"They" told me they improved in three frequency bands.@Gb3, did she also show improvements in the extended frequency tests where they test for sounds and not words?
"They" told me they improved in three frequency bands.@Gb3, did she also show improvements in the extended frequency tests where they test for sounds and not words?
This sucks. I hope severe hearing loss participants show improvements. If severe hearing loss participants showed a bit of improvements, what would some of those little improvements be for them?As in nothing at all happens in any individual? Then yeah, I would say it doesn't work or the delivery method is just atrocious considering it works in explants.
Ok so this is not word scores, this is actual improvements in the 3 frequency bands."They" told me they improved in three frequency bands.
Me too bro, me too.I pray to God
I can only speak from my trial interview but I only needed to show audiogram stability in the standard range over the longer term and then I had one extended audiogram from a few months prior to show them, too. I didn't qualify for other reasons (which I'm not going to lay out specifics for now especially obviously), though.I'm so confused. How can someone have "stability" and lie about their screening scores to get in? Did they not include WR scores as a component of stability? Did they create a trail of lies (>=6 month session and screening)? This seems unlikely.
This is what the clinical trial inclusion criteria says
2. Established diagnosis of stable sensorineural hearing loss by standard audiometric measures for ≥ 6 months prior to the Screening visit (no changes in air conduction greater than 10 dB at a single frequency or greater than 5 dB at two contiguous frequencies from the prior audiogram to the Screening audiogram in the study ear).
Also, if the baseline scores were higher than screening, doesn't that sort of mean that there was less placebo cheating? In other words, they may have exaggerated to get in, but felt safe once in to do the baseline and rest of the tests correctly?
They also had improved word scores and can now hear birds sing and crows. We both talked to the same person. They can also tell better where sounds are coming from. They also got only two doses of FX-322. This is an older gentleman who I doubt would lie to get into a trial."They" told me they improved in three frequency bands.
I'm still shocked that the Phase 2a trial was not successful. The irony is that we thought OTO-313 would fail due to the negative anecdote from someone on Tinnitus Talk, then out of the blue Otonomy posted that they had positive results.I feel so bad for everyone. This is obviously a major disappointment for various reasons and it's a massive delay, at minimum, to those of us who are just hanging on. But it is not a death knell.
@dan, I understand your skepticism. I understand your suffering. I understand the danger in believing in hope. Believe me, every single person on this forum just got the wind knocked out of them for the foreseeable future, and it feels like absolute shit. Just please hang on, everyone.
Me too bro, me too.
Sorry, I apologize, I didn't mean it. Same boat, yes.You asked, I answered, you don't need to be a jerk; we're all in the same boat here.
I agree with your second statement, however, I believe in the PCA treatment. Science is trial and error. They aren't done.
That's the thing that makes me really angry. The thought that say the drug worked, as Phase 1 showed, but enough people gamed the trial to get in. Infuriating beyond belief because a delay even could cost lives.Honestly I heard from someone who's very involved in the trials that they thought it was a miracle that after someone was treated with an unknown amount of placebo or FX-322 they were able to understand what was being said with her back turned while before that she had had to take her mask off to talk to them.
Please share the screenshots you posted a few months back, we really need them for a morale boost @Princebeyel.They also had improved word scores and can now hear birds sing and crows. We both talked to the same person. They can also tell better where sounds are coming from. They also got only two doses of FX-322. This is an older gentleman who I doubt would lie to get into a trial.
Honestly I heard from someone who's very involved in the trials that they thought it was a miracle that after someone was treated with an unknown amount of placebo or FX-322 they were able to understand what was being said with her back turned while before that she had had to take her mask off to talk to them.
I'm at a loss, I truly am, I'm seriously debating saying to hell with it and just getting cochlear implants, man. I can't go on the way I've been struggling everyday and now there's no telling when this will come out or even be available.
If I qualified for cochlear implants, I would get them.They also had improved word scores and can now hear birds sing and crows. We both talked to the same person. They can also tell better where sounds are coming from. They also got only two doses of FX-322. This is an older gentleman who I doubt would lie to get into a trial.
Honestly I heard from someone who's very involved in the trials that they thought it was a miracle that after someone was treated with an unknown amount of placebo or FX-322 they were able to understand what was being said with her back turned while before that she had had to take her mask off to talk to them.
I'm at a loss, I truly am, I'm seriously debating saying to hell with it and just getting cochlear implants, man. I can't go on the way I've been struggling everyday and now there's no telling when this will come out or even be available.
They also had improved word scores and can now hear birds sing and crows. We both talked to the same person. They can also tell better where sounds are coming from. They also got only two doses of FX-322. This is an older gentleman who I doubt would lie to get into a trial.
Honestly I heard from someone who's very involved in the trials that they thought it was a miracle that after someone was treated with an unknown amount of placebo or FX-322 they were able to understand what was being said with her back turned while before that she had had to take her mask off to talk to them.
I'm at a loss, I truly am, I'm seriously debating saying to hell with it and just getting cochlear implants, man. I can't go on the way I've been struggling everyday and now there's no telling when this will come out or even be available.
I say this half jokingly, but they should offer Compassionate Use as a preventative measure from further gaming of future trials. If anything, doesn't this show just how far people are willing to go for some sort of relief?That's the thing that makes me really angry. The thought that say the drug worked, as Phase 1 showed, but enough people gamed the trial to get in. Infuriating beyond belief because a delay even could cost lives.
I hope not. It's not even like my life is stable in its suck. It just keeps getting worse and worse.Sooooooooooo... Are we waiting 10 more years for hearing regeneration?
I doubt it but interesting thought.I say this half jokingly, but they should offer Compassionate Use as a preventative measure from further gaming of future trials. If anything, doesn't this show just how far people are willing to go for some sort of relief?
I actually really like this solution... that's one hell of an uno reversal. If I get them on the Tinnitus Talk Podcast again I'll bring my deck.I say this half jokingly, but they should offer Compassionate Use as a preventative measure from further gaming of future trials. If anything, doesn't this show just how far people are willing to go for some sort of relief?
What year is it now? I've lost track lol.We'll have real alternatives by 2025. I'm confident.
I think it will take 20 years or more.Sooooooooooo... Are we waiting 10 more years for hearing regeneration?
I hope they can unbind the results and find out those who faked their results and those that didn't. I think Phase 2a can be salvageable if they can get rid of the fake hearing tests by the participants and see if the results look better. A long shot is that Day 210 results may look even better and may show improvements like the positive anecdote had.That's the thing that makes me really angry. The thought that say the drug worked, as Phase 1 showed, but enough people gamed the trial to get in. Infuriating beyond belief because a delay even could cost lives.
What about Susan Shore's device? Isn't that the device that has actually made @kelpiemsp get over his tinnitus?There's no hope now, we're going to die with tinnitus.
10000% it's effed if the trial got screwed due to selfish people trying to game the system.That's the thing that makes me really angry. The thought that say the drug worked, as Phase 1 showed, but enough people gamed the trial to get in. Infuriating beyond belief because a delay even could cost lives.
What is the alternative?We'll have real alternatives by 2025. I'm confident.