Nimodipine

[HighleyTall]

Ever tried Gabapentin?

Yes, 3 x 400 mg. I had the feeling it helped but then I got 2 days of extremely elevated tinnitus without known cause. Sometimes you might get overconfident with sound exposure if you feel better, but that certainly was not the case. I don't even go out, except to the GP (walking distance). The ENT today was the first short car trip since my stupid noise accident 2 weeks ago. I turned the car key at arrival to turn the car off and it still made a sort of humming noise for a while. This time that sound bothered me, which it had never done so before.

 

[HighleyTall]

Back from the GP. He doesn't want to prescribe Verapamil either. And now I found out he has mild tinnitus. Those are the worst. He cannot prescribe me these medications based on experimental studies. Shouldn't you have been consistent and refused your patients the COVID-19 vaccine, then, I asked? After all, it was still in the research Phase III, and no informed consent. He laughed and said, I have to agree with you on that.

 

[dd314]

Nimodipine is used pretty exclusively for hemorrhagic strokes. It's not something used for chronic blood pressure.

 

[Hottopic29]

I have experience with Amlodipine. It spiked my tinnitus a lot. I can't sleep now.

Did you stop taking the Amlodipine? Did your tinnitus go back to baseline? Or was the spike permanent?

 

[HighleyTall]

I have had some bad nights for some time now, but last night, I was able to sleep pretty well and felt not that bad this morning. I was cleaning out my medication drawer this morning and found an unused box of Felodipine (5 mg). Amlodipine and Felodipine are calcium antagonists of the dihydropyridine type. Both block the voltage-dependent L-type calcium channels. Hurrah!

I wanted to switch hypertension medication the previous year, and my GP prescribed me Felodipine, but I never tried it. So, I took 5 mg of Felodipine this morning. I don't think I've ever had such a bad day. Burning tinnitus and also hyperacusis is much worse, and I had a really terrible headache all day. I took a couple of Ibuprofen and Tramadol, but nothing helped. I spent the afternoon mostly lying on the sofa but wasn't able to sleep. Now, 8 hours later, I'm feeling a bit better. Could Felopdipine have caused this?

 

[Kev]

Apparently, Gateway Biotechnology's nasal spray for tinnitus in development is just a nasal formulation of Nimodipine to enhance delivery and reduce systemic side effects.

 

[Nick47]

Apparently, Gateway Biotechnology's nasal spray for tinnitus in development is just a nasal formulation of Nimodipine to enhance delivery and reduce systemic side effects.

Indeed, you are correct. It's for noise-induced tinnitus.

 

[Sironketchup]

Did you have a chance to discuss this with doctors yet? Any thoughts?

Not yet; I'm figuring out options to discuss at the moment.

I have Memantine, Piracetam, Nimodipine, Glycine, and Taurine.

For now, I'm only on Taurine, but I will talk to my doctor in time. If not, I'll just let myself be the guinea pig. As a pharmacist, I can access that stuff.

Apparently, Gateway Biotechnology's nasal spray for tinnitus in development is just a nasal formulation of Nimodipine to enhance delivery and reduce systemic side effects.

Very interesting. Do you know anything about the dose?

 

[AverageJoe12]

Not yet; I'm figuring out options to discuss at the moment.

I have Memantine, Piracetam, Nimodipine, Glycine, and Taurine.

For now, I'm only on Taurine, but I will talk to my doctor in time. If not, I'll just let myself be the guinea pig. As a pharmacist, I can access that stuff.

Very interesting. Do you know anything about the dose?

Is Taurine helping with your tinnitus?

 

[StoneInFocus]

As a pharmacist, I can access that stuff.

Do you really have access to any drug you want?

FYI, Memantine, Nimodipine and Taurine did not help my tinnitus.

I have had some bad nights for some time now, but last night, I was able to sleep pretty well and felt not that bad this morning. I was cleaning out my medication drawer this morning and found an unused box of Felodipine (5 mg). Amlodipine and Felodipine are calcium antagonists of the dihydropyridine type. Both block the voltage-dependent L-type calcium channels. Hurrah!

I wanted to switch hypertension medication the previous year, and my GP prescribed me Felodipine, but I never tried it. So, I took 5 mg of Felodipine this morning. I don't think I've ever had such a bad day. Burning tinnitus and also hyperacusis is much worse, and I had a really terrible headache all day. I took a couple of Ibuprofen and Tramadol, but nothing helped. I spent the afternoon mostly lying on the sofa but wasn't able to sleep. Now, 8 hours later, I'm feeling a bit better. Could Felopdipine have caused this?

I advise you to take antioxidants, especially when experimenting with new medication.

Felodipine is also an anti-mineralocorticoid, which might have something to do with your reaction.

Anyway, it seems like these L-type calcium channel blockers are hit or miss. But mostly miss.

 

[StoneInFocus]

Do you really have access to any drug you want?

FYI, Memantine, Nimodipine and Taurine did not help my tinnitus.

I advise you to take antioxidants, especially when experimenting with new medication.

Felodipine is also an anti-mineralocorticoid, which might have something to do with your reaction.

Anyway, it seems like these L-type calcium channel blockers are hit or miss. But mostly miss.

I just read that Nimodipine is an anti-mineralocorticoid, too, just like Nifedipine and Amlodipine. I should specify that it was just a guess that this property had something to do with @HighleyTall's reaction.