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It's probable that they can be regrown, unless pillar and phalangeal cells are destroyed. On the other hand I found a view where proliferation of supporting cells also happens.

I wonder if FX-322 doesn't damage the order of the hair cells. Playing with notch signaling can lead to unexpected proliferation of hair cells. Anyone know something about this? B - acceptable? What do you think? A - No treatment B - Atoh1 over-expression C - g-secretase inhibitor in the...

Say at least that it's better than year ago...

Maybe you should try some ordinary Curcuma Longa (turmeric). I read somewhere that it could have some other effects than the version processed to Curcumine Extract.

@tarmaced it is not so funny if I tell you that I had pneumatic drills in my ears when I was on doxycycline for treating Lyme's disease. I had eaten 5-10g curcumin daily month by month and the tinnitus kept fluctuating, but overall it was fading. I remember that it was very quiet and I heard it...

I would rather recommend you something with piperine. "For example, piperine is the major active component of black pepper and, when combined in a complex with curcumin, has been shown to increase bioavailability by 2000%. " https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5664031/

Please try everything what can affect NGF, TRKB/BDNF/NT-3 or IGF-1 like big doses of curcumin + piperine or big doses of CBD oil. Use this long term and don't give up. If the problem is the brain being hyperactive, neuromodulation will surely help this. There is a big probability that in many...

And you cured your tinnitus with curcumin?

Didn't you have acoustic trauma?

Why do you think that?

The problem is in the potassium channels of the synapses that are between any given neuron chain and the rest of the nervous system. We should ask some specialist about that who knows how the process of the neuro and synaptogenesis and synaptoplasticity according to KV channels appears and what...

New neurons using deformed channels of old neurons? Is this even possible?

What's the difference?

I think long term use of big doses of CBD can be very useful. It protects and regenerates the brain's neurons and increases BDNF factor.

It would be better if you used that money on alcohol.

Garlic, Citrus and Ginkgo (100 mg) + some vitamins? 60 capsules for $70. Curcumin 600 mg 95% curcuminoids capsules x 60 for $70. Lol. Nice joke and not nice SCAM. Here you can get 98% curcuminoids, 600mg capsules x 60 + piperine (45:1 extract) 95% for 7.3$...

I think spontaneus regeneration is possible but it is a long process in case of central hearing loss. Maybe something natural but i did not find any crucial herbs yet. Maybe stem cells will help in the future. Stimulation of synapse formation between stem cell-derived neurons and native...

Just check your hair cells by doing OAE test. One specific brain region where all cranial nerves are rooted. Spinal cord and other nerves provide most of information by it. Brainstem contain 3/4 of all neurons in brain and is very susceptible to all kind of toxins. In damaged or brang in...

Although curcumin is otoprotective, do not take curcumin after acute trauma because it blocks extraction of Atoh1 and can stop spontaneous regeneration of hearing. Extraction of Atoh1 is a main condition during self healing of the hearing that happen during the first weeks after trauma. It's...

Yes. Brain toxicity can improve for many months/years. You don't know if you have dead hair cells. The best way to know that is to do high frequency OAE test up to 20 kHz. It tests if your hair cells physically exist. The same damage to high frequency was made to one member of Tinnitus Talk who...

@Jack Straw Hi, I'm fine thanks. What about you? My tinnitus is fading day by day. I think in a year or maybe half I will be tinnitus free but this is so unusual. I did some research. I did some vestibular tests and caloric test say that I have damaged left labyrinth but I have also ear canal...

Exclusion criteria: (...) or asymmetric hearing worse than 25 dB at any frequency in either ear, (...) I think they couldn't find suitable people.

Hair cells won't be perfect. Problem can be that inner hair cells that should be oval, will be probably V-shaped, like outer hair cells. Moreover problem can be the length of inner hair cells from their roof. "In summary, mammalian inner ears contain several HC subtypes that vary in their...

1) Hair cells are placed in the inner ear 2) If a hair cell doesn't work, probably it doesn't exist

It is how FX-322 works. It's dividing progenitor cells and differentiating them to HC. "PCA Regeneration transiently causes innate progenitor cells to divide and differentiate to initiate repair, in a way similar to naturally regenerating tissues such as the skin and intestine."

I know, @katri. Stem cells, for now, don't work in most cases of hearing loss, and, adipose stem cells won't work at all. Nothing will work without viral/molecular genetic manipulation. And obviously not without any gene expression if there are dead hair cells. Maybe there is a way to induce...

"In humans, curcumin bioavailability was increased by 2,000% at 45 minutes after co-administering curcumin orally with piperine, whereas in rats, it has been found that concomitant administration of piperine 20 mg/kg with curcumin 2 g/kg increased the serum concentration of curcumin by 154% for...

Don't forget about piperine, it increases curcumin's bioavailability by 2000%.

There are some similarities. Even the thought about FX-322 acts on me as an antianxiety and anticonvulsant.

Yes. And this beautiful healthy input will lead the brainstem and cerbellum out from the states of hyperactivity and cross-activity that are causing tinnitus and hyperacusis.

FX-332.

So I think on hearing loss of -60 dB it should work excellently.

Did he say that it promotes synapse regeneration in HC that are damaged and already exists?

Prescription medicines can do demyelination for sure. Many of them are neurotoxic.

You provided a source: https://news.usc.edu/140224/new-study-shows-hope-for-hearing-loss/ "The pairing of the two delivered the breakthrough solution, the researchers said, as neurons responded to the molecule, regenerating synapses in mouse ear tissue that led to repair of the hair cells and...

To stop them for retracting during therapeutic window is quite easy it seems. https://patents.google.com/patent/WO2014014828A1/en Thread: Nicotinamide Riboside "Next, spiral ganglia neurites in NR-treated animals were examined. Noise exposure in NR-treated animals resulted in minimal neurite...

I think unless hair cells are dead, there is a possibility to repair IHC/OHC synapses. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132175/ "Although exogenous NT-3 and BDNF are equally effective in promoting SGN neurite growth and synaptogenesis in vitro, we show here that growth of SGN axons...

Hair cell regeneration after ATOH1 gene therapy in the cochlea of profoundly deaf adult guinea pigs https://www.ncbi.nlm.nih.gov/m/pubmed/25036727/ "Adenoviral vectors containing ATOH1 alone, or with neurotrophin-3 and brain derived neurotrophic factor were injected into the lower basal scala...

I think shitnitus is caused by hypersensitivity of brainstem especially cochlear nucleuses. This can be caused by wrong input from cochlea (damaged HC or synapses) or damaged VIII nerve. Neural mechanisms underlying somatic tinnitus https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2566901/...

Yes, it can. After one of my acoustic traumas from AK-47 it faded at one moment after month from the onset.

TRT is the same thing as making yourself crazy and when you finally lose your sense of reality enough to accept how it is gonna to be from now on and lose enough money on this, then you feel cured.

https://www.ncbi.nlm.nih.gov/m/pubmed/11226475/

Radix astragali injection enhances recovery from sudden deafness. https://www.ncbi.nlm.nih.gov/pubmed/22306788 Effects of compound injection of Pyrola rotundifolia L and Astragalus membranaceus Bge on experimental guinea pigs' gentamicin ototoxicity. https://www.ncbi.nlm.nih.gov/pubmed/7747908...

What are your lyme-related symptoms?

Yes, I believe there is a treatment but it is not a simple case.

I don't understand the question.

I was diagnosed by myself by kki test. Coinfections - only chlamydia pneumoniae

Screening to Identify Commonly Used Chinese Herbs That Affect ERBB2 and ESR1 (...) https://www.hindawi.com/journals/ecam/2014/965486/

Isolated animals have suddenly developed the mind and the ability to predict forthcoming environmental changes, and then they have rooted this thought through telepathy within their own species and passed it on to next generations, which forced their will to force their bodies to change in them...

Not me. If that existed, people would be adapted to hearing loss, and formed mechanisms of regeneration. Fish had jumped ashore from a sea, and her legs grew. WTF.

Thread's title is a provocation, isn't it?

If I wanted to get rid of my somatic tinnitus, would I have to use this device regularly?

Vinpocetine protects from aminoglycoside antibiotic-induced hearing loss in guinea pig in vivo https://www.sciencedirect.com/science/article/pii/S0006899300023337

Good. With a little bit of luck, everything is going to be ok.

Is disappearance of tinnitus and hearing complete silence (complete silence, even my reactive tinnitus from ultra high frequency hearing loss in right ear) normal thing? I woke up and had some hum but I slept for some hours more, wake up and it was normal. Like before. Zero. Last days are the...

World's leading fabulist. Nice theory. PS. Habituation is not returning to silence.

Not good. Are you going to stop?

I know. I will pay with a smile for this treatment. In the US health care is only private?