct2/show/NCT03621735

Are you talking about a different trial? If not, then why are you worried about an MRI?

A lot of misinformation and misunderstanding on this forum... I can't say I haven't been guilty of it myself. But I notice people took modulation to mean quieting. Modulation does not mean quieting.

Yes, I advise people with tinnitus not to get an MRI unless absolutely medically necessary. I wouldn't even get one until you have a CT scan if for the purpose of ruling out other tinnitus causes.

Cheers.

That is the trial. I went to the interview and screening and they want me to get an MRI to rule out an acoustic neuroma.

 

[Paul1980]

That is the trial. I went to the interview and screening and they want me to get an MRI to rule out an acoustic neuroma.

That seems like a huge ask. An MRI machine can reach 110 dB levels for periods of time. You can wear 32 dB reduction earplugs, inserted properly, which I did, but I can tell you that I thought it made my tinnitus very slightly worse, and in the end I didn't have a positive MRI. Or, it might be my anxiety ramping up the tinnitus.

I find it hard to believe this study wants you to possibly do a procedure that can damage your hearing, so that they can study a remedy for tinnitus. On the other hand, if the device works, it would reduce any tinnitus you got from the MRI, which again, you probably won't get, but might.

I would ask if they would accept a CT, which can find an acoustic neuroma according to this.

 

[asey20]

I did an MRI last November and although my tinnitus was really loud while in the machine, it didn't affect my tinnitus afterwards. If anything it made it less worse because I got over my fear of noises which cannot harm me and my tinnitus continued to improve after that.

 

[Dolgoruki]

I did an MRI a couple months ago. I was wearing earplugs + earmuffs that they provided which made the experience manageable (although still stressful).

Personally I find loud high-frequency sounds to be the worst for my tinnitus, while the sounds in the MRI seemed to mostly be lower frequencies with a ton of thumping and banging.

 

[Demigod]

I was supposed to be part of the clinical trial in January 2020, but got pregnant and then had a miscarriage.

And then COVID-19 happened and I couldn't do the trial.

My tinnitus is getting worse. What I'm nervous about is they won't let me join the trial unless I get an MRI. I read the horror stories on here of getting an MRI.

Is it worth it getting an MRI to be able to join the trial?

I 've just had two done in the last 3 months, I had ear plugs on and I did not have any problems afterwards, not even a small spike. To be honest they were pretty modern MRI machines, so you should express your concerns to the radiologist and speak to him about it, they are also aware of the complications that the loud sound to the older MRI machines can have on some people.

 

[Ricardo1991]

...unless I get an MRI. I read the horror stories on here of getting an MRI.

I've had an MRI with my tinnitus. To be honest, I was worried too but then they gave me earplugs and I almost fell asleep while in the machine. It was fine in the end.

 

[asey20]

If anything, ask for a silent MRI or get into a 1.5T machine instead of a 3T machine. Those are also a bit quieter. Take NAC for a few days before and after.

 

[Gb3]

Where are you guys getting your MRIs done? Mine was quiet.

 

[Orions Pain]

An MRI made both my tinnitus and hyperacusis worse. Most people seem to be okay with them, but it is a risk. Probably less risky if the tinnitus wasn't initially from an acoustic trauma.

 

[Halsy]

I was supposed to be part of the clinical trial in January 2020, but got pregnant and then had a miscarriage.

And then COVID-19 happened and I couldn't do the trial.

My tinnitus is getting worse. What I'm nervous about is they won't let me join the trial unless I get an MRI. I read the horror stories on here of getting an MRI.

Is it worth it getting an MRI to be able to join the trial?

MRI horror stories? You mean actually getting a date for one or the actual scan itself?

It's definitely claustrophobic. I'm a pretty big guy so when they first shot me inside they did it really fast and my shoulders were a bit pushed in and it freaked me out. After I knew what I was in for, I just kept my eyes closed and daydreamed about random stuff until it was done.

I'm actually more curious why you haven't had one yet. Your ENT and/or neurologist should have ordered one and a CT scan in order to rule out some obvious stuff. They never would have caught my condition - SSCD - without them.

As far as I'm concerned, what the Shore Lab is working on, is probably the best shot - at least in the near future - for a device to minimize or resolve tinnitus outright. So yeah, I'd say it's worth it.

Where are you guys getting your MRIs done? Mine was quiet.

I got two done in two different places and they were both loud as hell. The CT scans were still loud but they were quieter comparatively. Just bring earplugs, not a big deal.

 

[Halsy]

Huh, there's a lot of specifics to this trial.

Inclusion Criteria:

• Must report constant, subjective, preferably unilateral tinnitus without any active external or middle ear pathology.
• No greater than a mild hearing loss up to 6 kHz, and no greater than a moderate hearing loss at the tinnitus frequencies.
• Must be able to modulate their tinnitus with a somatic maneuver
• Preferably onset of tinnitus less than one year ago, but present for at least 6 months. Tinnitus should be bothersome.
• Absence of retrocochlear pathology/8th nerve lesion
• No participation in a tinnitus treatment regimen within the past six months or participation in the University of Michigan stage 1 clinical trial.

Exclusion Criteria:

• Diagnosis of Meniere's disease
• Diagnosis of Semicircular Canal Dehiscence
• Unilateral or bilateral cochlear implant recipients
• Diagnosis of acoustic neuroma
• Evidence of retrocochlear disease
• Certain medications and conditions (will be reviewed at screening)

Well the dehiscence rules me out, dammit. They're also only looking for people who have somatosensory tinnitus. Still, if you can get in, it's worth a shot.

 

[Flyingsheep]

Huh, there's a lot of specifics to this trial.

Inclusion Criteria:

• Must report constant, subjective, preferably unilateral tinnitus without any active external or middle ear pathology.
• No greater than a mild hearing loss up to 6 kHz, and no greater than a moderate hearing loss at the tinnitus frequencies.
• Must be able to modulate their tinnitus with a somatic maneuver
• Preferably onset of tinnitus less than one year ago, but present for at least 6 months. Tinnitus should be bothersome.
• Absence of retrocochlear pathology/8th nerve lesion
• No participation in a tinnitus treatment regimen within the past six months or participation in the University of Michigan stage 1 clinical trial.

Exclusion Criteria:

• Diagnosis of Meniere's disease
• Diagnosis of Semicircular Canal Dehiscence
• Unilateral or bilateral cochlear implant recipients
• Diagnosis of acoustic neuroma
• Evidence of retrocochlear disease
• Certain medications and conditions (will be reviewed at screening)

Well the dehiscence rules me out, dammit. They're also only looking for people who have somatosensory tinnitus. Still, if you can get in, it's worth a shot.

I fit every criteria except that I've had bothersome tinnitus for over 2 years, but they are stating that it is a preference. The only potential exclusion criteria in my situation is being slightly over 100 miles away.

I recently sent them an email about the upcoming clinical trial anyway, so let's see what they say.

 

[frpp]

I fit every criteria except that I've had bothersome tinnitus for over 2 years, but they are stating that it is a preference. The only potential exclusion criteria in my situation is being slightly over 100 miles away.

I recently sent them an email about the upcoming clinical trial anyway, so let's see what they say.

Just from reading the criteria, this thing sounds like a bust and looks more and more like Susie's been milking UMichigan for all she can get. Lenire 2.0 incoming.

 

[Demigod]

Has anybody, that was recently contacted by Dr. Shore's Lab, gotten into the trial?

 

[Jrblovsky]

Just from reading the criteria, this thing sounds like a bust and looks more and more like Susie's been milking UMichigan for all she can get. Lenire 2.0 incoming.

You're absolutely correct. I doubt it will work at all. Regenerative medicine is the way to go. Fixing the hearing loss will eliminate the tinnitus in most cases I suspect. The pill for hidden loss will deal with the others.

 

[Jimmyboi]

The inclusion criteria look reasonable to me, they've been upfront about targeting somatic tinnitus and the rest mainly rules out various other causes.

The only shame is the less than one year onset but it is only a preference, remember this has worked for people in the forum so I certainly hold out hope for more positive results.

 

[Spiral]

The trial treatment should last for 6 weeks. But the results are not expected until May 2022. Unbelievable how long it all takes. At this rate, it will be on the market in year 3500.

Yeah, but I'd rather have a working, tested product than something that was rushed out with terrible results.

 

[Jrblovsky]

Yeah, but I'd rather have a working, tested product than something that was rushed out with terrible results.

Hasn't this thing been in development since the early 90s?

 

[ajc]

Hasn't this thing been in development since the early 90s?

Not that long, but this is the home stretch.

I hope to God Dr. Shore's device will beat the crap out of Lenire.

 

[Jrblovsky]

Not that long, but this is the home stretch.

I hope to God Dr. Shore's device will beat the crap out of Lenire.

Hopefully. That Lenire sounds like a total bust.

 

[weab00]

Not that long, but this is the home stretch.

I hope to God Dr. Shore's device will beat the crap out of Lenire.

My piece of shit cochlea is too far gone for neuromodulation. Going to need to actually regenerate the cells.

 

[GlennS]

Hasn't this thing been in development since the early 90s?

Sure seems like it.

 

[Orions Pain]

The way they draw these things out is SO ridiculous. People are suffering, c'mon man.

 

[Rb86]

The way they draw these things out is SO ridiculous. People are suffering, c'mon man.

Totally agree. And for a damn device!? It's not like it's a drug. I actually don't pay much attention or hope in this method... It has been the least productive "chase" of a cure out of them all.

 

[Jrblovsky]

Totally agree. And for a damn device!? It's not like it's a drug. I actually don't pay much attention or hope in this method... It has been the least productive "chase" of a cure out of them all.

Honestly I think she is dragging it out on purpose. She will ride this out until she can retire and release it. I live in Michigan and have been to U of M for tinnitus care and to see an ENT. My whole experience was shit. I wouldn't recommend anyone go there.

 

[Paul Walter]

I have just received notification from the University of Michigan that recruitment for a second trial for subjective tinnitus is now underway which I have enrolled.

I'm just wondering if anyone else is going to take part in this trial?

The concept is exciting. I hope it really works.