Inner Ear Hair Cell Regeneration — Maybe We Can Know More

I haven't checked forums about tinnitus since 2009

 

i liked these lines from the decibel article.

" Data suggests “by restoring the synapse, the inner ear hearing circuit can be preserved, and hearing can be restored and maintained,” the company said. "

"Decibel is not the only company looking at new therapies for hearing loss. Other companies in the field include Otonomy(OTIC), Auris Medical (EARS), Autifony Therapeutics, and Audion Therapeutics. On Aug. 1, Otonomy announced the successful completion of a one-year, multiple-dose clinical safety trial of OTO-104 in patients with Ménière’s disease. In July, the U.S. Food and Drug Administration granted Fast Track Designation to Auris’ Keyzilen for acute peripheral tinnitus. "

like i said... this is the worst time to give up, something good for us is gonna come out soon

 

Acousia Therapeutics

http://www.biocentury.com/biotech-p...s-to-generate-hair-cells-for-hearing-loss-a05

It's not news that Acousia Therapeutics works with Boehringer Ingelheim ad they cooperate with Kyoto University
But it's new to me that they compare their approach diractly with the Novartis Trial.

 

So Acusia, Boehringer and Kyoto are working together?

 

I did misunderstand.

 

Yes interesting. It does look like that to me too when I read the summary. Already preparing for competition?

The first thing I focussed on was the word "preserved". This would be too late for me.
But than I read "restored" and "maintained", which sound much more attractive to me. Especially restored.

 

Yes, Boehringer has Acousia in it's portfolio and they work with Kyoto University.
Acousia is a small conpany founded by the same guy who founded one of the first company doing research on hair cell regeneration back in the 90's called Otogen.
One part of Otogene founded Soundpharmaceuticals.
So both might have a similar base of hair cell regeneration technology (speculation).

 

Everyday I do the lotto and the funny thing is I couldn't care less about the money,I just want to win so I can donate it all to this research lol

 

i actually do the same, not daily but every month i buy lottery tickets so i can donate!!

 

If you want to make the most of your money for research, you're better off giving the money you spend on lotto directly to research, and not buy your lotto ticket.
That's how, statistically speaking, research is going to get the most money from you.

You'd be surprised how much you can collect that way. It adds up quickly.

 

I don't think the money matters anymore. Too many start-ups now competing for a multi-billion dollar business. Money talks and companies listen.

 

If I won on lotto I would instead buy a beach house on some beautiful beach in tropical Asia with jungle sounds in the backyard and ocean sounds in front and inside the house and I would indulge in lifetime natural masking sounds of nature

 

I already donated some higher amouts directly to a research lab, they are very very thankful and it's also a motivation if they see that people care about their work.
I know, it's a little drop on a very hot stone, but it's something I can do.
Believe me, they are doing absolutely passionate research no because of the money, they do research to help people!.

But yes, every lottery bilionaire is welcome to donate!

 

Too many startups competing for a treatment for Tinnitus? Are you joking?

 

Lol yeah your probably right,I don't know why but I hate giving little donations as it seems minuscule in the grand sceam of things but it's all I have to give right now.I dream of being able to send 10,20,30 maybe even 40 mill to worthy caring organisations that are genuinely trying to fix this problem,presuming that my numbers came out for the EuroMillions.I know though,it's nearly impossible to win but screw it who knows,nothing would get those labs working harder than 40 mill getting thrown their way

 

Not tinnitus, hearing loss. We are in the inner ear hair cell regeneration thread, but Yeah good point. No one cares about T. Hair cell regeneration could help or cure T though as a side affect if the T is caused by loss of hair cells. That is probably a ways out though. I'm thinking the first treatments will get people from severe/profound to moderate. Even that won't cure T since even moderate is at least 50db away from perfect hearing and you can get T with as little as a 10db loss.

 

Nothing would get them spending more than having 40 mil thrown their way, working not so much.

 

I am thankful to you too sir.

Just think. People that do experience hearing problems (tinnitus, hyperacusis, Ménière, etc....) have difficulty understanding to what extend it can effect one's life. There already is much better understanding if someone in ones family has hearing issues.

Don't expect people to donate to research if there is no personal experience in this debilitating affliction.

I too donate what I think I can spare every month. (I need to put money aside for a future cure though)

I am thankful to all the people that donate!

 

Which institutes are worth donating? I donated once to harvard and once to some UK institute

 

I am donating to Action On Hearing Loss, Stanford initiative to cure hearing loss and Hearing Health Foundation.

 

yes i mean standford not harvard. and second was HHF so its same.

 

Unfortunately I have to agree with you there,seeing 40 mill sitting in their account brings out the greed in people with complete disregard for the greater good which is why I probably wouldn't give to them in one big payment but more so spread out payments in an effort to cut out reckless spending.Theres no point even discussing this though,sadly my numbers aren't coming in anytime soon lol.

 

It is difficult to choose. There are more universities that do excellent work.
I choose HHF and Action On Hearing Loss because they are not commercial undertakings.
Also they bring together different researchers.

On a you-tube clip from 2012 Stanford talked about a 10 year "roadmap" initiative to cure hearing loss. (First clinical trial in ten years from 2012).
I have not yet heard that this 10 year estimate has changed. So they are still "on track"? Or at least no big disappointments.
www.youtube.com/watch?v=z7cXcmEynIQ

 

I mean Bull shit for that est., so, reading is argent. member 8930

 

All that 10 year talk was replaced to within our lifetime. I'm pretty sure that whole 10 year thing is out the window as they realized it wasnt going to happen in such a short period of time. I remember comments like, "its a lot harder than we first though", etc etc and then they replaced the 10 year window with the lifetime pitch. It could still happen now that private companies have jumped on the bandwagon, but I don't think anyone foresaw that this early in the game.

 

more than 13 years ago, some companies wrote that hair cell regeneration will be available today. The 10 years term is equ than "we don't know but there is a chance to get there"
But when I look back the last 10 years, we have some clinical trials running now, that's great! Next 10 years will bring even more exciting things imagine we could enhance some sensitivity in hearing or lowering T for some degree....I don't thing there will a diamond treatment soon.
I hope one of the companies like Auris can earn some big money and invest in more advanced treatments like regeneration.

 

Call me Optimistic but i believe it can take less than 10 years.
Science is moving so fast since 2010.
its incredible the amount of news and articles about the subject we get per month.

 

I am disappointed now. I did not realise this.
But the first clinical trial has started some time ago and the next starts in 2017?
Not too long ago Action On Hearing Loss made a bold statement that in the next 5 years clinical trials could start. Very general, but positive anyway.
I agree with @tomytl. Things seems to be happening.

 

....and there are maybe more coincidences like the finding, that an Alzheimer candidate is potentionally able to trigger hair cell regeneration in some degree.
Probably the timeline for stem cells and an application for a treatment is more in the future than a drug based treatment developed from the knowlegde aquired by stem cell research in the auditory system.
Stem cell replacement would probably tue gold standard, but I believe there are some silver and bronze inbetween....

 

Could it be like this?: For a drug based treatment researcher need to understand in detail how to manipulate cell division/trans differentiation. All the molecules, steps, processes, etc...
In stem cell therapies it is the stem cells that "steer" the processes and have all the information in DNA and RNA. Often like nature/evolution "intended".
More serendipity with stem cell therapies. We would call it serendipity because all the processes are not yet mapped.
I already read several times that stem therapies did unexpected healing.

Or is this too simple or even complete rubbish?