Rinri Therapeutics

#31
Having objective measurements is a great promise. Otonomy and Frequency Therapeutics previously relied solely on audiograms and patient subjective reports.
 
#32
Muggumbo said:
Even if their treatment doesn't work out, the delivery method they found should be useful to future trials.
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I know they are genuinely confident. The preclinical work spans at least a decade. They expect significant increases in audiogram readings, from severe profound to moderate. The small cohort is elderly patients with age-related hearing loss.
 
#33
Nick47 said:
I know they are genuinely confident. The preclinical work spans at least a decade. They expect significant increases in audiogram readings, from severe profound to moderate. The small cohort is elderly patients with age-related hearing loss.
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That's absolutely great to hear. I can't wait to see its effect on tinnitus in the future.
 
#35
Note said:
Isn't auditory neuropathy hidden hearing loss that isn't detected in audiograms?
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If it heals hearing loss in general, I assume that it would heal the hidden hearing loss. The audiogram is just one way to measure it, I suppose.
 
#36
→ Beyond Biotech - Can Cell Therapy Tackle Hearing Loss?

Using its OSPREY platform, UK-based Rinri Therapeutics is developing a portfolio of off-the-shelf regenerative cell therapy products to address sensorineural hearing loss, a significant global medical challenge.

The company's lead asset, Rincell-1, is designed to regenerate auditory neurons and provide a novel treatment for patients with severe-to-profound age-related hearing loss or auditory neuropathy. The company is looking to start first-in-human trials in 2025.

Today, on the podcast we have a conversation with Rinri CEO Simon Chandler about the different kinds of hearing loss, what's being done to tackle them, and Rinri's novel approach to treatments.
 
#39
Aussie Lea said:
Is it like 10-15 years on average between pre-clinical and market availability...
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Yes, unless you get in a clinical trial. That's why I always encourage people to be proactive and GET IN CLINICAL TRIALS.

All too often, I hear things like 'I don't want to be a Guinea pig,' 'There is an MRI', 'It involves surgery, etc.'

Okay, then wait 10 to 15 years.
 
#41
Nick47 said:
Yes, unless you get in a clinical trial. That's why I always encourage people to be proactive and GET IN CLINICAL TRIALS.

All too often, I hear things like 'I don't want to be a Guinea pig,' 'There is an MRI', 'It involves surgery, etc.'

Okay, then wait 10 to 15 years.
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I understand the spirit and intention behind this advice, and it is indeed valuable for people who are seriously contemplating ending their lives. However, for most others, it seems dangerous.

For those of us with families, especially young ones, this mindset isn't viable. Even if life is a living hell most of the time, if I can survive and provide for my family, that's just how the cookie crumbles. There is no way I can risk worsening to the point where survival is no longer possible or where I can't give my family the quality of life they deserve. I suspect many here, even in the worst of spirits, are hanging on for their loved ones.

I can't afford to spend tens to hundreds of thousands of dollars on flights and missed time from work.

For every study with even moderate efficacy, you'll find tens to hundreds of others that are akin to a slightly polished Unit 731. Some leading figures in tinnitus research, according to this forum, regularly prescribe narcotic "cocktails" that have about as much scientific backing as trying to pray tinnitus away.

It's probably best to wait for results, even if they don't come until after we're gone. Hopefully, with advances in AI and other research, these answers can come in years rather than decades.
 
#42
IYIiKe said:
I understand the spirit and intention behind this advice, and it is indeed valuable for people who are seriously contemplating ending their lives. However, for most others, it seems dangerous.

For those of us with families, especially young ones, this mindset isn't viable. Even if life is a living hell most of the time, if I can survive and provide for my family, that's just how the cookie crumbles. There is no way I can risk worsening to the point where survival is no longer possible or where I can't give my family the quality of life they deserve. I suspect many here, even in the worst of spirits, are hanging on for their loved ones.

I can't afford to spend tens to hundreds of thousands of dollars on flights and missed time from work.

For every study with even moderate efficacy, you'll find tens to hundreds of others that are akin to a slightly polished Unit 731. Some leading figures in tinnitus research, according to this forum, regularly prescribe narcotic "cocktails" that have about as much scientific backing as trying to pray tinnitus away.

It's probably best to wait for results, even if they don't come until after we're gone. Hopefully, with advances in AI and other research, these answers can come in years rather than decades.
Click to expand...
Valid points.

My main point is that @linearb has found Auricle to be effective for him, and it's just a matter of time since he was in the Phase 1 trial 7-8 years ago.

Stem cells, gene therapies, and implants are still far off. A reputable company like Rinri Therapeutics prioritizes safety and regularly monitors patients in trials.

This is slightly off-topic, but for patients considering trials, the two Extracochlear ones and Neurosoft are definitely worth looking into.
 
#45
This is pretty cool, but it's probably not something that will be commercially available this decade. I'm curious whether success in this area could help determine if CNS hyperactivity or dysfunction—when tinnitus is the only symptom—might improve with enhanced neural function. Alternatively, it's possible that the plastic changes leading to tinnitus generation won't simply reverse with neural healing.

I'm not familiar with the political climate in the U.K., but in the U.S., I anticipate that stem cell therapies will face significant hurdles in marketing and trials, especially with opposition targeting the NIH. I really hope politics don't interfere with the development of this promising therapy.
 
#46
IYIiKe said:
Alternatively, it's possible that the plastic changes leading to tinnitus generation won't simply reverse with neural healing.
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Cochlear implants often reduce tinnitus so hearing restoration likely will as well.
IYIiKe said:
I'm not familiar with the political climate in the U.K., but in the U.S., I anticipate that stem cell therapies will face significant hurdles in marketing and trials, especially with opposition targeting the NIH. I really hope politics don't interfere with the development of this promising therapy.
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The political climate has always been similar, but nowadays, people tend to largely ignore politics. In the past, there was much more division.

Many people now recognize that the main political parties are heavily influenced by international organizations like the WEF, the Gates Foundation, and the United Nations. As a result, it often feels like an illusion of choice, making it seem less worthwhile to argue or fall out over political differences.
 
#47
Nick47 said:
Cochlear implants often reduce tinnitus so hearing restoration likely will as well.

The political climate has always been similar, but nowadays, people tend to largely ignore politics. In the past, there was much more division.

Many people now recognize that the main political parties are heavily influenced by international organizations like the WEF, the Gates Foundation, and the United Nations. As a result, it often feels like an illusion of choice, making it seem less worthwhile to argue or fall out over political differences.
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Government restrictions on research can certainly be a barrier in Europe. However, in the States, they often circumvent such restrictions by conducting experiments in third-world countries. While this approach might not be entirely ethical, it's not necessarily illegal.

Companies could justify their actions by pointing out that in many U.S. (and European) cities, people are already filling themselves with cocaine, crystal meth, and whatever else the pushers are selling. So, they might argue, What's the big deal?
 
#48
#49
lello said:
Should I assume that it will target only the auditory nerve and not the hair cells?
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Yes, this is a stem cell treatment in which the cells are programmed to develop into auditory neurons, rather than hair cells or synapses. The condition often worsens with age.
 
#51
lello said:
So, this is not suitable for sensorineural deafness like mine?
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@lello, it might help, as there could be nerve damage involved as well. What medication caused your hearing loss? Do you experience severe tinnitus? I reviewed your posts, but there isn't much information about your situation. Since this is the Rinri thread, please keep it brief here. You can continue the discussion on my profile page for general chat.
 
#52
I have been severely to profoundly deaf for over half a century. I discovered my hearing loss as a boy, and doctors have always told me that the cause was likely the streptomycin I was given as a child to treat another serious illness. They also believe the measles I had as a child may have contributed.

In a few years, I will probably have to stop using hearing aids and switch to a cochlear implant. However, if a cure were to become available in the meantime, I would be absolutely thrilled. I thought Rinri Therapeutics might be the right solution for me, but unfortunately, it is not.
 
#54
#55
Street Novelist said:
Wait, so they will not be injecting through the eardrum?
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@Street Novelist, to me, it's not entirely clear. In the feasibility study, they are using cochlear implant recipients, so I don't expect the approach involves going through the eardrum. However, what it does indicate is that they access the auditory nerve through the round window.
 
#56
Nick47 said:
@Street Novelist, to me, it's not entirely clear. In the feasibility study, they are using cochlear implant recipients, so I don't expect the approach involves going through the eardrum. However, what it does indicate is that they access the auditory nerve through the round window.
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Well, that would involve going through the skull, which means surgery. This procedure would need to be performed under anesthesia in a hospital setting. It is significantly different from a simple injection done at your ear doctor's office.
 
#57
Re delivery; the needle trajectory absolutely does require the scraping or drilling of bone - "trephining" as the study refers to it. This occurs at the modiolous wall of the cochlear "for a median depth of 1.48mm". Access to that part of the anatomy would be gained via the round window with initial entry at the ear canal. It'd appear, therefore, that no drilling of the actual skull (ala CI) takes place. With that said, however, 1.48mm in such a tight and clinically vulnerable space would most likely require a level of surgical control necessitating zero physical movement from the patient. I can't see how that could be achieved without a general anesthetic.
 
#58
UKBloke said:
Re delivery; the needle trajectory absolutely does require the scraping or drilling of bone - "trephining" as the study refers to it. This occurs at the modiolous wall of the cochlear "for a median depth of 1.48mm". Access to that part of the anatomy would be gained via the round window with initial entry at the ear canal. It'd appear, therefore, that no drilling of the actual skull (ala CI) takes place. With that said, however, 1.48mm in such a tight and clinically vulnerable space would most likely require a level of surgical control necessitating zero physical movement from the patient. I can't see how that could be achieved without a general anesthetic.
Click to expand...
It would take time to develop the technique. The patient would receive a general anesthetic and be securely restrained. The high-precision surgery would then take place, performed either by a surgeon, a computer-controlled keyhole surgery system, or a combination of both.

If it's not feasible now, I can easily imagine it becoming available in the future.

Or perhaps I'm just being overly optimistic.
 
#59
Joeseph Stope said:
It would take time to develop the technique. The patient would receive a general anesthetic and be securely restrained. The high-precision surgery would then take place, performed either by a surgeon, a computer-controlled keyhole surgery system, or a combination of both.

If it's not feasible now, I can easily imagine it becoming available in the future.

Or perhaps I'm just being overly optimistic.
Click to expand...
Re delivery; I believe there are already suitable systems out there. For example, I can't see why a modified TORS machine couldn't be used.
 
#60
The technique has already been developed and would almost certainly be performed under sedation. It has also been successfully replicated on cadavers.
 

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