Inner Ear Hair Cell Regeneration — Maybe We Can Know More

[Contrast]

Tinnitus can be induced by silent chamber/ear plugs and go away once removed
http://www.tinnitus.org/HB_Nov00.pdf
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366980/

Tinnitus from stadectomies (middle ear damage) usually can go away when the original problem is correctly

http://www.tinnitusjournal.com/arti...on-tinnitus-in-patients-with-otosclerosis.pdf



Tinnitus from sensori-neural hearing loss (inner ear damage) can usually be reduced or go away via cochlear implants.

http://www.tinnitusjournal.com/articles/can-cochlear-implants-decrease-tinnitus.pdf

Can researchers please address curing hearing loss as the most convincing way of treating tinnitus?
or prove these studies wrong

 

[jeff W]

Some work on SGN's, glad to see it.

 

[jeff W]

Here guys have a look at this, this injury (now called uvl)



which is roughly the equivalent of sudden sensorineural hearing loss, there is much debate (some of it more like fighting) over what exactly causes this injury, one theory set out here is that the different vascular layouts vary slightly in their pathways and this may be the reason for the disorder and also the reason for "rare" spontaneous recovery, as it is considered an irreversible deficit, what I found worrying was the described difference in skill/talent of preparing donated temporal bones for inspection, this means that the knowledge at the bench (if not correctly recorded for future generations) could be lost. The amount of information that goes through nerve viii is quite incredible,



Do have a peep, its an unusual paper.

 

[IvanRus]

Are there any positive news regarding the Regain project?

Until recently, I considered them to be the most promising project for hearing regeneration, but there is very little information lately. As I understand, they can be enrolled for clinical trials.

Who lives in the UK? Do you know something about this project?

Spoiler: link

https://www.regainyourhearing.eu/

Spoiler: link2

https://www.actiononhearingloss.org...earing-loss-to-take-part-in-a-clinical-trial/

 

[bell]

Whats about this? I haven't heard about this company

https://www.xconomy.com/boston/2018...secures-50m-for-hearing-loss-gene-therapy-rd/

 

[dmorg]

I haven't heard of Akous but I have heard of Spark Therapeutics as they are near Philadelphia. They did treat a boy with a gene therapy for his eyes that has been effective. I believe they charged a mere $425,000 per eye.

 

[lymebite]

A new blog post today by Gulf Coast Stem Cell in Mississippi, USA:

"Could Stem Cells Prove to Be Music to the Ears of Tinnitus Sufferers?"

http://www.gulfcoaststemcell.com/stem-cells-music-to-the-ears-of-tinnitus-sufferers/

It seems a bit unclear from the blog post whether or not they are suggesting their currently available stromal vascular fraction (SVF) stem cell therapy could be effective for tinnitus, or if they are just referring to the possibility in the future when places like Frequency Tx, Decibel Tx, and others make available targeted therapies developed specifically for hearing disorders.

 

[Contrast]

 

[Flamingo1]

View attachment 20762

What is OHC???

 

[Contrast]

What is OHC???

outer hair cell

 

[JohnAdams]

What is OHC???

Over Head Camshaft.

 

[Contrast]

We can make this a reality in 5 years or so

 

[Manny]

View attachment 20845

"treatments include cochlear hair cell regeneration" I know it's just Google's thing probably made by a bot...but still nice to see, obviously it's on the radar.
EDIT: Scammed by Contrast ;/

 

[Manny]

View attachment 20762

"OHCs die at a rate of .5% per year." I find that very interesting because that actually means the rate of decay slows as one ages.
Where's that a quote from?

 

[Contrast]

"treatments include cochlear hair cell regeneration" I know it's just Google's thing probably made by a bot...but still nice to see, obviously it's on the radar.

no read the post, it's an edit I made to show what the future could be if we are diligence.

 

[JohnAdams]

We should be excited. At this point Frequency knows if it works, and they wouldnt be attracting top scientists if they had a dud on their hands. My theory is that it does work, and they are quickly moving to expand this technology into other fields. We may see regenerative cures for all kinds of stuff coming soon.

https://www.businesswire.com/news/h...trengthens-Scientific-Advisory-Board-Addition

 

[JohnAdams]

"OHCs die at a rate of .5% per year." I find that very interesting because that actually means the rate of decay slows as one ages.
Where's that a quote from?

That's just like your nephrons in your kidneys.

 

[Jim51042]

Most people here throw around the word "cure" when the word they intended to use was treatment. Everyone here would be ecstatic for regenerative treatment which improves hearing and reduces tinnitus. This is much more likely in the near term then a cure. That said what would people consider a "cure". I would maybe say a 40 dB improvement in hearing at your worst freq over the 16KHz span and hearing silence with 30dB earplugs in. The earplug test is a good one and you can try them to see how loud your tinnitus is

 

[Iliasp]

Cure is defined by success of the treatment
Relief from symptoms to an adequate degree or full recovery is what everyone seeks and that would be cure "more or less"

 

[Contrast]

Why cochlear hair cell regeneration and or ribbon synapse repair (curing sensori-neural hearing loss) should help reduce tinnitus based on evidence in current hearing loss treatments

Treatments for sensori-neural hearing loss induced tinnitus
http://www.tinnitusjournal.com/articles/can-cochlear-implants-decrease-tinnitus.pdf
https://blog.medel.com/cochlear-implants-tinnitus-cure/
Cochlear implants reduce tinnitus

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315113/
electro stimulation of the audiotory nerve reduces tinnitus

Treatments for conductive hearing loss induced tinnitus
https://www.ncbi.nlm.nih.gov/pubmed/15379354
middle ear surgery reduces tinnitus

Treatments and experiments if blockage or ear wax was the cause of tinnitus
https://www.tinnitus.org.uk/ear-wax
ear wax removal

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366980/
Roland Schaette's ear plug experiments.

https://tinyurl.com/yd6jepka
1953 similar study to Roland's study.

@85dB T
@Autumnly

 

[jeff W]

Why cochlear hair cell regeneration and or ribbon synapse repair (curing sensori-neural hearing loss) should help reduce tinnitus based on evidence in current hearing loss treatments

Treatments for sensori-neural hearing loss induced tinnitus
http://www.tinnitusjournal.com/articles/can-cochlear-implants-decrease-tinnitus.pdf
https://blog.medel.com/cochlear-implants-tinnitus-cure/
Cochlear implants reduce tinnitus

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315113/
electro stimulation of the audiotory nerve reduces tinnitus

Treatments for conductive hearing loss induced tinnitus
https://www.ncbi.nlm.nih.gov/pubmed/15379354
middle ear surgery reduces tinnitus

Treatments and experiments if blockage or ear wax was the cause of tinnitus
https://www.tinnitus.org.uk/ear-wax
ear wax removal

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366980/
Roland Schaette's ear plug experiments.

https://tinyurl.com/yd6jepka
1953 similar study to Roland's study.

@85dB T
@Autumnly

Yes! It's the information where the hi-tech is!

 

[RingerBell]

Harvard Medical School: The Hearing Molecule

https://hms.harvard.edu/news/hearing-molecule

 

[IvanRus]

Everything would have been before.

Now Frequency might well have already completed clinical trials, or even enter the market.

It's all about George W. Bush, Jr., who severely banned any research and use of stem cells, as president of the United States.

It was stagnation, lasting as long as 8 years.

And it was not until 2009 that Barack Obama came and lifted the ban on research and use of stem cells.

He said people are waiting now, not tomorrow!
I really respect Obama for that.

 

[Contrast]

Everything would have been before.

Now Frequency might well have already completed clinical trials, or even enter the market.

It's all about George W. Bush, Jr., who severely b-nned any research and use of stem cells, as president of the United States.

It was stagnation, lasting as long as 8 years.

And it was not until 2009 that Barack Obama came and lifted the b-n on research and use of stem cells.

He said people are waiting now, not tomorrow!
I really respect Obama for that.

They aren't using embryonic stem cells, they are using progenitor cells, silly. But yeah I agree to lift the ban on embronic stem cells.

 

[jeff W]

Everything would have been before.

Now Frequency might well have already completed clinical trials, or even enter the market.

It's all about George W. Bush, Jr., who severely banned any research and use of stem cells, as president of the United States.

It was stagnation, lasting as long as 8 years.

And it was not until 2009 that Barack Obama came and lifted the ban on research and use of stem cells.

He said people are waiting now, not tomorrow!
I really respect Obama for that.

Bushes ban on es cell line use was the greatest thing that ever happened to the field, it shone a light on the area and provided media attention and funding opportunities they could have only dreamed of. It backfired badly.

 

[Ozwel]

Here guys have a look at this, this injury (now called uvl)



which is roughly the equivalent of sudden sensorineural hearing loss, there is much debate (some of it more like fighting) over what exactly causes this injury, one theory set out here is that the different vascular layouts vary slightly in their pathways and this may be the reason for the disorder and also the reason for "rare" spontaneous recovery, as it is considered an irreversible deficit, what I found worrying was the described difference in skill/talent of preparing donated temporal bones for inspection, this means that the knowledge at the bench (if not correctly recorded for future generations) could be lost. The amount of information that goes through nerve viii is quite incredible,



Do have a peep, its an unusual paper.

It is VERY interesting to see HSV (virus) studies related to ear damage.

It is not the first time I see this virus linked to meniere and tinnitus studies.

It would be very interesting to see who here has already tried to check if he has HSV (1 and 2) in his blood. I guess we'd be surprised to see the results... But it is also known as "mouth and genital herpes" so my other guess is that most of us wouldn't tell if we have it (even though we are all pretty much anonymous). For info 60% of infected people have this virus without herpes showing up on skin/mouth/genitals.

Now those whose tinnitus is due to HSV infection, the question is: it is impossible to cure that virus (very common one) so if we use an antiviral treatment (which exists) to make the virus sleep, will the tinnitus go away?

 

[jeff W]

It is VERY interesting to see HSV (virus) studies related to ear damage.

It is not the first time I see this virus linked to meniere and tinnitus studies.

It would be very interesting to see who here has already tried to check if he has HSV (1 and 2) in his blood. I guess we'd be surprised to see the results... But it is also known as "mouth and genital herpes" so my other guess is that most of us wouldn't tell if we have it (even though we are all pretty much anonymous). For info 60% of infected people have this virus without herpes showing up on skin/mouth/genitals.

Now those whose tinnitus is due to HSV infection, the question is: it is impossible to cure that virus (very common one) so if we use an antiviral treatment (which exists) to make the virus sleep, will the tinnitus go away?

Could be, or it could be an overblown response to the pathogen because of genetic contributions from the host. Another one is how does it get to into the ear? Gacek reckons the route it enters the ear could indicate the pathology. One of the reasons this is relevant to this thread is that we need to know if the damage caused by viruses like hsv is similar to toxic medications or old age or even ischemic damage, so we can find out of the inury sites respond to cell therapies. This chap has some mesmerizing IHMC talks, in fact he was brought back to do more due to the popularity of his interview, a leader in the field.

 

[IvanRus]

Why so slow and inert? I do not understand.

Sometimes I want to break into their labs (those who do hair cell research) and cling to a microscope to speed up the research itself. Time is running.

Now is the time, scientists need to hurry to excel in regeneration. We live at the peak of human development and at the peak of the use of cheap oil. Soon oil will begin to be a deficit, it will lead to a decline in science and economy. It would seem that everything is ready for regeneration now. The knowledge base is accumulated, there are super-powerful microscopes and computers, there are investments.

Why is a man in the 21st century still having to suffer such an invisible and killing fuck as a tinnitus? It is unacceptable.

We must declare in all ears. Create a film about tinnitus and hearing, on our collected money, spreading it on the Internet as a virus.

 

[Benoves]

It is VERY interesting to see HSV (virus) studies related to ear damage.

It is not the first time I see this virus linked to meniere and tinnitus studies.

It would be very interesting to see who here has already tried to check if he has HSV (1 and 2) in his blood. I guess we'd be surprised to see the results... But it is also known as "mouth and genital herpes" so my other guess is that most of us wouldn't tell if we have it (even though we are all pretty much anonymous). For info 60% of infected people have this virus without herpes showing up on skin/mouth/genitals.

Now those whose tinnitus is due to HSV infection, the question is: it is impossible to cure that virus (very common one) so if we use an antiviral treatment (which exists) to make the virus sleep, will the tinnitus go away?

That's interesting because I wondered it myself many times. I have HSV like this:

It's showing up every once in a while and when it does my tinnitus is much worse 1/2 days before till 1 days after. I think I have a bad spike and then the HSV shows up and I think oh it's just the HSV it'll go back to "normal" .

 

[Ozwel]

The point is, if a virus is involved and this virus can't be killed (hsv-like), can we simply regrow the ear cells and have no vertigo + T issues anymore?

I've actually been through 10+ years of T and now vertigo is getting in for a bit more than a year. My hope is that we can regrow hair cells thanks to the ongoing research at Frequency th. (fx322). My fear is that regrowing hair cells won't be enough...

Well, I've been waiting for 10 years, so now what is it to wait for another 10? Meanwhile, I have lost my youth and will never be able to live it again. Sorry for the personal thoughts.

That's interesting because I wondered it myself many times. I have HSV like this:

View attachment 21398

It's showing up every once in a while and when it does my tinnitus is much worse 1/2 days before till 1 days after. I think I have a bad spike and then the HSV shows up and I think oh it's just the HSV it'll go back to "normal" .

For info, there's a cure than can "block" HSV you can try if you feel like you must avoid HSV crisis. It won't kill the virus but will prevent it to go "on".