Frequency Therapeutics — Hearing Loss Regeneration
- Thread starter RB2014
- Start date
Member
The new "right to try" laws should technically allow us to get this treatment right now, so long as being driven to suicide would classify tinnitus as a fatal disease and frequencytx was willing to sell it. I emailed them and asked about that and there has been no response.
We need a White House petition. I'm working with an advocate for military veterans to get it promoted when I create it.
We need to coordinate wisely because it needs 100,000 signatures in 30 days of creation. We would all have to work hard to achieve this.
This does show that they are very methodical and serious so I do like that.
Do you think they are making it themselves to be more cost efficient? There's always that possibility.
Whenever you buy something that is manufactured, you have to take into account all the machinery they've used etc.
What if Frequency Therapeutics bought the machinery and the tools to make an abundance?
I seriously doubt they are just buying and mixing shit with millions of dollars.
Whenever you buy something that is manufactured, you have to take into account all the machinery they've used etc.
What if Frequency Therapeutics bought the machinery and the tools to make an abundance?
I seriously doubt they are just buying and mixing shit with millions of dollars.
From what I've read it's not really that expensive. And how much do they really need /patient? What's the volume of a cochlea?
@Contrast
https://www.sigmaaldrich.com/catalog/product/sigma/sml0506?lang=en®ion=US
25mg for $387
1 gram / 25mg is 1/.025 = 40
40×$387 = $15,480. Yeah whoopsie.
https://www.sigmaaldrich.com/catalog/product/sigma/sml0506?lang=en®ion=US
25mg for $387
1 gram / 25mg is 1/.025 = 40
40×$387 = $15,480. Yeah whoopsie.
"Patients received either an injection of FX-322 or a placebo in one ear with an initial follow up visit after two weeks and will continue to be monitored for the following three months"
.... Does it means that it is more than 2 weeks that they all have been injected?
.... Does it means that it is more than 2 weeks that they all have been injected?
Last edited:
- Mar 22, 2018
- 90
- Tinnitus Since
- 08/2017
- Cause of Tinnitus
- Hearing loss (stress + virus activation)
They inject the drug into the middle ear so you need the middle ear volume. It's 1cm3 so around 1ml. It travels from the middle ear into the cochlea. If this works the same like an intratympanic cortisone injection, the middle ear will be filled nearly to the maximum and you are not allowed to talk or do anything else that could open your eustachian tube, otherwise the drug will be in your stomach. (talk, swallow, yawn, ...) After some time you can open the tube again of course...but this happens automatically anway.
What I don't understand right now is why you can't take it orally if it can so easily reach your stomach? Maybe they modified a lot or I misunderstood the workflow.
A single injection into middle ear of
FX-322L (0.05mL)
A single injection PlaceboL (0.05mL)
A single injection FX-322H (0.2mL)
A single injection PlaceboH (0.2mL)
The drug was assigned by chance, like flip of a coin.
-----
@Deathtotinni was supposed to do the screening and get the injection, I haven't heard anything from him since then. I was going to send him some help.
The study will last 3 to 4 months, so we might get the results by December or January.
Unwanted side effects. very scary.They inject the drug into the middle ear so you need the middle ear volume. It's 1cm3 so around 1ml. It travels from the middle ear into the cochlea. If this works the same like an intratympanic cortisone injection, the middle ear will be filled nearly to the maximum and you are not allowed to talk or do anything else that could open your eustachian tube, otherwise the drug will be in your stomach. (talk, swallow, yawn, ...) After some time you can open the tube again of course...but this happens automatically anway.
What I don't understand right now is why you can't take it orally if it can so easily reach your stomach? Maybe they modified a lot or I misunderstood the workflow.
- May 7, 2015
- 1,052
- Tinnitus Since
- 29.09/2014
- Cause of Tinnitus
- Acoustic trauma using headphones
Following Frequency´s work and this thread really is a thriller.
In all my agony of tinnitus and hyperacusis, following this thread the last couple of years is the only way I still have a concept of time passing. Every day the same... All I´m doing, is waiting for this to succeed, that's all the purpose I still have in life.
Sad? Probably, yes! But it won't be after my ears are fixed. Then I´ll live like nobody has ever lived
Go Frequency Therapeutics!
In all my agony of tinnitus and hyperacusis, following this thread the last couple of years is the only way I still have a concept of time passing. Every day the same... All I´m doing, is waiting for this to succeed, that's all the purpose I still have in life.
Sad? Probably, yes! But it won't be after my ears are fixed. Then I´ll live like nobody has ever lived
Go Frequency Therapeutics!
It's in slow release gel, so do you think it has some sticky properties or something? If it passed the first safety test, I wouldn't worry about it. As long as the surgery is done correctly.They inject the drug into the middle ear so you need the middle ear volume. It's 1cm3 so around 1ml. It travels from the middle ear into the cochlea. If this works the same like an intratympanic cortisone injection, the middle ear will be filled nearly to the maximum and you are not allowed to talk or do anything else that could open your eustachian tube, otherwise the drug will be in your stomach. (talk, swallow, yawn, ...) After some time you can open the tube again of course...but this happens automatically anway.
What I don't understand right now is why you can't take it orally if it can so easily reach your stomach? Maybe they modified a lot or I misunderstood the workflow.
I am confused by their timeline. I thought they were already in phase 2 but actually no, they are just going to start phase 2 in 2019 and how many sub-phases are there going to be for the phase 2 as they speak of phase 2a?
Hopefully the final phase 3 will be quicker and the FDA approval process won't be too long.
Hopefully the final phase 3 will be quicker and the FDA approval process won't be too long.
Street Novelist
Member
- Apr 2, 2018
- 293
- Tinnitus Since
- February 2018
- Cause of Tinnitus
- Listening to loud music through headphones
I talked to the guy administering the trial in San Antonio.
He said the results will be posted on Frequency's website in December, probably around Christmas.
He said if it is a success, they will begin the next phase early next year; all high doses in clinics spread across the USA, not just San Antonio.
He said the results will be posted on Frequency's website in December, probably around Christmas.
He said if it is a success, they will begin the next phase early next year; all high doses in clinics spread across the USA, not just San Antonio.
I think it's going by fairly quickly. They produced good results and announced them last year before deciding to give us another trial less than a year after. If it continues at this rate, including their approach to strengthen the signals, we could have something in 2-3 years.
- Mar 22, 2018
- 90
- Tinnitus Since
- 08/2017
- Cause of Tinnitus
- Hearing loss (stress + virus activation)
I think it will stick everywhere around the middle ear and also at the part of the cochlea that reaches that area especially the oval window and after a while it will go into the fluid of the cochlea. The ratio between the sticky component and the active ingredient will be important - so I think they try to measure the highest dose and still have a sticky fluid that stays in the area as long as needed to go into the cochlea.
Thanks! That's a good news to begin the weekend!
"Hypothetical scenario"
If damaged auditory nerve fibers cause painful hyperacusis, and regenerating hair cells ends up giving patients cases of this awful condition, there will never a be a cure.
This worries me sick.
If damaged auditory nerve fibers cause painful hyperacusis, and regenerating hair cells ends up giving patients cases of this awful condition, there will never a be a cure.
This worries me sick.
Nerves can heal. Hyperacusis, as far as, I know isn't always due to nerve damage. Dr. Susan Shore talks about this in a lecture that can be found here on the forums and on YouTube. There are haircells that are for sound of certain frequencies and then there are haircells that are for sound amplification. And when the amplifying cells get damaged people get Hyperacusis. I might be off on the details here since it was a long time I saw the lecture but this is what I recall from it.
Yes, the static noise of tinnitus and hyperacusis come from loss of outer hearing cells which focus more on amplification, while the pure tones of tinnitus are from the loss of inner hearing cells which focus on frequency/pitch like that of a piano.
That may explain why for a lot of us, we can still hear the tinnitus tone and match it.
I just saw that Frequency Therapeutics updated their clinical.gov description of FX-322. It happened a couple of days ago but does anyone know what they updated? I might've missed that part of discussion.
- May 7, 2015
- 1,052
- Tinnitus Since
- 29.09/2014
- Cause of Tinnitus
- Acoustic trauma using headphones
Just that they are done with their enrollment for phase l/ll.
24 participants.
Somebody probably got their injection already!
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