Inner Ear Hair Cell Regeneration — Maybe We Can Know More

[BobK544]

Yes this is definitely great progress and it makes a lot of sense because scientific efforts elsewhere have recently been able to turn regular skin cells into pluripotent stem cells using CRISPR and that tells me that the approach they're using in the following article is right in line with that same concept, but i like the following approach more as they're using a small molecule drug instead of snipping the DNA itself:
https://www.technologyreview.com/lists/innovators-under-35/2018/inventor/will-mclean/

 

[Flamingo1]

Imagine if Frequency and Novartis openly shared there ideas with as many scientist as possible on how to regenerate hearing and navigate the cochlea to weigh in on other opinions and have the best ideas possible. Instead of business men buying scientist to compete with each other for the exact same goal that humanity needs.

Frequency Tx researchers have published several papers on their technology and so has probably Novartis. In fact, that's why scientific journals exist, for the sharing and propagation of ideas!!

 

[Silvio Sabo]

Do clinical trials become treatments within 5-10 years, or is it just a trial and error process that takes a better part of a century? If so even waiting till 2030 makes me want to off myself.

It depends greatly on the outcome of the trial. If the trial is successful, then yes. But evidently we haven't had a successful one to date.

Patience is golden when it comes to enduring tinnitus. And if you don't already have it, you will in time...

 

[jeff W]

have a look at the opening scene and the end. Very interesting, the concept of cellular repair will now be normalized across media and the public.

 

[Flamingo1]

have a look at the opening scene and the end. Very interesting, the concept of cellular repair will now be normalized across media and the public.

Did the guy in the opening scene ever get his eyesight back??

 

[John Young]

Do clinical trials become treatments within 5-10 years, or is it just a trial and error process that takes a better part of a century? If so even waiting till 2030 makes me want to off myself.

.

When a medical breakthrough becomes a corporate secret that cannot be openly shared with other scientist theres a problem.

I agree. There should a way for sufferers to contribute financially and make the knowledge open source.

 

[jeff W]

Did the guy in the opening scene ever get his eyesight back??

Not sure, I think this footage is very new, I came across a vision restoration concept called Molyneux's problem recently, it ties in with the concept of whether hearing restoration will reverse tinnitus. I will be posting it on the other thread here now.

 

[RB2014]

.


I agree. There should a way for sufferers to contribute financially and make the knowledge open source.

There's lots of ways to do that. You can give to any of the Universities supporting hearing loss research or the BTA or the Hearing health foundation. I have given to the Stanford cure for hearing loss, but there is also USC, and others that are working on hearing loss cures. They share the information they find and make publications. The hearing loss companies will then take this information and start devising a cure.

 

[Contrast]

There's lots of ways to do that. You can give to any of the Universities supporting hearing loss research or the BTA or the Hearing health foundation. I have given to the Stanford cure for hearing loss, but there is also USC, and others that are working on hearing loss cures. They share the information they find and make publications. The hearing loss companies will then take this information and start devising a cure.

sounds like a plan.

 

[xCyborg]

>"patients are now being actively recruited for the third and final part."

Is anyone in this forum participating in Novartis' final trial?
And does anyone know if their Phase II results are published?

 

[jeff W]

>"patients are now being actively recruited for the third and final part."

Is anyone in this forum participating in Novartis' final trial?
And does anyone know if their Phase II results are published?

They won't talk.

 

[Terrel]

>"patients are now being actively recruited for the third and final part."

Is anyone in this forum participating in Novartis' final trial?
And does anyone know if their Phase II results are published?

It's in Texas right?

 

[PetitGarsTimide]

>"patients are now being actively recruited for the third and final part."

Is anyone in this forum participating in Novartis' final trial?
And does anyone know if their Phase II results are published?

According to this

We're maybe talking about one of the greatest breakthrough in this field and I feel like nobody cares, moreover they seem to have succeed in phase 2 and once again nothing about it ? Can somebody tell me why

 

[Autumnly]

Maybe they're talking about the final part of the phase 1/2 trial instead of starting phase 3? I think we would have heard it if phase 1/2 had been finished successfully..

 

[RB2014]

According to this

We're maybe talking about one of the greatest breakthrough in this field and I feel like nobody cares, moreover they seem to have succeed in phase 2 and once again nothing about it ? Can somebody tell me why

There were mixed results out of the phase 2 study. One of the participants went on to get a cochlear implant in that ear. They also use your supporting cells to create new cells which is probably not a good thing. There really hasnt been any updates on how they are progressing. We can only speculate at this point as to why they are going on to a phase 3 trial.

 

[rsmcfar]

Interesting layman's article on recent study.

https://www.scientificamerican.com/article/ba-boom-there-goes-your-hearing/

 

[Contrast]

Can someone please do a study to confirm or dis-confirm if regeneration of hearing via hair cell regrowth will reduce tinnitus or not?

 

[ee9892]

Can someone please do a study to confirm or dis-confirm if regeneration of hearing via hair cell regrowth will reduce tinnitus or not?

We dont even know if regeneration improves hearing in humans yet lol. Someone with hearing loss will have tinnitus as well in the trials though

 

[Silvio Sabo]

Can someone please do a study to confirm or dis-confirm if regeneration of hearing via hair cell regrowth will reduce tinnitus or not?

There is no way we can confirm or dispute whether regeneration of hair cells will do anything before we actually manage to regenerate hair cells. For now all we can have are speculations.

 

[Silvio Sabo]

Can someone please do a study to confirm or dis-confirm if regeneration of hearing via hair cell regrowth will reduce tinnitus or not?

There is no way we can confirm or dispute whether regeneration of hair cells will do anything before we actually manage to regenerate hair cells. For now all we can have are speculations.

With that said I would speculate that if a regenerated hair cell also would make a connection with a nerve there is a good chance it will also effect tinnitus. I'm basing this on the research by Susan Shore PhD, where she has found that tinnitus starts in the Dorsal Cochlear Nucleus. And boosting input to the DCN from the cochlea should down regulate hyperactivity in the DCN since it seems to be caused by loss of input from the cochlea. But as I said this is only speculation. Nobody knows until we finally manage to successfully regenerate hair cells.

I will supply you with a couple of links below. I suggest you watch the lecture in the second one. It's really interesting stuff!

For more info see this thread:
https://www.tinnitustalk.com/threads/new-university-of-michigan-tinnitus-discovery-—-signal-timing.2805/

And this lecture by Susan Shore, PhD:

 

[Contrast]

7:52
If we can achieve that goal of hair cell restoration regrowth and make those hair cells connect up with the auditory nerve and fibers that connect to the brain that would be a marvelous thing for hearing loss and would in all likely hood correct tinnitus as well.

Hearing Health foundation stated this

 

[Contrast]

Let's see if the ATA and BTA will test this hypothesis in animal models.

two groups of rodents

12 control group
12 treated with a drug that is suppose to regenerate hair cells

1: Get a whole bunch of rats, expose them to 120 decibel loud noise for several hours and give them aspirin to highely increase the likely hood they develop tinnitus.

2: Determine anxiety in rats, or possibly even ways of measuring brain activity like Susan Shore does to indicate which rats have tinnitus

3: 24 rats now all have tinnitus and hearing loss

4: Wait 3 months to see which rats develop chronic tinnitus

5: 12 of them get treated with a hair cell regeneration agent a month post trauma, control group doesn't

6: confirm the hearing loss agent works

7: follow up for the next 6 months to see if reduction of tinnitus occurs in the treated group

publish results and also try to include hyperacusis to the factor as well

 

[Flamingo1]

1: Get a whole bunch of rats, expose them to 120 decibel loud noise for several hours and give them aspirin to highely increase the likely hood they develop tinnitus.

Now THAT'S cruel!!!

 

[JohnAdams]

Let's see if the ATA and BTA will test this hypothesis in animal models.

two groups of rodents

12 control group
12 treated with a drug that is suppose to regenerate hair cells

1: Get a whole bunch of rats, expose them to 120 decibel loud noise for several hours and give them aspirin to highely increase the likely hood they develop tinnitus.

2: Determine anxiety in rats, or possibly even ways of measuring brain activity like Susan Shore does to indicate which rats have tinnitus

3: 24 rats now all have tinnitus and hearing loss

4: Wait 3 months to see which rats develop chronic tinnitus

5: 12 of them get treated with a hair cell regeneration agent a month post trauma, control group doesn't

6: confirm the hearing loss agent works

7: follow up for the next 6 months to see if reduction of tinnitus occurs in the treated group

publish results and also try to include hyperacusis to the factor as well

I was taking a

Now THAT'S cruel!!!

Just imagine how relieved the rodents would be after they were cured though.

 

[JohnAdams]

7:52
If we can achieve that goal of hair cell restoration regrowth and make those hair cells connect up with the auditory nerve and fibers that connect to the brain that would be a marvelous thing for hearing loss and would in all likely hood correct tinnitus as well.

Hearing Health foundation stated this

http://truthatlas.com/researchers-develop-scaffolding-for-stem-cells/#sthash.gP8BGeXs.dpbs

from the last part;
"Stem cells are now used to treat blindness and hearing loss, but also diseases like Parkinson's and diabetes"
...hearing loss, where?

I actually had a consultation with a texas based stem cell clinic and they were willing to try and treat my tinnitus with adipose stem cells. The consultor said he has seen it work but I dont know exactly what to think about that. So technically yeah they are using stem cells to treat hearing loss, the question is effectiveness which may be as much as those stupid ring relief pills. I would think that if the cure for T was as simple as adipose stem cell injections into the blood stream that many users here would have done it already and be sharing their stories.

 

[JohnAdams]

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3417821/​

"Overexpression of β-catenin caused an increase in hair cell marker-positive cells"


https://www.ncbi.nlm.nih.gov/pubmed/24328990

​

"Common food additive carrageenan stimulates Wnt/ β-catenin signaling in colonic epithelium by inhibition of nucleoredoxin reduction."


https://en.wikipedia.org/wiki/Carrageenan

it's in edible red seaweed.

"Carrageenan has been studied in laboratory animals for its potential effects on intestinal and immune functions following oral intake or gavage, with no effects on organ pathology, clinical chemistry, hematology, or normal health.[26] Dietary carrageenan had no carcinogenic, genotoxic, developmental, or reproductive effects in laboratory animals, and was found to be safe in one study on human infants.[26] "

but then there's this.

https://wellnessmama.com/2925/what-is-carrageenan/

"Although derived from a natural source, it appears to be particularly destructive to the digestive system, triggering an immune response similar to that your body has when invaded by pathogens like Salmonella. The result: "It predictably causes inflammation, which can lead to ulcerations and bleeding"

So, here's this.

https://www.modernistpantry.com/car...MI7frz3JvA3AIVE4nICh18xw3uEAkYASABEgIZxPD_BwE

I (out of desperation) wonder if eating lot's of this stuff could trigger spontaneous regeneration of hair cells. Or give us cancer.

once again:
"Common food additive carrageenan stimulates Wnt/ β-catenin signaling in colonic epithelium by inhibition of nucleoredoxin reduction." "Overexpression of β-catenin caused an increase in hair cell marker-positive cells".

Food for thought. This seems to me to be as plausible as adipose stem cell injections. Definitely better that that nasty Apple Cider Vinegar or the over the counter pills that don't so jack squat.
​

 

[Samir]

Now THAT'S cruel!!!

They truly are the unsung heroes of our time!

 

[IvanRus]

I already talked about this. But probably it is worth saying again.

The whole horror of the situation is that those who have a slight hearing loss for a long time, causing tinnitus, or a loss above 8 kHz, which does not reflect on the usual audiogram, are probably in vain cherishing the hopes associated with the regeneration of the cochlear hair cells.

Hope, of course, should be, and it is not groundless! But I will remind one fact - the auditory system is very complicated, perhaps this is the most complex system of the human body. When some cochlear cells (responsible for the perception of certain sound frequencies) die or are damaged, then over time zones of the auditory cortex of the brain, which are not receiving these sounds for a long time, also begin to atrophy.

I know cases where people years after the loss of hearing and the beginning of tinnitus began to use hearing aids, the noise became quieter, yes. But the sounds of damaged frequencies, even if amplified by a hearing aid, were perceived unnaturally, or, more accurately, not at all perceived by the auditory cortex (brain).

 

[Contrast]

I already talked about this. But probably it is worth saying again.

The whole horror of the situation is that those who have a slight hearing loss for a long time, causing tinnitus, or a loss above 8 kHz, which does not reflect on the usual audiogram, are probably in vain cherishing the hopes associated with the regeneration of the cochlear hair cells.

Hope, of course, should be, and it is not groundless! But I will remind one fact - the auditory system is very complicated, perhaps this is the most complex system of the human body. When some cochlear cells (responsible for the perception of certain sound frequencies) die or are damaged, then over time zones of the auditory cortex of the brain, which are not receiving these sounds for a long time, also begin to atrophy.

I know cases where people years after the loss of hearing and the beginning of tinnitus began to use hearing aids, the noise became quieter, yes. But the sounds of damaged frequencies, even if amplified by a hearing aid, were perceived unnaturally, or, more accurately, not at all perceived by the auditory cortex (brain).

i guess i'll just kill myself if they can't restore my hearing due to the outdated 1940's audiogram

 

[IvanRus]

i guess i'll just kill myself if they can't restore my hearing due to the outdated 1940's audiogram

hearing aids don't amplify tinnitus.

Why are they obsolete?

They use the most modern digital apparatus with an extended range of amplification