Microdosing worsened my tinnitus last August.
The first time I tried it, it quietened my tinnitus to a whisper. But then that night, I ended up with a big spike that lasted several days.
Seeing that the spike was only temporary and that my tinnitus was actually quietened while microdosing (I hoped that I could permanently quieten it through neuroplasticity), I decided to try it again, two weeks after my first dose.
I ended up doing this 3 or 4 more times, microdosing every two weeks. And every time, I ended up with a temporary spike. But the volume of my tinnitus never lowered again, like the first time. However, it really had a positive effect on my life in other ways. If it wasn't for my tinnitus, I'd still be microdosing today.
Anyway, then I did something stupid out of desperation. I microdosed 3 days in a row. At the end of the 3rd day, I had the loudest tinnitus I'd ever experienced, with multi tones in my left ear (a first for me) and I was getting a lot of clicking in my left ear too. Something I've only ever experienced after a loud noise insult.The multi tones and clicking receded over the following days and the volume did slowly drop over time. But I did end up with a louder and more piercing baseline than before.
I did some digging around recently and found a study from 2020 on the effects of magic mushrooms on the brain. In the study, they believe they found Psilocybin increases Glutamate in certain parts of the brain and lowers it in other parts.
I wonder if this explains what happened to me? Increased Glutamate levels caused my temporary spikes and then I experienced some excitotoxicity from the combined doses?
Me, myself, bye: regional alterations in glutamate and the experience of ego dissolution with psilocybin
The first time I tried it, it quietened my tinnitus to a whisper. But then that night, I ended up with a big spike that lasted several days.
Seeing that the spike was only temporary and that my tinnitus was actually quietened while microdosing (I hoped that I could permanently quieten it through neuroplasticity), I decided to try it again, two weeks after my first dose.
I ended up doing this 3 or 4 more times, microdosing every two weeks. And every time, I ended up with a temporary spike. But the volume of my tinnitus never lowered again, like the first time. However, it really had a positive effect on my life in other ways. If it wasn't for my tinnitus, I'd still be microdosing today.
Anyway, then I did something stupid out of desperation. I microdosed 3 days in a row. At the end of the 3rd day, I had the loudest tinnitus I'd ever experienced, with multi tones in my left ear (a first for me) and I was getting a lot of clicking in my left ear too. Something I've only ever experienced after a loud noise insult.The multi tones and clicking receded over the following days and the volume did slowly drop over time. But I did end up with a louder and more piercing baseline than before.
I did some digging around recently and found a study from 2020 on the effects of magic mushrooms on the brain. In the study, they believe they found Psilocybin increases Glutamate in certain parts of the brain and lowers it in other parts.
"Specifically, participants who received psilocybin demonstrated higher relative glutamate concentration levels in the mPFC, and lower relative glutamate concentration levels in the hippocampus."
I wonder if this explains what happened to me? Increased Glutamate levels caused my temporary spikes and then I experienced some excitotoxicity from the combined doses?
Me, myself, bye: regional alterations in glutamate and the experience of ego dissolution with psilocybin