Inner Ear Hair Cell Regeneration — Maybe We Can Know More

[kelpiemsp]

Does anyone know if lieberman has determined how a process that lasts microseconds (an impulse noise) leads to the overproduction of a neuro transmitter (glutamate)? The last study of his I read, published in 2017, stated this as a problem with his current model and a direction for future research. Insinuating something other than impulse noise seems to be causing this. But I haven't read extensively.

 

[JohnAdams]

Does anyone know if lieberman has determined how a process that lasts microseconds (an impulse noise) leads to the overproduction of a neuro transmitter (glutamate)? The last study of his I read, published in 2017, stated this as a problem with his current model and a direction for future research. Insinuating something other than impulse noise seems to be causing this. But I haven't read extensively.

That's interesting because I have noticed myself that the duration of certain noises, not the intensity super spikes my tinnitus. I fell asleep with my fan on 2 and woke up 3 hours later and tinnitus was going insane. Super super loud, turned my fan down to 1, and woke up this morning feeling like a normie.

 

[JohnAdams]

Interesting video. It's dated 2013. I realize mice and humans are both mammals, but jumping from mice to humans feels like a huge step to overcome. Maybe that's what they've been working on for the last five years. I want this to work as much as anyone, but this is the therapy I'm having the hardest time getting excited about.

They already tested it in a donated human cochlea and it worked.

 

[Paulmanlike]

https://www.openaccessgovernment.or...aring-loss-and-tinnitus-towards-a-cure/54155/

Nothing new to the long term followers, but a general insight on how things are improving in terms of funding for hearing loss compared to a decade ago. A brief mention of GenVec with their gene therapy and talk about stem cells and University of Sheffield.

Nevertheless, some hope for any HL sufferers out there. Personally, a cure for tinnitus is all I want - I think the title is misleading mentioning tinnitus as the leading HL companies are hoping to kill two birds with 1 stone and we are waiting to still see if any of these therapies would solve tinnitus.

 

[rsmcfar]

This came across my news feed.

https://tendaily.com.au/news/austra...-s-military-fund-australian-research-20181108

 

[JohnAdams]

Looks like the balls are roll'in. God please hurry these people up.

 

[Frédéric]

For those who are interested and able to understand: see attached file.
ACTIVITY-DEPENDENT CHANGES AT THE AUDITORY NERVE SYNAPSE

 

[reeseth]

This came across my news feed.

https://tendaily.com.au/news/austra...-s-military-fund-australian-research-20181108

A little bit more information can be found here. But else it's the same news.

https://mobile.abc.net.au/news/2018...ible-for-common-form-of-hearing-loss/10477498

 

[1000]

A little bit more information can be found here. But else it's the same news.

https://mobile.abc.net.au/news/2018...ible-for-common-form-of-hearing-loss/10477498

The treatment is still a few years away from human trials, but the US Department of Defence is so excited by the prospect it has committed $1.1 million to the research.

 

[RB2014]

https://hearinghealthfoundation.org...uIWMgh-cx-iGKerBM8sHXo__iVC1xkYMjQG0plYzkzgCA

HHF article that just came out on various research.

 

[Reinier]

Not sure if this is the correct thread to post this question, but I don't think it is worth a new thread.

Does the Stanford initiative to cure hearing loss still exists?
I can not find it on their website when I want to donate.

 

[GregCA]

Not sure if this is the correct thread to post this question, but I don't think it is worth a new thread.

Does the Stanford initiative to cure hearing loss still exists?
I can not find it on their website when I want to donate.

Here: https://hearinglosscure.stanford.edu/giving/

 

[Ozwel]

For those who are interested and able to understand: see attached file.
ACTIVITY-DEPENDENT CHANGES AT THE AUDITORY NERVE SYNAPSE

Is there a way someone makes a summary of this?

I had a look at the abstract but didn't get where this could lead us to...

 

[Reinier]

Here

Thanks for that.
I bookmarked it for my next donation.
Also relieved they continue researching.

 

[newarrior]

Thanks I just posted to my 1000's of Twitter, Facebook and Linkedin followers...

"Hearing loss is becoming an epidemic/pandemic and the general public as well as as businesses are ill informed as to the dangers of loud noise. The #1 disability veterans and former and current military suffer from is hearing loss/tinnitus.

Your donations are heartily requested!

And turn down the volume!

https://hearinglosscure.stanford.edu/"

 

[lapidus]

Researchers in Israel have created "the first map of "methylation" — one of the body's main epigenetic signals — that reflects the functioning of the inner ear in its entirety."

Their analysis "revealed a large number of new genes that are critical for the development of the inner ear and the onset of hearing itself."

"Epigenetic signals — among them methylation — don't allow the genes that could regenerate hair cells to be turned on, If we can discover how these genes are controlled — how they're turned on and off — we may be able to modify these signals to allow regeneration to happen."

https://www.aftau.org/weblog-medici...SRnea301ebVmHoT9gN0fBfBHgcOVBT2k3MsfVfJd2niKc

http://kbalab.com/?fbclid=IwAR3kzhbPDfab3vPUJdrEvT-HRt1ZZaIxvXyTAJj6ZTDhNIVGza4uRe3_vPw

 

[JohnAdams]

If we can discover how these genes are controlled — how they're turned on and off — we may be able to modify these signals to allow regeneration to happen."

Aren't they already doing this and testing it in humans?

 

[newarrior]

Is this good or bad news ? Damage to the cochlea is serious news

 

[RB2014]

New company for hearing loss

Also launching today is San Francisco-based Spiral Therapeutics. The company secured $3.7 million in Series A financing to support the Phase I trial of its lead candidate LPT99, which targets prevention and treatment of hearing loss. Since Spiral was initially founded in 2016, the company has raised more than $8.3 million. The Series A was co-led by Savoir Capital and Camden Partners. Spiral said it intends to secure additional funding as part of this financing round.

Spiral said it intends to initiate the Phase I trial in Australia with 32 healthy patients. The study is expected to be completed by the second quarter of 2019. Hugo Peris, the founder and CEO of Spiral, said the trial confirms the company's development capabilities, as well as its understanding of inner ear disorders.

"We will continue to leverage our core competencies in advancing the development of LPT99 and expanding our pipeline," Peris said.

 

[Contrast]

Charles Limb?
Spiral Therapeutics


This sounds like a mockup of
Charles Liberman
Decibel Therapeutics


strange coincidence.

 

[Bambam0]

While remaining ever so skeptical yet optimistic, I'd say that the race has officially begun.

 

[PDodge]

View attachment 24975
Charles Limb?
Spiral Therapeutics


This sounds like a mockup of
Charles Liberman
Decibel Therapeutics


strange coincidence.

Weird

 

[john paul]

^^ What the hell?

 

[john paul]

That's interesting because I have noticed myself that the duration of certain noises, not the intensity super spikes my tinnitus. I fell asleep with my fan on 2 and woke up 3 hours later and tinnitus was going insane. Super super loud, turned my fan down to 1, and woke up this morning feeling like a normie.

Could be the fan, could be interrupted sleep pattern. In the early days if I woke up in the middle of night my tinnitus was always going mad. It stopped doing it after a few months thankfully.

 

[Manny]

Okay everybody on this board who has a son please name them Charles, maybe that way we'll get a shit ton of researchers and get cured ASAP

 

[Pero1234]

Okay everybody on this board who has a son please name them Charles, maybe that way we'll get a shit ton of researchers and get cured ASAP

Or he may end up in a wheelchair, running a school for mutants!

 

[JohnAdams]

Weird

And it's Spiral Therapeutics????

 

[PDodge]

And it's Spiral Therapeutics????

Yes!?! Go Charles(s)

 

[Deathtotinni]

It won't help severe hearing loss.

Quit pretending it will.

It might man.

 

[ruben ruiz]

Is it true that the current USA administration has outlawed adipose stem cell therapy?