Inner Ear Hair Cell Regeneration — Maybe We Can Know More

[spingee]

I have lived in my fathers house for nearly two years now bc of my T. I have suicidal thoughts all day every day and the depiction in my head of him finding me dead really is the one thing that gets to me. I burst out in tears every time. But I want it to be him that finds me. Feels comforting to me in a way.

The one good thing about crying though is that I find it help me to cope for atleast a little while after.

Anyway, maybe I should keep this to myself. This at least is not the tread for it I know!

But I have another thing at heart here: We have talked alot about how audiograms may or may not explain our T, the frequency, the loudness and how severe it affects us.

Look at my audiogram and bear in mind I have unilateral T. in my right ear. Now, I have done a T. frequency-matching test and it is in the 11000-12500 HZ region. Look at the steep dip I have in my right ear in excactly that region.
I mean, its self explanatory, right? But I have as much hearingloss in my left ear, but not as steep curve as in my right ear. I have contemplated selfafflicted damage to my right ear to even the curve out, looking more like my left ear. But how can I destroy hair cells only sensitive in the 10.000Hz field. Not possible, right?
My dad, who is a engineer in aucoustics says the curve follows classic filter theory, but I really don´t understand what it means.
View attachment 11142

Anyway, maybe someone finds this interesting, I don´t know. Thanks for reading!
Hopefully I´ll live to see the day, when HC regeneration will level that fucking curve out and I can have a life again!

That dip can be becouse you dont hear tone above your T tone

 

[grate_biff]

That dip can be becouse you dont hear tone above your T tone

Interesting, but I doubt it, cause how would I then hear better the even higher tones. As you see, my hearing improves in the levels above my dip. Also I was on a healthy dose of benzo when I took the test and my T. was very faint at that perticular time.

 

[Reinier]

Tinnitus is an enigma.
My right ear has most hearing loss at 9-10kHz. My tinnitus is 9.5 kHz.
My left ear has not got this dip at 9-10 kHz.
Yet I hear a 9.5 kHz tinnitus in my left ear too. Sometimes louder than my more damaged right ear.
The only correlation I see is the frequency of tinnitus versus dip in audiogram of my right ear. Exactly what your audiogram shows. Not the amount of hearing loss seem to be correlated to tinnitus loudness. But that already has been proved many times, reading experiences on this forum.

Also 9.5 kHz is not a typical noise damage according to audiologists. Yet this dip was the result of noise.
So in my humble opinion this typical noise damage idea needs revision. Perhaps typical is important in this context.

My dad, who is a engineer in aucoustics says the curve follows classic filter theory, but I really don´t understand what it means.

What I think he means is that the downwards slope in your audiogram is a certain number of dB per octave. This is how acoustic or electronic filters in audio are described.

I agree with @spingee . I sometimes experience the uncomfortable feeling of tinnitus, yet my tinnitus is not loud.
I wonder if we experience tinnitus at high frequencies we can not hear any more for whatever reason.
It is often younger people that experience tinnitus frequencies higher than 10 kHz. Not older people.

But this does not mean that you are not able to hear higher frequencies from outside the ear above your tinnitus frequency. Just look at your audiogram.
But this is only the thoughts of a layman(-;

 

[grate_biff]

Tinnitus is an enigma.

Yeah, since its all processed in the brain I guess it is.
But it seems that our brain can process a more gradual hearingloss better than a sudden one. Atleast when it comes to T.

Also 9.5 kHz is not a typical noise damage according to audiologists

I know. I think 4kHz is more sensitive to noise damage. Thats what my audiologist says.
This is my audiogram for the lower frequensis:

Again this correlates with my T, as I have a tonal T at that frecuenzy aswell(4 kHz). Again you can see a steeper dip in the right ear. This T just doesnt bother me as much. The T. around 12.000 Hz is the one thats killing me. Electrical as hell.

 

[Aaron123]

Could we return the discussion to research on the inner ear? There are separate sub-forums on Awareness and Fundraising and Support to discuss these other issues.

 

[Ears Hurt]

I have lived in my fathers house for nearly two years now bc of my T. I have suicidal thoughts all day every day and the depiction in my head of him finding me dead really is the one thing that gets to me. I burst out in tears every time. But I want it to be him that finds me. Feels comforting to me in a way.

The one good thing about crying though is that I find it help me to cope for atleast a little while after.

Anyway, maybe I should keep this to myself. This at least is not the tread for it I know!

But I have another thing at heart here: We have talked alot about how audiograms may or may not explain our T, the frequency, the loudness and how severe it affects us.

Look at my audiogram and bear in mind I have unilateral T. in my right ear. Now, I have done a T. frequency-matching test and it is in the 11000-12500 HZ region. Look at the steep dip I have in my right ear in excactly that region.
I mean, its self explanatory, right? But I have as much hearingloss in my left ear, but not as steep curve as in my right ear. I have contemplated selfafflicted damage to my right ear to even the curve out, looking more like my left ear. But how can I destroy hair cells only sensitive in the 10.000Hz field. Not possible, right?
My dad, who is a engineer in aucoustics says the curve follows classic filter theory, but I really don´t understand what it means.
View attachment 11142

Anyway, maybe someone finds this interesting, I don´t know. Thanks for reading!
Hopefully I´ll live to see the day, when HC regeneration will level that fucking curve out and I can have a life again!

I'm sorry to read your post. We all suffer here. It's just crazy there is nothing that can help us. I think if they could even find a medicine that quiets the T to give people a break from it would be a big step on the right direction. It kills me that mine is the fault of another human. I have a hate in me that I thought could never exist.

Aaron is right this post is for something for hair cell regeneration. An important topic for all of us to hopefully get a cure soon.

 

[Mario martz]

Strengthening Cells To Prevent Or Reverse Hearing Loss

"Guthrie is in the process of developing drug therapies to repair damaged ear cells and prevent hearing loss. Some day he hopes to produce a pill to take, say, before a construction worker uses a jackhammer, or after you come back from a loud concert."

http://knau.org/post/brain-food-strengthening-cells-prevent-or-reverse-hearing-loss#stream/0

 

[Mricha37]

Anybody have any more interesting reads they have found on the internet?

 

[lapidus]

Anybody have any more interesting reads they have found on the internet?

Well there's this. Posted August 16. Maybe not entirely on topic for this thread but still.
http://hearinghealthmatters.org/hearinginternational/2016/new-look-cochlear-physiology/

 

[Mario martz]

this might be importanto to have here...

 

[Mario martz]

For me Marcelo Rivolta/Charmes Liberman
or... Kyoto University are the ones who are gonna come up with a surprise.

 

[Mricha37]

If you're not excited about that list there...not sure if tinnitus and hearing loss is your problem lol.

 

[Reinier]

If you're not excited about that list there...not sure if tinnitus and hearing loss is your problem lol.

There are probably also many people that, after many years of reading about, "breakthroughs" are getting sceptical.
I hope I still can get enthusiastic about these breakthroughs in 5 years time.
Breakthroughs give me positive energy(-;

 

[tomytl]

Some probably good signs:
http://www.fiercebiotech.com/biotech/genvec-we-re-not-a-victim-novartis-r-d-cuts

 

[Christian78]

because I was discussing hair cell regeneration already 10 years ago, and now it's a clinical trial running by Novartis and it's likely that within the next 3 years there are some more clinical trials with the aim to "cure" some hearing.
Maybe it's "easier" to do this, than look for some chemicals to stop a phantom noise nobody exactly knows where it coming from.
Ofcourse it's always a very long way that a drug will get it to the market.
But while hair cell regeneration is a new class of medicine, we might be move into a new way of how things will work.
It's a very specific treatment, reprogramming a cell cycle.

And thanks for the PDF regarding this new findings.

i think honestly as world is going nowhere they will start testing on humans in China and India, death raw prisinors and so...

 

[Vinnitus]

Some probably good signs:
http://www.fiercebiotech.com/biotech/genvec-we-re-not-a-victim-novartis-r-d-cuts

Still, these are the things that make me nervous. Companies suddenly cutting budgets for no apparent reason (at least not stated in the article). If ever a working treatment for hearing loss will take more than 10 years, things like this will be the reason for it. Not so much the technology or dedication of the researchers, but as always; funds.

For now, they are saved... I would be even more bummed if they got cut down in phase 2 or 3...

 

[Mricha37]

Not getting funds cut for those labs is a good sign to me. They might be putting all their eggs in one basket because they are that confident there will be positive results.

 

[Reinier]

Some probably good signs:
http://www.fiercebiotech.com/biotech/genvec-we-re-not-a-victim-novartis-r-d-cuts

Interesting to see what stock prices are going to do after the weekend.
I sure hope you are correct and good things will happen with these first ever hair cell regeneration trials.

 

[Neilpk]

I thought Aut-0063 failed already.

 

[grate_biff]

I thought Aut-0063 failed already.

Its trialed for different things

 

[Aaron123]

Its trialed for different things

True, but so far AUT00063's track record is not good.

• On October 13, 2015, Autifony halted the trial for tinnitus.
• On August 9, 2016, Autifony announced that it failed to show a benefit in the trial for age related hearing loss.

A trial for Cochlear Implant users is on-going. That's the last hearing related trial listed on their web page as well as the last listed trial for AUT00063. They also have a schizophrenia using a different compound.

 

[Mricha37]

I didn't have high hopes for them anyways.

 

[Neilpk]

I tried looking online but I couldn't see what AUT00063 is potentially being used for.

Any ideas?

 

[Aaron123]

I tried looking online but I couldn't see what AUT00063 is potentially being used for.

Any ideas?

See my post two above yours.

 

[Candy]

Would all the drugs above only target Tinnitus where hearing loss is present?
Is there anything in the pipeline for neutron over activity, which I believe would cover every type of Tinnitus?

 

[cornelius]

Maybe not bad news that autifony stopped. Many oral drugs are often full of serious side effects, like Trimetazidine which was praised to the skies by some presumteous Ent doctors and drug representatives in last decades for tinnitus treatment. 15 years ago an ent doctor prescribed me a vasodilator pill, also sold as "tinnitus treatment" and tinnitus was raised along with serious detuned hearing. And by the way Autifony is trying to treat schizophrenia with an oral drug, and it is known that until nowadays, every oral drug to treat it either finishes to kill the patient or make him worse than without drugs. Therefore it may be better they are left out from inner ear research. Though saving lives in some emergency cases, pills should further in the future become a thing from the past because of the low benefit proportions compared to serious side effects. "Tinnitus pill" here, "tinnitus pill" there, we know the routine.

 

[grate_biff]

Maybe not bad news that autifony stopped. Many oral drugs are often full of serious side effects, like Trimetazidine

What was the sideeffects of this drug? Been pondering trying it for T.

 

[Aaron123]

What was the sideeffects of this drug? Been pondering trying it for T.

There's a separate thread on Trimetazidine. (https://www.tinnitustalk.com/threads/vastarel-trimetazidine.6609/) Probably makes more sense to ask there.

 

[grate_biff]

There's a separate thread on Trimetazidine. (https://www.tinnitustalk.com/threads/vastarel-trimetazidine.6609/) Probably makes more sense to ask there.

Well, I saw now that I had. Its a short tread indeed!

 

[grate_biff]

This was posted in another tread by @beeeep. Just thought I´d post it here aswell as its very relevant to this tread

https://www.actiononhearingloss.org...-transport-stem-cells-into-the-inner-ear.aspx