Autifony Therapeutics Phase II Study for AUT00063, for the Treatment of Hearing Loss and Tinnitus
- Thread starter attheedgeofscience
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@Mario martz
@Beste
There were 4 people from this forum who got into the autifony trial. 2 of them reported success. Mrs. D and Tomm. It's all in this thread:
https://www.tinnitustalk.com/threads/autifony-phase-ii-trial-participants-experiences.8339/
This is why so many people on here had high hopes for autifony since 50% of "our group" had success. But that didn't reflect the overall study very well since the results were so bad they had to abort the whole thing mid trial.
And yeah, Mpt is the user who first tried Trobalt.
@Beste
There were 4 people from this forum who got into the autifony trial. 2 of them reported success. Mrs. D and Tomm. It's all in this thread:
https://www.tinnitustalk.com/threads/autifony-phase-ii-trial-participants-experiences.8339/
This is why so many people on here had high hopes for autifony since 50% of "our group" had success. But that didn't reflect the overall study very well since the results were so bad they had to abort the whole thing mid trial.
And yeah, Mpt is the user who first tried Trobalt.
Thanks for the clarification.
Aut seemed to work better for our little group than it AM101 has, yet AM seems on track to hit the market. Obviously our sample set is irrelevant in the grand scheme. Either way, if Aut hits the market for clarity, I'm going to try it
Aut seemed to work better for our little group than it AM101 has, yet AM seems on track to hit the market. Obviously our sample set is irrelevant in the grand scheme. Either way, if Aut hits the market for clarity, I'm going to try it
Do you have these?? Why would this work for them?Maybe AUT00063 would work for erectile dysfunction or hemmoroids as a salvage use??
AM102 may help? AM101 also may help chronic sufferers, it's just not being trialed on us. SF may be trialed, and so on. Autifony is sure to continue their work as well. There are great minds working on it, so some sort of relief is sure to come at some point (hopefully sooner than later). I see your T started in Feb, so you're still in that initial panic state. We've all been there, but rest assured there's a good chance you'll habituate. When my T originally got bad, I freaked out completely. Now a few years later, I'm used to it, and know what situations are just best to avoid...like extremely silent places. Just hang in there my friend
Hi guys,just letting you know received a letter from Birmingham University today telling me i had the placebo!
I presume all participants will be told,is anyone still in touch with Corrine Dwyer as this seemed to work 100 per cent for her,would like to know it wasn't just placebo effect!
I presume all participants will be told,is anyone still in touch with Corrine Dwyer as this seemed to work 100 per cent for her,would like to know it wasn't just placebo effect!
Founder
But in this thread we speak about AUT00063?
It has not failed the attempt on this drug?
Or it's a my mistake?
Yes the trial of AUT00063 was terminated (for tinnitus; the age-related hearing loss trial is still on-going).
Now it looks like people are receiving letters stating if they received placebo or the active drug in that trial back in last year.
Ah ok! Thank you.
PS. I tagged you in Microtransponder post. Serenity System probably it will be released in October (for Europe).
undecided
Member
Maybe they screwed up and gave everyone the placebo.
The guy handing out the actual drug was a t sufferer, kept all the good shit for himself.
There, mystery solved.
The guy handing out the actual drug was a t sufferer, kept all the good shit for himself.
There, mystery solved.
I sure hope Corrine and Tomm got the drug. Even If it just worked for 2 people out of the 49 (or whatever the count was exactly), I'm sure Dr. Large wants to know why and how. I thought about this back when they killed it... A 4% success rate is a statistical failure in such a trial, however if it really worked for 2 of 49, that could mean help for 4 million sufferers, if there were 100million sufferers world wide. Just dreaming out loud I suppose
monacco
Member
I think you should go for itHi guys is there any hope ,?shall I cancel my trip to thailand?
I do not think any other treatment will be more efficient than stem cell therapy.
- Jan 25, 2013
- 3,596
- Tinnitus Since
- 2008
- Cause of Tinnitus
- TMJ disorder, airplane barotrauma, noise exposure.
I sure hope Corrine and Tomm got the drug. Even If it just worked for 2 people out of the 49 (or whatever the count was exactly), I'm sure Dr. Large wants to know why and how. I thought about this back when they killed it... A 4% success rate is a statistical failure in such a trial, however if it really worked for 2 of 49, that could mean help for 4 million sufferers, if there were 100million sufferers world wide. Just dreaming out loud I suppose
Not even 49, It was only 20 something.
Wow, that's it?! Again, a 10% efficacy rate is essentially a failure, until you think of changing someone's quality of life. What if this was a stage 4 cancer drug that "only" worked 10% off the time? It would be 100% worth trying. I'm getting ahead of myself, of course, as we don't yet know if Tomm and Corrine got the drug.
The trial was stopped with data on 58 people (http://www.autifonytherapeutics.com/publications/Autifony_QUIET_interim_review_13Oct2015_FINAL_2.pdf) and the ultimately they had data on 76 people and complete data on 71 (http://www.autifony.com/publications/Autifony_QUIET_Final_data_FINAL_28April2016.pdf). I don't recall seeing information on how many received the treatment and how many received the placebo, and I would be interested if someone has a link.
If in fact there are subgroups that respond to the treatment, the small sample sizes make it very difficult or impossible to reliably identify them.
If in fact there are subgroups that respond to the treatment, the small sample sizes make it very difficult or impossible to reliably identify them.
Oops. Got that wrong then. I was thinking about how many got the actual drug. Pretty sure half of those 58 got the drug and the other half placebo.
The small sample size was why so many were surprised when it was terminated. 58 total doesn't seem like a statistically valid sample size, but they'd know better than I.
i dont understand the relation between autifony & schizophrenia...
Pfizer-backed GSK spinout advances schizophrenia drug following PhI success
Autifony Therapeutics is gearing up to test its schizophrenia candidate AUT00206 in a pair of Phase Ib studies. The advance of the asset, which comes one year after Pfizer Venture Investments and others bankrolled Autifony's expansion into schizophrenia, is underpinned by safety data from a 60-person Phase I trial.
http://www.fiercebiotech.com/biotec...nces-schizophrenia-drug-following-phi-success
Pfizer-backed GSK spinout advances schizophrenia drug following PhI success
Autifony Therapeutics is gearing up to test its schizophrenia candidate AUT00206 in a pair of Phase Ib studies. The advance of the asset, which comes one year after Pfizer Venture Investments and others bankrolled Autifony's expansion into schizophrenia, is underpinned by safety data from a 60-person Phase I trial.
http://www.fiercebiotech.com/biotec...nces-schizophrenia-drug-following-phi-success
Well, seems like AUT00063 is useless for age-related hearing loss, too.
They just posted results for the CLARITY-1 study, and it didn't do anything...
Autifony Announcement
However,
They just posted results for the CLARITY-1 study, and it didn't do anything...
Autifony Announcement
However,
Ian Mac
Member
- Jun 1, 2016
- 321
- Tinnitus Since
- 2011
- Cause of Tinnitus
- Vestibular Nueritis, loud music (dubstep)
I think that mammals are such because of how we hear, I think that changing our hearing would make us no longer mammals, if we can actually do it we will have the keys to alter our brains, and by changing our hearing and brains and turning off tinnitus and playing around we might start to resemble birds as we evolve, like the Egyptian carvings of advanced civilizations that look like man-birds, if you believe ancient aliens... I think that sounds (really vibrations) have that much power... And I think it will take that level of magnitude to cure tinnitus, diverging from our mammalian past, something that astounding will have to occur.
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