MemberI'm currently stacking my 125mg of NR with 500mg of L-Citrulline and 1g of Lion's Mane mushroom. My T is down to my pre-spike level which started in July of 2018. I'm still waiting for my NMN.
Vitamin Supplement (Nicotinamide Riboside) Successfully Prevents Noise-Induced Hearing Loss
- Thread starter exodus
- Start date
- May 17, 2017
- 909
- Tinnitus Since
- 07/2016
- Cause of Tinnitus
- Ototoxic earwax drops, worsened by MDs (Muppet Doctors)
Interesting. Patent for NR and preventing hearing loss.
https://patents.google.com/patent/WO2014014828A1/en
https://patents.google.com/patent/WO2014014828A1/en
- May 17, 2017
- 909
- Tinnitus Since
- 07/2016
- Cause of Tinnitus
- Ototoxic earwax drops, worsened by MDs (Muppet Doctors)
I'm not sure where you are getting the 1000mg/kg twice daily from. The big players in the NR field are Tru Niagen and Basis. Tru Niagen is now 150mg twice daily. Basis is 125mg twice daily.
- May 17, 2017
- 909
- Tinnitus Since
- 07/2016
- Cause of Tinnitus
- Ototoxic earwax drops, worsened by MDs (Muppet Doctors)
@spingee was referencing the dosage used in research that is in the patent link above.
I figured that much but still didn't see it in the link. In general, I wouldn't use dosages given to mice as a reference.
I've been taking the recommended doses of NR or NMN (a related compound, also a NAD precursor) for about a year and a half. I had slight hearing loss in both ears (10 dB or so) and complete loss of a small range of frequencies in my right ear due to a car backfiring right next to me. I'm now able to hear those frequencies again, and I estimate that my hearing is maybe 75-80% back to normal.
I think that the NR/NMN are finally starting to have a positive effect on my tinnitus. I've seen a number of people say that NMN actually made their tinnitus louder. It did that for me as well but not enough to make me stop taking it. However, in the last month I've started to have short periods of complete silence, and that's new. So I'm cautiously optimistic that my brain is finally figuring out that it doesn't need to keep making all that noise.
I get NR from Amazon or from the TruNiagen web site. As someone noted, TruNiagen sells 150 mg capsules and Basis has only 125 mg. In addition, Basis also contains pterostilbene (a chemical related to resveratrol), so their capsules contain even less NR. (Some studies have shown that pterostilbene raises levels of LDL "bad cholesterol", so it may be a good idea to avoid it if you're watching your cholesterol.)
- May 17, 2017
- 909
- Tinnitus Since
- 07/2016
- Cause of Tinnitus
- Ototoxic earwax drops, worsened by MDs (Muppet Doctors)
I'm doing the same thing with alternating between NR and NMN daily. But I'm only taking a single dosage as a way the stretch out the expense. Have you always taken 2x daily?
I've had no spiking from NMN vs. NR. My T is now back to my normal level and I think NR really helped. The only issue I'm having now is pain in my right ear. My left ear has always had louder T and minor hearing loss, but no pain. My right ear has little T, almost normal hearing, but pain.
I'm on a cocktail of supplements still which I feel is probably only taking the edge off emotionally (like the st. john's wort). The bioflavonoids aren't really doing much although I'm still on them.
In lieu of neuromodulation I think I'm going to have to continue down this road, knowing how unlikely any of these things are going to have a measurable impact.
I've followed this thread but it's sort of coming from the vantage point that people reading it already know the lingo and such. But it would be nice to get a primer with recommendations.
I'm maybe about six months or so into what is either a stubborn spike or a new normal, probably the latter. I used to be able to get by with masking alone but I am going to need to find some combination that helps me cope better. The three things I see mentioned that I haven't tried are the NR/NMN, shrooms, or CBD/THC. I think I am just going to have to systematically go down the list.
I vary the dosage, and even skip several days from time to time. I started with 125 mg of NR twice a day, but I take the sublingual NMN powder four times a day up to around 100 mg per dose. In my experience, both seem to have similar benefits, although there are differences - for me, NMN has no side effects and NR has a few minor ones. Both seem to help with neurological issues (eg. eliminating migraine auras). I think NMN increases the loudness of my tinnitus more than NR does, but because of the side effects business, I rely on NMN to get my total dosage up.
Everybody is different, though, so you need to experiment to see what works best for you.
What brand of NMN are you taking? I waited on NMN until I found a reliable source which is GenEx. Much like Dr. Brenner's research sold me on Tru Niagen, Dr. Sinclair sold me on GenEx. I understand the financial interests they both have but at least you know you are getting the real thing.
Alive by Nature. You can order directly from the company or from Amazon. They have sublingual tablets that are more convenient than the powder, but the tablets have stevia in them which I don't want or need. I think the powder tastes fine by itself.
I'll check out GenEx, though.
I take that back. Although Dr. Sinclair is featured all over the GenEx website, there is no affiliation. I'll still look for a 3rd party verification. I like the sublingual idea from Alive by Nature and will give them a try next.
Hi Kste Adams,
You mentioned that you have done self testing of your hearing with computer and results were positive. Besides self testing, did you test your hearing with audiologist and compare old audiograms with new audiogram?
I haven't yet, I'm waiting until I think that my hearing has stopped improving. I'll definitely post the results when I have a new audiogram.
I've been on 330mg of Nicotinamide Riboside alongside 400mg of Resveratrol since February, according to David Sinclair Resveratrol potentiates NAD+ substantially by boosting the sirtuins.
The vibrating I've had in my right ear for the last 2 years is entirely gone (yes, completely, and it was loud). The loud ringing that was in my left ear is now a very faint hiss, and it's a very faint hiss I can only hear when I go to bed at night. I can also hear higher frequencies (have tested), almost to 19,000 Hz. Before I started NR, I could only hear max 16,500hz.
I think NAD+ does restore hearing, but you need to take it for a long, long time. All the other benefits for me though have been astounding.
Hopefully the faint hiss that's left will leave, but if it doesn't then I leave it to neuromodulation to take care of the rest of it. =)
The vibrating I've had in my right ear for the last 2 years is entirely gone (yes, completely, and it was loud). The loud ringing that was in my left ear is now a very faint hiss, and it's a very faint hiss I can only hear when I go to bed at night. I can also hear higher frequencies (have tested), almost to 19,000 Hz. Before I started NR, I could only hear max 16,500hz.
I think NAD+ does restore hearing, but you need to take it for a long, long time. All the other benefits for me though have been astounding.
Hopefully the faint hiss that's left will leave, but if it doesn't then I leave it to neuromodulation to take care of the rest of it. =)
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Glad it's helping. You're been taking it since February of 2019? Is that what you consider to be a long time? I've been tempted to try Resveratrol. Sinclair takes 1000mg a day in powder form and mixes it with his morning yogurt. He doesn't take NR, only NMN. He also doesn't sponsor any NMN products so I'm staying with Tru Niagen NR. Can you post your audiograms?
- May 17, 2017
- 909
- Tinnitus Since
- 07/2016
- Cause of Tinnitus
- Ototoxic earwax drops, worsened by MDs (Muppet Doctors)
I read pterostilbene is better absorbed amongst other things than reservatrol. I took it for a while but decided to cut back on the number of supps. Getting too ex.
It's still not entirely gone in my left ear, but it feel as the weeks go by it slowly fades more and more. I should also mention I'm pretty young(25). It appears that the younger you are, the quicker things happen. I wanted to start taking it sooner but the guys on r/longevity told me to begin at 25. It may also be the Resvertrol *combined* with NAD+, Sinclair said it potentiates NR/NMN's regenerative effects in the body's cells quite substantially. So that may also be why my T in my right ear left in a matter of months after starting. And the Ring turned into a faint hiss that's only audible in 30-35db rooms.
The original reason I began taking NR/Resvertrol was for anti aging purposes, not tinnitus. But I noticed around late march(about 2 and a half months after I began) the vibrating I had in my right ear for the last 2+ years is gone, I say that as I sit in a silent room. The old Ringing I've had since I was 15 in my left ear is just that faint hiss now. It's not a ringing anymore.
I can sleep without masking now, I haven't been able to do that since I was 15(around the time I got the T in my left ear). NAD+ definitely does something regenerative in the cochlea.
NR/NMN are pretty interchangeable, NR is just much cheaper. I believe NMN just has one less step to go through before being converted into NAD+.
Audiograms in my area only go to to 8,000hz(Not high enough), so I have been doing it at home online at the same volume on my speakers every few weeks. Before I began, my left ear could hear up to around 16,500hz as mentioned previously. My right ear could hear around 17,000hz. As of now, My left ear can hear around 18,000hz, and my right ear(the ear without T anymore) can hear around 19,200hz. So like Kste, it appears I can pick up higher frequencies, I also noticed my hearing in general has improved. I can hear the volume on my iphone at the 1 setting for volume about 20 inches from my head, I couldn't do that last year. I had to turn it up to at least 2 or 3 before I'd start hearing anything.
As I said prior, I originally began taking this to make it to LEV (Aubrey De Grey call this longevity escape velocity), but that's a whole other discussion that's meant for Reddit and this not forum.
All I know is, that stuff is doing something, so I'm going to stay on it for good.
I'm also a daily Marijuana smoker/grower. Cannabis doesn't lower or spike my T(I'm an outlier on this forum in that regard) but it does always help me take my mind off it.
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What brand names do you use?
6 month ago I took 125-250 nicotinamide Riboside everyday for 3 months or so and didn't feel any positive change in my tinnitus, but I'm ready to try again combined with Resveratrol.
- May 8, 2012
- 1,601
- Tinnitus Since
- 04/15/2012 or earlier?
- Cause of Tinnitus
- Most likely hearing loss
I am mostly against supplements having tried mostly everything over the past almost 10 years.
However, I have been using Tru NR based on the positive research for about 4 months now. I am doing 125 mg x2 daily. I have noticed I have more energy and generally feel better especially in late afternoon since taking it. I have always been pretty active and have noticed sometimes that I get heart palpitations at weird times unexpectedly where it would beat faster than normal even if I wasn't exerting myself. I did not get this before taking NR. So far nothing really for my hearing or tinnitus that I can tell.
Maybe I will double the dose for the next month or so and give that a shot.
However, I have been using Tru NR based on the positive research for about 4 months now. I am doing 125 mg x2 daily. I have noticed I have more energy and generally feel better especially in late afternoon since taking it. I have always been pretty active and have noticed sometimes that I get heart palpitations at weird times unexpectedly where it would beat faster than normal even if I wasn't exerting myself. I did not get this before taking NR. So far nothing really for my hearing or tinnitus that I can tell.
Maybe I will double the dose for the next month or so and give that a shot.
I've noticed my energy is through the roof constantly, are you experiencing something similar? I only sleep 5-6 hours ever since I began taking it. I've also found I can put out 3x what I normally could in my workouts. It sort of feels like I'm always on caffeine, sometimes coffee gets me too speedy and I find I can't sit still. Never had this prior to starting XD
You should try stacking some Resvertrol with it. I usually take 400mg as 600mg made my heart beat a little hard. But it's supposed to make NR's/NMN's anti aging effects much more potent.
The research said SIRT3 is responsible for NR's hearing effects, perhaps it's the resveratrol pumping the sirtuins to work harder that makes the effects stronger.
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