Frequency Therapeutics — Hearing Loss Regeneration

[PolishSoldier87]

Oral LY411575 at 50 mg/kg body weight for 5 days decreased the noise-induced threshold shift at 4, 8, and 16 kHz (Figure S2A). Outer hair cell numbers were increased and the new hair cells had stereociliary bundles and appeared to be innervated (Figure S2B). The treated mice suffered significant side effects (Figure S2B). A lower dose (10 mg/kg body weight) had no therapeutic benefit.


Does it mean that eating this for 5 days is regrowing hair cells and that's all?. It wouldnt be easier to get rid od side effects of this than testing news way thru the middle ear?


https://www.sciencedirect.com/science/article/pii/S0896627312009531

But this time It will be intratymphanic not oral.

 

[katri]

How can you know the exact price?

It's online. Labs order it.

 

[katri]

Oral LY411575 at 50 mg/kg body weight for 5 days decreased the noise-induced threshold shift at 4, 8, and 16 kHz (Figure S2A). Outer hair cell numbers were increased and the new hair cells had stereociliary bundles and appeared to be innervated (Figure S2B). The treated mice suffered significant side effects (Figure S2B). A lower dose (10 mg/kg body weight) had no therapeutic benefit.

https://www.sciencedirect.com/science/article/pii/S0896627312009531

But this time It will be intratymphanic not oral.

I think we are in average shape if we don't need multiple grams of it. Otherwise it'd cost part of a house. Some places list 100 mg as $900+ so we'll see

 

[grate_biff]

Oral LY411575 at 50 mg/kg body weight for 5 days decreased the noise-induced threshold shift at 4, 8, and 16 kHz (Figure S2A). Outer hair cell numbers were increased and the new hair cells had stereociliary bundles and appeared to be innervated (Figure S2B). The treated mice suffered significant side effects (Figure S2B). A lower dose (10 mg/kg body weight) had no therapeutic benefit.


Does it mean that eating this for 5 days is regrowing hair cells and that's all?. It wouldnt be easier to get rid od side effects of this than testing news way thru the middle ear?


https://www.sciencedirect.com/science/article/pii/S0896627312009531

But this time It will be intratymphanic not oral.

That must be the most interesting article, that I didn´t understand, I´ve read in my life!

What I thought I gathered was that hair cells at the base, i.e. high frequencies are harder to regenerate, both IH and OH???? Is this true?

 

[dan26]

1: if you have cochlear implants you are disqualified from this treatment

2: if you have severe, profound hearing this treatment may not work as well on you

3: if you have mild hearing loss insurance will not cover this, especially if you have a mental illness to go with it

Modearate hearing loss is the Goldelocks zone

oh and should I mention the outdated tonal audiogram will be the final judgement for this test.

I have a CI so I'm out... and on and on... It goes.

 

[PolishSoldier87]

High frequencies are easier to regenerate because they are placed in the beginning of the cochlear snail.

 

[Contrast]

High frequencies are easier to regenerate because they are placed in the beginning of the cochlear snail.

What if the medicine travels down the cochlea too fast and only regenerates the lower frequencies after the effect of gravity?

 

[Flamingo1]

You're saying this only works for mild and moderate? Im moderate but this totally upsets me!

Always consider the source. (This is a general rule, not an attack!) Before tearing your hair out or jumping off a bridge, ask what the basis is for that person's assertions. I don't think anybody knows with 100% certainty what will work on who until the trials are done. We are all in a state of conjecture.

 

[katri]

What if the medicine travels down the cochlea too fast and only regenerates the lower frequencies after the effect of gravity?

I think it's possible but I also think we shouldn't assume what they haven't really talked about. If they have had positive results elsewhere then it looks good for us too. We'll see after this.

 

[JohnAdams]

You're saying this only works for mild and moderate? Im moderate but this totally upsets me! I wish everyone had the cure, fuck this, everyone is worthy of a good research in order to find a cure to help people! This makes me mad, this is pure torture. This is hell. I really wish they continue doing their research in order to find a cure for all of us.

This isn't about curing tinnitus, its about hearing loss, tinnitus is just going to be the secondary issue.

 

[JohnAdams]

What if the medicine travels down the cochlea too fast and only regenerates the lower frequencies after the effect of gravity?

You'd have to do a flip. Plus it's going to be in some gel.

 

[Felix Dujardin]

What if the medicine travels down the cochlea too fast and only regenerates the lower frequencies after the effect of gravity?

Enjoy that bass heavy music then!

 

[Striveon]

Always consider the source. (This is a general rule, not an attack!) Before tearing your hair out or jumping off a bridge, ask what the basis is for that person's assertions. I don't think anybody knows with 100% certainty what will work on who until the trials are done. We are all in a state of conjecture.

That's what's killing me! Not knowing exactly who it'll help! I want to know for sure it'll help me and I'll be okay, not okay but at least with a hope :/ and I really hope it helps others as well! We've all been through enough hell and we deserve our freedom. I hope there's a cure for all of us :/

 

[Striveon]

This isn't about curing tinnitus, its about hearing loss, tinnitus is just going to be the secondary issue.

I see :/ I really hope it cures tinnitus though, that's the hardest part to deal with...

 

[PolishSoldier87]

Oral LY411575 at 50 mg/kg body weight for 5 days decreased the noise-induced threshold shift at 4, 8, and 16 kHz (Figure S2A). Outer hair cell numbers were increased and the new hair cells had stereociliary bundles and appeared to be innervated (Figure S2B). The treated mice suffered significant side effects (Figure S2B). A lower dose (10 mg/kg body weight) had no therapeutic benefit.


https://www.sciencedirect.com/science/article/pii/S0896627312009531

This article is wrong.

"Treatment with LY411575 by injection intraperitoneally at 50 mg/kg daily for 5 days
increased the responsiveness of the ear at low frequency after 2-4 months. Significant
improvements in threshold of the ABR were found between 1 and 3 months at 4, 8 and 16 kHz."

 

[katri]

This article is wrong.

"Treatment with LY411575 by injection intraperitoneally at 50 mg/kg daily for 5 days
increased the responsiveness of the ear at low frequency after 2-4 months. Significant
improvements in threshold of the ABR were found between 1 and 3 months at 4, 8 and 16 kHz."

That's good, but it says the article came out in 2013. Do you have anything else? Frequency has claimed to be able to produce a larger amount of cells so there's a possibility that there is a larger recovery range.

Also ly411575 is used to make progenitor cells turn into hair cells. Another drug must activate progenitor cells to divide at a higher rate.

 

[JohnAdams]

I see :/ I really hope it cures tinnitus though, that's the hardest part to deal with...

Super ultra mega agree.

 

[Spiral]

How many grams of LY411575 will be needed? 25 mg is $189.

Where are you looking??

 

[Spiral]

Oral LY411575 at 50 mg/kg body weight for 5 days decreased the noise-induced threshold shift at 4, 8, and 16 kHz (Figure S2A). Outer hair cell numbers were increased and the new hair cells had stereociliary bundles and appeared to be innervated (Figure S2B). The treated mice suffered significant side effects (Figure S2B). A lower dose (10 mg/kg body weight) had no therapeutic benefit.


Does it mean that eating this for 5 days is regrowing hair cells and that's all?. It wouldnt be easier to get rid od side effects of this than testing news way thru the middle ear?


https://www.sciencedirect.com/science/article/pii/S0896627312009531

But this time It will be intratymphanic not oral.

So you're telling me that you'd need to take 50 mgs per kg?? Let's do some simple math...

180 lbs = 81.647 kgs
81.647 kgs x 50 mgs =
4,082.35 mgs per dose
$812 per 50 mgs
81.647 x $812 =
$66,297.37 (cent rounded up) single dose
$66,297.37 x 5 days =
$331,486.85

Yeah, maybe when I win the fuckin' lottery. lol

 

[Coleoptere]

Audion uses LY411575 in their trials by injections. Taking this orally daily means that you need for example for a 80 kg person: 50mg x (80 / 10) = 4 gram daily. So not only expensive but also tricky as it seems to have side effects.

But let's stay ontopic (FX).

 

[streeter1985]

Also if it doesn't work for everyone (like me for example) I am very thankful to live in a time where I can at least hope for cure. If it works it will be the first real treatment for hearing loss since mankind exists. Of course I hope for tinnitus too.

This is the first step! We need positive results to go on with research and treatment options. First approach can't always be a perfect spot landing but it shows the way and the possibilities.

Think about millions of people who had no chance at all and only a few hundred years ago thought it was Satan screaming in their ears like Luther described it. No hearing aids, no cochlear implants, no idea what's going on, pure anxiety. We are not that far away from that time! Maybe his tinnitus was even a motivation to create a complete religion - that is strength!

In a time where you think all your hope and luck is gone the release of a treatment (also if it is not 100% perfect) to cure hearing loss is still a bright day.

 

[Flamingo1]

That's what's killing me! Not knowing exactly who it'll help! I want to know for sure it'll help me and I'll be okay, not okay but at least with a hope :/ and I really hope it helps others as well!

The prospect of a cure is what has calmed me down ever since I was diagnosed with tinnitus. I have FAITH that hearing regeneration will become a reality in my lifetime and will alleviate tinnitus.

In the meantime, I do whatever I can to protect my ears.

 

[Striveon]

The prospect of a cure is what has calmed me down ever since I was diagnosed with tinnitus. I have FAITH that hearing regeneration will become a reality in my lifetime and will alleviate tinnitus.

In the meantime, I do whatever I can to protect my ears.

I agree, faith that a cure is on its way is the best motivation we have but the fear of looking into the future and seeing daily tinnitus is haunting me. But you're right, keep looking into that there will be a cure and protecting ears from further damage is the KEY

 

[JohnAdams]

So you're telling me that you'd need to take 50 mgs per kg?? Let's do some simple math...

180 lbs = 81.647 kgs
81.647 kgs x 50 mgs =
4,082.35 mgs per dose
$812 per 50 mgs
81.647 x $812 =
$66,297.37 (cent rounded up) single dose
$66,297.37 x 5 days =
$331,486.85

Yeah, maybe when I win the fuckin' lottery. lol

Yo yo yo!!!!!!
The 50mg/kg was the oral dose the mice were fed but they suffered horrible side effects. Do not buy this stuff and take it orally, you will more than likely get cancer and die!

This stuff has to be injected into the middle ear by a trained specialist. Besides it was 50mg/kg for 5 days. The cost of that is like hundreds of thousands of dollars.

 

[d'Wooluf]

https://www.businesswire.com/news/h...utics-Completes-Enrollment-Single-Dose-Safety

 

[JohnAdams]

https://www.businesswire.com/news/h...utics-Completes-Enrollment-Single-Dose-Safety

Nice! Now we just need to hear from @Deathtotinni. Last I heard he was on his way to SAT.

I'm guessing he had to sign an NDA.

 

[Gorbeh3]

https://www.businesswire.com/news/h...utics-Completes-Enrollment-Single-Dose-Safety

Two things

"The safety trial is a randomized, double-blind, placebo-controlled, single-dose, multi-center study of FX-322, which was administered in patients with stable sensorineural hearing loss and is being conducted at several leading otolaryngology clinics in the United States."

This is interesting, I have been following this pretty closely and I was under the impression that San Antonio was the only place where this was being done

"The advancement of FX-322 from our first study in cochlear implant patients into patient volunteers with stable sensorineural hearing loss should enable us to open our future studies in the office-based setting," said Carl LeBel, Ph.D., Chief Development Officer of Frequency. "If successful, the current study will position us to advance to our Phase 2a program where we'll be looking to identify and characterize a hearing restoration signal and proof of biological concept in sensorineural hearing loss."

Does this mean that in the next phase they could administer the treatment in several different locations including their own offices in New England? If so this is huge for people like me who don't live anywhere near Texas.

 

[Manny]

https://www.businesswire.com/news/h...utics-Completes-Enrollment-Single-Dose-Safety

"...If successful, the current study will position us to advance to our Phase 2a program where we'll be looking to identify and characterize a hearing restoration signal and proof of biological concept in sensorineural hearing loss." [said Carl LeBel, Ph.D., Chief Development Officer of Frequency.]

I'm guessing that would be to further specify which hearing loss subtypes may benefit, and to allow wiggle room in case of practical cure failure in trial patients, but still "2a" and not 2/3 or 3? ://
Oh well, I guess that's the way it works. Not sure why they can't do the above in this trial though.

 

[dmorg]

"...If successful, the current study will position us to advance to our Phase 2a program where we'll be looking to identify and characterize a hearing restoration signal and proof of biological concept in sensorineural hearing loss." [said Carl LeBel, Ph.D., Chief Development Officer of Frequency.]

I'm guessing that would be to further specify which hearing loss subtypes may benefit, and to allow wiggle room in case of practical cure failure in trial patients, but still "2a" and not 2/3 or 3? ://
Oh well, I guess that's the way it works. Not sure why they can't do the above in this trial though.

That's what I'm hoping for. I'm assuming the group they are testing now in the trial are those they believe would most likely benefit. If it is successful they broaden the study a wider range of people.

 

[rid0871]

See, they're just stringing us along.

Was there even any improvement from phase 1?

Again it's all about money.

Just a con job to string it along for more what little funding they do get.

If they had anything that worked, people would be throwing money at them.

Yes I'm very mad and tired of living this HELL. If the CDC was involved things would move faster.

All these years and not one dam thing to help us.

Hell there are even meds for people with HIV and that was because of the CDC.

I'm sorry for being so upset. I'm just venting... I begged them to let me in the trial but they said NO. I'm so tired of the lies and games from these people. It's nothing but wait, wait, wait.

WAIT for what?

You have not shown anything so far.

I'm sorry for being so upset, my brain is screaming so DAMN LOUD...

Rick