Vitamin Supplement (Nicotinamide Riboside) Successfully Prevents Noise-Induced Hearing Loss

[vttbx]

After a recent spike, I tried to double my NR to the recommended dosage of 150mg twice a day. My T became worse and has been better since I stopped. This was very similar to my experience with niacin which would always give me a spike after extended usage. I'm staying with NMN for now.

 

[eroteme]

Personally, I'm extremely cautious when it comes to supplements that aren't being sold by reputable and well regulated suppliers.

In the case of NR I couldn't find any well known chemists or health stores that were selling it in the UK, so I contacted the two largest brands of both the former and the latter (in my opinion); Boots and Holland&Barrett. These were their responses:

Thanks for contacting us about the availability of Nicotinamide Riboside in our stores and online.
Unfortunately, I'm unsure if this product will be introduced in the future as we don't have access to that information from here in Boots Customer Care. However we do collect feedback when customers ask about certain products, so you can be sure I'll be reporting your views to the product team for them to review this further.

So that was pretty unhelpful...

But the response from Holland&Barrett was more interesting:

Thanks for contacting Holland & Barrett.
We do not have any plans to stock this product I'm afraid, as most of these supplements can provide over the safe limit of convertible niacin. So the amount of NAD you end up supplementing gets converted into too much niacin, This then needs to be methylated to be excreted, this can reduce methyl groups within the body such as creatine and choline.
I hope I have successfully answered your query but please do not hesitate to contact me again if you have any further questions.

So, my understanding of nutrition and/or biochemistry is as close as you can get to non-existent, but I thought this may be of some use to those of you who have done the research.


Take what you like and leave the rest.

 

[Gman]

Personally, I'm extremely cautious when it comes to supplements that aren't being sold by reputable and well regulated suppliers.

In the case of NR I couldn't find any well known chemists or health stores that were selling it in the UK, so I contacted the two largest brands of both the former and the latter (in my opinion); Boots and Holland&Barrett. These were their responses:



So that was pretty unhelpful...

But the response from Holland&Barrett was more interesting:



So, my understanding of nutrition and/or biochemistry is as close as you can get to non-existent, but I thought this may be of some use to those of you who have done the research.


Take what you like and leave the rest.

I won't think twice about taking it if I am exposed to noise that I feel is potentially dangerous as this stuff has research to back it up. But I also wouldn't be taking it everyday or at high doses.

It is the same case with many "normal" supplements, that if you take too much of one thing it can cause others to be depleted. Plenty of the supps these outlets sell can do this. Eating too much of one food can do it too for that matter.

Pharmacies do need to weigh up pros and cons of what they sell. But they also sell things like valerian root which have been known to cause organ failure if taken too much/often.

I would be more concerned about making sure I buy the highest quality supplements. There's a lot of junk brands out there, full of impurities and toxic stuff and are sold by these big name pharmacies. The supplements industry being unregulated is a big problem.

 

[alex1975]

Alright everyone, just Amazoned Tru Niagen NR and NOW Supplements Resveratrol 200.
Getting them on Sunday, I shall keep you all posted with results...

 

[Heinrich_S7]

Update,

Yeah, NR/NAD+ eliminating my tinnitus is definitely not placebo. I went off it for the month of September and up to yesterday October 15th. My tinnitus in my left ear came back slightly a couple days ago. But it's nowhere even close to how horrible it was last year.

I went back on NR today, an hour after I took the dose, I got TOTAL silence again. And I still have silence.

I think NR can cure certain types of tinnitus. I'm not sure if the reason mine slightly came back after almost two months off the supplement was just because I was only on it for six months. I believe my tinnitus is related to my neck with a little NIHL to boot.

I've decided I'm going to permanently stay on NAD+ supplements alongside Lion's Mane. I more or less considered myself cured at this point (as long as I stay on the supplement).

Perhaps if I let NR, Cannabis and Lions Mane repair my hearing/nerves for a couple years I can come off the NR without the tinnitus ever returning. But at this point I might just stay on it for its age reversal effects in general.

Anyway, it looks like I won't need a bimodal device at this point. I'll probably just wait for FX-322.

 

[Daniel Lion]

Update,

Yeah, NR/NAD+ eliminating my tinnitus is definitely not placebo. I went off it for the month of September and up to yesterday October 15th. My tinnitus in my left ear came back slightly a couple days ago. But it's nowhere even close to how horrible it was last year.

I went back on NR today, an hour after I took the dose, I got TOTAL silence again. And I still have silence.

I think NR can cure certain types of tinnitus. I'm not sure if the reason mine slightly came back after almost two months off the supplement was just because I was only on it for six months. I believe my tinnitus is related to my neck with a little NIHL to boot.

I've decided I'm going to permanently stay on NAD+ supplements alongside Lion's Mane. I more or less considered myself cured at this point (as long as I stay on the supplement).

Perhaps if I let NR, Cannabis and Lions Mane repair my hearing/nerves for a couple years I can come off the NR without the tinnitus ever returning. But at this point I might just stay on it for its age reversal effects in general.

Anyway, it looks like I won't need a bimodal device at this point. I'll probably just wait for FX-322.

Happy days... enjoy it.

 

[FGG]

Update,

Yeah, NR/NAD+ eliminating my tinnitus is definitely not placebo. I went off it for the month of September and up to yesterday October 15th. My tinnitus in my left ear came back slightly a couple days ago. But it's nowhere even close to how horrible it was last year.

I went back on NR today, an hour after I took the dose, I got TOTAL silence again. And I still have silence.

I think NR can cure certain types of tinnitus. I'm not sure if the reason mine slightly came back after almost two months off the supplement was just because I was only on it for six months. I believe my tinnitus is related to my neck with a little NIHL to boot.

I've decided I'm going to permanently stay on NAD+ supplements alongside Lion's Mane. I more or less considered myself cured at this point (as long as I stay on the supplement).

Perhaps if I let NR, Cannabis and Lions Mane repair my hearing/nerves for a couple years I can come off the NR without the tinnitus ever returning. But at this point I might just stay on it for its age reversal effects in general.

Anyway, it looks like I won't need a bimodal device at this point. I'll probably just wait for FX-322.

This might me helping me, too. I have been taken NAD+ for about 5 months now (I'm have also been taking Winter Savory for the past few weeks but i have been much less consistent about taking it).

Currently, my tinnitus is about half of what it was and, last night, the "tonal" sound was the same loudness as the "cicadas" sound. Usually, it's the much louder and more bothersome of the two sounds.

My hearing is slightly better in noise but otherwise no different that i can tell. I don't think I have much, if any, hyperacusis left but that was very slowly fading on its own since March, anyway.

Music sounds the same (unlistenable), unfortunately, and i still need subtitles for TV when there is any background music but I think I'm catching a few more words here and there (if there is a difference it is slight).

I have had tinnitus for close to a year now so who is to say if I'm just acclimating or if finally having complete no contact with my abusive ex is helping but it does feel like NAD is doing something. Wish it would help my hearing more...

 

[vttbx]

Update,

Yeah, NR/NAD+ eliminating my tinnitus is definitely not placebo. I went off it for the month of September and up to yesterday October 15th. My tinnitus in my left ear came back slightly a couple days ago. But it's nowhere even close to how horrible it was last year.

I went back on NR today, an hour after I took the dose, I got TOTAL silence again. And I still have silence.

I think NR can cure certain types of tinnitus. I'm not sure if the reason mine slightly came back after almost two months off the supplement was just because I was only on it for six months. I believe my tinnitus is related to my neck with a little NIHL to boot.

I've decided I'm going to permanently stay on NAD+ supplements alongside Lion's Mane. I more or less considered myself cured at this point (as long as I stay on the supplement).

Perhaps if I let NR, Cannabis and Lions Mane repair my hearing/nerves for a couple years I can come off the NR without the tinnitus ever returning. But at this point I might just stay on it for its age reversal effects in general.

Anyway, it looks like I won't need a bimodal device at this point. I'll probably just wait for FX-322.

What's your dosage of NR? Do you always stack it with Lion's Mane?

 

[shasta0863]

What's your dosage of NR? Do you always stack it with Lion's Mane?

What brand are you guys buying?

 

[Heinrich_S7]

What's your dosage of NR? Do you always stack it with Lion's Mane?

250mg.

I've only been on Lion's Mane for about 2 months. About the time I quit NR, but nowadays I take them both. I'm just throwing the Lion's Mane in there for CNS repair.

 

[Lucifer]

Update,

Yeah, NR/NAD+ eliminating my tinnitus is definitely not placebo. I went off it for the month of September and up to yesterday October 15th. My tinnitus in my left ear came back slightly a couple days ago. But it's nowhere even close to how horrible it was last year.

I went back on NR today, an hour after I took the dose, I got TOTAL silence again. And I still have silence.

I think NR can cure certain types of tinnitus. I'm not sure if the reason mine slightly came back after almost two months off the supplement was just because I was only on it for six months. I believe my tinnitus is related to my neck with a little NIHL to boot.

I've decided I'm going to permanently stay on NAD+ supplements alongside Lion's Mane. I more or less considered myself cured at this point (as long as I stay on the supplement).

Perhaps if I let NR, Cannabis and Lions Mane repair my hearing/nerves for a couple years I can come off the NR without the tinnitus ever returning. But at this point I might just stay on it for its age reversal effects in general.

Anyway, it looks like I won't need a bimodal device at this point. I'll probably just wait for FX-322.

What brand and dosage are you taking for NR and NAD?

 

[Heinrich_S7]

What brand and dosage are you taking for NR and NAD?

TruNiagen 250mg. I get the six month package for a discount, don't buy from Amazon.

It's not gonna heal your hearing in one month, it takes a long time. So don't think one bottle is gonna change anything. Mine only went away so quickly because I was already on it for a long cycle already. It just came back a very little bit 2-3 days ago after being off it for 7 or so weeks, and it shut it down again.

It's amazing that the scientific community found something that protects/regenerates hearing and yet Big Pharma never picked it up as a prescribed therapy. Goes to show how little the medical community cares about tinnitus.

 

[FGG]

TruNiagen 250mg. I get the six month package for a discount, don't buy from Amazon.

It's not gonna heal your hearing in one month, it takes a long time. So don't think one bottle is gonna change anything. Mine only went away so quickly because I was already on it for a long cycle already. It just came back a very little bit 2-3 days ago after being off it for 7 or so weeks, and it shut it down again.

It's amazing that the scientific community found something that protects/regenerates hearing and yet Big Pharma never picked it up as a prescribed therapy. Goes to show how little the medical community cares about tinnitus.

I take the same product and dose. It's so expensive. Thanks for the tip. It's much cheaper off Amazon. I had no idea.

 

[alex1975]

TruNiagen 250mg. I get the six month package for a discount, don't buy from Amazon.

It's not gonna heal your hearing in one month, it takes a long time. So don't think one bottle is gonna change anything. Mine only went away so quickly because I was already on it for a long cycle already. It just came back a very little bit 2-3 days ago after being off it for 7 or so weeks, and it shut it down again.

It's amazing that the scientific community found something that protects/regenerates hearing and yet Big Pharma never picked it up as a prescribed therapy. Goes to show how little the medical community cares about tinnitus.

Did you get any acid reflux from it? Unfortunately I get that pretty easily with most supplements...

 

[Greg Sacramento]

TruNiagen 250mg

I know a pharmacist PhD clinical who has tinnitus from going to many concerts. He takes TruNiagen 300mg. Half in the morning and half in late afternoon. He also takes NAC. A little Turmeric Curcumin, one half of a vitamin C daily and Magnesium Glycinate 400 - always one hour before going anywhere where there may be noise. He takes a half tablet of Mag Glycinate 400 during the day and a half again before going to bed to help sleep.

Mag is good for muscle release, but if not enough is taken, muscles may start to ache - asking for more. Mag taken without a break after several weeks use can loosen muscles too much placing pressure onto bones. He uses other meds so there's a two hour window between med intake and vitamin use. He feels that NAC taken with food is what really helps his T level. Mag is needed to support auditory threshold. He doesn't take calcium because of digestion issues. Calcium is needed with mag, so he eats a fair amount of foods that has calcium. For all other vitamins needs, such as D3 - he get them from foods. He gets his blood tested every six months.

 

[friend74]

TruNiagen 250mg. I get the six month package for a discount, don't buy from Amazon.

It's not gonna heal your hearing in one month, it takes a long time. So don't think one bottle is gonna change anything. Mine only went away so quickly because I was already on it for a long cycle already. It just came back a very little bit 2-3 days ago after being off it for 7 or so weeks, and it shut it down again.

It's amazing that the scientific community found something that protects/regenerates hearing and yet Big Pharma never picked it up as a prescribed therapy. Goes to show how little the medical community cares about tinnitus.

Could it be possible, that this stuff is US only? Can't find anything like this in Germany.

So you take the TruNiagen. Some other stuff also?

 

[razo]

What do you think of this as a source of NAD+?
https://uk.iherb.com/pr/Now-Foods-N...-3BsoFkuZTfuoCpAIUUaAl4YEALw_wcB&gclsrc=aw.ds

 

[Heinrich_S7]

I take the same product and dose. It's so expensive. Thanks for the tip. It's much cheaper off Amazon. I had no idea.

Could it be possible, that this stuff is US only? Can't find anything like this in Germany.

So you take the TruNiagen. Some other stuff also?

I'm in Canada, perhaps you could go through another retailer? It's cheapest to buy it directly from TruNiagen in the long run, compared to retail like Amazon. Amazon is cheaper if you buy a single bottle, but if you plan on using it for an extended period you're better off buying in bulk like most products.

Did you get any acid reflux from it? Unfortunately I get that pretty easily with most supplements...

I actually had surgery to fix my chronic GERD back in March (was born with it), so I can't really answer this question honestly, I have a magnetic implant around my lower esophageal sphincter (LINX) to prevent reflux. But no, no reflux (again though, I can't really have reflux anymore). But when I did have GERD, every little thing, even water, came back up. But that was before I was even on NAD+.

 

[vttbx]

I know a pharmacist PhD clinical who has tinnitus from going to many concerts. He takes TruNiagen 300mg. Half in the morning and half in late afternoon. He also takes NAC. A little Turmeric Curcumin, one half of a vitamin C daily and Magnesium Glycinate 400 - always one hour before going anywhere where there may be noise. He takes a half tablet of Mag Glycinate 400 during the day and a half again before going to bed to help sleep.

Mag is good for muscle release, but if not enough is taken, muscles may start to ache - asking for more. Mag taken without a break after several weeks use can loosen muscles too much placing pressure onto bones. He uses other meds so there's a two hour window between med intake and vitamin use. He feels that NAC taken with food is what really helps his T level. Mag is needed to support auditory threshold. He doesn't take calcium because of digestion issues. Calcium is needed with mag, so he eats a fair amount of foods that has calcium. For all other vitamins needs, such as D3 - he get them from foods. He gets his blood tested every six months.

What's his reason for taking NAC with food? I've always thought amino acids in general need to be taken on an empty stomach. I take my NAC first thing in the morning prior to breakfast.

 

[vttbx]

What do you think of this as a source of NAD+?
https://uk.iherb.com/pr/Now-Foods-N...-3BsoFkuZTfuoCpAIUUaAl4YEALw_wcB&gclsrc=aw.ds

It's not the same. You need nicotinamide riboside.

 

[Ruse]

Tru Niagen for 6 months here.

No change what so ever so I will be discontinuing as it's fairly expensive.

Haven't had any noticeable change from a supplement and not convinced I ever will.

 

[razo]

It's not the same. You need nicotinamide riboside.

Can you explain that some more?

"Niacinamide (Vitamin B-3) is a form of Niacin, a water soluble B-Vitamin. It is a derivative of Niacin that does not cause the "flush" normally associated with taking high doses of Niacin. Niacinamide is readily converted into the bioactive forms of Niacin, NAD+, NADH, NADP, and NADPH, which are vital cofactors in cellular energy production and are critical for the maintenance of DNA stability."

vs

https://en.wikipedia.org/wiki/Nicotinamide_riboside

 

[razo]

What I meant to ask, is NR so much better than NAD+?

 

[Artemis2K]

Isn't this stuff a huge cancer risk? I'd be all for it if it wasn't, but I don't want to make that much of a risk.

 

[Heinrich_S7]

Isn't this stuff a huge cancer risk? I'd be all for it if it wasn't, but I don't want to make that much of a risk.

Feeds Cancer =/= Causes Cancer. Different things.

Telomeres therapy is showing the same outcome, they used to say it helped cancer grow (which is true) but only if you already *have* cancer.

If you feed it to the trillions of healthy cells you have 99.99% of your body, it seems to prevent cancer in the future.

It's safe as long as you don't have cancer already, and it should make it so your cells don't mutate or degrade to begin with.

NAD+ is produced when NADH is oxidized in complex I of the electron transport chain. This is a basic part of the aerobic respiration that your entire body depends on. If you stop producing NAD+ you die. Saying that cancer cells depend on this reflects the fact that cancer cells are derived from cells, and all cells depend on NAD+ production.

 

[Artemis2K]

Feeds Cancer =/= Causes Cancer. Different things.

Telomeres therapy is showing the same outcome, they used to say it helped cancer grow (which is true) but only if you already *have* cancer.

If you feed it to the trillions of healthy cells you have 99.99% of your body, it seems to prevent cancer in the future.

It's safe as long as you don't have cancer already, and it should make it so your cells don't mutate or degrade to begin with.

NAD+ is produced when NADH is oxidized in complex I of the electron transport chain. This is a basic part of the aerobic respiration that your entire body depends on. If you stop producing NAD+ you die. Saying that cancer cells depend on this reflects the fact that cancer cells are derived from cells, and all cells depend on NAD+ production.

Holy crap. That sounds awesome. What are the best supplements to take for this?

 

[Heinrich_S7]

Holy crap. That sounds awesome. What are the best supplements to take for this?

Either ChromaDex or TruNiagen are both reliable brands. You *can* use NMN for the same effect but it's newer and more expensive, Nicotinamide Riboside is the same thing, just a precursor to NMN which is a precursor to NAD+.

 

[ajc]

You *can* use NMN for the same effect but it's newer and more expensive, Nicotinamide Riboside is the same thing, just a precursor to NMN which is a precursor to NAD+.

This article says NMN is crap compared to NR.

https://www.truniagen.co.nz/blogs/news/8-key-differences-between-nmn-nr

 

[Artemis2K]

Either ChromaDex or TruNiagen are both reliable brands. You *can* use NMN for the same effect but it's newer and more expensive, Nicotinamide Riboside is the same thing, just a precursor to NMN which is a precursor to NAD+.

I have no idea what any of this means and will need to do more research lol.

 

[vttbx]

Can you explain that some more?

"Niacinamide (Vitamin B-3) is a form of Niacin, a water soluble B-Vitamin. It is a derivative of Niacin that does not cause the "flush" normally associated with taking high doses of Niacin. Niacinamide is readily converted into the bioactive forms of Niacin, NAD+, NADH, NADP, and NADPH, which are vital cofactors in cellular energy production and are critical for the maintenance of DNA stability."

vs

https://en.wikipedia.org/wiki/Nicotinamide_riboside

Good info in this podcast at around 31:00.

https://player.fm/series/take-contr...-dr-david-sinclair-on-extending-your-lifespan