I have a new idea about tinnitus and sleep but I will need feedback. As you all know I have written on sleep cycles before but I was missing a key bit of information. REM sleep rebound.
A little refresher on the sleep cycles: There are 5 stages of sleep. 4 NREM stages (labeled 1-4) and 1 REM stage of sleep. If you need to learn more, please look it up in an encyclopedia. It is very interesting.
I'm wondering if part of the problem with people who can wake up with low or loud T based on their sleep is due to REM sleep and REM rebound. REM rebound is caused when REM is suppressed during sleep. According to Wikipedia:
"REM rebound is the lengthening and increasing frequency and depth of rapid eye movement (REM) sleep which occurs after periods of sleep deprivation. When people have been prevented from experiencing REM, they take less time than usual to attain the REM state."
Many drugs have an effect on REM sleep, for example anti-depressants:
REM suppression includes elevated REM latency, reduced REM time, and decreased REM density. (Source 2)
However, when you withdraw from anti-depressants, notice what happens:
Withdrawal of REM-suppressing antidepressants is followed by REM rebound. During REM rebound, REM latency is shortened, and REM time and REM density are elevated. All these variables exceed baseline values. In healthy volunteers who were treated with antidepressants for 2 weeks, the REM rebound persisted 1 week after cessation. (Source 2)
It seems that once a body's REM sleep gets disturbed it can take a while to "catch up". In the above example, for 2 weeks on an anti-depressant, it took 1 week for the rebound effect to go away.
I would assume the REM supression would depend on the type of drug, the dosage, when it was taken (due to half life and peak plasma times), and other medication and physical characteristics of a person. In addition, how much sleep that person receives. I found the following example graphic that shows a tricyclic anti-depressant on the right and another one the left and how they affect REM sleep cycles.
(Source 2)
If you look at day 2, you will see that the body does not reach REM sleep til after 4 and a half hours. My question is, if someone took that drug and on day 2, slept 4 hours and woke up with low T, could it possibly be due to the suppression of REM sleep? Secondly, if someone took a nap, after that 4 hours, would it be easier for the body to wake up with louder T due to entering REM? What if the reverse were true and REM sleep lowered tinnitus?
Also, is it possible that if someone is weening off a drug, part of the increase could be due to REM rebound? Let me know what you think?
Source 2-
https://www.dovepress.com/sleep-ele...depression-peer-reviewed-fulltext-article-CPT
A little refresher on the sleep cycles: There are 5 stages of sleep. 4 NREM stages (labeled 1-4) and 1 REM stage of sleep. If you need to learn more, please look it up in an encyclopedia. It is very interesting.
I'm wondering if part of the problem with people who can wake up with low or loud T based on their sleep is due to REM sleep and REM rebound. REM rebound is caused when REM is suppressed during sleep. According to Wikipedia:
"REM rebound is the lengthening and increasing frequency and depth of rapid eye movement (REM) sleep which occurs after periods of sleep deprivation. When people have been prevented from experiencing REM, they take less time than usual to attain the REM state."
Many drugs have an effect on REM sleep, for example anti-depressants:
REM suppression includes elevated REM latency, reduced REM time, and decreased REM density. (Source 2)
However, when you withdraw from anti-depressants, notice what happens:
Withdrawal of REM-suppressing antidepressants is followed by REM rebound. During REM rebound, REM latency is shortened, and REM time and REM density are elevated. All these variables exceed baseline values. In healthy volunteers who were treated with antidepressants for 2 weeks, the REM rebound persisted 1 week after cessation. (Source 2)
It seems that once a body's REM sleep gets disturbed it can take a while to "catch up". In the above example, for 2 weeks on an anti-depressant, it took 1 week for the rebound effect to go away.
I would assume the REM supression would depend on the type of drug, the dosage, when it was taken (due to half life and peak plasma times), and other medication and physical characteristics of a person. In addition, how much sleep that person receives. I found the following example graphic that shows a tricyclic anti-depressant on the right and another one the left and how they affect REM sleep cycles.
(Source 2)
If you look at day 2, you will see that the body does not reach REM sleep til after 4 and a half hours. My question is, if someone took that drug and on day 2, slept 4 hours and woke up with low T, could it possibly be due to the suppression of REM sleep? Secondly, if someone took a nap, after that 4 hours, would it be easier for the body to wake up with louder T due to entering REM? What if the reverse were true and REM sleep lowered tinnitus?
Also, is it possible that if someone is weening off a drug, part of the increase could be due to REM rebound? Let me know what you think?
Source 2-
https://www.dovepress.com/sleep-ele...depression-peer-reviewed-fulltext-article-CPT
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