Otomagnetics — A New Drug Delivery System for the Inner and Middle Ear

[weab00]

Free masons were knocked out of power and now we can proceed with curing every ailment in the body, cyborgs, and spatial/oceanic colonization. Once we're done curing ourselves, we can cure the universe.

 

[Tau]

I see a few issues with this approach.

First, the magnetic NPs, even though they claim they are biodegradable, may be toxic. I have worked with nanoparticles (and even magnetic NPs), and you don't want them inside you most of the time. I wonder how they made the magnetic ones biodegradable, if they likely contain iron oxide.

Second, this will require an intratympanic injection anyway. So I would like to see a comparison with a slow release gel (Otonomy and Frequency Therapeutics approaches).

 

[Gb3]

I see a few issues with this approach.

First, the magnetic NPs, even though they claim they are biodegradable, may be toxic. I have worked with nanoparticles (and even magnetic NPs), and you don't want them inside you most of the time. I wonder how they made the magnetic ones biodegradable, if they likely contain iron oxide.

Second, this will require an intratympanic injection anyway. So I would like to see a comparison with a slow release gel (Otonomy and Frequency Therapeutics approaches).

How will it require an injection anyway? The whole point of this is that it can penetrate the ear drum and round window without an injection.

 

[Tau]

How will it require an injection anyway? The whole point of this is that it can penetrate the ear drum and round window without an injection.

You need the fluid with the MNPs inside your middle ear for the particles to diffuse along a B field gradient.

Edit: If you have no liquid in your middle ear, the particles which had just been transported through the tympanic membrane will simply get stuck to any wet surface and that's it really.

 

[Bunz]

I've been trying to find any news on this project but all the stuff I was able to find dates back to late 2020.

Is the project dead? Are they just staying quiet?

 

[StoneInFocus]

I've been trying to find any news on this project but all the stuff I was able to find dates back to late 2020.

Is the project dead? Are they just staying quiet?

I haven't found anything about it either, I wouldn't get your hopes up for this project to be honest.

However, according to this review article published last year, "Many new drug delivery systems specifically for the inner ear are under development or undergoing clinical studies."

I haven't read the article very carefully but these new drug delivery systems might provide promising avenues for drug treatments of tinnitus and hyperacusis.

Local Delivery of Therapeutics to the Cochlea Using Nanoparticles and Other Biomaterials