You feel nothing but your ear being filled with liquid. Just like when water enters there. I participated in the AM-101 trial and was really scared about the procedure (intratympanic injection) and then realized it was nothing.
I participated being near the end of the three months time limit they set for acute stage. Thing was Christmas got in the middle of all the appointments and holidays made it impossible for me to get the injections administrated as the protocol marked. I was able to do it but the clinic was closed. A mess. Then I'll never know if what I got in the first round was the actual drug or if I fell in the placebo group.
I feel like AMPA receptor blockers would have value very acutely but I can't see it helping after that point because the glutamine surge would have done it's damage at that point. Just my opinion. I think there was probably little chance it would help long term. I personally think it would be universally helpful if given the first few weeks but since most tinnitus fades during that time it would be hard to prove without a crystal ball it was better than placebo.
I publicly declare myself a total fan and follower of your posts! Always feel gratitude for your input and keeps me feeling sober in the middle of all this confusion and suffering.
So I take it no one else could find a link to the substance of this talk either?
It's a synaptopathy drug like OTO-413 and the Hough Pill.
Very promising. Praying and thinking it might be sooner. Seems significant strides have been made into research around it and now firms are just trying to get it to work in the best possible manner they can.
Tinnitus is the biggest untapped market there is. It's essentially a giant oil field waiting to be tapped. Whoever figures out the slightest way to lower the tone at at least even 50% is looking to make BILLIONS. Whether it be through a drug, treatment, or procedure.
Not necessarily. Now there are people showing normal hearing on their audiogram, however they indicate they have tinnitus. These cases are believed to be examples of people with synapse dysfunction. Research by Hough Ear Institute from their pill trial indicated restoring synapses (which their pill has shown to successfully do) eliminates tinnitus in individuals who have consumed it.
Absolutely along with hearing recovery. Really since the evidence links them both, it is a double deal for whatever organisation can come up with the treatment. This will happen I am quite confident about it, it is just a matter of going through the trials and tinkering with the medication. The experts know what works, will be just a matter of refining. I think it is only a couple of years away at best because these companies want to release really in order to make the mega profit profit.
Per my correspondence with Pipeline a while back, they think it will have a minor effect on OHCs relative to the synapses but still really cool that it can do both.
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