Frequency Therapeutics — Hearing Loss Regeneration

[Pero1234]

I am guessing the procedure will be expensive, but similar procedures are already conducted. I underwent a series of intratympanic steroid injections and they were considered a surgical procedure for billing purposes. I think it was around $3,000 per injection procedure. There was some complexity given the level of care taken to not damage the ear drum. And since the steroid injections are given as a series over several weeks, the specialist also aimed for the same injection location every time.

Another point, due to the ear drum puncture, increased tinnitus was a potential side effect. The risk was worth it for me given my hearing loss.

So I guess I am advising that if this drug makes it to patient markets, based on the injection procedure make sure you see a skilled ear surgeon and not your everyday ENT.

I would guess if Frequency Therapeutics is successful, the market for this is big enough to start investigating different methods to apply this cure.

I read something about a method not involving needles in a different thread. It was a delivery method just sitting there, waiting for a cure to deliver

Here it is:
https://www.tinnitustalk.com/thread...ry-system-for-the-inner-and-middle-ear.31653/

Also, take away the risk of (increased) tinnitus because of a punctured eardrum and this cure will become a lot more attractive for people with (only) high frequency hearing loss.

 

[Ed209]

I'm not going to say anything, in December we will talk again.

It will be early next year at some point when they will give an update.

 

[Tinker Bell]

I would guess if Frequency Therapeutics is successful, the market for this is big enough to start investigating different methods to apply this cure.

I read something about a method not involving needles in a different thread. It was a delivery method just sitting there, waiting for a cure to deliver

Here it is:
https://www.tinnitustalk.com/thread...ry-system-for-the-inner-and-middle-ear.31653/

Also, take away the risk of (increased) tinnitus because of a punctured eardrum and this cure will become a lot more attractive for people with (only) high frequency hearing loss.

Eventually they could transition to other delivery methods, but so could steroid injections. It seems this possible delivery method is still in early testing phases, too.

Even with the risk of eardrum damage, injections for severe hearing loss are already appealing. The procedure was simple. I wouldn't hesitate to do it again.

 

[Benoves]

Interesting. I do not know if it will have something to do with that, but sometimes I accidentally expose myself to moderately loud sounds (and I worry) and find that after that moderate exposure my tinnitus decreases. I do not know if it's because the brain "receives sound" or because my mind filters it a little bit. Mysteries of tinnitus.

I experience the same for sure. Yesterday I was for business in a loud house. I'm worried but my tinnitus was MUCH lower that evening. This summer I went to a loud party and drink a lot of beer, the day after was the quietest in 14 months of tinnitus.

 

[JohnAdams]

@Tinker Bell
So why do you think Frequency Therapeutics would want to misrepresent the safety or efficacy of FX-322?

 

[Tinker Bell]

@Tinker Bell
So why do you think Frequency Therapeutics would want to misrepresent the safety or efficacy of FX-322?

I do not think that.

That would put Frequency Therapeutics at a huge risk for litigation, which is why they will want accurate safety and efficiency data from their clinical trials.

I trust that they understand the importance of solid data. They are clearly smart enough to realize it is better to fully understand the potential side effects and the long term impact versus rushing to market with a product tested on less than 20 people. They stand to benefit the most — not the FDA — from fully testing their drug.

And I believe that Frequency will request their drug to be fast tracked if they want it to be.

Anyone eager to access the drug should keep an eye out for future clinical trials. I have several family members who participated in clinical trials for cancer drugs. It's a good way to benefit medical research and potentially help yourself.

 

[JohnAdams]

That would put Frequency Therapeutics at a huge risk for litigation, which is why they will want accurate safety and efficiency data from their clinical trials.

Right, and they will have that, but the FDA reporting system is there to verify their data and make sure they aren't liars or incompetent.

Seeing as how the FDA approved drugs that gave many of us here tinnitus, I'd say their the incompetent ones.

Frequency Therapeutics has unlocked regenerating human tissues, they are geniuses, not incompetent. The FDA has no legitimate role here.

In the case of Frequency Therapeutics, the FDA are like arsonists trying to supervise firefighters that are putting out the fires they they themselves started.

 

[JohnAdams]

If you have severe hearing loss, wouldn't it make more sense to be put under, and have them drill into your cochlea and inject the cochlea directly?

 

[Paulmanlike]

Seeing as how the FDA approved drugs that gave many of us here tinnitus"

@JohnAdams you don't half ramble on. My mate got his tinnitus from drugs used to treat his cancer. It was a life with tinnitus versus possibly being dead. You are so negative at times, very little drugs are completely risk free.

Besides, a good doctor will outweigh the risk to potential reward of being on medications. A good one - not ones that prescribe them like sweets to ignorant innocent patients.

 

[JohnAdams]

Besides, a good doctor will outweigh the risk to potential reward of being on medications. A good one - not ones that prescribe them like sweets to ignorant innocent patients.

Once again, I am getting criticism for speaking out against the FDA.

What I'm trying to do here is advocate for us to potentially get treatments faster by using rational arguments against slow beurocracy. I'm really just blown away by all you that worship the state and have no ability to think for yourselves. All you're doing is being an impediment to being treated sooner.

 

[GregCA]

If you have severe hearing loss, wouldn't it make more sense to be put under, and have them drill into your cochlea and inject the cochlea directly?

Er, no... a hole in the cochlea is not something you want to carry around. Ask me how I know.

 

[85dB T]

Besides, a good doctor will outweigh the risk to potential reward of being on medications. A good one - not ones that prescribe them like sweets to ignorant innocent patients.

The type of doctor you mention is becoming a thing of the past based on my life experience.

The thing in common I've noticed among young doctors is a photographic memory. Having common sense and being a good technician? Universities don't test for this.

Hospitals, insurance and big pharma are now shaping healthcare. Doctors are becoming employees following corporate policy and protocol.

 

[Tinker Bell]

If you have severe hearing loss, wouldn't it make more sense to be put under, and have them drill into your cochlea and inject the cochlea directly?

No. A hole in your cochlea is not a good idea. Not to mention the proximity of other nerves. A friend has facial paralysis due to a failed ear surgery.

Studies on intratympanic injections found the steroid does travel through the cochlea. I am sure Frequency Therapeutics' drug will do the same.

 

[Don Tinny]

The type of doctor you mention is becoming a thing of the past based on my life experience.

The thing in common I've noticed among young doctors is a photographic memory. Having common sense and being a good technician? Universities don't test for this.

Hospitals, insurance and big pharma are now shaping healthcare. Doctors are becoming employees following corporate policy and protocol.

It's terrible. And they do not accept any information that comes from the Internet.

And you should be happy to live in the USA or the UK. If I search the Internet in Spanish for "FX-322 hearing loss" there is only one website that is very poorly translated. No other search result. And most doctors do not speak English, so...

 

[85dB T]

Frequency Therapeutics has unlocked regenerating human tissues, they are geniuses, not incompetent. The FDA has no legitimate role here.

There is so much truth in this statement.^^^

 

[JohnAdams]

I understand the world is crazy and confusing, but please trust me. It's hard for many of you to trust my radical call for activism. I have been tragically misunderstood many times. It's not that radical. I'm an American and most Americans do scrutinize our government harshly. I've met a significant amount of people that even think our government was behind the 9/11 attacks to start the middle east wars. People over here are majorly suspicious of the American Government.

Frequency Therapeutics is not Daniel Toh. They are amazing geniuses that don't need an honesty nanny to verify their work. They are trying to help people and change the course of medical technology and human history. Fuck the United States government. Trust me, I probably now more about our history and the big picture than every person on this site. Including all Americans. I probably know more about British/world history than most Brits on this site too. I also happen to know a lot about medical science from my education. One of my favorite dudes in history is Francis Drake because he was an epic military troll and Elizabeth I was the greatest leader in all of British history. Far beyond Churchill. I also think British rock and roll is far superior to American. Pink Floyd, Led Zeppelin, Gary Numan. And sorry to admit it The Beatles were revolutionary. Your culture at a time was beyond all else.

End of story. The FDA should have no oversight of Frequency Therapeutics. Argue with that, you are 1 pawn trying to defeat 5 queens on the chessboard.

 

[JohnAdams]

No. A hole in your cochlea is not a good idea. Not to mention the proximity of other nerves. A friend has facial paralysis due to a failed ear surgery.

Studies on intratympanic injections found the steroid does travel through the cochlea. I am sure Frequency Therapeutics' drug will do the same.

I really hope you are right.

 

[JohnAdams]

No. A hole

You don't have to call me names.

 

[Tinker Bell]

You don't have to call me names.

I see what you did there, but there's no comma!

 

[Tinker Bell]

I really hope you are right.

I thought their presentation mentioned that they have found the drug makes it to the cochlea. Or maybe I'm confusing things and that's what they hope to determine/prove with this trial.

 

[GregCA]

I see what you did there, but there's no comma!
View attachment 24228

Nice. I bought this book a few years ago: "Eats (,) shoots (,) and leaves" - https://epdf.tips/eats-shoots-amp-l...tionc513ddbdecaf80c0d7c6fcb8a0eacf8a3057.html

 

[JohnAdams]

I thought their presentation mentioned that they have found the drug makes it to the cochlea. Or maybe I'm confusing things and that's what they hope to determine/prove with this trial.

Yeah but how far is my question.

 

[Tinker Bell]

Nice. I bought this book a few years ago: "Eats (,) shoots (,) and leaves" - https://epdf.tips/eats-shoots-amp-l...tionc513ddbdecaf80c0d7c6fcb8a0eacf8a3057.html

I love quirky punctuation and grammar books!

Yeah but how far is my question.

Studies on steroid intratympanic injections found it traveled fully through the cochlea but with lesser amounts reaching the inner coil.

Also, with steroid injections improvement was more likely with higher frequencies possibly due to their cochlear placement.

I've posted this before, but I do not think I did so on this thread. I think it helps illustrate why — if Frequency's drug works — higher frequencies should improve.

 

[JohnAdams]

I love quirky punctuation and grammar books!

Studies on steroid intratympanic injections found it traveled fully through the cochlea but with lesser amounts reaching the inner coil.

Also, with steroid injections improvement was more likely with higher frequencies possibly due to their cochlear placement.

I've posted this before, but I do not think I did so on this thread. I think it helps illustrate why — if Frequency's drug works — higher frequencies should improve.View attachment 24235

Yes and the rodents seemed to respond better to higher frequencies. My concern is for people that have low frequency tinnitus.

 

[Striveon]

Yes and the rodents seemed to respond better to higher frequencies. My concern is for people that have low frequency tinnitus.

I never understood what high and low frequency tinnitus meant... so would FX-322 only work for certain frequencies in tinnitus? I though it would eliminate all of them...?

 

[JohnAdams]

I wonder if they have formulated a gel for FX-322 that stays viscous longer to stay in the high frequencies for those with higher frequency hearing loss and others that are medium viscosity to go onto the medium parts of the ear and another that is the least viscous to flow right into the apex for low frequency hearing loss.

 

[katri]

I thought Frequency Therapeutics came up with a new method to inject FX-322? He said it in a video once. That's the reason they've been able to produce so many cells.

 

[JohnAdams]

I never understood what high and low frequency tinnitus meant... so would FX-322 only work for certain frequencies in tinnitus? I though it would eliminate all of them...?

Low is bass sounds, high is like birds tweeting, @Tinker Bell posted a diagram of the cochlea. The opening is the high frequencies and the inner part of the spiral is low frequencies.

Imagine hitting all the keys of a piano from right to left, that goes from high to low. The FX-322 would seep into the cochlea and travel from high to low just like the piano example. Does that help?

 

[streeter1985]

I thought Frequency Therapeutics came up with a new method to inject FX-322? He said it in a video once. That's the reason they've been able to produce so many cells.

I only read that they use the already well established and known injection through the eardrum like the intratympanic steroid treatment for acute hearing loss. I don't know maybe the treatment might be "new" in some areas but what I heard from ENTs in middle EU it is very common in the US. In the EU I think most hospitals offer it. So ENTs who do this don't have to learn much about the treatment and it is done within seconds.

I think they can produce more cells based on the drug cocktail they created, that is duplicating existing supporting cells, that's the reason why they get more hair cells instead of using only the existing supporting cells.

I never understood what high and low frequency tinnitus meant... so would FX-322 only work for certain frequencies in tinnitus? I though it would eliminate all of them...?

The drug is a treatment for hearing loss not for tinnitus. It's just a theory that when you restore hearing, that it might mask or help to decrease tinnitus as well. You won't get an answer on tinnitus questions until they publish results with such information on it.

I don't know why many here talk about a "cure". It restores something that's what they say... people with hearing loss benefit from it. First of all it is a treatment for hearing loss patient to restore at least some of their hearing in not too strong damaged frequencies/areas, but you need much more than supporting cells. Based on other treatments that focus on supporting cells your cochlea can have different conditions (severe/profound) where the regeneration may not work. Flat epithelium or only Pillar and Deiter cells. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3637947/

I only talk about a cure in connection with hearing loss, when they can restore the initial state of the cochlea after a trauma, but this research is hopefully a perfect step in the direction to completely cure hearing loss soon and of course I hope it helps tinnitus sufferers.

I also don't blame any hearing aid company. We have hearing aids since... ear trumpets since 17th century? They helped millions of people over time so I am fair enough and say technology and science was not ready to give us anything else until now and whatever this might be, it is not on the market yet.

 

[reeseth]

Yes and the rodents seemed to respond better to higher frequencies. My concern is for people that have low frequency tinnitus.

Yeah, and people with Meniere's often have problems with hearing in low frequencies. Well initially, then it affects the whole spectra. Like myself. Time will tell.