Sea Pharmaceuticals — Oral Neurotherapeutics for Tinnitus, Epilepsy, and ALS

[Cmspgran]

Has anyone else noticed this? Ion channel modification comes up again, but I couldn't find any reference to it from these guys after a quick forum search.

Sea Pharmaceuticals Advancing Oral Neurotherapeutics as Potential Medicines for Tinnitus, Epilepsy, and ALS in Collaboration with TCG GreenChem

Sea's novel synthetic molecules act at the neurotransmitter glutamate pathway on two clinically validated targets in the central nervous system, "the CNS"

• Two potent, selective, pre-clinical stage molecules are being advanced as possible treatments for three therapeutic indications

Sea's lead SPM-0404 in investigational new drug-enabling studies for tinnitus, epilepsy, and ALS

• TCG GreenChem will conduct CMC (Chemistry, Manufacturing, & Controls) development on SPM-0404

 

[Nick47]

Has anyone else noticed this? Ion channel modification comes up again, but I couldn't find any reference to it from these guys after a quick forum search.

Alright, @Cmspgran!

These are glutamate channels, specifically AMPA and kainate receptors, which are much more abundant in the brains of tinnitus patients. It looks like they've done in vivo testing (in the body) with animals, and it seems they're now filing for human trials.

Topiramate also acts on these receptors, though not as effectively.

Great find!

 

[Kam75]

Wow, wow, wow! It's a pleasure to read articles like this. It gives us a bit of hope when we're really at rock bottom.

Thanks for sharing. I hope we learn more about these findings soon.