Inner Ear Hair Cell Regeneration — Maybe We Can Know More
- Thread starter Hopeful
- Start date
Member
Well, pretty much everything you read everyday is "allegedly". All the research papers shared on this forum can also be seen as "allegedly" since they're all written by the people who allegedly conducted the experiments. In the case of research papers there is actually more to be gained by lying, such as big research grants etc., than there is by claiming to have gone through a pricy treatment on an online forum.
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I wasnt trying to be a smart ass. If someone could explain objectively how stem cells help tinnitus I'd sell all of my belongings and fly my sorry butt down to Thailand tomorrow to stemcell21.
There is a lot of information in the treatments section in the threads about stem cells. There is also some research papers on the subject. Very recently a study using stem cell treatments on deaf children was published, I think it can be found here on the forums too.
There is also a lot of info about stem cells when it comes to treating other ailments and neurological issues that are relevant.
In short, stem cells secrete factors that promote healing and cell growth.
That treatment used cord blood, which you cannot get yet unless you use your own.
"To follow both these aspects we select donor umbilical cord tissue-derived mesenchymal stem cells (MSCs)."
Source: https://stemcells21.com/about-stem-cells/mesenchymal-stem-cells/
I kept my baby coord blood in a German coord bank in case she would need it. Could I (as her mother) get benefitted of taking a part of the Cord to treat my hearing lost or just my daugther would benefit in case she need it ?
clone yourself or trick adult stem cells into a state where they behave as juvenile stem cells.
Looks promising and quite unexpected:
https://www.prnewswire.com/news-rel...-of-sensorineural-hearing-loss-819015935.html
I think results are from this trial:
https://clinicaltrials.gov/ct2/show/NCT03331627
Anyone knows something more?
https://www.prnewswire.com/news-rel...-of-sensorineural-hearing-loss-819015935.html
I think results are from this trial:
https://clinicaltrials.gov/ct2/show/NCT03331627
Anyone knows something more?
I've literally been checking the news everyday for the past 3 years on this shit.
How am I just hearing about this now?
Well. The mention of "rescue" and the noted mechanism of "anti-inflammatory activity" in the below quote do seem to indicate it's for acute HL, as you said. But, the final sentence makes it sound like it could be for chronic too.
"Multiple beneficial effects" is mentioned too (I.e. not only anti-inflammatory).
I think it's possible they're not exactly sure themselves yet?
Quote:
"Through our work, we found that a single injection of STR001 into the middle ear is highly effective to promote restoration of hearing by rescue of auditory hair cells from noise-induced trauma in rats," said Dr. Fetoni. "We were excited to find that STR001 has multiple beneficial effects, including significant anti-oxidant and anti-inflammatory activity in critically important cochlear structures. This is an exciting time in hearing research, and we believe that STR001 offers the opportunity to positively impact the lives of people suffering from sensorineural hearing loss." (ibid)
PolishSoldier87
Member
- Jan 16, 2018
- 209
- Tinnitus Since
- 12/2017
- Cause of Tinnitus
- acustic trauma, neuro-lyme/rx co-op toxins
It's anti-inflammatory. It doesn't allow cells to die, so only for acute, I think. Nothing new.
Inclusion Criteria:
Inclusion Criteria:
- Male or female patients aged ≥ 18
- Patients with a SSHL within 96 hours of its perception
- Sudden Sensorineural Hearing Loss including
- idiopathic unilateral Sudden Sensorineural Hearing Loss or
- acute uni- or bilateral acoustic trauma-induced Sudden Sensorineural Hearing Loss
Rings-a-Bell
Member
Maybe not entirely true. I have experimental evidence! There have been 3 times that I have tried going on 60+mg of prednisone per day for a few days. Each time there was a notable reduction in my tinnitus and according to hearing tests, that I ran at the time there was a 10db improvement in my ability to hear at my most hearing impaired frequency of 4000hz. Prednisone is a strong anti-inflammatory and this indicates to me that both my noise induced hearing loss and my Tinnitus are partially contributed to by an ongoing inflammatory process. I ran my tests 4 months, 6 months and 9 months after initial onset, well outside the acute timeperiod. After going off prednisone (because you can't stay on high doses like that for long), my T and hearing returned to baseline.
MichaelF6161
Member
I'm not sure I follow your logic. If you suffered an acoustic trauma, that means the outer hair cells (more than likely) were damaged by said trauma. I don't think that indicates ongoing inflammation, but rather those structures are broken, almost like a bone is.
Stem cell research I have seen uses them to make those cells in that area regenerate new ones. I can't find the link to the paper right now, but I think there was some promising research done at the University of Washington in 2016 that was able to regenerate these cells in animal studies.
I may be completely wrong since I am new to this (unfortunately), and steroids had no effect on my T. Based on the number of posts on this forum with similar results, I don't think that outcome is that uncommon. Don't get me wrong. I'm glad you can get relief on high doses of prednisone. That certainly is a clue as to what may help you. It's too bad you can't stay on them. They completely made my life miserable for 10 days. Never, ever again.
Best of luck.
Rings-a-Bell
Member
Not logic so much as experimental observation. The first time I took prednisone was for an issue unrelated to my original acoustic trauma and hearing loss. I was surprised to note that my T reduced and hearing chart improved. I repeated the experiment twice and got the same result twice. Somehow prednisone helps my ears. Since it is primarily an anti-inflammatory, my only hypothesis is that there must be some sort of ongoing long term inflammation that was triggered by my original acoustic trauma.
You don't need your cord to get stamcells. Stamcells can be found in whole your body (blood, bone marrow...). The only problem now is to cultivate them and get enough numbers... extracting them them from the body is easy
MichaelF6161
Member
Well, I think that is good news in a way. Perhaps you can find some other form of anti-inflammatory supplement or diet that can help you. I hope that is the case. Good luck.
Rings-a-Bell
Member
I agree. Since then I have experimented a bit with natural supplements and am currently trying Fish Oil. It might help a bit, but nothing like pred. Note that it takes pretty massive doses of prednisone to have an effect. When I was tapering and down to 40mg, the T and hearing reverted to normal.. and 40mg is still a lot of that drug.
MichaelF6161
Member
You are correct about that. I tapered down to 40mg a day for several days before finally getting to 20mg to finish the course, and at 40 I felt awful. I mean just awful. Racing heart, couldn't sleep, aggravated, nocturia, etc.
Just glad to be off it. I was hopeful that it would do something since I was only about 3 weeks post-trauma, but alas, it did nothing beneficial.
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