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Yeah, you are right, I didn't say it correctly. It's a symptom of brain damage. Thank you for the correction bruh.

Tinnitus is brain damage, so there is your explanation.

Fix your circadian rhythm, eat healthy, go to nature as much as possible, avoid loud places (they drain energy from you), get a lot of sun (slowly build up resistance) etc. It will work. Trust me. Start slowly short cardio, swimming helps a lot.

FX-322 is hitting 8000-20000 Hz. Don't expect a lot from that on audiograms and various tests, since those frequencies are not as important to hearing as those below 8000 Hz.

You don't understand how hearing works. I am producer and hearing doesn't only improve by threshold, it's much more complicated and deep what hearing means, and that is why I trust them entirely. Just because something can't be seen on paper, doesn't mean it doesn't improve a person's life...

They will work. In the beginning there won't be a permanent one-time solution, but as years go by, treatments will become more and more effective, as with everything.

You can damage your hearing by noise exposure pretty easily afterwards, so just because you regain something, that doesn't mean you can't damage it again.

I am sorry to hear this bro. This world sucks so much, person can damage their hearing within seconds, but repairing it takes months/years if ever. I wish that you will overcome this, and that treatments become available as fast as possible. People need to understand that this is a serious...

It will work for whatever tinnitus, if it is based in ear.

They won't fail.

Well I suppose that if the body detects that there is something new, it connects it.

Maybe because they don't have to witness cars, trains, construction sites and all this throughout life :D

I am personally more interested in Inner Hair Cells than Outer Hair Cells as I have 5 dB across all frequencies tested up to 8 kHz, and my real problem is decreased clarity, which is far more important for me.

I thought they didn't test above 8 kHz in previous clinical trials, but it seems like they did, which is quite depressing for a person like me. If it is going to fail, that means nothing helpful is coming within the near few years, but thank you anyway for clarifying facts.

Naaah bruh, I think Frequency Therapeutics will pass Phase 2b, those results are clear, problem is that it only hits up to 8 kHz, that is why it is not such a tremendous result, but in this Phase 2b, they test also up to 16 kHz (they didn't test previously) and there are many other tests that...

Finally found out where to buy FREQ stock here in Slovakia, so I am going to buy.

I would love to buy their shares, but unfortunately I can't find a seller, web page or anything where it is sold here in Slovakia. If anyone knows of any seller that sells Frequency Therapeutics stock in Slovakia, let me know.

Wtf, age-related hearing loss is same as noise trauma/noise exposure hearing loss. Age-related hearing loss just took a little bit longer and wasn't triggered within a few days/hours, but was progressing slowly over years also from noise, just not that drastically.

I don't understand it really, why can't it just be injected through the eardrum, or is it different from the drugs by Otonomy or Frequency Therapeutics? I understand that back then there weren't proper delivery methods, but c'mon guys, we got them now, use them please.

Just hold on boys for one to two more years. If it works in Phase 2b, I think they will hurry up to get it on market, and I personally think that it doesn't matter how long you have had tinnitus, it will work for any duration.

Wow, I thought they had clinical trials only in the USA. Since I am from north Slovakia, this is fascinating for me. What town was that?

Patient Global Impression of Change. It's written down on the paper.

I wonder, if there are companies that can deliver drugs to the entire cochlea, why don't they collaborate with Frequency Therapautics, and bring such a delivery system to them, because then they can reach and treat the entire frequency range.

I will risk it. If the body doesn't understand that it needs to build up back those structures, then it doesn't deserve to live.

That's actually amazing if it produces more rows, of course if it works properly.

Nobody really knows what is reason behind it, if it is happening at all, maybe it's not, and there is another reason behind it.

Was yours noise-induced or how did it start? Also, if you are going to gigs and concerts, does the tinnitus come back or is silence your new reality?

Why don't they start with the FX-345 trial right now, as they have already chosen the compound, why wait until autumn?

As fast as possible please, this hearing damage is just the worst thing I have experienced in my life, and I got some serious problems.

Lovely city, living there right now, you are welcome to come visit anytime.

I think most important thing when fasting is to be exposed to a lot of sunlight for that period, as you need to replenish energy in yourself, just not by eating.

Velicna Slovakia here lol, off to America as soon as I finish my physiotherapy college.

Lol, go there, knock them on the door and tell them to hurry up, because someone living in Slovakia believes the genetic approach will be the most effective.

I wish I could buy shares somewhere, but since I am from fcking Slovakia, can't find a broker for FREQ.

That would happen then in all of them, not just dosed.

Another reason rodents are used as models in medical testing is that their genetic, biological and behavioral characteristics closely resemble those of humans, and many symptoms of human conditions can be replicated in mice and rats. "Rats and mice are mammals that share many processes with...

They can try it on me.

Marketing is important thing these days + it's important to explain people how does it work etc. They anyway can't do much in public domain right now, since they are in clinical trials with FX-322 and FX-345 going in clinical trials in autumn, so I don't know what do you expect them to do? I bet...

Most age-related hearing loss is due to noise, it's just not as fast as when you experience acoustic shock.

That is because FX-345 is actually second generation. Well that would be amazing. I think it will, even more than just 20 dB.

I wasn't expecting magic solution, so these are good results, to regain back good hearing, it will be more like multiple different treatments to stimulate different things.

I really would love to buy their stock, but since I am from Slovakia, I can't find a webpage or broker, or anything where can I buy. I am not doing it for money, to be honest, I just want to put my trust in them.

Exactly, it's just devastating, to know that from now on, there is not much joy to experience. Death seems like most exciting when there is not much hope.

Amount of money going for war and armies, and we are unable to fund from public money such great opportunity to regain hearing for millions of people, shame.

Early Q2 can be until end of April, so it's still early Q2.

The goal should be not to hear tinnitus at all.

There are 20-30 dB improvements, I don't think you can get such in 3 months by coincidence.

Interestingly, Frequency Therapeutics were able to push forward fast despite the pandemic.

Sensorion Update on SENS-401 Update from 17 March 2022. To be honest I am really confused why they failed with drug when there was a minimum of 10 dB improvement in 28 days as well as other bigger improvements in sub-groups. Can someone explain me please, isn't a 10 dB improvement a lot when...

I wish I can follow up your healing story, because I can't live without gigs and my symptoms were and are really similar to yours from the beginning. 4 months in.

Yeah, you are right about this, but I would definitely try it to see if it is a better or worse approach.

I understand that FX-322's cochlea penetration is not as great as FX-345's, hitting only up to 8 kHz, but have any of you ever wondered what would happen if you at the time of the FX-322/FX-345 treatment stimulated the blood flow in the cochlea by multiple strategies, like exercise, massage of...

Are you able to go to gigs, like big parties etc with you hearing now? Of course with earplugs.

Do Astellas still need to do Phase 2b phase in EU if the drug passes the Phase 2b in USA?

I contacted Astellas in Prague and London. What I heard from them is that they don't plan any clinical trials with Frequency Therapeutics, but I only had two calls, not really sure if they were with relevant people. It's a shame Astellas hasn't brought clinical trials to EU so far; like what...

How do you know that they are seeing 20-30% hearing improvements?

I hope they bring Phase 3 clinical studies also to EU.

I'm from the EU and would like to invest in Frequency Therapeutics, Otonomy as well as Lineage Cell Therapeutics. How can I when I am from the EU? I couldn't find a site where I can from EU as all of them were only for the US.

Decibel Therapeutics (DBTX) Reports Q4 Earnings, Provides Corporate Update (streetinsider.com)

They aren't a failed biotech. I checked them out, they are pretty successful from what I read about them.