Turmeric with Curcumin Seems to Be Helping

[jacob21]

@JohnAdams, so is curcumin good for tinnitus due to noise induced (hearing loss)?

 

[JohnAdams]

@JohnAdams, so is curcumin good for tinnitus due to noise induced (hearing loss) ?

I don't know for sure, but into the second week of taking 8 grams per day I started having long stretches of no tinnitus. I dont think you can stay on that much indefinitely. I stopped yesterday. Tinnitus is right back.

 

[PolishSoldier87]

I have been taking 9 tabs/day of this curcumin since yesterday and today is first quiet day since 4 months.

https://marketbio.pl/curcumin-98-pl...kh0hsot2Ig1faUEaDSdNgIElek1jEVkEaAqLEEALw_wcB

Almost silence.

I will try to double that dose in the future.

 

[jacob21]

Thank you! Great to hear. I think 800 mg is not too much. I see on Amazon reviews people are taking it for months, even more for arthritis etc ...

What kind of noise is your tinnitus, high pitch? Which frequency?

 

[PolishSoldier87]

800 mg is too little. You have to better take that standardised to >95% of curcuminoids and of course with piperine which is increasing absorption of curcumin by 2000%. I think 5-10g/day is ok.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3535097/

 

[PolishSoldier87]

Today even better than yesterday but changes are occurring very slowly.

In the morning I had silence but it's reactive a bit and my computer fan and other noises aggravate it.

But it's ok. I was in hell for some months. Now I am becoming myself again.

 

[JohnAdams]

I can say for my case, it works.
The "authorities" are not aware of this nor do they care about something that could drastically impact many people's quality of life for the better.

Does this mean they are not doing their jobs?

 

[Cape crusader]

Hello,

Has anyone had results with Turmeric?

 

[Jack Straw]

Interested to see if any other members have had positive results like many here.

 

[housemzk]

I've been taking it twice daily for close to 6 months now. I believe it's helped overall, but I'm also on many other supplements and doing daily exercises, so it's hard to say if my gains are directly linked or not.

Here's the product I use:
https://www.amazon.com/gp/product/B01MCUYRBO/ref=oh_aui_detailpage_o00_s00?ie=UTF8&psc=1

 

[Jack Straw]

I've been taking it twice daily for close to 6 months now. I believe it's helped overall, but I'm also on many other supplements and doing daily exercises, so it's hard to say if my gains are directly linked or not.

Here's the product I use:
https://www.amazon.com/gp/product/B01MCUYRBO/ref=oh_aui_detailpage_o00_s00?ie=UTF8&psc=1

Thank you for the response! @JohnAdams have you thought about trying it out again?

 

[Zeneth]

My mom drinks this tea that has turmeric and reishi in it, I'll try some and post here if anything happens.

 

[Samantha R]

I wanted to share my experience.
I had to take prednisolone for a skin issue a few months ago.
I noticed while taking it that my head hissing tinnitus was greatly reduced.
Once I stopped, it came back.
I thought maybe there was an inflammatory link to my main tinnitus - (Please note that I do have a mild ringing in my right ear due to a notech at 6000 kHz and this noise hasn't stopped since taking the curcumin).
I tried curcumin a little while afterward, and sure enough, reduced head hissing.
Not sure why now, but I discontinued use and head hissing came back to normal.
Just back on curcumin and head hissing greatly reduced.
I will continue for the foreseeable future and keep everyone updated.

 

[JohnAdams]

Thank you for the response! @JohnAdams have you thought about trying it out again?

Not right now. I'm currently taking egcg and I'm about to start taking it with thunder god extract. I'm not trying to just lower my t but heal myself.

Curcumin blocks atoh1 expression. I took it for 3 weeks in high doses and I'm pretty sure it's not regenerating my damaged cochlea.

 

[Zeneth]

I wanted to share my experience.
I had to take prednisolone for a skin issue a few months ago.
I noticed while taking it that my head hissing tinnitus was greatly reduced.
Once I stopped, it came back.
I thought maybe there was an inflammatory link to my main tinnitus - (Please note that I do have a mild ringing in my right ear due to a notech at 6000 kHz and this noise hasn't stopped since taking the curcumin).
I tried curcumin a little while afterward, and sure enough, reduced head hissing.
Not sure why now, but I discontinued use and head hissing came back to normal.
Just back on curcumin and head hissing greatly reduced.
I will continue for the foreseeable future and keep everyone updated.

I have a head hissing sound too and am interested, do you take circumin the same way @JohnAdams does it?

 

[Samantha R]

@Zeneth
No, I don't, I am getting results with much less.
My dosage at the moment is 800mg per day (split in to morning and night).
I suspect inflammation is the cause of my tinnitus, and I'm more sure now.
Results with prednisolone and now with Curcumin.
I do get hormonal fluctuations as well so will be interesting to see how things go throughout the month.

The background (quickly to my onset) - tinnitus 1 month after C-section delivery of twins, gestational diabetic. I was unwell shortly after the birth and felt "not right"for at least 2-3 weeks post birth.
OB told me at my 6 week check that there were some inflammatory markers in my blood when they ran some tests after I complained of feeling unwell.

I have a mild ring in my right ear that I believe is related to a 30db loss at 6,000khz. This remains unchanged on curcumin (and I can actually hear it now, it is normally dominated by the hiss). I am habituated fully to that noise.
The hiss however is much milder at the moment (I can't hear it unless in a relatively quiet environment and focusing on it).

 

[Jack Straw]

@Samantha R @JohnAdams

How long after taking curcumin did you notice a change in your T? I recently started taking it and am wondering if what I am feeling is placebo or actual side effects of curcumin.

 

[JohnAdams]

@Samantha R @JohnAdams

How long after taking curcumin did you notice a change in your T? I recently started taking it and am wondering if what I am feeling is placebo or actual side effects of curcumin.

Like a day or 2.

 

[Jack Straw]

Like a day or 2.

I'm going to wait a couple more days to post my experience, but it seems to be a recurring theme with curcumin and people's experiences here.

 

[Zeneth]

@Zeneth
No, I don't, I am getting results with much less.
My dosage at the moment is 800mg per day (split in to morning and night).
I suspect inflammation is the cause of my tinnitus, and I'm more sure now.
Results with prednisolone and now with Curcumin.
I do get hormonal fluctuations as well so will be interesting to see how things go throughout the month.

The background (quickly to my onset) - tinnitus 1 month after C-section delivery of twins, gestational diabetic. I was unwell shortly after the birth and felt "not right"for at least 2-3 weeks post birth.
OB told me at my 6 week check that there were some inflammatory markers in my blood when they ran some tests after I complained of feeling unwell.

I have a mild ring in my right ear that I believe is related to a 30db loss at 6,000khz. This remains unchanged on curcumin (and I can actually hear it now, it is normally dominated by the hiss). I am habituated fully to that noise.
The hiss however is much milder at the moment (I can't hear it unless in a relatively quiet environment and focusing on it).

Ah, I see, are you taking it as a pill or as powder with the butter and black pepper?

 

[Samantha R]

@Zeneth I am taking the pill form.
@Jack Straw not long, within a day almost.
I know mine is not placebo because my head hiss normally covers a mild tinnitus in my right ear. I can now hear that mild tinnitus so the hiss must have calmed down.

 

[PolishSoldier87]

It seems that curcumin is otoprotective if taken before trauma.

https://www.sciencedirect.com/science/article/pii/S1347861317301093

But after trauma if you take it, spontaneus regeneration (which is miserable itself) wont occur due to lack of Atoh1 expression.

"We have shown that the response of cells in the utricle to an ototoxic trauma involve changes of Notch signaling molecules and Atoh1 expression. Using qRTPCR we detected down-regulation of Hes5, up-regulation of Atoh1 and no changes in levels of Notch1, Jagged1 and Hes1

Atoh1 was not detected in the normal tissue but appeared after the trauma. qRTPCR data showed a post trauma decrease for Hes5 and an increase in Atoh1 after the lesion, with no significant change in Notch1, Jagged1 and Hes1."

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2902641/

Curcumin is just a factor whose presence stops expression of Atoh1. After washing it out, situation is reversed.

"To test the contribution of ongoing acetylation to hair cell differentiation, HATi was removed from some cultures at the 24 h time point. These washout experiments demonstrated that changes brought about by HATi were reversible, and differentiation resumed upon drug removal."

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2902641/

 

[Jack Straw]

It seems that curcumin is otoprotective if taken before trauma.

View attachment 23247
https://www.sciencedirect.com/science/article/pii/S1347861317301093

But after trauma if you take it, spontaneus regeneration (which is miserable itself) wont occur due to lack of Atoh1 expression.

"We have shown that the response of cells in the utricle to an ototoxic trauma involve changes of Notch signaling molecules and Atoh1 expression. Using qRTPCR we detected down-regulation of Hes5, up-regulation of Atoh1 and no changes in levels of Notch1, Jagged1 and Hes1

Atoh1 was not detected in the normal tissue but appeared after the trauma. qRTPCR data showed a post trauma decrease for Hes5 and an increase in Atoh1 after the lesion, with no significant change in Notch1, Jagged1 and Hes1."
View attachment 23248
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2902641/

Curcumin is just a factor whose presence stops expression of Atoh1. After washing it out, situation is reversed.

"To test the contribution of ongoing acetylation to hair cell differentiation, HATi was removed from some cultures at the 24 h time point. These washout experiments demonstrated that changes brought about by HATi were reversible, and differentiation resumed upon drug removal."
View attachment 23246
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2902641/

Being a stupid person I am offended you didn't include a TSTU (too stupid to understand) somewhat similar to a TLDR.

So what does this mean? Curcumin if taken before noise induced trauma can reduce the damage similar to NAC? Same thing for ototoxic drugs?

@JohnAdams weigh in?

 

[annV]

So what does this mean? Curcumin if taken before noise induced trauma can reduce the damage similar to NAC? Same thing for ototoxic drugs?

I'm going to start take curcumin along with NAC to prevent damage from any unexpected sudden noise.

 

[Jack Straw]

I'm going to start take curcumin along with NAC to prevent damage from any unexpected sudden noise.

I can still feel the burn you laid down on Jastreboff in MPP!

Please let us know how you feel about your tinnitus after a couple days of taking curcumin. We have been doing some experiments with it and there seems to be a similar outcome where tinnitus is suppressed a little. Not cured, but it seems to not be as intrusive. @JohnAdams even had silence a couple of times.

 

[PolishSoldier87]

Being a stupid person I am offended you didn't include a TSTU (too stupid to understand) somewhat similar to a TLDR.

So what does this mean? Curcumin if taken before noise induced trauma can reduce the damage similar to NAC? Same thing for ototoxic drugs?

@JohnAdams weigh in?

Yes. It can reduce.

Curcuma longa (curcumin) decreases in vivo cisplatin-induced ototoxicity (...)
https://www.ncbi.nlm.nih.gov/m/pubmed/24608370/

There are so many many plants that protect from noise and drugs. It's very common but mechanisms of action can be different. If you want I can write a list of some otoprotective herbs.

Harder is to find a thing that helps when damage is already done. This is the key.

 

[Jack Straw]

Yes. It can reduce.

Curcuma longa (curcumin) decreases in vivo cisplatin-induced ototoxicity (...)
https://www.ncbi.nlm.nih.gov/m/pubmed/24608370/

There are so many many plants that protect from noise and drugs. It's very common. If you want I can write a list of some otoprotective herbs.

Harder is to find a thing that helps when damage is already done. This is the key.

Yes, please provide a list that would be fantastic. Are there more studies that I can read into regarding reducing the damage of ototoxic drugs with supplementation?

Are drugs that cause tinnitus to temporarily spike considered ototoxic? Things like caffine or alcohol? I wonder if taking curcumin can reduce the spike caused by that in people who have problems with it.

I know @coffee_girl says he tinnitus spikes after coffee. I wonder if her supplementing curcumin could reduce it.

 

[PolishSoldier87]

Yes, please provide a list that would be fantastic. Are there more studies that I can read into regarding reducing the damage of ototoxic drugs with supplementation?

Are drugs that cause tinnitus to temporarily spike considered ototoxic? Things like caffine or alcohol? I wonder if taking curcumin can reduce the spike caused by that in people who have problems with it.

I know @coffee_girl says he tinnitus spikes after coffee. I wonder if her supplementing curcumin could reduce it.

There is little chance to reduce damage that is already done. At least for now. There is a therapeutic window in the first few days or weeks and after that hair cells or nerves or both become dead or permanently damaged. Next there can be some miserable spontaneous regeneration that can last a few months but in this case curcumin blocks the factor that is playing the main role in this.

I will write a list and provide research references as well but need some time.

Coffee or alcohol are not ototoxic but can affect symptoms of damage that was formed in your auditory system.
Which does not mean that tinnitus spike is not a sign of further damage for example when you use some medicines.

It is very nice that you take care of @coffee_girl. Maybe she should try some supplementation.

Definitely curcumin plays some role and can affect some genes. It is very anticancer (inter alia that's why it blocks atoh1 whose expression is spotted in tumors).

 

[coffee_girl]

Yes, please provide a list that would be fantastic. Are there more studies that I can read into regarding reducing the damage of ototoxic drugs with supplementation?

Are drugs that cause tinnitus to temporarily spike considered ototoxic? Things like caffine or alcohol? I wonder if taking curcumin can reduce the spike caused by that in people who have problems with it.

I know @coffee_girl says he tinnitus spikes after coffee. I wonder if her supplementing curcumin could reduce it.

I don't know anything about curcumin but nac pills work wonders on me...it eliminated the screeching completely... And it's safe to take everyday, perhaps try those too. I'm afraid to take pills so I try not to risk it. Coffee has worked to ease my anxiety and had never given me any problems besides a minor spike. But the benefits it gives me far exceed the consequences. Just my opinion.

 

[JuneStar]

I've been taking turmeric but my latest bottle doesn't have piperine... is it useless, then?