New University of Michigan Tinnitus Discovery — Signal Timing

The clinicaltrials.gov website has the estimated primary completion date as September 2022 and the estimated study completion date as January 2023. Four years from now. How can it possibly take that long?
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literally dude, there are people in the FDA that want to hold back bio-medical research and scientific advancements. Lobbyist are everywhere.
 
Then what is the main challenges for finding a cure?
1. Finding the medicine that will regenerate the hair cells. Mammals aren't supposed to regenerate them so it takes time finding something that will reverse our natural biology in a way that doesn't cause adverse effects.
2. Administering the drug, making sure the right amount gets into the right place. The middle ear is one of the hardest places to navigate as it is behind one of the hardest bones in the human body.
3. Even of the other two were figured out today they will still have to go through years of trials and the results will have to be reviewed by the scientific/medical community. A blessing and a curse, I suppose.
 
Are we even near #1?
There are a few candidates which are potential winners but it will take years before we will have an officially approved FDA treatment in the US. Your best bet for treatment is bimodal stimulation which is right around the corner in the next year or so which might lower the tinnitus. A cure is much further off.
 
Here is one of my worries with a device like this. Susan Shore, neuromod, etc... the only results I've seen mention some patients have gotten months of relief following treatment. That sounds good. So I'm assuming at the end of that time period a repeat use of the device is necessary. Again not a big deal. My question is will our brains build resistance to the treatment. Just like we build a resistance to drugs over time making them less or non effective.
 
Here is one of my worries with a device like this. Susan Shore, neuromod, etc... the only results I've seen mention some patients have gotten months of relief following treatment. That sounds good. So I'm assuming at the end of that time period a repeat use of the device is necessary. Again not a big deal. My question is will our brains build resistance to the treatment. Just like we build a resistance to drugs over time making them less or non effective.
I doubt it. They've been working and doing multiple trials for years. If it wasn't good, then patients from the past would say something to them.
 
Good point. However, I doubt those patients from the first trial were allowed to keep those devices and continue treatment past the trial.
You don't know that. I've seen articles about a guy that got it first after a really bad car wreck. I think if he had problems then he'd like to update the story.
 
Here is one of my worries with a device like this. Susan Shore, neuromod, etc... the only results I've seen mention some patients have gotten months of relief following treatment. That sounds good. So I'm assuming at the end of that time period a repeat use of the device is necessary. Again not a big deal. My question is will our brains build resistance to the treatment. Just like we build a resistance to drugs over time making them less or non effective.
The results continued to get better overtime.
 
Here's the Paper:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5863907/
Here's the relevant graph.
nihms942971f6.jpg
 
I don't want to sound unthankful or not eager to get my hands on this device, but if I'm reading those notes and graphs correctly it looks like they got an average decibel reduction of 12.2 decibels.

That's better than nothing, but not terribly large.

Sure I'd pay handsomely for a 12 dB reduction right now, but hopefully those numbers get slightly better as testing continues.
 
I don't want to sound unthankful or not eager to get my hands on this device, but if I'm reading those notes and graphs correctly it looks like they got an average decibel reduction of 12.2 decibels.

That's better than nothing, but not terribly large.

Sure I'd pay handsomely for a 12 dB reduction right now, but hopefully those numbers get slightly better as testing continues.
Well...remember, the decibel scale is logarithmic, with every 10 DB increase presenting a doubling of perceived loudness, on average. So it seems like a 12 db decrease is *50-55% (edited) volume reduction! I think??
 
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Well...remember, the decibel scale is logarithmic, with every 10 DB increase presenting a doubling of perceived loudness, on average. So it seems like a 12 db decrease is a 55% volume reduction! I think??
And some estimates actually put the average DB to doubled perceived loudness ratio at a 6 DB increase (https://geoffthegreygeek.com/amplifier-power/ - sorry, best source I could find)
- which would mean that a 12 DB decrease is an approximately 75% (*edited) decrease in perceived volume!
 
I think Dr. Shore has a few tricks under her sleeve. She has been working / studying on it for 2 decades. I think she is the number one person to understand tinnitus so far.

I am sure there are things the public does not know about her strong belief why it will work.

I think she is getting closer to solve the issue of tinnitus or at least start to treat it.

Dr. Shore has even less publications than Dirk de Ridder / Paul vd Heyning. So why should she solve it?
Don't mean to be skeptical but don't understand why we put so much faith into non hard evidence aka research papers.
 

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