- Jul 8, 2019
- 1,160
- Tinnitus Since
- 1991
- Cause of Tinnitus
- Loud Music / family history
Hey Hans,Yes.
I also came up with an explanation on what might have happened to me (first timing made matters better, second timing made them worse).
Source 1: Neuromod's clinical trial protocol https://pubmed.ncbi.nlm.nih.gov/31573942/
Source 2: Susan Shore's 2018 study https://pubmed.ncbi.nlm.nih.gov/29298868/
Findings:
This means that according to Shore's research, the difference between Lenire's PS1 and PS4 timings is large enough to cause completely opposite effects. So what I've experienced is explained by the research. And what's still better, this predicts that PS1 will work again for me.
- PS1 is Lenire's first setting, for everyone. "PS1 consists of a sequence of tones mixed with structured wideband noise, in which the tones are synchronized in time with electrical pulses presented to the tongue" [1]
- PS4 was the second setting for me, though this varies per patient. "PS4: Similar to PS1, except that a randomly
varying short delay (0-30 ms) is introduced between the tone and tongue stimuli" [1]- Shore's trial has determined that the effect of bimodal stimulation is very dependent on timing. She found that delays as low as 5 couple ms mean the difference between increasing or decreasing tinnitus. "We show, in vivo, that auditory-somatosensory stimulation strengthened or weakened neural synchrony between fusiform cells, depending on the bimodal stimulus order and timing." [2]
By the way I had another of those nights when I just stayed up listening to how quiet my tinnitus is. Knock on wood, hope not to jinx it, but maybe I've entered the "Lenire is working its magic" phase again.
I think this is a very important observation you've made. Did you report it to Neuromod?