Inner Ear Hair Cell Regeneration — Maybe We Can Know More

I don't think, that the reconnection of one single nerve can give you the strong sensation of fleeting T.
I rather expect it to be some biochemical reaction affecting many hearing cells or nerves at once.

 

Looks good!
Do you have some background information?
They already are talking about being able to move quickly into clinical testing. (not specific, but in general)

 

Hi,
no I don't have specific information about.
I just know, that some of these people work for very long in their field and very seriouse, so I think, when they found a company and have a strategy, there might be something behind

 

Thanks.
I agree.
I think it is very positive that new companies are founded, in cooperation or perhaps even initiated, by people from research. A logical next step from research if they expect things to happen.
Yet another company to put on my short-cut list (-;.

 

Maybe this is of interest:
http://hearinghealthfoundation.org/blog?blogid=246

"the researchers found that intense noise exposure significantly altered the expression of six genes (Ccl12, Tlr2, Oprd1, II1b, Ntrk1 & Kcnq3) in the cochlear nucleus (Manohar et al., Molecular and Cellular Neuroscience 75 (2016) 101–112). These results suggest that noise-induced inflammation in the parts of the central auditory pathway that also processes sensory information related to pain might, in turn, activate the central pain pathway thus producing ear pain. Determining whether neuro-inflammation is directly responsible for ear pain will open the door for novel interventions to treat hearing loss and hyperacusis."

 

My thoughts on T with my DIY hearing loss treatment,
https://www.tinnitustalk.com/thread...wth-factor-1-as-sshl-salvage-treatment.16310/

tl;rd - although hearing is being restored, Tinnitus (and magnitude of) remains the same. Suspect vascular issue.

 

I remember reading this earlier. And now I found something similar on the internet.
http://www.dkf.unibe.ch/downloads/rc/Conference_September_2016.pdf

Quote:
We then developed a method to generate otic cells from human embryonic stem cells (hESCs) using molecules that induce the formation of the ear in vivo. In this way we generated otic progenitors that can produce sensory hair cell-like cells and auditory neurons. When hESC-derived otic progenitors were transplanted into an animal model of auditory neuropathy, they survived, engrafted and differentiated into neurons. Moreover, they connected with the hair cells and the brain and, more remarkably, they elicited a functional recovery represented by improved ABR thresholds
End quote.
Fascinating that the neurons connected with the hair cells and brain.

 

Indeed, I remember reading something similar. We don't know why it's happening yet, but it seems to happen.
In some ways, I don't care if we don't know the cause, as long as it happens. Although for science purposes, it'll be good to know why.

 

The speed at which we are gaining knowledge on how we hear is just crazy. Better think of something soon because the headphones generation will be doomed in 10 - 15 years.

Thought provoking read for sure, thanks.

 

I would just be curious about a date or rough timeframe that hair cell regeneration might be possible .

 

Nobody can predict it of course, so we can all provide wild guesses. My own guess is that we'll be able to start clinical trials in 2022, and available to "the public" in 2025.
You don't want to know where I pulled those numbers from. (out of thin air is the answer! what were you thinking?)

 

So much in science is serendipity. Where would we be if there was no serendipity? This reconnecting was not anticipated.
But, yes, as long as it works. Later, scientists can find ways to understand why it works(-;.
I suppose it must have something to do with DNA in cells. DNA or RNA is the only part in a cell that has the information how to build.

I could live with that

 

Not very good news I think. Another part that could be damaged after NIHL. )-;
It is good for the understanding of the whole process.

 

There is ongoing trial already and Audion is filling papers for trial in 2017

 

If we find that we can regenerate hair cells by 2020, We will push that therapy fairly quickly through the system. I'm estimating 2023 I'll be able to ask my doctor about getting the treatment.

 

I can live with that too
We are already writing down years. 2025, 2023....
Tricky but nevertheless interesting to read the reasons for estimation.

 

My estimate came from three years ago we were just talking about clinical trials. Now we are in clinical trials. And if they are successful, three years from now we will be able to fine tune the treatment. Three years after that would hopefully be mainstream in some hospitals.

I believe there is a Moore's law to the medical world. Especially if you have as much research and money being thrown at it as the hearing world is right now.

 

@Mricha37
Outcomes from clinical trials can also be very disappointing.
But I agree that next year we should have 2 clinical trials already. (Genvec and Audion?).
Also the starting of companies by researchers is a positive indication that some things could materialize.

 

Again someone like myself who has owned multiple businesses in the past, you don't bum rush a failing industry/idea. It seems like a lot of researchers know more than we think if they are starting their own labs and actually getting outside funding. I think everyone will be surprised what happens within the next 3 years.

 

Hi, very good finding!
Maybe I can join this conference, it's just 3 hours by car from my city.

 

It would be interesting to know how many researchers in otology recently liaisoned or started companies in this field.

 

Which trial targets hair cell regeneration? Is there a paper or entry on clinicaltrials.gov ?

 

Yes, https://clinicaltrials.gov/ct2/show/NCT02132130?term=CGF166&rank=1

 

Thanks! That's quite encouraging!

 

There is already 3 trials, going on... So no one knows for sure.

 

One for hair cell regeneration. Am I correct?

 

I recently read about some advances in cross section palsy research. A team at university Zuerich are moving to phase II clinical trials.
It has some similarities to hair cell research, both are about connecting nerves.
A big difference is the lenght of the nerve endings. While in the inner ear webspeak about probably some milimeters, in a cross section palsy patient they need to regrow centimeters.
I know, it's something completly different, but it's amazing to see the advances in other fields of regenerative medicine.

 

was this already posted, i found it today..



http://www.eurekalert.org/pub_releases/2016-08/sfn-jhf081716.php

 

If I regain hearing and my problem becomes that the number of supporting cells gets depleted, then I think it's a good problem to have. The alternative is to not have any new hair cells, so I'll take the depletion of supporting cells anytime.

 

Just a coincident that I was reading about neuroscience and in vivo reprogramming for CNS repair.
I wonder if breakthroughs in other fields of medicine can and will boost hearing related issues. It makes sense to me.

http://www.cell.com/neuron/fulltext...896-6273_20160817_91_4_&elsca4=Cell Press

Quote: In the past 3 years, we have witnessed rapid advances for a new technology with the potential to transform the CNS repair field through in vivo reprogramming internal glial cells into functional neurons.

And: In vivo reprogramming is still in its early stages, but the technology is already showing great promise for cell regeneration and tissue repair. While many people in the stem cell field are still working on in vitro stem cell differentiation before in vivo transplantation, scientists have increasingly realized the potential of in vivo reprogramming as an effective regeneration strategy.
End quote.