Tell Me the Truth... Is a Cure Realistic?

[Rubenslash]

Are any of the companies or treatments targeting fixing the synapses. The more I've been trying to find answers the deeper I sink. I started looking at threads from 2011 and 2012 and it still doesn't seem that we are approaching a cure. Other companies have failed and AM102 has been in pre trial since at least 2014 and people still say its for acute onset tinnitus.

Otonomy and hough ear institute are in a preclinical stage with their drug that specifically aims to restore synapses. Both have announced that they will start a clinical trial in the (near) future

 

[Greg Sacramento]

Yes, an almost cure may have been found this week. Three public companies have all made major advancements in drug trials for stress and depression this week. The stock trading of these companies are at the top of the stock market volume boards this week with enormous price gains. It's possible that these drugs will greatly benefit those with tinnitus.

My neuro group believes stress and depression is a major reason why some get tinnitus and a factor on T getting worse. This group has 250 neuros in the Western States. They told me that somatic tinnitus (jaw and neck) is now believed to be caused by stress causing muscle tenderness to the upper trapezius, then bending head improperly. Subjective (noise exposure) is also greatly caused from stress or excitement.

 

[Aaron123]

Three public companies have all made major advancements in drug trials for stress and depression this week. The stock trading of these companies are at the top of the stock market volume boards this week with enormous price gains. It's possible that these drugs will greatly benefit those with tinnitus.

what trials?

 

[attheedgeofscience]

what trials?

NSI-189 (Neuralstem) would be one of them. I don't know about the other two (at least not off-the-top of my head).

NSI-189 has nothing to do with tinnitus, however (for several reasons).

 

[Paulmanlike]

Yes, an almost cure may have been found this week.

What?!!!

What??

 

[Paulmanlike]

NSI-189 failed in phase 2 in July this year didn't it?

 

[Greg Sacramento]

@attheedgeofscience @Aaron123 SAGE - brexanolone synthetic allopregnanolone. CUR and IGXT need to be watched. AXSOME - AXS - 05. FDA are fast tracking.

 

[Paulmanlike]

@attheedgeofscience @Aaron123 SAGE - brexanolone synthetic allopregnanolone. CUR and IGXT need to be watched. AXSOME - AXS - 05. FDA are fast tracking.

Greg how can these drugs help tinnitus though? Do u mean help people cope better rather than actually reduce the volume/diminish the actual sound?

 

[attheedgeofscience]

NSI-189 failed in phase 2 in July this year didn't it?

No, it ended up doing just fine. There are some insights into why that is...

https://globenewswire.com/news-rele...ropsychopharmacology-ACNP-Annual-Meeting.html

 

[attheedgeofscience]

@attheedgeofscience @Aaron123 SAGE - brexanolone synthetic allopregnanolone. CUR and IGXT need to be watched. AXSOME - AXS - 05. FDA are fast tracking.

Don't know the pipeline, specifically (since it falls outside of my area of interest). But NSI-189 is highly specific to the hippocampus. I don't see why it would particularly interesting to the area of tinnitus.

 

[Paulmanlike]

There was indications of nsi-189 potentially helping other conditions than just depression on Wikipedia.

Tinnitus was NOT one of them.

I don't see how these 3 compounds indicate they help tinnitus (a lookup on google) rather they might help in managing it though?

 

[Greg Sacramento]

@attheedgeofscience Yes. Correct. So much more, but I shouldn't comment too much on mentioning public companies. Besides having some medical education, I have mentioned (just once before) that I have involvement in biotech public company investment. Degreed and certified.

 

[Paulmanlike]

@attheedgeofscience Yes. Correct. So much more, but I shouldn't comment too much on mentioning public companies. Besides having some medical education, I have mentioned (just once before) that I have involvement in biotech public company investment. Degreed and certified.

Greg why did you say an almost cure may of been found this week? What did you mean by that?

 

[Greg Sacramento]

@Paulmanlike Some of these drugs should help beyond coping and actually lower the volume. I know ones who are tracking this new research closely. No public drug company will say to the public or on label that a drug will help with tinnitus. Case in point, the manufacturers of Xanax and Prednisone.

 

[threefirefour]

@Paulmanlike
It's a shame these are for depression with a chance of helping tinnitus. Apparently research for meme diseases matters more than something that actually matters like tinnitus.

 

[dpdx]

I can not accept that this condition is for life, at least not when it is as intrusive as it is right now.

What comforts me is the thought of one day being able to hear silence again and be free of this torment, but how realistic is it really?

I have no knowledge of what is being done in tinnitus research. Are there people working hard out there to find us a cure? And by cure I don't necessarily mean a 100% elimination of tinnitus (although that would be amazing) but maybe a reduction or something that can make it go away for a short while, maybe a couple of hours a day.

Is it realistic to believe we will have something like this in say 10 years? 20 years?.......longer?

Yes, but you will have to wait 20-30 years.

 

[just1morething]

Yes, but you will have to wait 20-30 years.

How many of us with severe tinnitus will still be on the green side of the grass in 20-30 years? I'm looking at current treatments to manage tinnitus, not future unknowns. Our lifetime is just too short to be thinking out that far.

 

[Greg Sacramento]

@TheDanishGirl These depression and stress drugs (actually 12 public companies) are central nervous system drugs in Phase 2 or Phase 3. There's has never been discovery like this before. Some have been given fast track status by the FDA and EU.

Some target the hippocampus and that's the control center in the brain for tinnitus stress perception. I have posted links on the this recently and you gave a response of WOW - with something like OH my God. Keep faith, these drugs will help greatly as never seen before.

 

[dpdx]

How many of us with severe tinnitus will still be on the green side of the grass in 20-30 years? I'm looking at current treatments to manage tinnitus, not future unknowns. Our lifetime is just too short to be thinking out that far.

I am sorry but the medical community dosent prioritize TMJ or Tinnitus, it will take some time to get a cure. Most diseases dont even have a cure.

 

[Onsdag]

How many of us with severe tinnitus will still be on the green side of the grass in 20-30 years? I'm looking at current treatments to manage tinnitus, not future unknowns. Our lifetime is just too short to be thinking out that far.

People who are now under 25 have a better chance of getting that cure, older people will be dead before.

 

[just1morething]

People who are now under 25 have a better chance of getting that cure, older people will be dead before.

True. I was thinking of people that could self-destruct because of severe tinnitus at any age.

 

[Greg Sacramento]

NSI 189 and Sage 017 are not only targeting the hippocampus, but the caudate. Research caudate and tinnitus. The hippocampus is noted by many notable neuro researchers as being the control center of tinnitus. I've given impressive links about this recently. Research hippocampus and tinnitus. The hippocampus is in the temporal lobe - a part of the brain that controls emotions. The hippocampus can be damaged by stress. The caudate is part of the frontal lobe and emotions are processed there too.

Sage 017 is showing in a quick and fast trial of just weeks that the hippocampus can be healed. If you can control depression from both these areas, homes of tinnitus, then there's a good chance of tinnitus improvement. Tinnitus is a neuro disease.

I really like what the CEO had to say in press conference. I really like the research that some of the public companies are doing on depression. We should know more in weeks or maybe months, but not years.

 

[Gman]

I absolutely believe there will be a cure eventually, but an effective treatment for T would be a good in the interim. Then these hilarious ENTs can retire their favourite 'just have to deal with it' line and they can do what doctors are really good at - prescribing drugs for big pharma.

 

[just1morething]

@Greg Sacramento, That sounds very technical to me, but encouraging. I've had a lot of stress the past few years, so it could be related to abnormalities in the brain and depression.

 

[threefirefour]

I absolutely believe there will be a cure eventually, but an effective treatment for T would be a good in the interim. Then these hilarious ENTs can retire their favourite 'just have to deal with it' line and they can do what doctors are really good at - prescribing drugs for big pharma.

That will be a sad day for ENTs everywhere. Now they actually have to do this awful thing called work whenever someone walks in with tinnitus.

 

[Greg Sacramento]

I don't see these depression drugs as a cure for T.

It could be that there's many areas of the brain that correlate to T. If the regions for distress and depressive states are related to depression as many think, then these new depression drugs should at least help with coping.

Tinnitus loudness may be mostly related to the default mode network and multi-sensory information. So it might help a little in calmness of nerves and muscles, but I do doubt if T loudness could be lowered by much.

 

[Michael Leigh]

That will be a sad day for ENTs everywhere. Now they actually have to do this awful thing called work whenever someone walks in with tinnitus.

I think many people do not fully understand the role of an ENT doctor and what they are supposed to do when treating and diagnosing a patient with tinnitus. I can only speak of what goes on in the UK and my experience with them over many years. I would like people tell me of their experience with an ENT doctor and whether they were advised at some point to seek the help of a Hearing Therapist or Audiologist, that is trained in the treatment and management of tinnitus.

In the UK , when a tinnitus patient is seen by and ENT doctor they are asked a series of questions about the condition. How long have they had tinnitus and if they have any idea what might have caused the onset which can be many things. As most people know exposure to loud noise is the common cause. Typically it is headphone use or going to places were loud music is played.

A person will asked to have a hearing test and MRI scan. If these tests show no abnormalities then a person might be advised to wait a while. The tinnitus can go away or a person naturally habituates. If they are having difficulty coping with the tinnitus they might be advised of medication that can help or be referred to a Hearing Therapist/Audiologist that is trained in the management and treatment of tinnitus. I have been told on more than one occasion by ENT doctors, they do not treat tinnitus that isn't caused by an underlying medical problem of which there aren't many. In straight forward tinnitus caused by "loud noise" exposure, a patient is usually referred to the medical professionals I've mentioned, where there are usually treatment options available which can include counselling.

Michael

 

[Benoves]

I don't see these depression drugs as a cure for T.

It could be that there's many areas of the brain that correlate to T. If the regions for distress and depressive states are related to depression as many think, then these new depression drugs should at least help with coping.

Tinnitus loudness may be mostly related to the default mode network and multi-sensory information. So it might help a little in calmness of nerves and muscles, but I do doubt if T loudness could be lowered by much.

I would love to see how these things work on people with tinnitus. There is a lot of reasearch going on. Someone might find the solution by accident i think.

 

[Gman]

@Michael Leigh I think people DO understand what the role of an ENT dr is. Sure ENTs don't know much about tinnitus, that's fine. But they tend to either be arrogant and/or extremely dismissive. Not supportive. It's as though their egos can't deal with what they do not know.

For the record I was not offered an MRI or hearing test despite seeing my first ENT three times in about 6-7months. I had to pay an exorbitant amount for ear wax removal with a bad attitude and this was at a decent private hospital.

 

[Benoves]

I don't see these depression drugs as a cure for T.

It could be that there's many areas of the brain that correlate to T. If the regions for distress and depressive states are related to depression as many think, then these new depression drugs should at least help with coping.

Tinnitus loudness may be mostly related to the default mode network and multi-sensory information. So it might help a little in calmness of nerves and muscles, but I do doubt if T loudness could be lowered by much.

Greg, for some reason i can't start a conversation with you. Can you explain why you think this stuff might work?