Inner Ear Hair Cell Regeneration — Maybe We Can Know More

I have a roadie who lost hearing due to too many of our concerts, and thus developed T as well. He got hearing aids last summer, and they stop the T completely. I'm assuming this is due to re-establishing the lost frequencies. When he takes them out, it doesn't take long before the T returns...talking minutes. Kind of makes me question the chronic versus acute thing too. He had T for years before getting the hearing aids, so if the brain "adapted", wouldn't the T remain regardless? T certainly is an enigma!

I have worn a hearing aid/masker for 14 months now and my T hasn't improved at all. Your roadie is lucky and would assume, he has minimal or moderate hearing loss, not severe, SSHL? My masker is set at 65db's and my T can drown out the masker most of the time.
 
Hello,
(excuse me for intruding like this in the chat)

Man, your words just described the feelings I have experienced since the last few years....

As well i fight these symptoms since 2012 i also ungrateful punishment for not having protected myself while it was time.
I do not depend of music to pay my bills but music is still part of my way of life and i have to be super disciplined to me not exceed the limits of what my ears can now support (unfortenaly they can not follow up the excitement of my soul).

Well, I know the miracle cure has not yet arrived but I share here a youtube link that have been helped me at least a little (could be placebo but hepls me to concentration at work and i have the real feeling this estimulate a bit my inner cells/ auditory nerve...)



It costs nothing to try this "therapy" (its free of $$££€€) and you can used all the time you need.

All the best!
Cheers,
Ricardo


Thanks for showing me this Ricardo. The bad news is that I tried using this therapy about 2 months ago while I still had some feelings of myself and a little bit of hearing sensations left. Unfortunately it didn't do anything and my hearing continued to change to what it is now although I thought it was helping for a little bit. I still appreciate your generosity!
 
Well @Nick Pyzik,

as i said i didnt expect to give you any miracle solution / just share something that helps me a little as i found similar symptoms in your reports (maybe other members wanna try and find interesting....)

I usually watch this thread and your words touched me / i know some day will be a cure or at least a better relieve!
...in the meantime we have to support each other the best we know or can.
Cheers,
Ricardo
 
What do you think of all of that tomytl? I wish they talked a bit more in depth about treatments that were being developed but it was still interesting. It would of been cool if stem cells had been brought up in it.
Hi Nick,
I think they didn't talk about stem cells because it's the most complex approach in hair cell regeneration and therefore the most far away treatment to test in human.
I just mean with the article that the professionals have very different timetables.
So everything is possible in the next 10 years. I hope we will see a further trial (hopefully a molecular therapy) with a regenerative approch.
 
I have worn a hearing aid/masker for 14 months now and my T hasn't improved at all. Your roadie is lucky and would assume, he has minimal or moderate hearing loss, not severe, SSHL? My masker is set at 65db's and my T can drown out the masker most of the time.

He's got pretty bad hearing, and just wears "standard" hearing aids; no masker in them. He certainly could be one of the lucky ones.
 
Hi Nick,
I think they didn't talk about stem cells because it's the most complex approach in hair cell regeneration and therefore the most far away treatment to test in human.
I just mean with the article that the professionals have very different timetables.
So everything is possible in the next 10 years. I hope we will see a further trial (hopefully a molecular therapy) with a regenerative approch.
Although hair cell regeneration is extremely important for those who are deaf and those who have damaged their frequency range levels with the hair cells in the cochlea, I just wish the neurons working with the hair cells were looked at in the same way too. They are just as important and sometimes I think play much more of a unique and helpful way to ones mental health and hearing capabilities. I mean sure I'm more worried about this because it's what's going on with my hearing but I believe it's very much associated with age-related hearing loss when talking about new nerves that reach out and take the place of the original neurotransmitting afferent/efferent nerves. I think stem cells differentiated in the correct way could help resolve these problems and not just regenerating hair cells because like I said above. The nerves play just as much of an important and unique role in hearing/processing/emotions like the hair cells do with converting sound waves in the frequency range they work with.
 
@tomytl I checked out your link and ended up at Rockefeller university.
They have an interesting laboratory of sensory neuroscience department where a lot about our hearing is explained.
talking about complexity: http://lab.rockefeller.edu/hudspeth/
thank you for sharing, it's indeed interesting. Rockefeller, Harvard, MEI, Draper.. all this labs doing such great research and I'm sure, all knowledge together will end in some usable and needed treatment. I guess most of us would be happy with a 50% enhancement if the situation, if it's tinnitus or hearing loss.
 
@tomytl I checked out your link and ended up at Rockefeller university.
They have an interesting laboratory of sensory neuroscience department where a lot about our hearing is explained.
talking about complexity: http://lab.rockefeller.edu/hudspeth/
Still no mention of auditory nerve synapse damage. Much more vulnerable to acoustic trauma than hair cells.

But still good progress and news!
 
Still no mention of auditory nerve synapse damage. Much more vulnerable to acoustic trauma than hair cells.

But still good progress and news!

Once I talked to a hair cell regeneration specialist and he mentioned, that if they can trigger hair cell regneration, the cell should magically make a proper connection to the auitory nerve.
Ofcourse, everything is speculative, because no human got this treatment, but researchers are optimistic.
 
Once I talked to a hair cell regeneration specialist and he mentioned, that if they can trigger hair cell regneration, the cell should magically make a proper connection to the auitory nerve.
Ofcourse, everything is speculative, because no human got this treatment, but researchers are optimistic.
When did you talk to them? That's good to hear. I'm just very curious with the new study of how new nerves form with the cochlea hair cells when we lose our original auditory nerve fibers due to noise/old age. There are attributes about these new forming nerves that aren't good. I'm just wondering if the brain would form new well working afferent/efferent nerves that would have the right neurotransmitting functions that a healthy auditory nerve should have.
 
When did you talk to them? That's good to hear. I'm just very curious with the new study of how new nerves form with the cochlea hair cells when we lose our original auditory nerve fibers due to noise/old age. There are attributes about these new forming nerves that aren't good. I'm just wondering if the brain would form new well working afferent/efferent nerves that would have the right neurotransmitting functions that a healthy auditory nerve should have.

It's not soo long time ago. Maybe I could send him some questions people in this thread would like to know.
But I can't promise if he is willing to make speculative statements to the public.
I could ask if he would like to.
 
It's not soo long time ago. Maybe I could send him some questions people in this thread would like to know.
But I can't promise if he is willing to make speculative statements to the public.
I could ask if he would like to.
That would be great! I was talking to another organization that's working on developing a hair cell treatment in their office that should be ready in 5-6 years and they explained a little bit about the way the treatment would work with sensory cell regeneration and auditory nerve functions. They even explained that they would need to regenerate a new sensory cell to take the place of the newly formed mature hair cell that was once a sensory hair cell....if that makes sense.
 
That would be great! I was talking to another organization that's working on developing a hair cell treatment in their office that should be ready in 5-6 years and they explained a little bit about the way the treatment would work with sensory cell regeneration and auditory nerve functions. They even explained that they would need to regenerate a new sensory cell to take the place of the newly formed mature hair cell that was once a sensory hair cell....if that makes sense.

ok, that's interesting. I think they are all on a good way and pushing some similar buttons, but I guess
the combination might be the key. But first we all would be happy to have a silver standard of a cure.
Imagine, there is just absolutely NO drug on the market who has a profen and causal outcome.
So if there is 30% relief from the first drugs would be fantastic.
 
ok, that's interesting. I think they are all on a good way and pushing some similar buttons, but I guess
the combination might be the key. But first we all would be happy to have a silver standard of a cure.
Imagine, there is just absolutely NO drug on the market who has a profen and causal outcome.
So if there is 30% relief from the first drugs would be fantastic.
Yes it would be nice for people to get relief from tinnitus although I don't fully support the whole system of just aiming to get rid of the noise....it would still be great progress. I just hope that this back and forth email I had with this company wasn't just jibberish and they actually are trying to accomplish this feat by the next 5-8 years.

They also said they would have a tinnitus drug treatment out by the next 2-3 years.
 
Once I talked to a hair cell regeneration specialist and he mentioned, that if they can trigger hair cell regneration, the cell should magically make a proper connection to the auitory nerve.
I am pretty sure that this is what has been shown to happen. If I can find the document I will post it. I remember because I was amazed that information stored in our cells do just that. I do not remember too what extend this happens.
When people hear new frequencies after hair cell regeneration, these regenerated hair cells are connected to the auditory nerve. It is very well possible that these new connections are rudimentary. Not integrated and functional at the same degree like lost connection where. This is why I am interested to know if the repair mechanism in birds are only partial. I read that birds are able to recognise other birds again after regenerated hearing. But our hearing is more evolved and has perhaps more complex tasks to perform. So, we do see the new hair cells after hearing damage in birds. But do we know to what extend the new connections are made?

http://lab.rockefeller.edu/hudspeth/research/Cellular_projections
Also look at this "synaptogeneses" The word says it all.
 
Yes it would be nice for people to get relief from tinnitus although I don't fully support the whole system of just aiming to get rid of the noise....it would still be great progress.
I agree. I have tinnitus and hyperacusis. Yet I am more interested in an approach to repair the damage. It would be wonderful if in the mean time a "quick fix" would be available. But if getting rid of my tinnitus and hyperacusis means I will not be eligible for a hearing restoration in future I would persevere and wait another 10-15 years. This is me personally. I read that other people have more severe tinnitus and hyperacusis.
 
Once I talked to a hair cell regeneration specialist and he mentioned, that if they can trigger hair cell regneration, the cell should magically make a proper connection to the auitory nerve.
Ofcourse, everything is speculative, because no human got this treatment, but researchers are optimistic.

I think this is what part of scientists believe, perhaps the bigger part. But there is a difference of opinion in the community, targeting re-connection of these synapses by boosting NT3 (Neurotrophin-3) is G.Korfas' work and they are not dealing with regenerating hair cells. They claim it is a different thing altogether: http://www.claimseval.com/research-aims-to-reverse-noise-induced-hearing-loss/

We of course read lately there are even more methods , such as stem cells, etc, with a different approach. I think you posted a very interesting link above (not sure where it is) with all the possible restoration directions and universities, including NT3 method, I am not sure where exactly it is, but it is a great posting...
 
Interesting is the fact this is an article from a company that is a: " accredited Independent Review Organization providing timely, objective and conclusive reviews to the Workers' Compensation, Disability, Auto, Liability and Group Health markets. review"
Quote:
"In the future, insurers and employers could find themselves paying for the restoration of some claimants' hearing instead of hearing aids".
End quote.
Can this imply that, according to their assessment, hearing restoration is not a pipe dream and could become reality?
Another quote:
"Claims Eval are committed to providing objective, defendable, evidence-based, peer-to-peer consultation surrounding medical necessity, causality and appropriateness of care."
End quote.
This is looking at the hearing regeneration field from another angle.
In my defence : I am new at this. I only got my hearing damaged 8 months ago. Perhaps news like this has been around for a lot longer.
 

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