Inner Ear Hair Cell Regeneration — Maybe We Can Know More

[Reinier]

I just hope that mammals still have some of the mechanism in place that fish or birds have. Unlocking this, perhaps does not mean every step of building an inner ear has to be understood. (yet).
Is this not what Frequency Therapeutics wants to achieve? Start this process, that at the moment is blocked, and than let nature take over?
http://www.frequencytx.com/our-approach/frequencys-origins.php
Quote: The process is intended to activate those cells in a way that allows the body to heal itself.
But I think many of us have read these kind of articles many times

 

[Berik]

What do you guys expert with regards to long term hearing damage? Im afraid that tissue will form, whereafter this might not work for us. What's your view on this?

 

[Iliasp]

FT speaks the words "body healing" everytime they mention their therapy procedure, thus administer a drug and then the inactive healing mechanism becomes active and the body itself manages the regeneration! Nobody knows for sure till they let us know what they have figured out already, cause starting clinical trials for me means that they know a lot till now, but the public also needs too (its crucial also for the medical field crowd, apart from VCs and money gathering)

 

[Iliasp]

What do you guys expert with regards to long term hearing damage? Im afraid that tissue will form, whereafter this might not work for us. What's your view on this?

Its nothing like scar healing, its an apoptotic mechanism, imagine like a skin cell apoptosis but without the regeneration

 

[tomytl]

Hi, here a video which is well explained what Frequency TX might do

 

[jeff W]

What do you guys expert with regards to long term hearing damage? Im afraid that tissue will form, whereafter this might not work for us. What's your view on this?

https://www.tinnitustalk.com/bookmarks/3284/view-item

 

[jeff W]

ENT's are great for advice on financial investments, always try to get some advice on this before you leave the office, so at the very least you can come out with "something".

 

[dan26]

ENT's are great for advice on financial investments, always try to get some advice on this before you leave the office, so at the very least you can come out with "something".

did i miss something here? ear nose and throat doctor. he also does a lot of research regarding hearing loss and cochlear implants and all that jazz.

 

[Iliasp]

I have mentioned inner ear regeneration to six of them and nobody knew nothing, imagine i was quite careful not to be heard as a fool
I would also stick to financial advice, they seem to be doing good without doing anything (at least for the majority of us in here with tinnitus and hearing loss )

 

[Berik]

I have mentioned inner ear regeneration to six of them and nobody knew nothing, imagine i was quite careful not to be heard as a fool
I would also stick to financial advice, they seem to be doing good without doing anything (at least for the majority of us in here with tinnitus and hearing loss )

Even my audiologist knew little about it. Only thing he mentioned was "the inner ear is such a complex organism that I don't believe they would achieve regeneration in the next 30 years".
If you have a "specialist" which does not keep up with today's developments (reads little professional literature), how can you expect them to say anything useful about it?
For an ENT we are easy money; "You have tinnitus. Nothing can be done. Good luck with it. That's $300."
Bet 9 out of 10 forum members have studied into this topic more then a regular ENT.
Hearing regeneration impossible; the word says it; I'm possible.

 

[swc5150]

Agreed, beware of some "specialists"! My eye Dr told me nothing can be done about eye floaters too, completely unaware that there is a floater laser removal clinic two hours away from our town.

 

[jeff W]

Serious professionals are serious about their equipment and serious about the progress of their field, ENT's are mostly serious about making money and their indemnity protection. Don't give these dickheads sore throat drs your money if you are not satisfied with the answers to your questions.

 

[acufenero]

Agreed, beware of some "specialists"! My eye Dr told me nothing can be done about eye floaters too, completely unaware that there is a floater laser removal clinic two hours away from our town.

You got him wrong! Of course he was aware of that clinic two hours away, but it was not his, so he couldn't milk more money from you!

 

[Coleoptere]

On the serious part: this is what will complicate the roll out of a cure.

 

[NatureHiker]

Even my audiologist knew little about it. Only thing he mentioned was "the inner ear is such a complex organism that I don't believe they would achieve regeneration in the next 30 years".
If you have a "specialist" which does not keep up with today's developments (reads little professional literature), how can you expect them to say anything useful about it?
For an ENT we are easy money; "You have tinnitus. Nothing can be done. Good luck with it. That's $300."
Bet 9 out of 10 forum members have studied into this topic more then a regular ENT.
Hearing regeneration impossible; the word says it; I'm possible.

On reddit I've talked to Biology PhD Candidates researching the inner ear whom had no clue cochlear regeneration was even a thing. They had no clue companies like Frequency tx, Decibel tx, Acousia tx, Audion, etc. even existed.

It literally blew my mind that they didn't even know about any of this. Is cochlear regeneration so niche' of a topic?

 

[Berik]

On reddit I've talked to Biology PhD Candidates researching the inner ear whom had no clue cochlear regeneration was even a thing. They had no clue companies like Frequency tx, Decibel tx, Acousia tx, Audion, etc. even existed.

It literally blew my mind that they didn't even know about any of this. Is cochlear regeneration so niche' of a topic?

Perhaps its such a recent development it is not yet in their study books... And off course, there's no successful treatment out their yet.

 

[parsky]

On reddit I've talked to Biology PhD Candidates researching the inner ear whom had no clue cochlear regeneration was even a thing. They had no clue companies like Frequency tx, Decibel tx, Acousia tx, Audion, etc. even existed.

It literally blew my mind that they didn't even know about any of this. Is cochlear regeneration so niche' of a topic?

Unless they are reading published journals on a regular basis, they likely won't know.

 

[Rubenslash]

On reddit I've talked to Biology PhD Candidates researching the inner ear whom had no clue cochlear regeneration was even a thing. They had no clue companies like Frequency tx, Decibel tx, Acousia tx, Audion, etc. even existed.

It literally blew my mind that they didn't even know about any of this. Is cochlear regeneration so niche' of a topic?

My brother studies medicine and they have learned about hair cell regeneration, although very limited.

 

[RB2014]

You guys are being awful hard on these ENT's. To be fair there is nothing out now and no one knows when it will come out. All we have is lots of research going on that might lead to something. I was pretty excited about the Genvec trials and that lead nowhere. Frequency is next and hopefully that leads to something but there are no guarantees how or on who it will work. I hate to say it but they are right. My ENT said non-reversible hearing loss and tinnitus. At first I was mad and thought he was pretty heartless, but he was and still is right and he will be right for at least 5 years from now at a minimum.

 

[frankhovin]

The clue here is "as of now", or "until science discovers otherwise", isn't it? Of course, a practicing doctor will have to relate to what is actually known. If they should discuss or involve themselves in every research area or project in their field, they wouldn't have time to be practicing medicine.

Where I live we have two kinds of doctors (of the kind that treat patients): State-funded and private practitioners. The first group is covered by the health care system, and the second is not. I'm not sure if there's a difference between those groups with regards to being open and having the time to keep up with new research. All I know is that the private practitioners are those with the shortest waiting lists, and if you can afford them they're the best choice. Not due to their expertise, which is almost certainly the same, but because of the waiting time. I'm lucky enough to have insurance from my employer which lets me use the private practitioners, which saves me months of waiting time. However, the private one I went to the last time didn't have anything else to say or suggest than the state-funded ones. After doing the normal tests, he went straight to talking about audio therapy and related stuff, all targeted at dealing with it and habituating. Which is fine, of course. I'd just like to know that not all of them is unaware that there ARE actual hopes of doing more in the future. Personally, I don't care exactly what helps me, whether it be audio therapy and habituiation or some kind of healing/cure; The important thing is that it helps, and that I'm able to function normally with my family, colleagues and friends.

 

[cornelius]

On reddit I've talked to Biology PhD Candidates researching the inner ear whom had no clue cochlear regeneration was even a thing. They had no clue companies like Frequency tx, Decibel tx, Acousia tx, Audion, etc. even existed.

It literally blew my mind that they didn't even know about any of this. Is cochlear regeneration so niche' of a topic?

Many of us were asking the same question about the Bitcoin not so long ago : )

 

[jer]

I just saw this article about what is coming up. Its an interesting read, but its not the most optimistic perspective out there.

 

[Flamingo1]

I just saw this article about what is coming up. Its an interesting read, but its not the most optimistic perspective out there.

What article?

 

[jer]

Sorry, I thought I attached it. I closed it already. I'll try and find it again.

 

[spingee]

http://www.findmarketresearch.org/2...t-into-the-global-scaffold-technology-market/

 

[Berik]

https://www.genengnews.com/gen-news...g-loss-might-be-a-double-edged-sword/81255139

http://www.prweb.com/releases/2017/11/prweb14885503.htm

 

[Reinier]

Information is very general on this "Draper" device.
I understand that they are able to make the hardware even smaller with less change of radio wave interference.
Does anyone know how medication is reaching the cochlea?
I can't make this up from reading the news item.

 

[Berik]

Information is very general on this "Draper" device.
I understand that they are able to make the hardware even smaller with less change of radio wave interference.
Does anyone know how medication is reaching the cochlea?
I can't make this up from reading the news item.

This will give you some additional info...

 

[dingaling]

Interesting that "lower-order" animals such as birds and fish can regenerate their ears as hearing is crucial to their survival. Not the case with "higher order" animals such as man.

Can't see hair cell regeneration in man happening in my lifetime but clearly a hot topic at present

 

[acufenero]

Can't see hair cell regeneration in man happening in my lifetime but clearly a hot topic at present

It's already happening.