Sensorion, the Specialist in Inner Ear Diseases, to Start Human Clinical Trial Phase

[tomytl]

Hi,

I had never heard much about this company before.

→ Sensorion, the Specialist in Inner Ear Diseases, Completes a New Funding Round to Begin the Human Clinical Trial Phase

 

[Rube]

Exciting times for us tinnitus sufferers. Something good has to come out of all these new medicines.

 

[James White]

This stems from INSERM, the same laboratory who developed models that led to AM-101.

 

[Champ]

The race to be the first with a legitimate treatment continues.

Sometimes I don't mind living in a capitalist society because since we have such a common condition, tons of companies are jumping over themselves to figure out how to make us satisfied

 

[David S]

This is really exciting news. This is a new H4 receptor antagonist aimed at treating tinnitus going to clinical trials.

The active substance is called SENS-111:

Montpellier, France-based Sensorion is swinging for a €12 million ($12.9 million) IPO to finance the advancement of its pipeline of inner ear disease drugs through early and mid-phase clinical trials. Around one-third of the cash is earmarked for a Phase II trial of SENS-111, a histamine H4 receptor antagonist originally developed by Spain's Palau Pharma as a treatment for allergic rhinitis. Sensorion has repurposed the drug as a possible treatment for acute vertigo or tinnitus and advanced it into Phase Ib using up to €4 million it raised from Innobio and Inserm Transfert Initiative in January.

Then they have another one called SENS-218:

Sensorion spun out of Inserm--the French public health research institution--in 2009 and set about building a pipeline of drugs for diseases affecting the inner ear. The next drug scheduled to enter Phase II is SENS-218, a drug designed to prevent complications arising from lesions in the inner ear. Sensorion plans to allocate another third of its IPO haul to a Phase II trial of SENS-218, which is expected to get underway in the third quarter of 2016. The rest of the IPO cash will be divvied up between a preclinical program to protect the inner ear following chemotherapy and general tasks.

(Source)

 

[StoneInFocus]

Unfortunately, SENS-111 has been discontinued following disappointing performance in treating acute unilateral vestibulopathy in a Phase 2 trial. "Although the company says its SENS-111 was safe and well tolerated by trial participants, it did not meet the primary endpoint of vertigo intensity."

I wonder if SENS-111 as a tinnitus treatment is still on Sensorion's table. They filed a patent for H4 receptor inhibitors to treat tinnitus in 2018.

 

[JimmyStrong]

Unfortunately, SENS-111 has been discontinued following disappointing performance in treating acute unilateral vestibulopathy in a Phase 2 trial. "Although the company says its SENS-111 was safe and well tolerated by trial participants, it did not meet the primary endpoint of vertigo intensity."

I wonder if SENS-111 as a tinnitus treatment is still on Sensorion's table. They filed a patent for H4 receptor inhibitors to treat tinnitus in 2018.

All these trials are failing left, right and center. It's a shame.

 

[momus]

All these trials are failing left, right and center. It's a shame.

It's really not a surprise. Several decades ago I got tinnitus, and walked into the headquarters of the American Tinnitus Association in Portland, Oregon. First thing I read was, "tinnitus is permanent and non treatable", or words to that effect. Quite a blow!

But it is what it is, and inner ear damage is inner ear damage. That becomes a neural feedback sort of loop very quickly. In other words, it becomes hard wired in our brain, and the brain powers the mind. The mind is very associated w/ "hearing" tinnitus, as anyone who has ever spent much time online here or gone to a tinnitus self-help group. Simply bringing our attention to it seems to make it worse.

My mantra is just stay busy, avoid loud noises and eat and stay healthy. I don't hear mine when I'm engaged in something else, "when I'm immersed in it". Nature sounds, especially the ocean or a rapid stream often make me unaware of it. So there is some relief, and there are ways to mask it to a degree. I like to make sure my ears haven't built up earwax in them too, which is a very easy thing to overlook when our tinnitus amps up.

 

[DimLeb]

Not much of a "Specialist in Inner Ear Diseases" after all, since they haven't done anything for the inner ear after 9 years, lol.

 

[Toby1972]

That becomes a neural feedback sort of loop very quickly. In other words, it becomes hard wired in our brain, and the brain powers the mind. The mind is very associated w/ "hearing" tinnitus, as anyone who has ever spent much time online here or gone to a tinnitus self-help group. Simply bringing our attention to it seems to make it worse.

I think 95% of Tinnitus Talk members have tinnitus that just can't be ignored.

We would be grateful if we were in your situation, where the tinnitus is so slight that it is always noticeable, but can be ignored when distracted.

 

[gameover]

Simply bringing our attention to it seems to make it worse.

I can't speak for others, but this is not how it works for me. The tinnitus percept at a given moment is what it is. I can divert my attention away from it, depending on the intensity of the task, but I can go back and forth from paying attention to not paying attention and the percept is the same within a short time span (say under an hour). It changes on its own. Other sounds, time of the day and weather may influence the changes, but it just changes and I am there to "listen" it. The louder it is, the less I can divert my attention.

 

[Jammer]

I can't speak for others, but this is not how it works for me. The tinnitus percept at a given moment is what it is. I can divert my attention away from it, depending on the intensity of the task, but I can go back and forth from paying attention to not paying attention and the percept is the same within a short time span (say under an hour). It changes on its own. Other sounds, time of the day and weather may influence the changes, but it just changes and I am there to "listen" it. The louder it is, the less I can divert my attention.

This is my experience as well.

 

[Nick47]

I can't speak for others, but this is not how it works for me. The tinnitus percept at a given moment is what it is. I can divert my attention away from it, depending on the intensity of the task, but I can go back and forth from paying attention to not paying attention and the percept is the same within a short time span (say under an hour). It changes on its own. Other sounds, time of the day and weather may influence the changes, but it just changes and I am there to "listen" it. The louder it is, the less I can divert my attention.

Is this the fault of Sensorion?