Prof. Thanos Tzounopoulos Receives $2 Million Grant

[Joey72]

I see this thread as dead. In February he said he would have a lead candidate in 6 months. He has contributed to research but he is a million miles away from treatment.

So is Prof. Tzounopoulos on the grift?

 

[Nick47]

So is Prof. Tzounopoulos on the grift?

I wouldn't say grift. He was awarded a large amount of our tax money that kept him in a well paid job for years. If nothing comes of it, he still gets paid. I do think these grants should have a performance related element to them. He was babbling on about going down the epilepsy route last time I heard. The thread is simply dead.

 

[grate_biff]

I wouldn't say grift. He was awarded a large amount of our tax money that kept him in a well paid job for years. If nothing comes of it, he still gets paid. I do think these grants should have a performance related element to them. He was babbling on about going down the epilepsy route last time I heard. The thread is simply dead.

 

[Luca73]

30 years.

30 years? He has been receiving funds since 2010 (I read this on the ATA website) from the US Defence Department. What results has he obtained? Why are they still paying him? For what? For nothing?

 

[BB23]

Did Prof. Tzounopoulos not say XEN1101's mechanism of action is quite similar to that of his drug? Their half activation voltages are quite similar meaning there shouldn't be too much difference between the two. Meaning we would know if his research had any merit or not three years from now.

Also, if he wants to leave an impact, he'd better switch over to the elusive Compound 60 instead of wasting time with his RL-81, I mean why not, he couldn't figure out a solution for the toxicity issues of his product for years now. From the looks of Compound 60, it is the stronger Kv7 opener and may lead to shorter treatment periods with more effective results.

 

[BB23]

Prof. Tzounopoulos' latest research:

Zinc provides new clue for why loud noise causes hearing loss

 

[JeffToob]

Prof. Tzounopoulos' latest research:

Zinc provides new clue for why loud noise causes hearing loss

Those poor mice. 2 hours straight of 100 decibels in their ears.

 

[BB23]

I wouldn't say grift. He was awarded a large amount of our tax money that kept him in a well paid job for years. If nothing comes of it, he still gets paid. I do think these grants should have a performance related element to them. He was babbling on about going down the epilepsy route last time I heard. The thread is simply dead.

Nah. @Nick47 is right.

If this helped at all, it would have been out already. Hell, they'd fast-track it. They'd be in a rush to get it out before XEN1101. Billions of dollars are at stake here, and you don't want to be outdone by the competition.

Yeah. Well played, Prof. Tzounopoulos.

 

[UHPTS]

Yeah. Well played, Prof. Tzounopoulos.

We can say that Prof. Tzounopoulos and Dr. Shore are high-performing scientists.

Now that XEN1101 is most likely out of the tinnitus game, is there anything else left?

 

[Utdmad89]

Now that XEN1101 is most likely out of the tinnitus game, is there anything else left?

Who has said XEN1101 is most likely out of the tinnitus game? You're full of optimism, aren't you?

 

[UHPTS]

Who has said XEN1101 is most likely out of the tinnitus game? You're full of optimism, aren't you?

I hate to be pessimistic, but besides people having theories, is there any real evidence from any source that XEN1101 helps with tinnitus?

 

[StoneInFocus]

How many years does Prof. Tzounopoulos need to develop his drug?

I think he dropped this endeavor. $2 million has gone up in smoke.

His last publication was a literature review on Zinc's role in neuromodulation.

Maybe someone can check his X to see what he is up to? I don't have an X account.

 

[Varda]

Prof. Tzounopoulos' latest research:

Zinc provides new clue for why loud noise causes hearing loss

Are Zinc supplements ototoxic?

 

[Nick47]

Are Zinc supplements ototoxic?

I hope not, otherwise I will have to stop eating.

 

[Varda]

I hope not, otherwise I will have to stop eating.

Of course, we still need to keep eating, but I'd like to start taking the "zinc-trapping compound" mentioned in the article as soon as possible. Does anyone know the name of this compound? Is it something you can buy on iHerb?

 

[IvanRus]

I'll explain why I don't believe in the likelihood of a real drug (pill) being released to treat tinnitus.

The main reason is that it's a business: to recoup development costs and turn a profit, they would need high and frequent sales.

However, if such a pill truly existed and could reduce or eliminate tinnitus for even six hours, I believe most people wouldn't need it long-term. In that case, the brain would likely learn quickly that tinnitus is not a threat, eventually adapting to filter out the sound on its own.

The core issue with tinnitus is that the brain perceives it as a threat, especially because we lack effective ways to influence or control it.

There are few things in the world that we have no means of influencing, and tinnitus is one of them. For this reason, it's unlikely that pharmaceutical companies would invest heavily in this area.

Yet, as far as I understand, hasn't the neurochemistry of tinnitus already been thoroughly studied? If so, creating a pill shouldn't be too difficult.

 

[ccpjc]

I'll explain why I don't believe in the likelihood of a real drug (pill) being released to treat tinnitus.

The main reason is that it's a business: to recoup development costs and turn a profit, they would need high and frequent sales.

However, if such a pill truly existed and could reduce or eliminate tinnitus for even six hours, I believe most people wouldn't need it long-term. In that case, the brain would likely learn quickly that tinnitus is not a threat, eventually adapting to filter out the sound on its own.

The core issue with tinnitus is that the brain perceives it as a threat, especially because we lack effective ways to influence or control it.

There are few things in the world that we have no means of influencing, and tinnitus is one of them. For this reason, it's unlikely that pharmaceutical companies would invest heavily in this area.

Yet, as far as I understand, hasn't the neurochemistry of tinnitus already been thoroughly studied? If so, creating a pill shouldn't be too difficult.

I believe solving tinnitus could become a trillion-dollar industry. If 10% to 20% of the world's population suffers from tinnitus, that's nearly a billion people on the low end and over two billion on the high end.

If you market a product for $1,000, the potential revenue could surpass the GDP of many nations.

 

[IYIiKe]

Yet, as far as I understand, hasn't the neurochemistry of tinnitus already been thoroughly studied? If so, creating a pill shouldn't be too difficult.

It has not been successfully identified, and potential treatments that showed promise in animal models have failed to work in human studies so far.

At this point, there is only theory.

 

[Ferna]

I'll explain why I don't believe in the likelihood of a real drug (pill) being released to treat tinnitus.

The main reason is that it's a business: to recoup development costs and turn a profit, they would need high and frequent sales.

However, if such a pill truly existed and could reduce or eliminate tinnitus for even six hours, I believe most people wouldn't need it long-term. In that case, the brain would likely learn quickly that tinnitus is not a threat, eventually adapting to filter out the sound on its own.

The core issue with tinnitus is that the brain perceives it as a threat, especially because we lack effective ways to influence or control it.

There are few things in the world that we have no means of influencing, and tinnitus is one of them. For this reason, it's unlikely that pharmaceutical companies would invest heavily in this area.

Yet, as far as I understand, hasn't the neurochemistry of tinnitus already been thoroughly studied? If so, creating a pill shouldn't be too difficult.

In my opinion, given how widespread, common, and debilitating tinnitus is, if an effective treatment were discovered, investors would be eager to capitalize on the opportunity. They would likely compete intensely to secure a share of the profits.