Inner Ear Hair Cell Regeneration — Maybe We Can Know More

[tomytl]

Let us just hope the GenVec trial started a snowball effect.
http://www.dizziness-and-balance.com/disorders/bilat/regeneration.htm
Quote: "this is not accompanied by functional improvements in hearing (Atkinson et al, 2014). The hair cells generated are not functional."
End quote.
I am confused now.
I distinctly remember different Pubmed summaries where hearing was improved after haircell regeneration in animals. Also I read that the new haircells connect. (They have to in order to improve hearing threshold).
Most of all: will GenVec/Novartis start clinical trials in humans when there was no improvement in hearing threshold in animals?

This is exactly what I'm asking myself too.
If there were no signs of hearing regeneration, why doing human trials? I asked this question to a hair cell researcher. He mentoined, that nobody else in the field could regenerate hearing using Atoh1 and that this is likely to fail...
He just mentioned, that they probably hide something in their labs because if there is a commercialisation it's not public anymore.
I also found following article which sounds interesting, but I don't think Genvec is using this method.
http://journals.lww.com/thehearingj...ser_to_a_Gene_Therapy_for_Hearing_Loss.6.aspx

Another top notch researcher I don't want to undisclose said, that the have much better ways to regenerate almost any form of deafness/hearing loss in the pipeline.
From what I read one of the biggest problem is to regenerate sufficient number of hair cells in the adult cochlea.

But as soon researchers can screen drugs in an "ear in a petri dish" or equivalent I think they have many good candidates.
With tools like the Draper Pump they could apply it to the inner ear.

I think a lot of critical tools and drug candidates are here, the next year gonna be exciting!

Another thing mentioned in an article I read that Novartis invested 500 Mio Dollars in Atoh1 research... I don't know if it's true or if Atoh1 research is just used for ears...

 

[tomytl]

Another interview from Mr. Parker concerning Atoh1
http://www.audiologypractices.org/t...in-audiology-an-interview-with-dr-mark-parker

 

[Reinier]

He just mentioned, that they probably hide something in their labs because if there is a commercialisation it's not public anymore.

Yes this makes sense.
The other links I found interesting reads.
Especially this I find interesting:
http://www.audiologypractices.org/t...in-audiology-an-interview-with-dr-mark-parker
Quote: Quite frankly, our current methods (i.e. obtaining an audiogram) are crude assessments of the auditory system because we cannot determine whether the hearing loss is due to hair cell or spiral ganglion damage. They both present the same on an audiogram. This is important in terms of biological treatments because we need more precise tests to determine whether a hearing loss is due to hair cell damage, which would lead to Atoh1 gene therapies for hair cell replacement, or due to spiral ganglion degeneration, which could lead to cell-based therapies for spiral ganglion replacement. Measuring hidden hearing loss and dead regions of the cochlea are hot topics of auditory research and are leading to better tests to assess of the integrity of inner hair cells, outer hair cells, and spiral ganglion cells. So, to answer your question, I see the growing role of audiologists as the experts in diagnosing the otopathology of sensorineural hearing loss and measuring the effectiveness of these future treatments.
End quote.
I knew it.
But the hearing pill will not be available for quit some time.

 

[tomytl]

Here is the official site of the Regeneration Project and Audion Therapeutics.
http://www.regainyourhearing.eu/

 

[BohemianLife]

Here is the official site of the Regeneration Project and Audion Therapeutics.
http://www.regainyourhearing.eu/

This is exciting. I hope we won't hear bad gossips like Atoh project about this project. Do you have any information about when they will start to take volunteers or tests ?

 

[tomytl]

This is exciting. I hope we won't hear bad gossips like Atoh project about this project. Do you have any information about when they will start to take volunteers or tests ?

No, I don't have any other infos about this project. I hope this will be an initial start for hearing regeneration.I just hope, this treatment will be also for long term hearing loss not just acute hearing loss.

 

[Mario martz]

Here is the official site of the Regeneration Project and Audion Therapeutics.
http://www.regainyourhearing.eu/

Their design is so awful!!
i would re-design it for free or to trade for information

 

[Mario martz]

Another interview from Mr. Parker concerning Atoh1
http://www.audiologypractices.org/t...in-audiology-an-interview-with-dr-mark-parker

This is by far! the most interesting i have read in the past months.

 

[tomytl]

Genetic Reprogramming of Supporting Cells in Cochlea Generates New Hair Cells
Hair cells -- auditory receptors located in the cochlea -- fail to regenerate when damaged, and hair cell loss is the leading cause of hearing disorders. Supporting cells in the cochlea can differentiate into hair cells, but this often depletes the population of supporting cells. Researchers have found a way to genetically reprogram supporting cells in the mouse cochlea so that they both proliferate and differentiate into hair cells, which may suggest new ways to stimulate hair cell regeneration in hearing disorders

http://www.eurekalert.org/pub_releases/2016-08/sfn-jhf081716.php

 

[Mario martz]

Genetic Reprogramming of Supporting Cells in Cochlea Generates New Hair Cells
Hair cells -- auditory receptors located in the cochlea -- fail to regenerate when damaged, and hair cell loss is the leading cause of hearing disorders. Supporting cells in the cochlea can differentiate into hair cells, but this often depletes the population of supporting cells. Researchers have found a way to genetically reprogram supporting cells in the mouse cochlea so that they both proliferate and differentiate into hair cells, which may suggest new ways to stimulate hair cell regeneration in hearing disorders

http://www.eurekalert.org/pub_releases/2016-08/sfn-jhf081716.php

I posted about this a week ago, but i dont understand where to find more info about it...

 

[gotyoubynuts]

Genetic Reprogramming of Supporting Cells in Cochlea Generates New Hair Cells
Hair cells -- auditory receptors located in the cochlea -- fail to regenerate when damaged, and hair cell loss is the leading cause of hearing disorders. Supporting cells in the cochlea can differentiate into hair cells, but this often depletes the population of supporting cells. Researchers have found a way to genetically reprogram supporting cells in the mouse cochlea so that they both proliferate and differentiate into hair cells, which may suggest new ways to stimulate hair cell regeneration in hearing disorders

http://www.eurekalert.org/pub_releases/2016-08/sfn-jhf081716.php

I posted about this a week ago, but i dont understand where to find more info about it...

See the PDF document I uploaded...

 

[Christian78]

Can someone tell me why we discuss about cell regeneration when this will not happen in next 10 years?

 

[Christian78]

See the PDF document I uploaded...

lucky mouses they get always tinnitus fixed and regenerations, just humans never

 

[gotyoubynuts]

Can someone tell me why we discuss about cell regeneration when this will not happen in next 10 years?

What else is there to discuss. Auris Medical failed with their trial and trials take 10 or more years to complete.

Hair cell regeneration is our next big hope

Or else we will be trapped with the tinnitus forever!!

 

[Christian78]

well tinnitus is more located in limbic system that is connected with audio cortex, so i think some kind of chip is going to be solution. Brain is big computer and some pill will not really help, eather they invent artificial ear or they implement some kind of chip that will be implanted. I dont beleave in chemistry.

And btw chemistry did not solve any of neurological simptoms, like essential tremors and simmular...

Tinnitus is as i see not important, more is war with illegal immigrants and terorism

 

[Mario martz]

The topic of this thread is inner hear cell regeneration.
and thats what we are discussing....

 

[Alue]

What else is there to discuss. Auris Medical failed with their trial and trials take 10 or more years to complete.

Hair cell regeneration is our next big hope

Or else we will be trapped with the tinnitus forever!!

I have lost all hope in any kind of cure anytime soon. Potassium channel openers (trobalt) pose an interesting form of 'treatment' albeit not cure, if a more targeted one were to be developed. IT NMDA receptor antagonists were a relatively simple treatment when compared to regenerative medicine and even that took a decade and did not yield very positive results.

I don't think, that the reconnection of one single nerve can give you the strong sensation of fleeting T.
I rather expect it to be some biochemical reaction affecting many hearing cells or nerves at once.

I don't know what to make of it, but I stopped getting fleeting T after my open label AM101 injections. Could be coincidence, but I don't think so. Unfortunately it did nothing for the dog whistle in my head.

 

[tomytl]

Can someone tell me why we discuss about cell regeneration when this will not happen in next 10 years?

because I was discussing hair cell regeneration already 10 years ago, and now it's a clinical trial running by Novartis and it's likely that within the next 3 years there are some more clinical trials with the aim to "cure" some hearing.
Maybe it's "easier" to do this, than look for some chemicals to stop a phantom noise nobody exactly knows where it coming from.
Ofcourse it's always a very long way that a drug will get it to the market.
But while hair cell regeneration is a new class of medicine, we might be move into a new way of how things will work.
It's a very specific treatment, reprogramming a cell cycle.

And thanks for the PDF regarding this new findings.

 

[Reinier]

@gotyoubynuts
I read the PDF you attached.
I wonder if we can expect some real interesting developments from China after reading the document.
In 2015 they talked about this in vitro and one year later in vivo. That is pretty fast I think.

 

[racerfish]

When I first got T 11 years ago, there was nowhere near all the research stuff that I'm reading here. I used to use the Yuku Tinnitus board which I think is still active. Reading all these research articles gives me hope that there will be a cure sooner rather than later. And it definitely helps reduce my anxiety.

 

[Mario martz]

When I first got T 11 years ago, there was nowhere near all the research stuff that I'm reading here. I used to use the Yuku Tinnitus board which I think is still active. Reading all these research articles gives me hope that there will be a cure sooner rather than later. And it definitely helps reduce my anxiety.

Yes this are the type of comments that really matters,
science is going faster than ever, more than 10 years ago.

 

[tomytl]

@gotyoubynuts
I read the PDF you attached.
I wonder if we can expect some real interesting developments from China after reading the document.
In 2015 they talked about this in vitro and one year later in vivo. That is pretty fast I think.

Many Chinese researchers are some of the top people. Many also work in coorporation with western universities or labs.

 

[Mricha37]

2023 I'll be getting my regeneration done, just gotta decide on which facility ;-)

 

[Reinier]

2023 I'll be getting my regeneration done, just gotta decide on which facility ;-)

Do you know something we don't know? Please elaborate

 

[tomytl]

Do you know something we don't know? Please elaborate

yes please ;-)

 

[BohemianLife]

@tomytl
@Reinier
He wrote about this on his previous message. I wondered what he intend when he said "Some kind of hearing".

 

[tomytl]

ok, some will not occure in the next 5 years...
http://www.hearingreview.com/2015/04/drugs-hearing-loss-prevention-expected-5-years/

 

[tomytl]

@tomytl
@Reinier
He wrote about this on his previous message. I wondered what he intend when he said "Some kind of hearing".

Maybe, some amount of hearing.
I would be absolutel happy if I would get 20dB boost on 1-2 khz... ohhh, this would be cool... or maybe some more clearness...
Then it would mask my T better.

 

[Reinier]

ok, some will not occure in the next 5 years...

That link was 2015. We are in 2016 now. So it is 4 years.
But I agree. The first treatments will be for preventing after a noise incident. The next step perhaps very moderate gain.
Me too will be very happy with 20dB. And this blasted distortion and hyperacusis is like torture every single day.

 

[grate_biff]

He came home to find his youngest son lifeless. He told me it's the worst feeling in the world to loose a child and he started to cry.

I have lived in my fathers house for nearly two years now bc of my T. I have suicidal thoughts all day every day and the depiction in my head of him finding me dead really is the one thing that gets to me. I burst out in tears every time. But I want it to be him that finds me. Feels comforting to me in a way.

The one good thing about crying though is that I find it help me to cope for atleast a little while after.

Anyway, maybe I should keep this to myself. This at least is not the tread for it I know!

But I have another thing at heart here: We have talked alot about how audiograms may or may not explain our T, the frequency, the loudness and how severe it affects us.

Look at my audiogram and bear in mind I have unilateral T. in my right ear. Now, I have done a T. frequency-matching test and it is in the 11000-12500 HZ region. Look at the steep dip I have in my right ear in excactly that region.
I mean, its self explanatory, right? But I have as much hearingloss in my left ear, but not as steep curve as in my right ear. I have contemplated selfafflicted damage to my right ear to even the curve out, looking more like my left ear. But how can I destroy hair cells only sensitive in the 10.000Hz field. Not possible, right?
My dad, who is a engineer in aucoustics says the curve follows classic filter theory, but I really don´t understand what it means.

Anyway, maybe someone finds this interesting, I don´t know. Thanks for reading!
Hopefully I´ll live to see the day, when HC regeneration will level that fucking curve out and I can have a life again!