Autifony Therapeutics Phase II Study for AUT00063, for the Treatment of Hearing Loss and Tinnitus

[Christian78]

I don't think they will stop their research. They might fail with the trial in US as well but that doesn't mean that they will shut down their business.

When I wrote with dr Large he said that aut063 will need some twitching. This was before failure of AUT0063 .


This was not of interest for me becouse my tinnitus got worse few times in last 2 years (7) and now again last few days i got new tone.

 

[Christian78]

I think Champ was referring to Scifluor, Auris and Otonomy.

Otonomy:

We expect this study to be completed in the first half of 2016, with initiation of a Phase 2 study in tinnitus patients to begin in the second half of 2016.

 

[Nucleo]

I don't think they will stop their research. They might fail with the trial in US as well but that doesn't mean that they will shut down their business.

They might not shutdown depending on the development of their other drugs not tinnitus related. As far as I understand, it doesn't look like to me they have something else in mind for tinnitus.

 

[Silvio Sabo]

Fast forward a year from now and I doubt that Autifony Therapeutics will still exist. To my knowledge, Autifony Therapeutics does not have in-house research and so any further research will involve collaboration with an outside entity. I therefore do not think that we are likely to see"AUT00063 version 2.0" just around the corner.

Early stage research is unlikely to be undertaken (= financed) by a small pharma company. And even if Autifony Therapeutics did undertake such research, it would be a while before the fruits of such research could be harvested.

The above is, of course, just my opinion. Rather than speculating, asking Autifony Therapeutics for a statement would be the correct approach - although any response would probably be limited. I will, however, have to leave the liaison between TT and Autifony Therapeutics to someone else...

I'm not saying they won't but I think it's more likely that they will try to expand into other areas. They will trial their drug for schizophrenia for instance. But it is possible that they will abandon their research for hearing disorders or that they perhaps will disappear from the grid for a while to work on something new.

 

[amandine]

But it is possible that they will abandon their research for hearing disorders or that they perhaps will disappear from the grid for a while to work on something new.

Who cares until they come up with a drug to help us? What is the point of the conversation?

 

[Silvio Sabo]

Who cares until they come up with a drug to help us? What is the point of the conversation?

None at this point really. I would however prefer it if they continued their research inspite of their hick-up with the trial.

 

[newarrior]

Hi David,


Apologies for delayed response and Thank you for contacting us regarding your potential participation in the QUIET-1 study for tinnitus. On October 12th 2015 we announced that QUIET-1 was to be discontinued following a planned analysis that was conducted half way through the study { http://autifony.com/autifony-tinnitus-phase-IIa-trial.asp }, which indicated that AUT00063 was safe and well tolerated, but did not show evidence of efficacy on peoples tinnitus. Naturally this is a disappointment for everyone involved with the trial, but it is not unusual in early stage clinical trials of novel drugs.

Please feel free to contact us for any queries you may have.

Kind Regards,

Poonam

Poonam Chowdhary

Clinical Trial Associate

Autifony Therapeutics Limited

 

[Champ]

Who is this from? This seems like a response to an email?

 

[newarrior]

Who is this from? This seems like a response to an email?

This is from the Autifony

 

[Nick Pyzik]

Tinnitus caused by hearing loss...

I agree people with ringing in their head will have that range of hearing *masked* but no matter what you do to amp up the hearing in that range there's no fixing damaged hearing when it's not damaged. That's where the potassium drugs would come into play to hopefully fix the sounds that mask it.

I don't mean to make this post sound rude to you but I figured I'd let you know that with hearing loss, there is a huge difference between frequencies heard by hair cells and the nerve fibers that actually play a role in how well you hear that certain frequency. It's been researched and found that these nerve fibers have a larger chance of being damaged. Once these nerves are damaged, hyperacusis and tinnitus will start and overtime they will retract back into the brain thus causing the person to have to live with the sound heard 24/7. That's why people who still have normal hearing with their audiograms have tinnitus.

 

[attheedgeofscience]

This is the "final nail in the coffin" so-to-speak (in relation to the QUIET-1 study)

 

[Reinier]

Finding out why something isn't effective could be just as beneficial as finding why it does work.
Let us hope they will find why it wasn't doing what was expected.

 

[Dutchy]

I guess that explains why i'm not getting a reply from them.(trial)

 

[c0ldsun]

Trail for AUT00206 has started: http://autifony.com/autifony-news.asp
A treatment for schizophrenia. Probably it helps also for tinnitus who knows.

Edit: i just see it's from end of Nov, but i didnt know this and maybe some other find it interesting too

 

[Poyraz]

I want to ask about this study. Will it work for T caused from ETD?

 

[attheedgeofscience]

A treatment for schizophrenia. Probably it helps also for tinnitus who knows.

Perhaps toothpaste also helps. Who knows.

 

[just1morething]

Maybe AUT00063 would work for erectile dysfunction or hemmoroids as a salvage use??

 

[swc5150]

I wonder how Aut is doing with the Clarity trial? I could use some clearing up with my hearing. Ironically, early today I was just thinking about this drug, and how I read few raving reviews of it during the trial (Corrine being one). I haven't read one raving review of AM101, but it must be doing well since the trial is so advanced. I realize just reading internet posts on how a med works or doesn't really doesn't mean anything, but it just struck me as something odd. Oh well, moving on...

 

[attheedgeofscience]

We discovered antibiotics by chance and at the time it wasn't known how it worked or why it worked. The important thing was that it DID WORK.

Very true. In fact, one of the axioms of tinnitus pharmacology relates to the fact that tinnitus can be modulated by intravenous Lidocaine injections. The suppressive results are short lived, long term side effects unacceptable, but it is known to work (although no one knows exactly how...).

 

[Silvio Sabo]

Very true. In fact, one of the axioms of tinnitus pharmacology relates to the fact that tinnitus can be modulated by intravenous Lidocaine injections. The suppressive results are short lived, long term side effects unacceptable, but it is known to work (although no one knows exactly how...).

Yes. I really think that we have to focus more on creating a bulletproof way of determining whether someone has tinnitus and the severity of it in an objective way. It has to be an objective way, it can't depend on that persons subjective view. We also need to do the same in animal models. I'm understanding that this is not really done yet and seems to be one of the issues in why Autifony's drug failed. They used aspirin to induce tinnitus in the animals.

If we do that. If we find a way to be 100% sure that an individual has tinnitus in an objective way. A brain scan or whatever way we can do it. Then we can throw all the drugs known to mankind on it! Every new drug coming out for whatever else we can throw at it and actually see if it does something to tinnitus. We don't have to know how they work or anything. Just test it out and see if it does something or not. But we have to have that objective way of diagnosing tinnitus.

We can have bio- and organic chemists playing with creation of new compounds and eventually we will come across something that works.

I may sound like an immoral prick now but I really don't understand why they aren't using primates as test animals. They are less then 1,5% different from us genetically and they can be trained to respond to questions. We can actually ask a chimp if it has tinnitus or not. And if you are really sensitive and won't use chimps. Use another type of monkey that is a bit less intelligent but still a much closer relative to us than a rat!

 

[lonestar651]

Well, first of all there is a difference between "helps" and "cures". Of course, maybe in some cases, it does, and I'm glad it did for Danny Boy, but until now, research seem to consider it doesn't work any better than a placebo (and the failure of AUT63 is just about that).
He doesn't believe much in the AM101 approach either, he said the gel was very slimy, that it was particularly difficult to inject it, and that when people were asked if they wanted to continue with the study most of them refused.

What does being slimy have to do with anything you are talking out of your ass. Of course it is " slimy it is meant to be that way to stop the the product from draining.

 

[_Patrick_]

What does being slimy have to do with anything you are talking out of your ass. Of course it is " slimy it is meant to be that way to stop the the product from draining.

It has nothing to do, those are two different sentences, one of them answering a question someone asked me, which was, what do my ENT think about AM101 since he is a very well-known tinnitus specialist and participated in the AM101 study. Slimy in a way that it is too dense and too hard to inject. Those are his words, not mine, but of course, translation is never very accurate as you can see I am French.
So before you start being rude, maybe you should learn how to read more carefully and use your brain... Trust me, that helps.

 

[Mic]

Apparantly Dr. Large still has some trust in Kv3.1 modulation. AUT1 and AUT2 are on their way for clinical trails...some day...probably...

More information to be found in the abstract of another interesting research paper of mice brain:

http://m.jn.physiology.org/content/early/2016/04/04/jn.00174.2016

 

[swc5150]

I've had numerous correspondences with Dr. Large, and it was very clear he didn't intend to abandon testing and research for T just because 063 didn't show overall efficacy.

 

[grate_biff]

I've had numerous correspondences with Dr. Large, and it was very clear he didn't intend to abandon testing and research for T just because 063 didn't show overall efficacy.

Glad to hear it!

 

[Champ]

Everytime they fail the next attempt is that much better

 

[swc5150]

Has anyone else seen that a new Aut63 trial is about to begin for those with cochlear implants? I wonder if this means their Clarity trial is showing some positive results? Regardless of how it gets to market, I'd like to try it. Maybe I'd have luck like Mrs.D

 

[Mario martz]

Has anyone else seen that a new Aut63 trial is about to begin for those with cochlear implants? I wonder if this means their Clarity trial is showing some positive results? Regardless of how it gets to market, I'd like to try it. Maybe I'd have luck like Mrs.D

Whos Mrs D?

 

[swc5150]

She's one of the TT member who had success in the Aut trial for her T. There was another as well, I think MPT was the username?

 

[Beste]

She's one of the TT member who had success in the Aut trial for her T. There was another as well, I think MPT was the username?

Isn't MPT the one who got cured hinself with Trobalt?